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Neural Regeneration Research 2012年第22期7卷 1715-1721页

作者： Sung Eun Kim ll Gyu Ko Mal Soon Shin Chang Ju Kim Young Gwan Ko Hanjin Cho Department of Physiology College of Medicine Kyung Hee University Department of Emergency Medicine College of Medicine Kyung Hee University Department of Emergency Medicine Korea University Ansan Hospital

Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyI-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death.

关键词： wintracerebral hemorrhage organotypic hippocampal slice culture bovine colostrum apoptotic celldeath N-methyI-D-aspartic acid caspase-3 hippocampus memory

Long-term follow-ups of revascularized immature necrotic teeth:three case reports

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International Journal of Oral Science 2012年第2期4卷 109-113页

作者： Duck-Su Kim Hae-Jin Park Je-Ha Yeom Ji-Sung Seo Gil-Joo Ryu Ki-Ho Park Seung-Il Shin Sun-Young Kim Department of Conservative Dentistry School of DentistryKyung Hee UniversitySeoulKorea Good Will Dental Hospital BusanKorea Department of Orthodontics School of DentistryKyung Hee UniversitySeoulKorea Department of Periodontology School of DentistryKyung Hee UniversitySeoulKorea

Revascularization of immature necrotic teeth is a reliable treatment alternative to conventional apexogenesis or apexification. In case 1, a 12-year-old boy had his necrotic, immature mandibular left second premolar treated with a revascularization technique. At a 24-month follow-up, periapical radiolucency had disappeared and thickening of the root wall was observed. In cases 2 and 3, a lO-year-old boy had his necrotic, immature, bilateral mandibular second premolars treated with the same modality. At 48-month （in case 2） and 42-month （in case 3） follow-ups, loss of periapical radiolucencies and increases in the root wall thickness were also observed.

关键词： revascularization pulp necrosis mineral trioxide aggregate antibiotic mixture immature tooth

Comparative pollen morphology of Glechoma and Marmoritis(Nepetinae,Lamiaceae)

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Journal of Systematics and Evolution 2010年第6期48卷 464-473页

作者： Tae-Soo JANG Suk-Pyo HONG Laboratory of Plant Systematics Department of BiologyInstitute of Basic SciencesKyung Hee University

The pollen morphology of 13 taxa(34 specimens) of the genera Glechoma L.,and Marmoritis *** investigated in detail using light,scanning electron,and transmission electron *** grains of all studied taxa are small to large in size(P = 32.5-60.4 μm,E = 20.2-50.5 μm),prolate-spheroidal to prolate in shape and mostly hexacolpate(the amb more or less circular or rarely ellipsoid) with granular *** sexine ornamentation of Glechoma is bireticulate;the muri of the primary reticulum are irregularly circled,and lumen size is *** contrast,the sexine surfaces of the Marmoritis pollen tend to more elongate or wider at the muri of the primary reticulum than those of the *** pollen wall stratification of selected taxa(three from Glechoma and one from Marmoritis) is characterized by unbranched columellae,and continuous or distinctly discontinuous endexine based on transmission electron microscopy *** results of Glechoma and Marmoritis reveal rather similar pollen morphological features,however,fine details of sexine ornamentation are characteristic to differentiate the pollen *** these differences may be useful in establishing the taxonomic boundary between two genera,they are too weak to segregate diagnostic characters.

关键词： Glechoma Lamiaceae Marmoritis Nepetinae pollen morphology scanning electron microscope sexine ornamentation transmission electron microscope.

Neuroprotective effects of Fructus Chebulae extracts on experimental models of cerebral ischemia

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Journal of Traditional Chinese Medicine 2014年第1期34卷 69-75页

作者： Bhakta Prasad Gaire Hocheol Kim Department of Herbal Pharmacology College of Korean MedicineKyung Hee University

OBJECTIVE:To investigate the neuroprotective effects of Fructus Chebulae extract using both in vivo and invitromodels of cerebral ***:As an in vitro model,oxygen glucose deprivation followed by reoxygenation(OGD-R)and hydrogen peroxide(H2O2)induced cellular damage in rat pheochromocytoma(PC12)cells was used to investigate the neuroprotective effects of extract of Fructus Chebulae.3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to calculate cell *** in vivo,occlusion of left middle cerebral artery on rats was carried out as a focal cerebral ischemic ***:Fructus Chebulae extract increases the PC12 cell survival against OGD-R and H2O2by 68%and 91.4%*** Chebulae also de-creases the cerebral infarct volume by 39%and extent of hemisphere swelling from 17%in control group to 10%in FructusChebulaetreated ***:Fructus Chebulae,as a traditional medicine,can rescue the neuronal cell death against ischemia related *** possible mechanism for the neuroprotection might be the inhibition of oxidative damages occurring after acute phase of cerebral ischemia.

关键词： Fructus Chebulae Pheochromocytoma Neuroprotection Brain ischemia Middle cerebral artery

Lump type crossed fused renal ectopia with bilateral vesicoureteral reflux: A case report

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World Journal of Clinical Cases 2019年第6期7卷 773-777页

作者： Taesoo Choi Koo Han Yoo Ran Song Dong-Gi Lee Department of Urology School of MedicineKyung Hee University Division of Rheumatology Department of Internal MedicineSchool of MedicineKyung Hee University

BACKGROUND Crossed fused renal ectopia is a rare congenital anomaly of the ascent of the kidney. This anomaly may be observed as a solitary kidney during initial evaluation. A solitary kidney must be evaluated for associated anomalies such as duplication,horseshoe kidney,or crossed renal *** SUMMARY An anomaly was observed in a 9-mo-old male child who was subsequently diagnosed with crossed fused renal ectopia and vesicoureteral reflux(VUR). In this condition,recurrent febrile urinary tract infection can be a serious problem,and can easily cause renal damage due to relatively short ureters and high pressure in the *** To prevent urosepsis and preserve renal function,early diagnosis and proper management including surgical correction should be considered for the management of renal ectopia with VUR.

关键词： Kidney Congenital abnormalities Vesicoureteral reflux Ureteroneocystostomy Politano-Leadbetter Case report

Therapeutic Effects of Traditional Herbal Medicine on Cerebral Ischemia:A Perspective of Vascular Protection

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Chinese Journal of Integrative Medicine 2013年第11期19卷 804-814页

作者： Youngmin Bu kyungjin Lee Hyuk-Sang Jung Sang-Kwan Moon Department of Herbal Pharmacology College of Korean MedicineKyung Hee University Department of Anatomy College of Korean Medicine Institute of Korean MedicineKyung Hee University Department of Cardiovascular and Neurologic Disease College of Korean MedicineKyung Hee University

Although many agents for acute ischemic stroke treatment have been developed from extensive preclinical studies, most have failed in clinical trials. As a result, researchers are seeking other methods or agents based on previous studies. Among the various prospective approaches, vascular protection might be the key for development of therapeutic agents for stroke and for improvements in the efficacy and safety of conventional therapies. Traditional medicines in Asian countries are based on clinical experiences and literature accumulated over thousands of years. To date, many studies have used traditional herbal medicines to prove or develop new agents based on stroke treatments mentioned in traditional medicinal theory or other clinical data. In the current review, we describe the vascular factors related to ischemic brain damage and the herbal medicines that impact these factors, including Salviae Miltiorrhizae Radix, Notoginseng Radix, and Curcumae Rhizoma, based on scientific reports and traditional medical theory. Further, we point out the problems associated with herbal medicines in stroke research and propose better methodologies to address these problems.

关键词： traditional medicine vascular protection ischemic stroke Salviae Miltiorrhizae Radix Notoginseng Radix Curcumae Rhizoma

Development of a valid and reliable seven emotions impairment questionnaire and assessment of its predictability for phlegm and blood stasis

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Journal of Traditional Chinese Medicine 2016年第4期36卷 547-554页

作者： Byoung-hee Lee Min-Yong Kim Young-Bae Park Young-Jae Park Department of Diagnosis and Biofunctional Medicine College of Korean MedicineKyung Hee University Seou102447 Korea Business School Kyung Hee UniversitySeou 102447 Korea Department of Diagnosis and Biofunctional Medicine College of Korean Medicine Kyung Hee University Seoul 02447 Korea Department of Diag-nosis and Biofunctional Medicine Kyung Hee UniversityHospital at Gangdong Seoul 05278 Korea.

OBJECTIVE:To develop and validate a Seven Emotions Impairment questionnaire(SEIQ),to define an optimum cut-off point for the SEIQ,and to examine whether SEI was predictive of Phlegm and Blood Stasis(BS).METHODS:Two hundred outpatients and 75 college students were asked to complete the SEIQ,the Profile of Mood States(POMS),Phlegm Pattern Questionnaire(PPQ),and BS Questionnaire(BSQ).Twelve clinicians determined whether the outpatients exhibited *** data were used to examine the internal consistency and determine validity for the ***,POMS,PPQ,and BSQ data were used to examine concurrent validity and predictability of SEI for Phlegm and BS in the college *** SEIQ scores and the clinicians' diagnoses of the outpatients were considered to define an optimum cut-off score for the ***:The 18-item SEIQ had satisfactory internal consistency(α = 0.905) and concurrent *** the construct validity test,four factors(chest-anxiety,fatigue-depression,working-family-troubles,and sleep-memory) were *** the receiver operator characteristic curve curve analysis,the sensitivity,specificity,and area under the curve of the SEIQ were 67.2%,72.1%,and 73%,*** optimum cut-off score was defined as nine *** scores were strongly predictive of Phlegm and BS(β = 0.862 and 0.673,respectively).CONCLUSION:Based on our results,we concluded that the SEIQ is a reliable and valid instrument for evaluating SEI,and is strongly predictive of Phlegm and BS.

关键词： Seven emotions Intermingled phlegm and blood-stasis Surveys and questionnaires Diagnosis Reference standards Mental health

Vasorelaxant effects of 50 commonly used traditional herbal prescriptions on isolated rat aortic rings

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Journal of Traditional Chinese Medicine 2020年第4期40卷 629-639页

作者： Bumjung Kim Cheolmin Jo Somin Lee Hanna Choi Kwang-Woo Kim Inhye Ham Ho-Young Choi kyungjin Lee Department of Oriental Health Management Kyung Hee Cyber UniversitySeoul 02447Republic of Korea Department of Herbal pharmacology College of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea Department of Herbal pharmacology Graduate SchoolKyung Hee UniversitySeoul 02447Republic of Korea Department of Biomedical Science and Technology Graduate SchoolKyung Hee UniversitySeoul 02447Republic of Korea

OBJECTIVE:To investigate the vasorelaxant activities of 50 common traditional herbal prescriptions(THPs)on isolated rat aortic ***:An electric extractor was used to extract *** aortic rings were precontracted using phenylephrine in organ chambers containing Krebs-Henseleit *** of THPs were added in increasing concentrations(10-1000μg/mL)to investigate vasorelaxant *** vasorelaxant effects of THPs were calculated as percentage of contraction in response to ***:Several THPs such as Tianwangbuxin Dan,Banxiaxiexin Tang,and Mahuang Tang,significantly relaxed precontracted aortic *** contrast,Xiaochaihu Tang,Shensuyin,and Guizhifuling Wan significantly contracted aortic ***,these THPs increasingly relaxed or contracted aortic rings relaxed by ***:Our findings suggest that hypertension can be treated using *** some THPs can counteract treatment of *** studies should be developed on use of THPs for treatment of hypertension are critical,and guidelines for use of traditional herbal medicines to treat hypertension.

关键词： Hypertension Vasodilation Vasoconstriction Herbal medicine

Coronary sinus endocarditis in a hemodialysis patient:A case report and review of literature

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World Journal of Clinical Cases 2021年第17期9卷 4348-4356页

作者： Hui-Jeong Hwang Sung-Wook Kang Department of Cardiology Kyung Hee University Hospital at GangdongKyung Hee University College of MedicineSeoul 05278South Korea Department of Pulmonary Allergy and Critical Care MedicineKyung Hee University Hospital at GangdongSeoul 05278South Korea

BACKGROUND Infective endocarditis is more common in hemodialysis patients than in the general population and is sometimes difficult to *** coronary sinus(CS)vegetation is extremely rare and has a good prognosis,but complicated CS vegetation may have a poorer clinical *** report a case of CS vegetation accidentally found via echocardiography in a hemodialysis patient with undifferentiated *** CS vegetation may have been caused by endocardial denudation due to tricuspid regurgitant jet and subsequent *** SUMMARY A 91-year-old man with dyspnea and hypotension was transferred from a nursing *** was on regular hemodialysis and had a history of severe grade of tricuspid *** was no leukocytosis or fever upon *** and sequential blood cultures revealed absence of microorganism *** computed tomography showed lung consolidation and a large pleural effusion.A mobile band-like mass on the CS,suggestive of vegetation,was observed on *** diagnosed him with infective endocarditis involving the CS,pneumonia,and septic shock based on echocardiographic,radiographic,and clinical *** of broad-spectrum antibiotics,fluid resuscitation,inotropic support,and ventilator care were ***,the patient died from uncontrolled infection and septic *** CS vegetation can be fatal in hemodialysis patients with impaired immune systems,especially when it delays the diagnosis.

关键词： Coronary sinus Endocarditis Renal dialysis Echocardiography Diagnosis,differential Case report

Reliability and validity of tongue color analysis in the prediction of symptom patterns in terms of East Asian Medicine

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Journal of Traditional Chinese Medicine 2016年第2期36卷 165-172页

作者： Young-Jae Park Jin-Moo Lee Seung-Yeon Yoo Young-Bae Park Department of Diagnosis and Biofunctional Medicine College of Korean MedicineKyung Hee UniversitySeoul 134-727Korea Department of Diagnosis and Biofunctional Medicine Kyung Hee University Hospital at GangdongSeoul 134-727Korea Department of Oriental Gynecology College of Korean MedicineKyung Hee UniversitySeoul 134-727Korea Department of Women Health Clinic Kyung Hee University Hospital at GancldonaSeoul 134-727Knrpa

OBJECTIVE:To examine whether color parameters of tongue inspection(TI)using a digital camera was reliable and valid,and to examine which color parameters serve as predictors of symptom patterns in terms of East Asian medicine(EAM).METHODS:Two hundred female subjects'tongue substances were photographed by a mega-pixel digital *** with the photographs,the subjects were asked to complete Yin deficiency,Phlegm pattern,and Cold-Heat pattern *** three sets of digital imaging software,each digital image was exposure-and white balance-corrected,and finally L*(luminance),a*(red-green balance),and b*(yellow-blue balance)values of the tongues *** examine intra-and inter-rater reliabilities and criterion validity of the color analysis method,three raters were asked to calculate color parameters for 20 digital image ***,four hierarchical regression models were ***:Color parameters showed good or excellent reliability(0.627-0.887 for intra-class correlation coefficients)and significant criterion validity(0.523-0.718 for Spearman's correlation).In the hierarchical regression models,age was a significant predictor of Yin deficiency(β=0.192),and b*value of the tip of the tongue was a determinant predictor of Yin deficiency,Phlegm,and Heat patterns(β=-0.212,-0.172,and-0.163).Luminance(L*)was predictive of Yin deficiency(β=-0.172)and Cold(β=0.173)***:Our results suggest that color analysis of the tongue using the L*a*b*system is reliable and valid,and that color parameters partially serve as symptom pattern predictors in EAM practice.

关键词： Medicine East Asian Traditional Complementary therapies Tongue inspection Yin deficiency Symptom pattern