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Biomaterial engineering strategies for modeling the Bruch's membrane in age-related macular degeneration

Neural Regeneration Research 2024年第12期19卷 2626-2636页

作者： Blanca Molins Andrea Rodríguez Víctor Llorenç Alfredo Adán group of Ocular Inflammation:Clinical and experimental Studies Institut d’Investigacions Biomèdiques AgustíPi I Sunyer(IDIBAPS)BarcelonaSpain Institut Clínic d’Oftalmologia(ICOF) Hospital Clínic BarcelonaSpain

Age-related macular degeneration,a multifactorial inflammatory degenerative retinal disease,ranks as the leading cause of blindness in the ***,there is a scarcity of curative therapies,especially for the atrophic advanced form of age-related macular degeneration,likely due to the lack of models able to fully recapitulate the native structure of the outer blood retinal barrier,the prime to rget tissue of age-related macular *** in vitro systems rely on 2D monocultures unable to adequately reproduce the structure and function of the outer blood retinal barrier,integrated by the dynamic interaction of the retinal pigment epithelium,the Bruch's membrane,and the underlying *** Bruch's membrane provides structu ral and mechanical support and regulates the molecular trafficking in the outer blood retinal barrier,and therefo re adequate Bruch's membrane-mimics are key for the development of physiologically relevant models of the outer blood retinal barrie *** the last years,advances in the field of biomaterial engineering have provided novel approaches to mimic the Bruch's membrane from a variety of *** review provides a discussion of the integrated properties and function of outer blood retinal barrier components in healt hy and age-related macular degeneration status to understand the requirements to adequately fabricate Bruch's membrane biomimetic ***,we discuss novel materials and techniques to fabricate Bruch's membrane-like scaffolds for age-related macular degeneration in vitro modeling,discussing their advantages and challenges with a special focus on the potential of Bruch's membrane-like mimics based on decellularized tissue.

关键词： age-related macular degeneration Bruch's membrane decellularization retinal pigment epithelium scaffold

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Recent Progress of Neutral Beam Injector and Bearn Emission Diagnosis in lhd

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Plasma Science and Technology 2009年第4期11卷 452-455页

作者： Katsunori IKEDA Kenichi NAGAOKA Yasuhiko TAKEIRI Masaki OSAKABE Katsuyoshi TSUMORI Osamu KANEKO 无 National Institute for Fusion Science lhd experimental group

Large size hydrogen neutral beam injectors （NBI） used a negative ion source （NNBI） as well as a proton source （PNBI） were developed for the large helical device （lhd）. The injected power from NNBI and PNBI have reached 16 MW and 6.8 MW, respectively, These injected powers have outstripped the nominal beam powers. A diagnostic system of beam-emitted hydrogen visible spectrum has been installed along the beam injection axis to estimate the energy fraction on PNBI. The full energy beam component is about half which is equivalent to 70% of injected beam power. The attenuation of high energy neutral beam is also observed on NNBI. The peak density distribution is effective to increase beam deposition power.

关键词： NBI spectroscopy lhd

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Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

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Genes & Diseases 2024年第1期11卷 189-204页

作者： Ebrahim H.Maleki Ahmad Reza Bahrami Maryam M.Matin Department of Biology Faculty of ScienceFerdowsi University of Mashhad*** MashhadIran Jagiellonian Centre for experimental Therapeutics(JCET) Jagiellonian University31-007 KrakowPoland Doctoral School of Exact and Natural Sciences Jagiellonian University30-348 KrakowPoland Industrial Biotechnology Research group Institute of BiotechnologyFerdowsi University of Mashhad*** MashhadIran Novel Diagnostics and Therapeutics Research group Institute of BiotechnologyFerdowsi University of Mashhad***MashhadIran Stem Cell and Regenerative Medicine Research group Iranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi Branch917751376 MashhadIran

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology,as it represents a major obstacle to effective cancer *** tumor cells are highly diverse at genetic,epigenetic,and phenotypic levels,intra-tumor heterogeneity can be assumed as an important contributing factor to the nullification of chemotherapeutic effects,and recurrence of the *** on the role of heterogeneous subpopulations of cancer cells with varying cell-cycle dynamics and behavior during cancer progression and treatment;herein,we aim to establish a comprehensive definition for adaptation of neoplastic cells against *** discuss two parallel and yet distinct subpopulations of tumor cells that play pivotal roles in reducing the effects of chemotherapy:"resistant"and"tolerant"***,this review also highlights the impact of the quiescent phase of the cell cycle as a survival mechanism for cancer *** understanding the mechanisms under-lying the quiescence,it provides an insightful perspective on cancer stem cells(CsCs)and their dual and intertwined functions based on their cell cycle state in response to ***-over,CSCs,epithelial-mesenchymal transformed cells,circulating tumor cells(CTCs),and disseminated tumor cells(DTCs),which are mostly in a quiescent state of the cell cycle are proved to have multiple biological links and can be implicated in our viewpoint of cell cycle heterogeneity in ***,increasing our knowledge of cell cycle heterogeneity is a key to identifying new therapeutic solutions,and this emerging concept may provide us with new opportunities to prevent the dreadful cancer recurrence.

关键词： Cancer stem cells(CSCs) Carcinoma Cell cycle heterogeneity Quiescence Therapy resistance Therapy tolerance Tumor dormancy

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Adaptive mutation sparrow search algorithm-Elman-AdaBoost model for predicting the deformation of subway tunnels

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Underground Space 2024年第4期17卷 320-360页

作者： Xiangzhen Zhou Wei Hu Zhongyong Zhang Junneng Ye Chuang Zhao Xuecheng Bian MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou 310058China Hangzhou Canal group Construction Management Co.LTD Hangzhou 310015China Ningbo Rail Transit Project Construction Headquarter Ningbo 315012China Center for Hypergravity experimental and Interdisciplinary Research Zhejiang UniversityHangzhou 310058China

A novel coupled model integrating Elman-AdaBoost with adaptive mutation sparrow search algorithm(AM-SSA),called AMSSAElman-AdaBoost,is proposed for predicting the existing metro tunnel deformation induced by adjacent deep excavations in soft *** novelty is that the modified SSA proposes adaptive adjustment strategy to create a balance between the capacity of exploitation and *** AM-SSA,firstly,the population is initialized by cat mapping chaotic sequences to improve the ergodicity and randomness of the individual sparrow,enhancing the global search *** the individuals are adjusted by Tent chaotic disturbance and Cauchy mutation to avoid the population being too concentrated or scattered,expanding the local search ***,the adaptive producer-scrounger number adjustment formula is introduced to balance the ability to seek the global and local *** addition,it leads to the improved algorithm achieving a better accuracy level and convergence speed compared with the original *** demonstrate the effectiveness and reliability of AM-SSA,23 classical benchmark functions and 25 IEEE Congress on Evolutionary Computation benchmark test functions(CEC2005),are employed as the numerical examples and investigated in comparison with some wellknown optimization *** statistical results indicate the promising performance of AM-SSA in a variety of optimization with constrained and unknown search *** utilizing the AdaBoost algorithm,multiple sets of weak AMSSA-Elman predictor functions are restructured into one strong predictor by successive iterations for the tunnel deformation prediction ***,the on-site monitoring data acquired from a deep excavation project in Ningbo,China,were selected as the training and testing ***,the predictive outcomes are compared with those of other different optimization and machine learning *** the end,the obtained results in this real-world geotechnical eng

关键词： Adjacent deep excavations Existing subway tunnels Adaptive mutation sparrow search algorithm Metaheuristic optimization Benchmark test functions Elman neural networks

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Improvements in properties of NdFeB magnets obtained via magnetron sputtering and thermal diffusion

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Journal of Rare Earths 2024年第9期42卷 1710-1716,I0003页

作者： Jin Tang Weichao Huang Dan Li School of Electronic Engineering Guangxi University of Science and TechnologyLiuzhou545006China China Rare Earth(Guangxi)Jinyuan Rare Earth New Materials Co. Ltd.Hezhou542603China China Rare Earth group Co. Ltd.Ganzhou341000China Center of experimental Teaching for Common Courses Panzhihua UniversityPanzhihua617000China

The grain boundary diffusion process(GBDP) of Dy and DyAl on sintered NdFeB magnets was conducted via magnetron-sputtering deposition of Dy and DyAl films to enhance coercivity(H_(cj)),The magnetic properties,microstructure and anti-corrosion properties of Dy-surface-alloying NdFeB magnets obtained via magnetron sputtering and thermal diffusion were *** H_(cj) of the Dy_(95)Al_(5)-NdFeB magnet increases by 32.68%,while the remanence declines ***,X-ray diffraction and microstructural analysis confirm the formation of Dy-rich shells,the higher-magnetic-anisotropy field of hard(Nd_(x)Dy_(1-x))2(FeAl)_(14)B magnetic phases and an optimised grain boundary structu re,contributing to the H_(cj)enhancement of the *** elemental distribution and diffusion mechanism of the magnets are also ***,the corrosion resistance of the Dy_(95)Al_(5)-NdFeB magnet is substantially improved by enhancing the electrochemical stability and optimising the distribution and morphology of the intergranular *** findings of this study are of substantial importance in the development of low-heavy rare-earth sintered NdFeB magnets.

关键词： Magnetron sputtering NdFeB Rare earths Microstructure Magnetic property Corrosion resistance

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Two become one:combination of two risk factors in a new glaucoma animal model

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Neural Regeneration Research 2024年第5期19卷 982-983页

作者： Nils Kluge Sabrina Reinehr experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

Glaucoma is a group of eye diseases characterized by progressive loss of retinal ganglion cells(RGCs)and optic nerve *** this process,the visual field is reduced,and blindness may ultimately ***,glaucoma is the second leading cause of blindness,with about 80 million people *** is a multifactorial disease and due to its complexity,the exact pathomechanisms are not fully understood ***,different risk factors,such as elevated intraocular pressure(IOP),age,or myopia,have been identified to date(EGS,2021).

关键词： elevated exact glaucoma

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Role of doxycycline in the treatment of dengue infection: An open-label, randomized, controlled, pilot trial

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 160-165页

作者： Banothu Vinod Kumar Kajal Kamboj Ashok Kumar Pannu Ashok Kumar Yadav Mandip Bhatia Atul Saroch Department of Internal Medicine PGIMER ChandigarhIndia Department of experimental Medicine&Biotechnology PGIMER ChandigarhIndia

Objective:To measure the effect of doxycycline on inflammatory marker[IL-6,TNF-α,ferritin and C reactive protein(CRP)]levels in patients with dengue ***:A single-centre,open-label,parallel-group randomized controlled trial was done in PGIMER Chandigarh from June 2021 to October *** were randomized using a simple randomization process into two groups:the doxycycline treatment group(n=35)and the control group(n=34).Patients in the treatment group were given oral doxycycline 100 mg twice daily for five days along with standard treatment,whereas patients in the control group received only standard *** objective was to measure the effect of doxycycline on inflammatory markers in dengue ***:On comparative analysis at day 5,there was a statistically significant reduction in the median values of ferritin and CRP in cases compared to the control group(ferritin:P=0.006 and CRP:P=0.006).No significant reduction was noted in the levels of IL-6 and TNF-α.Conclusions:Doxycycline treatment led to a reduction of inflammatory markers in dengue infection.

关键词： Dengue Cytokine Doxycycline Serum ferritin C reactive protein

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The current status and future development of high-temperature conventional superconductivity

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National Science Review 2024年第7期11卷 18-20页

作者： Mikhail I.Eremets High Pressure Chemistry and Physics group Max-Planck-Institut für Chemie

This survey highlights key advancements in high-temperature superconductivity in hydrogen-rich materials, emphasizing the robust evidence and reproducibility of superconductivity under challenging experimental conditions of megabar pressures. In the near future, achieving room-temperature superconductivity is highly probable, and the field is expected to transition towards near-ambient-pressure superconductivity.

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Transient receptor potential channels as predictive marker and potential indicator of chemoresistance in colon cancer

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Oncology Research 2024年第1期32卷 227-239页

作者： WEI HU THOMAS WARTMANN MARCO STRECKER ARISTOTELIS PERRAKIS ROLAND CRONER ARPAD SZALLASI WENJIE SHI ULF D.KAHLERT The Fourth Clinical Medical College of Yangzhou University Nantong Rich HospitalNantongChina Molecular and experimental Surgery Clinic for General-Visceral-Vascular and Transplant SurgeryFaculty of Medicine and University Hospital MagdeburgOtto-von-Guericke UniversityMagdeburgGermany Department of Pathology and experimental Cancer Research Semmelweis UniversityBudapestHungary

Transient receptor potential(TRP)channels are strongly associated with colon cancer development and *** study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature,with further validation of signature in real world samples from our hospital treated patient ***-Meier(K-M)survival analysis and receiver operating characteristic(ROC)curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts,***,the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional *** support vector machine algorithm was applied to evaluate the signature’s potential in predicting chemotherapy *** findings unveiled a novel three TRP channels-related gene signature(MCOLN1,TRPM5,and TRPV4)in colon adenocarcinoma(COAD).The ROC and K-M survival curves in the training dataset(AUC=0.761;p=1.58e-05)and testing dataset(AUC=0.699;p=0.004)showed the signature’s robust predictive capability for the overall survival of COAD *** of the immune infiltration landscape associated with the signature revealed higher immune infiltration,especially an increased presence of M2 macrophages,in high-risk group patients compared to their low-risk ***-risk score patients also exhibited potential responsiveness to immune checkpoint inhibitor therapy,evident through increased CD86 and PD-1 expression ***,the TRPM5 gene within the signature was highly expressed in the chemoresistance group(p=0.00095)and associated with poor prognosis(p=0.036)in COAD patients,highlighting its role as a hub gene of ***,this signature emerged as an independent prognosis factor for COAD patients(p=6.48e-06)and expression of model gene are validated by public data a

关键词： Colon cancer Transient receptor potential channels Prognostic signature Chemotherapy efficiency TRPM5

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MKEAH:Multimodal knowledge extraction and accumulation based on hyperplane embedding for knowledge-based visual question answering

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虚拟现实与智能硬件（中英文） 2024年第4期6卷 280-291页

作者： Heng ZHANG Zhihua WEI Guanming LIU Rui WANG Ruibin MU Chuanbao LIU Aiquan YUAN Guodong CAO Ning HU Tongji University Shanghai 2000092China Alibaba group Shanghai 200030China

Background External knowledge representations play an essential role in knowledge-based visual question and answering to better understand complex scenarios in the open *** entity-relationship embedding approaches are deficient in representing some complex relations,resulting in a lack of topic-related knowledge and redundancy in topic-irrelevant *** To this end,we propose MKEAH:Multimodal Knowledge Extraction and Accumulation on *** ensure that the lengths of the feature vectors projected onto the hyperplane compare equally and to filter out sufficient topic-irrelevant information,two losses are proposed to learn the triplet representations from the complementary views:range loss and orthogonal *** interpret the capability of extracting topic-related knowledge,we present the Topic Similarity(TS)between topic and *** experimental results demonstrate the effectiveness of hyperplane embedding for knowledge representation in knowledge-based visual question *** model outperformed state-of-the-art methods by 2.12%and 3.24%on two challenging knowledge-request datasets:OK-VQA and KRVQA,*** The obvious advantages of our model in TS show that using hyperplane embedding to represent multimodal knowledge can improve its ability to extract topic-related knowledge.

关键词： Knowledge-based visual question answering Hyperplane Topic-related

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