检索结果-南通市图书馆

Cancer/testis antigens： novel tools for discerning aggressive and non-aggressive prostate cancer

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2012年第3期14卷 400-404,I0006页

作者： Takumi Shiraishi Robert H Getzenberg Prakash Kulkarni Department of Urology James Buchanan Brady Urological Institute Baltimore M D 21287 USA Department of Urology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan Department of Oncology James Buchanan Brady Urological Institute Baltimore MD 21287 USA pharmacology and Molecular Sciences The Johns Hopkins University School of Medicine Baltimore MD 21287 USA

The introduction of serum prostate-specific antigen （PSA） in the 1980s has dramatically altered and benefited the initial diagnosis of prostate cancer. However, the widespread use of PSA testing has resulted in overdetection and overtreatment of potentially indolent disease. Thus, a clinical dilemma today in the management of prostate cancer is to discern men with aggressive disease who need definitive treatment from men whose disease are not lethal. Although several serum and tissue biomarkers have been evaluated during the past decade, improved markers are still needed to enhance the accuracy, with which patients at risk can be discerned and treated more aggressively. The cancer/testis antigens （CTAs） are a group of proteins that are restricted to the testis in the normal adult, but are aberrantly expressed in several types of cancers. Because of their restricted expression pattern, the CTAs represent attractive biomarker candidates for cancer diagnosis/prognosis. Furthermore, several studies to date have reported the differential expression of CTAs in prostate cancer. Here, we review recent developments that demonstrate the potential of the CTAs as biomarkers to discern the a^ressive Dhenotvoe of orostate cancer.

关键词： cancer/testis antigens DNA microarrays prostate cancer prostate carcinoma tumor antigen

Gastric carcinoma originating from the heterotopic submucosal gastric gland treated by laparoscopy and endoscopy cooperative surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2015年第8期7卷 118-122页

作者： Taisuke Imamura Shuhei Komatsu Daisuke Ichikawa Hiroki Kobayashi Mahito Miyamae Shoji Hirajima Tsutomu Kawaguchi Takeshi Kubota Toshiyuki Kosuga Kazuma Okamoto Hirotaka Konishi Atsushi Shiozaki Hitoshi Fujiwara Kiyoshi Ogiso Nobuaki Yagi Akio Yanagisawa Takashi Ando Eigo Otsuji Division of Digestive Surgery Department of Digestive Surgery Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Department of Pathology Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Department of Gastroenterology and Hepatology Kyoto Kuramaguchi Medical Center Kyoto 603-8151 Japan

Gastric carcinoma is derived from epithelial cells in the gastric mucosa. We reported an extremely rare case of submucosal gastric carcinoma originating from the heterotopic submucosal gastric gland(HSG) that was safely diagnosed by laparoscopy and endoscopy cooperative surgery(LECS). A 66-year-old man underwent gastrointestinal endoscopy, which detected a submucosal tumor(SMT) of 1.5 cm in diameter on the lesser-anterior wall of the upper gastric body. The tumor could not be diagnosed histologically, even by endoscopic ultrasound-guided fine-needle aspiration biopsy. Local resection by LECS was performed to confirm a diagnosis. Pathologically, the tumor was an intra-submucosal well differentiated adenocarcinoma invading 5000 μm intothe submucosal layer. The resected tumor had negative lateral and vertical margins. Based on the Japanese treatment guidelines, additional laparoscopic proximal gastrectomy was curatively performed. LECS is a less invasive and safer approach for the diagnosis of SMT, even in submucosal gastric carcinoma originating from the HSG.

关键词： Heterotopic submucosal gland Laparoscopyand endoscopy cooperative surgery Gastric carcinoma Gastric submucosal tumor Less invasive treatment

OXIDATIVE DNA DAMAGE AND VITAMINS IN DIABETUS MELLITUS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

OXIDATIVE DNA DAMAGE AND VITAMINS IN DIABETUS MELLITUS

Importance of histological evaluation in endoscopic resection of early colorectal cancer

第二届中日维生素国际学术研讨会

作者： Y.Naito G.Hasegawa E.Ichiishi K.Uchiyama H.Ichikawa H.Ochi T.Yoshikawa First Department of Medicine Kyoto Prefectural University of MedicineKyoto 602-8566 First Department of Medicine Kyoto Prefectural University of MedicineKyoto 602-8566 First Department of Medicine Kyoto Prefectural University of MedicineKyoto 602-8566 First Department of Medicine Kyoto Prefectural University of MedicineKyoto 602-8566 First Department of Medicine Kyoto Prefectural University of MedicineKyoto 602-8566 Japan Institute for the Control of Aging FukuroiShizuoka 437-0122Japan First Department of Medicine Kyoto Prefectural University of MedicineKyoto 602-8566

＜正＞Oxidative stress possibly causes various forms of thssue damage in human. Although manyexperimental studies have indicated the significalt and crucial role of oxygen-derived free radicalsin the pathogenesis of indammation, ischemic status, metabolic abnormalities. and carcinogenesis,it is important to establish a tool to evaluate oxidative stress and oxidative DNA damage in human,and to evaluate the perscnal genetic susceptibility to various stress. Oxidative stress is defined as adisturbance in the prooxidant-antioxidan balance in favor of the fomer, Oxidative products oflipld, protein. or DNA may be good markers for evaluating oxidative damage in patients with

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pathophysiology 2012年第2期3卷 51-59页

作者： Naohisa Yoshida Yuji Naito Nobuaki Yagi Akio Yanagisawa Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of MedicineGraduate School of Medical ScienceKyoto 602-8566Japan Department of Surgical Pathology Kyoto Prefectural University of MedicineGraduate School of Medical ScienceKyoto 602-8566Japan

The diagnostic criteria for colonic intraepithelial tumors vary from country to *** intramucosal adenocarcinoma is recognized in Japan,in Western countries adenocarcinoma is diagnosed only if the tumor invades to the submucosa and accesses the muscularis ***,endoscopic therapy,including endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD),is used worldwide to treat adenoma and early colorectal *** histopathological evaluation is important for the curativeness of these therapies as inappropriate endoscopic therapy causes local recurrence of the tumor that may develop into fatal ***,colorectal ESD and EMR are not indicated for cancers with massive submucosal ***,diagnosis of cancer with massive submucosal invasion by endoscopy is limited,even when magnifying endoscopy for pit pattern and narrow band imaging and flexible spectral imaging color of enhancement are ***,occasional cancers with massive submucosal invasion will be treated by ESD and *** histopathological evaluation of these lesions should be performed in order to determine the necessity of additional therapy,including surgical resection.

关键词： Endoscopic submucosal dissection Endoscopic mucosal resection Early colorectal cancer Histopathology

DEVELOPMENT OF FRASTA SIMULATION SOFTWARE

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2006年第3期19卷 165-170页

作者： K. Tanaka Department of Mechanical Systems Engineering Toyama prefectural university Toyama 939-0398 Japan

Fracture-surface topography analysis （FRASTA） was successfully used to simulate the process of crack and calculate parameters of crack such as the crack opening angle （COA） and crack-tip opening angle （CTOA）. But because the amount of calculation is large, errors are often made during the course of calculation. FRASTA simulation software, namely fracture surface analyst （FSA ） is developed and a series of center-cracked tension （CCT） and double edge notched （DEN） specimens of different materials with different sizes are tested, their fracture surfaces are scanned by non-contact 319 scanning system and the elevation data of the fracture surfaces is recorded. FSA used the recorded elevation data of fracture surfaces to simulate the process of crack based on the principle of FRASTA. Results show that FSA can accurately simulate the process and calculate the parameters of crack.

关键词： FRASTA (fracture-surface topography analysis) COA (crack opening angle) CTOA (crack-tip opening angle) CCT (center-cracked tension) DEN (double edge notched)

DETERMINATION OF SOME PARAMETERS OF CRACK BASED ON FRASTA SIMULATION

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2005年第5期18卷 594-602页

作者： K. Tanaka Department of Mechanical Systems Engineering Toyama Prefectural University Toyama 939-0398 Japan

A new method, using the fracture-surface topography analysis （FRASTA）, of determining the parameters of rotation factor and CTOA is provided. The fracture surfaces are scanned by laser microscope and the height data is recorded to analyze. By comparing the crack extension, plastic rotation factor and COA obtained by the method of double clip gauge and by this new method respectively, the validity of it is verified. It is then used to determine the CTOA. .The critical CTOA is well determined in this paper. Also by the new method, the variation of crack opening deformation （COA and CTOA） through specimen thickness can be obtained which can＇t be obtained by the usual methods. It also can provide much information of crack extension such as direction and ratio.

关键词： FRASTA COA CTOA rotation factor

Function Assessment for Rheumatoid Thumb Deformity

在线全文

学校读者我要写书评

暂无评论

Open Journal of Rheumatology and Autoimmune Diseases 2015年第3期5卷 92-96页

作者： Ryo Oda Daigo Taniguchi Hiroyoshi Fujiwara Shogo Toyama Daisaku Tokunaga Toshikazu Kubo Department of Orthopaedics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan

Objective: Nalebuff’s type I deformity of the rheumatoid thumb, which is the most common thumb deformity with rheumatoid arthritis, can be classified into three stages according to the range of motion of the thumb. However, a functional assessment for each stage has never been undertaken. Methods: The ranges of motion of the thumb metacarpophalangeal and interphalangeal joints were evaluated to determine Nalebuff’s clinical stage, and both the Modified Kapandji Index (MKI) and the simple test for evaluating hand function (STEF) were used to evaluate hand function in 32 rheumatoid arthritis patients with type I deformity. We assessed hand function in each stage, and examined the relationship between the three clinical stages and dysfunction of the hand. Results: The scores for both MKI and STEF were significantly reduced in parallel with advancing stage of thumb deformity. Conclusion: Nalebuff’s staging system is also useful for reflecting the level of thumb function.

关键词： Rheumatoid Arthritis Thumb Deformity Function Assessment

Synthesis and application of bilayer-surfactant-enveloped Fe_3O_4 nanoparticles: water-based bilayer-surfactant-enveloped ferrofluids

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2016年第2期23卷 234-240页

作者： Bai-yi Chen Jian-hui Qiu Hui-xia Feng Department of Machine Intelligence and Systems Engineering Faculty of Systems Engineering Akita Prefectural University College of Petrochemical Technology Lanzhou University of Technology

Superparamagnetic carbon-coated Fe3O4 nanoparticles with high magnetization（85 emu·g-（-1）） and high crystallinity were synthesized using polyethylene glycol-4000（PEG（4000）） as a carbon ***3O4 water-based bilayer-surfactant-enveloped ferrofluids were subsequently prepared using sodium oleate and PEG（4000） as *** using X-ray photoelectron spectroscopy,X-ray diffraction,and Fourier-transform infrared spectroscopy indicate that the Fe3O4 nanoparticles with a bilayer surfactant coating retain the inverse spinel-type structure and are successfully coated with sodium oleate and PEG（4000）.Transmission electron microscopy,vibrating sample magnetometry,and particle-size analysis results indicate that the coated Fe3O4 nanoparticles also retain the good saturation magnetization of Fe3O4（79.6 emu·g^-1） and that the particle size of the bilayer-surfactant-enveloped Fe3O4 nanoparticles is 42.97 nm,which is substantially smaller than that of the unmodified Fe3O4 nanoparticles（486.2 nm）.UV-vis and zeta-potential analyses reveal that the ferrofluids does not agglomerate for 120 h at a concentration of 4 g·L^-1,which indicates that the ferrofluids are highly stable.

关键词： magnetic fluids iron oxides nanoparticles bilayers sodium oleate polyethylene glycol

Effects of Abscisic Acid Treatment on Berry Coloration and Expression of Flavonoid Biosynthesis Genes in Grape

在线全文

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2016年第9期7卷 1325-1336页

作者： Ayako Katayama-Ikegami Tomoaki Sakamoto Kana Shibuya Takane Katayama Mei Gao-Takai Faculty of Bioresources and Environmental Sciences Ishikawa Prefectural University Ishikawa Japan Graduate School of Biostudies Kyoto University Kyoto Japan

In order to enhance berry coloration of bright-red grape cultivars, the effects of abscisic acid (ABA) treatment on the quantity and composition of anthocyanins as well as the expression of genes related to flavonoid biosynthesis in the berry were examined. Exogenous ABA treatment increased anthocyanin content, especially petunidin- and malvidin-type anthocyanins. Quantitative real-time PCR analysis revealed that ABA treatment around véraison resulted in the upregulation of genes encoding enzymes responsible for both general flavonoid and anthocyanin biosynthesis. On the other hand, the gene expressions of enzymes involved in proanthocyanidin synthesis were drastically decreased at véraison and remained extremely low even with ABA treatment. Thus, increases in the total amount and composition ratios of petunidin- and malvidin-type anthocyanins were mainly caused by ABA-induced upregulation of uridine diphosphate glucose flavonoid glucosyl transferase, glutathione S-transferase 4, O-methyl transferase and flavonoid 3’, 5’ hydroxylase expression, resulting in the deep coloration of berry of skin.

关键词： Abscisic Acid (ABA) Anthocyanin Biosynthetic Enzyme Gene Expression Transcription Factor