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Serum Soluble Vascular Endothelial Growth Factor Receptor 1 as a Potential Biomarker of Hepatopulmonary Syndrome

Journal of Clinical and Translational Hepatology 2023年第5期11卷 1150-1160页

作者： Yu-Jie Li Xian-Feng Wu Dan-Dan Wang Peng Li Hao Liang Xiao-Yan Hu Jia-Qi Gan Yi-Zhu Sun Jun-Hong Li Jun Li Xin Shu Ai-Lin Song Chun-Yong Yang Zhi-Yong Yang Wei-Feng Yu Li-Qun Yang Xiao-Bo Wang Karine Belguise Zheng-Yuan Xia Bin Yi Department of Anesthesiology Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Department of Anesthesiology Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengduSichuanChina Department of Anesthesiology Renji Hospital Affiliated to Shanghai Jiao Tong UniversityShanghaiChina lbcmcp Centre de Biologie Intégrative(CBI)Universitéde ToulouseCNRSUPSToulouseFrance Department of Anesthesiology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

Background and Aims:The results of basic research implicate the vascular endothelial growth factor(VEGF)family as a potential target of hepatopulmonary syndrome(HPS).However,the negative results of anti-angiogenetic therapy in clinical studies have highlighted the need for markers for ***,we aimed to determine whether VEGF family members and their receptors can be potential biomarkers for HPS through clinical and experimental ***:Clinically,patients with chronic liver disease from two medical centers were enrolled and examined for *** were divided into HPS,intrapulmonary vascular dilation[positive contrast-enhanced echocardiography(CEE)and normal oxygenation]and CEE-negative *** information and perioperative clinical data were compared between HPS and non-HPS *** levels of VEGF family members and their receptors were *** parallel,HPS rats were established by common bile duct ***,lung and serum samples were collected for the evaluation of pathophysiologic changes,as well as the expression levels of the above ***:In HPS rats,all VEGF family members and their receptors underwent significant changes;however,only soluble VEGFR1(sFlt-1)and the sFlt-1/placental growth factor(PLGF)ratio were changed in almost the same manner as those in HPS ***,through feature selection and internal and external validation,sFlt-1 and the sFlt-1/PLGF ratio were identified as the most important variables to distinguish HPS from non-HPS ***:Our results from animal and human studies indicate that sFlt-1 and the sFlt-1/PLGF ratio in serum are potential markers for HPS.

关键词： Chronic liver disease Hepatopulmonary syndrome Placental growth factor Pathological pulmonary angiogenesis sFlt-1/PLGF ratio

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