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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

Nano-Micro letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui liu Chao Fang Qiuxia Peng Wen Qin Xuebing Yan Kun Zhang Central laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of stomatology and Central laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets signaling pathway

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Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro letters 2025年第1期17卷 216-261页

作者： Jian‑En Zhou Yilin li Xiaoming lin Jiaye Ye Key laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China school of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

lithium-ion batteries(lIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(sIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(lIBs,sIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues self-sacrificial template lithium-ion batteries sodium-ion batteries Potassium-ion batteries

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Energy based 3D trajectory tracking control of quadrotors with model-free based on-line disturbance compensation

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Chinese Journal of Aeronautics 2018年第7期31卷 1568-1578页

作者： Yasser BOUZID Houria sIGUERDIDJANE Yasmina BEsTAOUI IBIsC laboratory Université d'Evry Val d'Essonne Université Paris-Saclay l2s CentraleSupélecUniversité Paris-Saclay

In this work, a Revisited form of the so-called Model-Free Control（R-MFC） is ***, the MFC principle is employed to deal with the unknown part of a plant only（i.e., unmodeled dynamics, disturbances, etc.） and occurs beside an Interconnection and Damping AssignmentPassivity Based Control（IDA-PBC） strategy. Using the proposed formulation, it is shown that we can significantly improve the performance of the control through the reshaping properties of the IDA-PBC technique. Moreover, the control robustness level is increased via a compensation of the time-varying disturbances and the unmodeled system dynamics. This on-line compensation capability is provided by the MFC principle. The problem is studied in the case of Multi-Input Multi-Output（MIMO） mechanical systems with an explicit application to a small Vertical Take-Off and landing（VTOl） Unmanned Aerial Vehicle（UAV） where a stability analysis is also provided. Numerical simulations have shown satisfactory results, in comparison with some other control strategies, where an in-depth discussion with respect to the control performance is highlighted by considering several scenarios and using several metrics.

关键词： IDA-PBC Model-free control Nonlinear flight control Robust control Trajectory tracking

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Anthropometrics and electromyography as predictors for maximal voluntary isometric arm strength

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Journal of sport and Health science 2012年第2期1卷 107-113页

作者： lara A.Green David A.Gabriel Department of Kinesiology Brock UniversitySt.CatharinesON L2S 3A1Canada

Background:Muscular strength can be conceptually determined by two components:muscle activation and *** activation by the central nervous system can be measured by surface electromyography(sEMG).Muscular size reflects the amount of contractile protein within a skeletal muscle and can be estimated by anthropometric *** purpose of this study was to determine the relative contributions of size parameters and muscle activation to the prediction of maximal voluntary isometric elbow flexion strength. Methods:A series of anthropometric measurements were taken from 96 *** and root-mean-square(RMs) of the sEMG from the biceps brachii were averaged across three maximal voluntary isometric contractions.A multiple linear regression analysis was performed based on a Pearson's correlation matrix. Results:Body weight(BW) accounted for 39.1% and 27.3% in males and females,respectively,and was the strongest predictor of strength for *** length(l3) was the strongest predictor of strength in females(partial R^2 = 0.391).Elbow circumference(ElB) accounted for a significant(p les but not *** addition of sEMG RMs as a third variable accounted for an average of 10.1% of the variance excluding the equation of BW and l3 in *** strongest prediction equation included BW,l3,and ElB accounting for 55.6% and 58.5% of the variance in males and females,respectively. Conclusion:Anthropometrics provide a strong prediction equation for the estimation of isometric elbow flexion *** activation,as measured by sEMG activity,accounted for a significant(p st prediction equations,however,its contribution was comparable to an additional anthropometric variable.

关键词： Biceps brachii Biomechanics Gender differences Multiple linear regression Muscle force

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MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for sensitized Microwave Actuation and self‑Powered Motion sensing

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Nano-Micro letters 2025年第3期17卷 265-279页

作者： Yu‑Ze Wang Yu‑Chang Wang Ting‑Ting liu Quan‑liang Zhao Chen‑sha li Mao‑sheng Cao school of Materials science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China school of Materials science and Engineering Peking UniversityBeijing 100871People’s Republic of China school of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest self-sensing soft actuator

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High Fe‑loading single‑Atom Catalyst Boosts ROs Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro letters 2025年第2期17卷 187-203页

作者： si Chen Fang Huang lijie Mao Zhimin Zhang Han lin Qixin Yan Xiangyu lu Jianlin shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China shanghai Frontiers science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(sACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of sACs by exchanging zinc with *** constructed iron sACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GsH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine single-atom catalysts Reactive oxygen species(ROs) High metal loading Oxidase catalysis

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Inter‑skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference shielding,sensing and Thermal Management

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Nano-Micro letters 2025年第3期17卷 19-36页

作者： Xufeng li Chunyan Chen Zhenyang li Peng Yi Haihan Zou Gao Deng Ming Fang Junzhe He Xin sun Ronghai Yu Jianglan shui Caofeng Pan Xiaofang liu school of Materials science and Engineering Beihang UniversityBeijing 100191People’s Republic of China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191People’s Republic of China Tianmushan laboratory Xixi Octagon CityYuhang DistrictHangzhou 310023People’s Republic of China science and Technology On Electromagnetic scattering laboratory Beijing Institute of Environmental FeaturesBeijing 100854People’s Republic of China

Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable ***,its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during ***,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under *** inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMlM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive ***,the resistance change of AMlM-PM reaches four orders of magnitude under ***,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of liquid metal and increase the scattering area of EM ***-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon *** upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam liquid metal Electromagnetic interference shielding

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“Zero‑strain” NiNb_(2)O_(6) Fibers for All‑Climate lithium storage

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Nano-Micro letters 2025年第1期17卷 348-360页

作者： Yan Zhao Qiang Yuan liting Yang Guisheng liang Yifeng Cheng limin Wu Chunfu lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China school of Materials science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

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Bioinspired Passive Tactile sensors Enabled by Reversible Polarization of Conjugated Polymers

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Nano-Micro letters 2025年第1期17卷 361-377页

作者： Feng He sitong Chen Ruili Zhou Hanyu Diao Yangyang Han Xiaodong Wu school of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China school of software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China state Key laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition

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Optimization strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for sodium‑Ion Batteries

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Nano-Micro letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei li Qianqian liang li Xu Changsheng Ding Yu liu Yanfeng Gao school of Materials science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(sIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in sIBs.

关键词： sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

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