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Evolution of a Holocene banner bank controlled by morphodynamics and structural setting of a macrotidal coast: Saint-Brieuc Bay (NW-Europe)

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Geoscience Frontiers 2021年第5期12卷 166-181页

作者： Kalil Traoréa David Menier Erwan Gensac Pascal Le Roy Clément Lambert Paul Bessin Kevin Pedoja Anne Duperret Romain Le Gall Laboratoire Géoscience Océan UMR 6538CNRSUniversitéBretagne SudCampus de Tohannic56000 VannesFrance Laboratoire Géoscience Océan UMR 6538CNRSIUEMUniversitéBretagne Occidentale29280 PlouzanéFrance Laboratoire de Planétologie et Géodynamique UMR 6112CNRSLe Mans UniversitéAvenue Olivier Messiaen72085 Le Mans CEDEX 9France Laboratoire Morphodynamique Continentale et Côtière UMR 6143CNRSUniversitéCaen Normandiecampus 12-4Rue des Tilleuls14000 Caen cedexFrance Laboratoire Ondes et Milieux Complexes UMR 6294CNRSUniversitéLe Havre Normandie53 rue de PronyCS8054076058 Le Havre cedexFrance

The morphology and internal structure of the Horaine Bank(Bay of Saint-Brieuc,NW France)are described based on multibeam echosounder and high-resolution seismic datasets coupled with vibro-core *** Horaine Bank shows large-scale bedforms in the lee of a submerged rocky shoal,which allowed defining it as a Banner *** internal structure of the sandbank reveals four seismic units(U1-U4)on a Cambrian basement(U0).The basal unit U1 is interpreted as reworked lowstand fluvial sediments those infilled micro incised valleys during a rise in sea *** unit is overlain by paleo-coastal barrier sand-spit(U2)whose development was controlled by swell in the context of a rapid rise in sea *** successive prograding unit(U3)is interpreted as flooding deposits in continuity with unit *** unit U4 is characterized by oblique reflectors oriented in two opposite *** last unit,dated post 3500 yr BP,corresponds to migrating dunes superimposed on the bank and observable in the high-resolution bathymetric *** strong correlation between tidal currents and the apparent clockwise migration of dune crests suggests the presence of a tidal gyre controlling the present-day dynamics of most of the Horaine bank *** study proposes a new model for the construction of banner banks characterized by the gradual transition of a sand spit to a banner bank during marine transgression and ensuing hydrodynamic variability.

关键词： Sand banks Banner bank Holocene climate Geomorphology Sea level rise Tidal gyre

中能区64Zn+27Al反应中集体流的实验研究

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中能区64Zn+27Al反应中集体流的实验研究

Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma

第九届全国核物理大会

作者：贺智勇 J.Peter J.C.Angelique A.Auger G.Bizard R.Brou A.Buta C.Cabot E.Crema D.Cussol Y.El Masri Ph.Eudes M.Gonin K.Hagel A.Kerambrum C.Lebrun A.Peghaire R.Popescu R.Regimbart E.Rosato F.Saint-Laurent J.C,Steckmeyer B.Tamain E.Vient R.Wada 中国科学院近代物理研究所 lpc caen ISMRAIN2P3—CNRS14050 CAEN CEDEXFRANCE GANIL BP5027 14021 CAEN CEDEXFRANCE Institut de Physique Nuclear UCL1348 Louvain—La—NeuveBELGIUM LPN Universite de Nantes44072 NANTES CEDEXFRANCE Cyclotron Institut Texas A&M UniversityCollege StationTX77843USA

核物质集体流的研究是重离子碰撞中很重要的一个研究课题,通过它可以探讨核物质状态方程．压缩效应和重离子碰撞动力学等．最近,我们在中能区观察到了集体流及其消失,买验是在法国 GANIL 加速器上进行的,用49,57,69和79 MeV/u 的“Zn ...

核物质集体流的研究是重离子碰撞中很重要的一个研究课题,通过它可以探讨核物质状态方程．压缩效应和重离子碰撞动力学等．最近,我们在中能区观察到了集体流及其消失,买验是在法国 GANIL 加速器上进行的,用49,57,69和79 MeV/u 的“Zn 束轰击Al 靶．前角3°至30°间粒子的探测由96块塑料闪烁体片组成的塑闪墙完成,塑闪墙分七环,靶距210cm．中后角30°至150°间

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World Journal of Gastroenterology 2006年第26期12卷 4185-4190页

作者： Frédéric Di Fiore Stéphane Lecleire Olivier Rigal Marie-Pierre Galais Emmanuel Ben Soussan Isabelle David Bernard Paillot Jacques-Henri Jacob Pierre Michel Digestive Oncology Unit Hepatogastroenterology Department Rouen University HospitalFrance Digestive Oncology unit Francois Baclesse Centre CaenFrance Radiotherapy Department Henri Becquerel Centre RouenFrance

AIM： The aim of the study was to evaluate the predictive factors of survival in patients with locally advanced squamous cell esophageal carcinoma （LASCOC） treated with definitive chemoradiotherapy （CRT） regimen based on the 5FU/CDDP combination. METHODS： All patients with LASCOC treated with a definitive CRT using the 5FU/CDDP combination between 1994 and 2000 were retrospectively included. Clinical complete response （CCR） to CRT was assessed by esophageal endoscopy and C-F-scan 2 mo after CRT completion. Prognostic factors of survival were assessed using univariate and multivariate analysis by the Cox regression model. RESULTS： A total of 116 patients were included in the study. A CCR to CRT was observed in 86/116 （74.1%）. The median survival was 20 mo （range 2-114） and the 5-year survival was 9.4%. Median survival of responder patients to CRT was 25 mo （range 3-114） as compared to 9 mo （range 2-81） in non-responder patients （P 〈 0.001）. In univariate analysis, survival was associated with CCR （P 〈 0.001）, WHO performance status 〈 2 （P = 0.01）, tumour length 〈 6 cm （P = 0.045） and weight loss 〈 10% was in limit of significance （P = 0.053）. In multivariate analysis, survival was dependant to CCR （P 〈 0.0001）, weight loss 〈 10% （P = 0.034） and WHO performance 〈 2 （P = 0.046）. CONCLUSION： Our results suggest that survival in patients with LASCOC b＇eated with definitive CRT was correlated to CCR, weight loss and WHO performance status.

关键词： Definitive chemoradiotherapy Esophageal squamous cell carcinoma Predictive factors

Effects of extracts from Hibiscus macranthus and Basella alba mixture on testosterone production in vitro in adult rat testes slices

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Asian Journal of Andrology 2006年第1期8卷 111-114页

作者： Paul E Moundipa Silvère Ngouela Pierre Kamtchouing Etienne Tsamo Félicité M.Tchouanguep Serge Carreau Laboratory of Nutrition and Biochemical Toxicology Laboratory of Organic Chemistry Department of Animal Biology and Physiology University of Yaoundé IP.O.Box 812YaoundéCameroon Faculty of Science University of DschangP.O.Box 67DschangCameroon USC INRA-EA 2608.Laboratoire de Biochimie Esplanade de la paixUniversité de Caen14032 Caen-cedexFrance

Aim： To find an in vitro system for the measurement of the androgenic effects of different extracts of Hibiscus macranthus （Malvaceae） and Basella alba （Basellaceae）. Methods： The production of testosterone from testes slices incubated in two media, either Krebs-Henseleit buffer containing 0.5% Bovine serum albumin （BSA） or Dubecco＇s Modified Eagle＇s medium-F12 Ham nutrient mixture （DME/Ham F12）, under a mixture of 5% CO2 in 95% air was determined either in the presence or absence of cofactors and Hibiscus macranthus plus Basella alba （HMBA） extracts. Results： The testosterone production was increased in testes slices incubated in DME/Ham F12 medium in response to the cofactors （49%） and aqueous extracts （34%-60% according to dilutions）. Under the same atmospheric conditions, there was no positive response of the testes slices to either cofactor or HMBA extract stimulation in Krebs-Henseleit buffer containing 0.5% BSA, In further investigations related to the effect of HMBA, the DME/ Ham F12 medium was used. The results obtained from the in vitro test showed that the activity was present mainly in methylene chloride and methanol, since these extracts induced an increase in testosterone production by testes slices. Conclusion： The testes slice system is suitable to be used for further in vitro investigations of the isolation of androgenic bioactive components of plants. （Asian J Androl 2006 Jan; 8： 111-114）

关键词： testis testosterone plant extracts Hibiscus macranthus Basella alba

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充血性心力衰竭患者双室起搏治疗的临床观察

第三军医大学学报 2003年第17期25卷 1556-1558页

作者：周晗 Scanu Patrice 张嘉莹河南省人民医院心内科郑州450003 法国CHU de caen

目的　观察心室同步起搏对顽固性伴有室内传导或室间隔运动异常的充血性心衰的治疗效果。方法　选择 2 1例 ,其中男 18例 ,女 3例 ,年龄 ( 64± 11)岁 ,合并左束支阻滞的顽固性心衰患者给予双心室同步起搏治疗 ( 16例安装三腔起搏器 ,5... 详细信息

目的　观察心室同步起搏对顽固性伴有室内传导或室间隔运动异常的充血性心衰的治疗效果。方法　选择 2 1例 ,其中男 18例 ,女 3例 ,年龄 ( 64± 11)岁 ,合并左束支阻滞的顽固性心衰患者给予双心室同步起搏治疗 ( 16例安装三腔起搏器 ,5例安装三腔心脏自动交律除颤器 )。观察术中、术后 3、6月左室电极的起搏参数 ,同时观察术前、术后 3个月的QRS波时限、LVEF、LVDD、二尖瓣返流量、VO2 max以及临床症状的变化。结果　随访 3～ 2 0个月 ,左室电极的起搏阀值、阻抗及感知各参数值稳定 (P >0 .0 5 ) ,起搏功能良好。与术前相比 ,术后 3个月LVEF等心功能指标均明显改善 (P <0 .0 5 )。随访期间猝死 1例 ,接受心脏移植 1例。结论　心室再同步治疗是治疗存在室间传导异常的充血性心衰的有效的新方法。三腔起搏器可改善患者血流动力学、心功能和心衰的临床症状。左室电极的植入成功率高 ,性能稳定 ,安全可靠。三腔ICD不仅可治疗心衰。

关键词：充血性心衰心室再同步治疗三腔起搏器三腔ICD

REACTIONS WITH ~8HE AROUND THE COULOMB BARRIER

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REACTIONS WITH ~8HE AROUND THE COULOMB BARRIER

Duodenal intraepithelial T lymphocytes in patients with functional dyspepsia

The 10~th International Conference on Nucleus-Nucleus Collisions

作者： A,Navin Grand Acclrateur National d’Ions Lourds CEA/DSM-CNRS/IN~2P~3CaenFrance

＜正＞The nuclear fusion process,at energies around the Coulomb barrier,is an ideal tool to understand tunneling in quantum systems and nucleosynthesis in *** is also the path being used to extend the periodic table of the *** the last three decades the intrinsic properties of colliding stable nuclei have been shown to dramatically modify the tunneling

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World Journal of Gastroenterology 2007年第16期13卷 2333-2338页

作者： Gilles Gargala Stéphane Lecleire Arnaud Franois Serge Jacquot Pierre Déchelotte Jean Jacques Ballet Loic Favennec Philippe Ducrotté Parasitology Department Rouen University Hospital & EA 3234-IFRMP 23 University of Rouen France Gastroenterology Department Rouen University Hospital & EA 3234-IFRMP 23 University of Rouen France Pathology Department Rouen University Hospital France Immunology Department Rouen University Hospital & U.519-IFRMP 23 University of Rouen France Immunology Department Caen University Hospital & UPRES-EA 2128 University of Caen France

AIM： To quantify the intraepithelial lymphocytes （IELs） and to document the membrane expression of CD4, CD8, TCRγδ and adhesion and/or activation-associated molecules （CD103, CD28, CD44, CD69, HLA-DR, CD95/ Fas） in the duodenal mucosa of patients with functional dyspepsia （FD） in order to provide arguments for an immunological process in FD. METHODS： Twenty-six FD patients according to Rome Ⅱ criteria （20 were H pylori negative） were studied and compared to 12 healthy adults. IELs were isolated from five duodenal biopsy samples, then quantified by microscopy and flow cytometry while the membrane phenotypes were determined by cytofluorometry. RESULTS： Duodenal histological examination was normal. In H pylori negative patients, the number of IELs was not different from that in healthy controls. Median percentage expression of CD4, CD8, or TCRy8 and CD103, CD44, CD28, CD69 on CD3＋ IELs, among the adhesion/activation associated molecules tested, was not different from that in healthy controls. In contrast, the median percentage expression of CD95/ Fas [22 （9-65） vs 45 （19-88）, P = 0.03] and HLADR expressing CD3＋ IELs [4 （0-30） vs 13 （4-42）, P = 0.04] was significantly lower in the H pylori negative FD group than in healthy controls, respectively. The number of IELs was significantly greater in H pylori positive FD patients than in healthy controls [median ratio for 100 enterocytes 27.5 （6.7-62.5） vs 10.8 （3-33.3）, P = 0.02] due to a higher number of CD8＋ CD3＋ IELs. CONCLUSION： In H pylori negative FD patients, the phenotypic characterization of IELs suggests that we cannot exclude a role of IELs in FD.

关键词： Functional dyspepsia Intraepithelial T lymphocytes Gut CD95/Fas HLA-DR

硫酸镁与重度先兆子痫:当代临床实践中的应用

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世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 55-56页

作者： Girard B. Beucher G. Muris C. M. Dreyfus Serv. Gynecol. Obstet 高雪莲 Med. Repro. CHU de Caen avenue Clé menceau 14033 Caen Cedex France

Objective. To evaluate indications, mode of administration and safety of magnesium sulphate in severe preeclampsia. Material and methods. We conducted a retrospective descriptive study from January 2000 to December 2002, including patients with severe preeclampsia which was defined as elevated blood pressure ≥ 140 and/or 90 mmHg with proteinuria ≥ 0.3g per day, associated with one or more of the following: elevated blood pressure ≥ 170 and/or 110 mmHg, proteinuria >3g per day, functional symptoms such as headache, hyperreflexia, oliguria100 μ mol/I, HELLP syndrome. We studied a group of 57 women treated by magnesium sulphate (intravenous bolus of 4.5g during 20 minutes followed by a perfusion of 1.5g/h) associated or not with an antihypertensive treatment. Results. Treatment by magnesium sulphate was started antenatally in 53 women or during immediate postpartum in 4, associated (n=25) or not (n=32) with an antihypertensive treatment. Hyperreflexia was the main indication to start magnesium sulphate treatment (75% ). About half (47% ) of the cases occurred before 33 weeks of gestation No eclampsia occurred in this group. There was one overdosage which regressed when perfusion was stopped. One patient presented minor side effects attributed to magnesium sulphate. Conclusion. Providing a rigorous protocol, indications of magnesium sulfate therapy in severe preeclampsia are well defined. It seems that this treatment could be easily used without severe complications and major side effects.

关键词：重度先兆子痫临床实践硫酸镁治疗降压药治疗反射亢进尿蛋白快速静脉注射少尿肌酐静脉给药

每核子100MeV以下核—核碰撞中集体流的分量的研究

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每核子100MeV以下核—核碰撞中集体流的分量的研究