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The Archaeoseismology of Historical Buildings： A Model Study from the l＇aquila Area in Italy

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Journal of Civil Engineering and Architecture 2017年第10期11卷 971-977页

作者： Alessio Marchetti Fabio Redi Francesca Savini Ilaria Trizio ITC-CNR Institute for Construction Technologies Italian National Research Council L 'Aquila 67100 Italy DSU-Univaq Department of Human Studies University of L 'Aquila L 'Aquila 67100 Italy

Much of Italy is characterised by two features： an increased risk of seismic activity and a profusion of old and historic buildings. These factors force us to consider the relationship between building safety and practices of conservation and protection, and as such have a direct bearing on our approach to preserving the country＇s cultural heritage in general. The guidelines issued on the assessment and reduction of seismic risk to cultural heritage assets in the Prime Ministerial Decree （DPCM） of 9 February 201 l underline the importance of studying such properties in terms of their vulnerability to seismic activity, using ＂factors of confidence＂（FC） to translate the qualitative assessments produced during previous phases into quantitative measurements. In addition to the building survey, which describes the precise three-dimensional form of a structure and the relationships between its constituent parts, a substantial part of our knowledge of a building is provided by stratigraphic analysis of the above-ground elements. Similarly, a great deal of useful information can be derived from historical analysis. This paper outlines an archaeoseismological study developed by archaeologists from the University of l＇aquila and researchers from the ITC-CNR in the same city, which applies a multi-disciplinary approach to the study of historic buildings in areas of seismic activity.

关键词： Archaeoseismology cultural heritage knowledge conservation assessment.

Therapeutic advances in neural regeneration for Huntington’s disease

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Neural Regeneration Research 2024年第9期19卷 1991-1997页

作者： Francesco D’Egidio Vanessa Castelli Giorgia lombardozzi Fabrizio Ammannito Annamaria Cimini Michele d’Angelo Department of life Health and Environmental SciencesUniversity of L’AquilaL’AquilaItaly

Huntington’s disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the HTT gene which is responsible for the production of the huntingtin (Htt) protein. In physiological conditions, Htt is involved in many cellular processes such as cell signaling, transcriptional regulation, energy metabolism regulation, DNA maintenance, axonal trafficking, and antiapoptotic activity. When the genetic alteration is present, the production of a mutant version of Htt (mHtt) occurs, which is characterized by a plethora of pathogenic activities that, finally, lead to cell death. Among all the cells in which mHtt exerts its dangerous activity, the GABAergic Medium Spiny Neurons seem to be the most affected by the mHtt-induced excitotoxicity both in the cortex and in the striatum. However, as the neurodegeneration proceeds ahead the neuronal loss grows also in other brain areas such as the cerebellum, hypothalamus, thalamus, subthalamic nucleus, globus pallidus, and substantia nigra, determining the variety of symptoms that characterize Huntington’s disease. From a clinical point of view, Huntington’s disease is characterized by a wide spectrum of symptoms spanning from motor impairment to cognitive disorders and dementia. Huntington’s disease shows a prevalence of around 3.92 cases every 100,000 worldwide and an incidence of 0.48 new cases every 100,000/year. To date, there is no available cure for Huntington’s disease. Several treatments have been developed so far, aiming to reduce the severity of one or more symptoms to slow down the inexorable decline caused by the disease. In this context, the search for reliable strategies to target the different aspects of Huntington’s disease become of the utmost interest. In recent years, a variety of studies demonstrated the detrimental role of neuronal loss in Huntington’s disease condition highlighting how the replacement of lost cells would be a reasonable strategy to o

关键词： cell therapy exosomes extracellular vesicles Huntingtin Huntington’s disease medium spiny neurons neurodegenerative disease neurogenesis neuronal loss stem cells

Breaking the brain barrier:cell competition in neural development and disease

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Neural Regeneration Research 2024年第9期19卷 1863-1864页

作者： Patrizia Morciano Daniela Grifoni Department of“life Health and Environmental Sciences”University of L’AquilaItaly “INFN-laboratori Nazionali del Gran Sasso” AssergiItaly

General information on cell competition:Social behaviors are the basis of biological *** species and populations,cell communities experience Darwinian ecological interactions,and in case space and nutrient availabilit... 详细信息

关键词： neural barrier throughout

A giant scrotal pendulous fibroma mimicking a supernumerary testis

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Asian Journal of Andrology 2024年第2期26卷 227-228页

作者： luigi Quaresima Rocco Francesco Delle Fave Giordano Polisini Daniela Fasanella Willy Giannubilo Urology Division Civitanova Marche HospitalCivitanova Marche 62012Italy Department of Clinical and Specialist Sciences Division of UrologyPolytechnic University of the Marche Region Medical SchoolAncona 60126Italy Department of life Health and Environmental SciencesUniversity of L'AquilaL'Aquila 67100Italy

DearEditor,Pendulous fibroma,also called acrochordon,is a benign skin neoplasm,originating from the ***,small in size,it can arise from any point of the dermis(frequently from the axillary area,inguinal region,eyelid,or neck),and in some cases,it can be *** fibromas are more frequent in obese subjects,and most of the time,they are sporadic,although sometimes,they can be observed in Birt-Hogg-Dube *** some rare cases,they can reach considerable ***,they are associated with diabetes mellitus,obesity,and intestinal ***,the pedicle undergoes torsion,causing pain and ischemic necrosis of the fibroma,which requires rapid removal of the *** present a case of giant pendulous fibroma of the *** patient has given his consent to the publication of his clinical information and photographic images in an anonymous form.

关键词： frequent obesity clinical

Management of cerebral amyloid angiopathy and atrial fibrillation:We are still far from precision medicine

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World Journal of Cardiology 2024年第5期16卷 231-239页

作者： liuba Fusco Zefferino Palamà Antonio Scarà Alessio Borrelli Antonio Gianluca Robles Gabriele De Masi Deluca Silvio Romano luigi Sciarra Department of Cardiology University Hospital of NorthamptonshireNorthampton NN15BDUnited Kingdom Department of Cardiology Casa di Cura Villa VerdeTaranto 70124Italy Department of life Health and Environmental SciencesUniversity of l'AquilaL'Aquila 67100Italy Department of Cardiology GVM Care and ResearchSan Carlo di Nancy HospitalRome 00100Italy

The use of anticoagulation therapy could prove to be controversial when trying to balance ischemic stroke and intracranial bleeding risks in patients with concurrent cerebral amyloid angiopathy(CAA)and atrial fibrillation(AF).In fact,CAA is an age-related cerebral vasculopathy that predisposes patients to intracerebral ***,many AF patients require oral systemic dose-adjusted warfarin,direct oral anticoagulants(such as factor Xa inhibitors)or direct thrombin inhibitors to control often associated with cardioembolic stroke *** prevalence of both CAA and AF is expected to rise,due to the aging of the *** clinical dilemma is becoming increasingly *** patients with coexisting AF and CAA,the risks/benefits profile of anticoagulant therapy must be assessed for each patient individually due to the lack of a clear-cut consensus with regard to its risks in scientific *** review aims to provide an overview of the management of patients with concomitant AF and CAA and proposes the implementation of a risk-based decision-making algorithm.

关键词： Anticoagulation Atrial fibrillation Cerebral amyloid angiopathy Intracerebral hemorrhage Stroke Watchman Secondary prevention left atrial appendage closure

A novel approach to the dynamic response analysis of Euler-Bernoulli beams resting on a Winkler soil model and subjected to impact loads

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 389-401页

作者： Adolfo Foriero Filippo Santucci de Magistris Giovanni Fabbrocino Département de génie civil et de génie des eaux Pavillon Adrien-PouliotUniversitéLavalQuébecCanada Dipartimento di Bioscienze e Territorio Universitàdegli Studi del MoliseCampobassoItaly Construction Technologies Institute National Research CouncilITC-CNRL’AquilaItaly

This work presents a novel approach to the dynamic response analysis of a Euler-Bernoulli beam resting on a Winkler soil model and subjected to an impact *** approach considers that damping has much less importance in controlling the maximum response to impulsive loadings because the maximum response is reached in a very short time,before the damping forces can dissipate a significant portion of the energy input into the *** development of two sine series solutions,relating to different types of impulsive loadings,one involving a single concentrated force and the other a distributed line load,are *** study revealed that when a simply supported Euler-Bernoulli beam,resting on a Winkler soil model,is subject to an impact load,the resulting vertical displacements,bending moments and shear forces produced along the span of the beam are considerably *** particular,the quantification of this effect is best observed,relative to the corresponding static solution,via an amplification *** computed impact amplification factors,for the sub-grade moduli used in this study,were in magnitude greater than 2,thus confirming the multiple-degree-of-freedom nature of the problem.

关键词： beam-Winkler-soil model sub-grade moduli impact load impact distributed line load dynamic solution impact amplification factor

Minimally invasive surgical approach for abdominoscrotal hydrocele treatment:A case report

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Current Urology 2024年第3期18卷 244-246页

作者： Salvatore Siracusano Martina Monti Igino Andrea Magli Federico Romantini Maria Paola Di Bartolomeo Antonio Bernardini CarloVicentini Department of Urology L'Aquila UniversityMazzini HospitalTeramoItaly Department of Radiology Mazzini HospitalTeramoItaly

Abdominoscrotal hydrocele(ASH)is a rare clinical finding comprising fluid collection between the layers of the tunica vaginalis,extending from the scrotum to the abdominal *** present,there is no unique or recommended management for ASH,and different surgical treatments have been *** an open surgical approach being the most common treatment,the use of laparoscopy has also previously been *** most common intraoperative complication is devascularization of the testis due to damage to the spermatic cord,with consequent *** present a case of ASH treated with minimally invasive surgery,consisting of a right inguinotomy with puncture of the ASH by positioning a mono-J stent avoiding spermatic cord dissection and the risk of testis *** of the hydrocelic sac with iodopovidone through a mono-J stent was performed with healing from ASH and preservation of testicular *** months later,magnetic resonance imaging showed the presence of scar tissue replacing the previous ASH cavity.

关键词： Abdominoscrotal hydrocele Inguinotomy Minimally invasive approach Sclerotization

IgE-Mast cell mediated allergy: a sensor of food quality

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Signal Transduction and Targeted Therapy 2024年第1期9卷 8-9页

作者： Christopher C.Udoye Rudolf A.Manz Institute for Systemic Inflammation Research University of LübeckLübeckGermany

In two recent studies published in Nature,Florsheim et *** Plum et *** that allergic-specific reactions induced by immunoglobulin(Ig)E mediated mast cell activation is crucial for the timely induction of antigen-avoidance behaviour.1,2 These studies prove the concept that allergic sensitization triggers the formation of avoidance behaviour and define the underlying molecular mechanism.

关键词： allergic mechanism

The influence of resistance exercise training prescription variables on skeletal muscle mass,strength,and physical function in healthy adults:An umbrella review

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Journal of Sport and Health Science 2024年第1期13卷 47-60页

作者： Jonathan C.Mcleod Brad S.Currier Caroline V.lowisz Stuart M.Phillips Department of Kinesiology Faculty of ScienceMcMaster UniversityHamilton L8S4L8Canada

Purpose:The aim of this umbrella review was to determine the impact of resistance training(RT)and individual RT prescription variables on muscle mass,strength,and physical function in healthy ***:Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,we systematically searched and screened eligible systematic reviews reporting the effects of differing RT prescription variables on muscle mass(or its proxies),strength,and/or physical function in healthy adults aged>18 ***:We identified 44 systematic reviews that met our inclusion *** methodological quality of these reviews was assessed using A Measurement Tool to Assess Systematic Reviews;standardized effectiveness statements were *** found that RT was consistently a potent stimulus for increasing skeletal muscle mass(4/4 reviews provide some or sufficient evidence),strength(4/6 reviews provided some or sufficient evidence),and physical function(1/1 review provided some evidence).RT load(6/8 reviews provided some or sufficient evidence),weekly frequency(2/4 reviews provided some or sufficient evidence),volume(3/7 reviews provided some or sufficient evidence),and exercise order(1/1 review provided some evidence)impacted RT-induced increases in muscular *** discovered that 2/3 reviews provided some or sufficient evidence that RT volume and contraction velocity influenced skeletal muscle mass,while 4/7 reviews provided insufficient evidence in favor of RT load impacting skeletal muscle *** was insufficient evidence to conclude that time of day,periodization,inter-set rest,set configuration,set end point,contraction velocity/time under tension,or exercise order(only pertaining to hypertrophy)influenced skeletal muscle adaptations.A paucity of data limited insights into the impact of RT prescription variables on physical ***:Overall,RT increased muscle mass,strength,and physical function compared to no ***

关键词： Hypertrophy Resistance training Resistance training prescription variables Strength Umbrella review