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Lithium bromide catalyzed solvent free method for synthesis of 2-substituted benzimidazoles and imidazopyridines

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Chinese Chemical Letters 2010年第5期21卷 519-523页

作者： Deepak V.Dekhane Shivaji S.Pawar Sunil V.Gupta Murlidhar S.Shingare Shivaji N.Thore Department of Chemistry Vinyakrao Patil Mahavidyala VaijapurAurangabad 423701MSIndia Department of Chemistry Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431004MSIndia

The first successful lithium bromide mediated solvent free condensation of arylenediamine and esters to obtain 2-substituted benzimidazole and imidazopyridine in good to excellent yields is described.

关键词： Benzimidazoles Arylenediamine Aliphatic esters Lithium bromide Imidazopyridines

Analysis of docosanol using GC/ms:Method development,validation,and application to ex vivo human skin permeation studies

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Journal of Pharmaceutical Analysis 2022年第2期12卷 287-292页

作者： Vijay Kumar Shankar Mei Wang Srinivas Ajjarapu Praveen Kolimi Bharathi Avula Reena Murthy Ikhlas Khan Sathyanarayana Narasimha Murthy Department of Pharmaceutics and Drug Delivery University of MississippiOxfordMS38677USA Natural Products Utilization Research Unit Agricultural Research ServiceU.S.Department of AgricultureOxfordMS38677USA National Center for Natural Products Research Research Institute of Pharmaceutical SciencesSchool of PharmacyUniversity of MississippiOxfordMS38677USA Topical Products Testing LLC OxfordMS38677USA

Docosanol is the only US Food and Drug Administration(FDA)approved over-the-counter topical product for treating recurrent oral-facial herpes simplex *** analytical methods for docosanol are required to demonstrate the bioequivalence of docosanol topical products.A gas chromatography/selected ion monitoring mode mass spectrometry(GC/SIM-ms)method was developed and validated for docosanol determination in biological *** and isopropyl palmitate(internal standard)were separated on a high-polarity GC capillary column with(88%cyanopropy)aryl-polysiloxane employed as the stationary *** ions of m/z 83 and 256 were selected to monitor docosanol and isopropyl palmitate,respectively;the total run time was 20 *** GC/SIM-ms method was validated in accordance with US FDA guidelines,and the results met the US FDA acceptance *** docosanol calibration standards were linear in the 100-10000 ng/mL concentration range(R^(2)>0.994).The recoveries for docosanol from the receptor fluid and skin homogenates were>93.2%and>95.8%,*** validated method was successfully applied to analyze ex vivo human cadaver skin permeation *** applying Abreva®cream tube and Abreva®cream pump,the amount of docosanol that penetrated human cadaver skin at 48 h was 21.5±7.01 and 24.0±6.95 ng/mg,***,we concluded that the validated GC/SIM-ms was sensitive,specific,and suitable for quantifying docosanol as a quality control *** method can be used for routine analysis as a costeffective alternative to other techniques.

关键词： Docosanol Fatty alcohols Gas chromatography-mass spectrometry Topical formulation Skin permeation

Porous carbon catalysis in sustainable synthesis of functional heterocycles:An overview

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Chinese Chemical Letters 2024年第8期35卷 170-186页

作者： Uttam Pandurang Patil Department of Chemistry ACS CollegeShivaji UniversityPalus 416310MSIndia

Heterogeneous porous carbon(PC)materials have gained unique importance in the catalysis community due to their captivating properties,including high specific surface area,tunable porosity,and *** can play a prominent role in the sustainable synthesis of functional heterocycles,as they are a low-cost alternative while being an efficient and user-friendly *** review examines the prepa-ration and applicability of these carbonaceous materials used as catalysts or support for biologically active heterocycles synthesis,including hydrogenation,oxidation,oxidative dehydrogenation,cross-coupling,and other organic ***,the challenges,potential future development directions,and opportuni-ties in the synthesis of potent bioactive heterocycles over PC materials have been *** review will inspire further research to explore novel PC materials and their implications in heterocyclization.

关键词： Sustainable chemistry Heterogeneous catalysts Porous carbons Heterocycles synthesis

Chemical fixation of toxic metals in stainless steel pickling residue by Na2S·xH2O,FeSO4·6H2O and phosphoric acid for beneficial uses

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Journal of Environmental Sciences 2020年第4期32卷 364-374页

作者： Peidong Su Junke Zhang Yadong Li Department of Civil&Environmental Engineering Jackson State UniversityJacksonMS39217USA

The leaching concentrations of different metals in stainless steel pickling residue(SSPR)were determined and the toxic metals were treated using Na2 S·xH2 O,FeSO4·6 H2 O,and phosphoric acid.A modified European Community Bureau of Reference(BCR)sequential extraction was used to identify the speciation of the concerned *** showed that SSPR contains a large amount of Ca(58.41%),Fe(29.44%),Cr(3.83%),Ni(2.94%),Mn(2.82%)and some of Al,Cu,Mg,*** them,Cr and Ni were the most toxic metals in SSPR,thus the raw SSPR falls into hazardous waste category due to the leaching amount of *** addition,the leached Cr was identified as Cr6+(MgCr04)in the *** test revealed that risk assessment code(RAC)of Cr and Ni were 33.29%and 61.7%,indicating they posed"high"and"very high"risk to the environment,*** fixing by Na2 S·xH2 O and FeSO4·6 H2 O,the leaching concentrations of Cr and Ni were less than 1.5 and 0.5 mg/L,*** fixing by Na2 S·xH2 O and FeSO4·6 H2 O the tre ated SSPR can be safely reused as roadbed materials,concrete and cement *** study provides a useful implication in treatment and beneficial reuse of heavy metal-containing hazardous wastes.

关键词： Stainless steel pickling residue Leaching toxicity Cr(Ⅵ) Chemical fixation Beneficial reuses

Geometric Design of Letters in Times Roman Font via RBF Meshless Collocation Method

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Numerical Mathematics(Theory,Methods and Applications) 2023年第3期16卷 752-768页

作者： Lionel Amuzu C.S.Chen Kwesi Acheampong Huiqing Zhu School of Mathematics and Natural Sciences University of Southern MississippiHattiesburgMSUSA

Two mathematical models in the context of boundary value problems are proposed for the geometric design of letters in Times Roman *** adopt radial basis function meshless collocation method for numerically solving the two proposed mathematical models in 2D and *** this paper,B´ezier curves play an important role in the design of the *** examples with simply and multiply-connected domains in 2D and 3D are presented to demonstrate the visual effect of the letters in Times Roman font.

关键词： Kansa method Bezier curve implicit surface computer graphics image reconstruction meshless method radial basis functions

Oxalic acid as a catalyst for efficient synthesis of bis-(indolyl)methanes,and 14-aryl-14H-dibenzo[a,j]xanthenes in water

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Chinese Chemical Letters 2008年第10期19卷 1186-1189页

作者： Nagnnath D.Kokare Jaiprakash N.Sangshetti Devanand B.Shinde Department of Chemical Technology Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431004(MS)India New Drug DiscoveryWockhardt Research CentreAurangabad 431210(MS)India Department of Chemical Technology Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431004(MS)India

A simple, efficient, and environment benign route was developed for the preparation of bis-（indolyl）methanes and 14-aryl-14H- dibenzo[aj]xanthenes from condensation of various aromatic aldehydes or ketones with indole, and 2-naphthol, respectively, using oxalic acid catalyst in aqueous medium. Use of cheap and easily available catalyst, better yields and simple reaction protocol are the advantages of the present method.

关键词： Oxalic acid Bis-(indolyl)methanes 14-Aryl-14H-dibenzo[a,j]xanthenes Aldehydes

Oxalic acid catalyzed solvent-free one pot synthesis of coumarins

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Chinese Chemical Letters 2007年第11期18卷 1309-1312页

作者： Nagnnath D.Kokare Jaiprkash N.Sangshetti Devanand B.Shinde Department of Chemical Technology Dr.Babasaheb Ambedkar Marathwada University Aurangabad 431004 (MS)India Wockhardt Research CentreNew Drug DiscoveryAurangabad 431210 (MS)India Department of Chemical Technology Dr.Babasaheb Ambedkar Marathwada University Aurangabad 431004 (MS)India

Oxalic acid was found to be an efficient catalyst for Pechmann condensation, which includes the reaction between phenols and β-keto esters leading to formation of coumarin derivatives. The advantages of present methods are the use of cheap and easy available catalyst, solvent-free reaction conditions, better yields and shorter reaction time.

关键词： Coumarins Oxalic acid Solvent-free reaction Pechmann condensation β-Keto esters Phenols

Expeditious synthesis,antileishmanial and antioxidant activities of novel 3-substituted-4-hydroxycoumarin derivatives

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Chinese Chemical Letters 2016年第2期27卷 287-294页

作者： Zahid Zaheer Firoz A.Kalam Khan Jaiprakash N.Sangshetti Rajendra H.Patil Dr.Rafiq Zakaria Campus Y.B.Chavan College of PharmacyAurangabad 431001MSIndia Department of Biotechnology Savitribai Phule Pune UniversityPune 411007MSIndia

A series of novel 3-substituted-4-hydroxycoumarin derivatives 6（a-1） were synthesized in high yield using one-pot three component coupling reaction catalyzed by ceric ammonium nitrate. These compounds were evaluated for antileishmanial activity against Leishmania donovani promastigotes and antioxidant activity（DPPH-radical scavenging activity）. Two compounds, 6h（IC50= 9.90 μmol/L） and 6i（IC50= 6.90 μmol/L） displayed potent antileishmanial activity when compared with standard antileishmanial agents pentamidine（IC50= 16.15 μmol/L） and miltefosine（IC50= 12.50 μmol/L）. Three compounds, 6c（IC50= 10.79 μmol/L）, 6h（IC50= 10.60 μmol/L）, and 6i（IC50= 10.73 μmol/L） showed significant antioxidant activity favorably with the antioxidant standards butylated hydroxy toluene（IC50= 16.47 μmol/L） and ascorbic acid（IC50= 12.69 μmol/L）. A molecular docking study of compounds 6（a-1） suggested a possible mode of binding with the Adenine phosphoribosyltransferase enzyme of ***. ADME properties were predicted in silico and support the potential of 6（a-1） to show favorable drug-like properties.

关键词： 4-Hydroxycoumarin Ceric ammonium nitrate Antileishmanial activity Antioxidant activity Molecular docking study ADME properties

Nanotechnology-based approach for safer enrichment of semen with best spermatozoa

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Journal of Animal Science and Biotechnology 2019年第2期10卷 390-401页

作者： Casey L.Durfey Sabrina E.Swistek Shengfa F.Liao Mark A.Crenshaw Henry J.Clemente Rooban V.K.G.Thirumalai Christy S.Steadman Peter L.Ryan Scott T.Willard Jean M.Feugang Department of Animal and Dairy Sciences Mississippi State UniversityMississippi StateMSUSA Department of Biochemistry Molecular BiologyEntomology and Plant PathologyMississippi StateMSUSA Clemente Associates MadisonCTUSA Institute of Imaging and Analytic Technology(I2AT) Mississippi State UniversityMississippi StateMSUSA Department of Pathobiology and Population Medicine Biochemistry Mississippi State UniversityMississippi StateMSUSA.

Background: Advances in nanotechnology have permitted molecular-based targeting of cells through safe and biocompatible magnetic nanoparticles(MNP). Their use to detect and remove damaged spermatozoa from semen doses could be of great interest. Here, MNP were synthesized and tested for their ability to target apoptotic(annexin V) and acrosome-reacted(lectin) boar spermatozoa, for high-throughout retrieval in a magnetic field(nanoselection). The potential impacts of nanoselection on sperm functions and performance of offspring sired by sperm subjected to nanoselection were determined. Fresh harvested and extended boar semen was mixed with various amounts(0, 87.5, and 175 μg) of MNP-conjugates(Annexin V-MNP or Lectin-MNP) and incubated(10 to15 min) for 37 °C in Exp. 1. In Exp. 2, extended semen was mixed with optimal concentrations of MNP-conjugates and incubated(0, 30, 90, or 120 min). In Exp. 3, the synergistic effects of both MNP-conjugates(87.5 μg– 30 min)on spermatozoa was evaluated, followed by sperm fertility assessments through pregnancy of inseminated gilts and performance of neonatal offspring. Sperm motion, viability, and morphology characteristics were evaluated in all ***: Transmission electron microscopy, atomic force microscopy, and hyperspectral imaging techniques were used to confirm attachment of MNP-conjugates to damaged spermatozoa. The motility of nanoselected spermatozoa was improved(P 0.05).Conclusions: The findings revealed the benefit of magnetic nanoselection for high-throughput targeting of damaged sperm, for removal and rapid and effortles

关键词： Acrosome reaction Apoptosis Artificial insemination Boar Iron oxide nanoparticles Nanopurification Nanoselection Nanotechnology Reproduction Swine