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In vitro antioxidant,cholinesterase and tyrosinase inhibitory activities of Calophyllum symingtonianum and Calophyllum depressinervosum(Guttiferae)

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Journal of Coastal Life medicine 2015年第2期 126-131页

作者： Nurul Iman Aminudin Farediah Ahmad Muhammad Taher Department of Chemistry Faculty of ScienceUniversiti Teknologi Malaysia81310 Skudai JohorMalaysia kulliyyah of Pharmacy International Islamic University MalaysiaJalan Sultan Ahmad ShahBandar Indera Mahkota25200 KuantanPahangMalaysia

Objective:To screen the antioxidant,cholinesterase and tyrosinase enzymatic inhibition activities of the leaves and heartwood of Calophyllum symingtonianum(***),and the bark of Calophyllum depressinervosum(***).Methods:Samples of leaves and heartwood of *** and bark of *** were tested for their total phenolic content and in vitro antioxidant assay by 2,2-diphenyl-1-picrylhydrazyl radical scavenging and β-carotene *** inhibition by Ellman’s method and tyrosinase inhibition using L-3,4-dihydroxyphenylalanine as a substrate were also ***:All methanol extracts were found to exhibit strong 2,2-diphenyl-1-picrylhydrazyl radical scavenging *** from the heartwood of *** gave a low IC50(5.17±0.04)μg/mL followed by bark of ***[(7.30±0.14)μg/mL]and *** leaves[(15.70±1.43)μg/mL].The methanol extract of *** bark showed 95.08%inhibition ofβ-carotene *** extracts showed moderate inhibition towards tyrosinase activity with an IC50 of more than 100μg/*** methanol extract of *** stem bark showed the highest inhibition(78.46%)against ***:These results showed that both Calophyllum species are potential sources of antioxidant and cholinesterase *** study is needed for the isolation and characterization of the active metabolites responsible for both activities.

关键词： Calophyllum symingtonianum Calophyllum depressinervosum Antioxidant Cholinesterase Tyrosinase Guttiferae

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Zinc-doped hydroxyapatite-zeolite/polycaprolactone composites coating on magnesium substrate for enhancing in-vitro corrosion and antibacterial performance

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Transactions of Nonferrous Metals Society of China 2020年第1期30卷 123-133页

作者： Nida IQBAL Saman IQBAL Tanveer IQBAL H.R.BAKHSHESHI-RAD Ahmed ALSAKKAF Ahmad KAMIL Mohammed Rafiq ABDUL KADIR Mohd Hasbullah IDRIS H.Balaji RAGHAV Biomedical Engineering Centre University of Engineering and TechnologyKala Shah Kaku(KSK)CampusLahorePakistan Department of Physics University of the PunjabQuaid-e-Azam CampusLaborePakistan Department of Chemical Polymer&Composite Material Engineering University of Engineering and TechnologyKala Shah Kaku(KSK)New CampusLahorePakistan Advanced Materials Research Center Department of Materials EngineeringNajafabad BranchIslamic Azad UniversityNajafabadIran School of Mechanical Engineering Faculty of EngineeringUniversiti Teknologi MalaysiaJohorMalaysia kulliyyah of Science International Islamic University MalaysiaBandar Indera Mahkota CampusJalan Sultan Ahmad Shah25200 KuantanPahang Darul MakmurMalaysia School of Biomedical Engineering and Health Sciences Faculty of EngineeringUniversiti Teknologi MalaysiaJohorMalaysia Tissue Engineering Group(TEG) National Orthopaedic Centre of Excellence in Research and Learning(NOCERAL)Department of Orthopaedic SurgeryFaculty of MedicineUniversity of Malaya50603 Lembah PantaiKuala LumpurMalaysia

This work is focused on developing zinc-doped hydroxyapatite-zeolite(Zn HA-Zeo)and polycaprolactone(PCL)composite coatings on magnesium(Mg)substrate to improve the corrosion resistance and antimicrobial ***-coating technique was used to coat Zn HA-Zeo/PCL on the Mg substrate at room *** samples were subjected to field emission scanning electron microscopy(FESEM),X-ray diffraction(XRD),Fourier transform infrared(FTIR),energy dispersive X-ray spectroscopy(EDX)and antimicrobial *** demonstrated that composite coatings consist of HA,scholzite,zeolite,and PCL *** spectra indicated the presence of calcium(Ca),silicon(Si),aluminum(Al),zinc(Zn),phosphorus(P)and oxygen(O).The composite surface appeared in spherical-like microstructure on coating with thickness ranging 226-260μ***-doped HA-Zeo composite coating had a high corrosion resistance and provided sufficient protection to the Mg surface against galvanic *** Zn HA-Zeo coating samples exhibited superior disc inhibition by confirming antimicrobial activity against the *** as compared to HA-Zeo *** these results showed that the Zn HA-Zeo coatings not only improved the corrosion resistance,but also enhanced the antimicrobial property and hence they can be used as suitable candidates for implant applications.

关键词： biodegradable magnesium bioceramics coating corrosion resistance antimicrobial activity

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