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居住于交通繁华区与冠心病患病率的相关性

世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 25-25页

作者： Hoffmann B. Moebus S. Stang A. 刘相飞 institute for Medical Informatics Biometry and EpidemiologyUniversity HospitalUniversity of Duisburg-EssenHufelandstr. 5545122 EssenGermany

目的:长期暴露于城市空气污染环境下可能会加速动脉粥样硬化的发生及增加心肺疾病的死亡率。本研究旨在观察长期居住于交通繁华区与冠心病(CHD)患病率的相关性。

关键词：冠心病患病率心肺疾病城市空气污染基线资料流行病学证据亚组分析前瞻性队列研究

紫绀型先天性心脏病成人患者的血液黏度及其与铁缺乏症、症状和运动耐量的关系

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世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 52-页

作者： Broberg C.S. Bax B.E. Okonko D.O. 黄浙勇 Adult Congenital Heart Centre Royal Brompton Hospital and National Heart Lung Institute London England United Kingdom Dr.

Objectives: This study sought to determine the relationship between blood viscosity and iron deficiency and their impact on symptoms and exercise function in adults with cyanotic congenital heart disease. Background: Iron deficiency is believed to raise whole blood viscosity in cyanotic congenital heart disease, although available data are inconsistent. Methods: Thirty-nine cyanotic adults were prospectively assessed for iron deficiency(transferrin saturation ≤5%), hyperviscosity symptoms, and exercise capacity. Same-day measurement of whole blood viscosity and hematocrit(Hct) adjusted viscosity(cells resuspended in autologous plasma to Hct of 45%) was performed at shear rates ranging from 0.277 s-1 to 128.5 s-1. Results: Viscosity did not differ between patients with iron deficiency(n=14) and those without(n=25). Whole blood viscosity correlated with Hct(r=0.63, p< 0.001 at low shear and r=0.84, p< 0.001 at high shear) but not with red blood cell size or iron indices. Hyperviscosity symptoms were independent of iron indices but directly correlated with increased Hct-adjusted viscosity(r=0.41, p=0.01). Exercise capacity did not differ in iron-deficient patients. However, peak oxygen consumption was higher in those with Hct ≥65%(12.6±3.4 ml/kg/m2 vs. 9.8±2.6 ml/kg/m2,mean±SD, p=0.036) despite higher whole blood viscosity in these same individuals(p< 0.01 for all shear rates). Conclusions: Iron deficiency is common in cyanotic adults but does not alter viscosity. Hyperviscosity symptoms are associated with a higher Hct-adjusted viscosity independent of cell size or iron stores. Higher Hct is associated with better exercise capacity. Further work to understand the origin of hyperviscosity symptoms is warranted.

关键词：运动耐量铁缺乏症血液黏度成人患者紫绀型先天性心脏病心脏先天畸形

心脏手术和干预的年龄及性别相关应用:一项意大利的多中心研究

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世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 49-49页

作者： Boccia A. Damiani G. D' Errico M. M. G. Ricciardi 郭战宏 institute of Hygiene Cathol. Univ. Sacred Heart-Rome Largo Francesco Vito no. 1 Rome 00168 Italy

Cardiovascular diseases represent the leading cause of death in Italy and one of the most frequent cause of disability in the elderly. The aim of the study was to investigate the influence of age and sex of patient on the utilisation of cardiac procedure and interventions in Italy. Methods: Retrospective analysis of 2805 patients’ medical case notes in cardiology, internal medicine and elderly clinics in six Italian Regions during the period 1996- 1997, considering coronary catheterisation(CC), percutaneous transluminal coronary angioplasty(PTCA), coronary artery bypass grafting(CABG), thrombolysis(THR) and permanent pacemaker(PPM) implantation. Results: Older patients(more than 75 years old) were less likely to undergo CC(OR=0.062). Trends for age and sex did not achieve significance for CAGB(OR=0.815 for older patient). Age is a strong predictor of receiving PTCA, with the oldest group of patients being discriminated(OR=0.093 for people older than 75 years), and the same trend was observed for THR(OR=0.264 for patients older than 75 years). For PPM, older patient has a higher likelihood of receiving this type of intervention(OR=3.45 for 65- 74 years, and OR=7.77 for patients older than 75 years). As far as gender of patients is concerned, statistically significant differences for all cardiac procedures or interventions considered were not found. Conclusions: Clinical management of older patients with cardiac disease in Italy may be different from that of younger patients. One possible explanation would be that these patients are being discriminated against mainly because of their age.

关键词：心脏手术冠状动脉搭桥术老年心脏病心脏科永久起搏器心血管疾病死亡原因临床处理龄组病历记录

血管成形术联合药物干预与单纯溶栓治疗急性心肌梗死疗效的比较(CAPITAL AMI研究)

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世界核心医学期刊文摘（心脏病学分册） 2005年第12期1卷 57-57页

作者： Le May M. R. Wells G. A. Labinaz M. 武俊平 Ottawa Heart institute 40 Ruskin Street Ottawa Ont. K1Y4W7 Canada

OBJECTIVES:We compared a strategy of tenecteplase(TNK)-facilitated angioplasty with one of TNK alone in patients presenting with high-risk ST-segment elevation myocardial infarction(STEMI). BACKGROUND: Previous trials show that thrombolysis followed by immediate angioplasty for the treatment of STEMI does not improve ischemic outcomes compared with thrombolysis alone and is associated with excessive bleeding complications. Since the publication of these trials, however, significant pharmacological and technological advances have occurred. METHODS: We randomized 170 patients with high-risk STEMI to treatment with TNK alone(84 patients) or TNK-facilitated angioplasty(86 patients). The primary end point was a composite of death, reinfarction, recurrent unstable ischemia, or stroke at six months. RESULTS: At six months, the incidence of the primary end point was 24.4%in the TNK-alone group versus 11.6%in the TNK-facilitated angioplasty group(p=0.04). This difference was driven by a reduction in the rate of recurrent unstable ischemia(20.7%vs. 8.1%, p=0.03). There was a trend toward a lower reinfarction rate with TNK-facilitated angioplasty(14.6%vs. 5.8%, p=0.07). No significant differences were observed in the rates of death or stroke. Major bleeding was observed in 7.1%of the TNK-alone group and in 8.1%of the TNK-facilitated angioplasty group(p=1.00). CONCLUSIONS: In patients presenting with high-risk STEMI, TNK plus immediate angioplasty reduced the risk of recurrent ischemic events compared with TNK alone and was not associated with an increase in major bleeding complications.

关键词：急性心肌梗死 CAPITAL AMI 血管成形术再梗死出血并发症联合终点缺血症状终点指标出血率

Hypertension in the elderly:Are we all on the same wavelength?

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World Journal of cardiology 2011年第8期3卷 263-266页

作者： Sadip Pant Pritam Neupane Khatri Chhetri Ramesh Murari Barakoti Department of Internal Medicine University of Arkansas for Medical SciencesLittle RockAR 72205United States Medical College of Georgia AugustaGA 30192United States Mercy Catholoc Medical Center DarbyPA 19023United States institute of Medicine MaharajgunjKtm 20009Nepal

Hypertension is of frequent occurrence in the elderly *** systolic hypertension(ISH) accounts for the majority of cases of hypertension in the *** is associated with a 2-4-fold increase in the risk of myocardial infarction,left ventricular hypertrophy,renal dysfunction,stroke,and cardiovascular *** have been many studies to determine the optimal treatment for hypertension in the elderly. Why,when and how to treat hypertension in the elderly was the scope of the majority of these *** countless efforts many aspects remain *** a number of novel drugs are being developed,the issue of whether all antihypertensive drugs bestow parallel benefits or whether some agents offer a therapeutic advantage beyond blood pressure control remains of crucial ***,the response of theelderly to different antihypertensive agents also differs from that of younger patients and may explain some of the disparities in outcomes of trials conducted in elderly patients with hypertension.

关键词： Hypertension Myocardial infarction Left ventricular hypertrophy Antihypertensive agents

NBCe1 Na+-HCO3-cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo

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World Journal of cardiology 2018年第9期10卷 97-109页

作者： Kanimozhi Vairamani Vikram Prasad Yigang Wang Wei Huang Yinhua Chen Mario Medvedovic ohn N Lorenz Gary E Shull Cancer and Blood Diseases institute Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45229-3026United States Department of Pediatrics Cincinnati Children’s Hospital Medical CenterUniversity of CincinnatiCincinnatiOH 45229-3039United States Department of Pathology University of CincinnatiCollege of MedicineCincinnatiOH 45267-0529United States Division of Developmental Biology Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45229-3039United States Department of Environmental Health University of CincinnatiCollege of MedicineCincinnatiOH 45267-0056United States Department of Pharmacology and Systems Physiology University of CincinnatiCollege of MedicineCincinnatiOH 45267-0575United States Department of Molecular Genetics Biochemistry and MicrobiologyUniversity of CincinnatiCollege of MedicineCincinnatiOH 45267-0524United States

AIM To investigate the hypothesis that cardiomyocytespecific loss of the electrogenic NBCe1 Na^+-HCO3^- cotransporter is cardioprotective during in vivo ischemiareperfusion(IR)*** An NBCe1 (Slc4a4 gene) conditional knockout mouse(KO)model was prepared by gene *** performance of wildtype (WT) and cardiac-specific NBCe1 KO mice was analyzed by intraventricular pressure measurements,and changes in cardiac gene expression were determined by RNA Seq *** to in vivo IR injury was analyzed after 30 min occlusion of the left anterior descending artery followed by 3 h of reperfusion. RESULTS Loss of NBCe1 in cardiac myocytes did not impair cardiac contractility or relaxation under basal conditions or in response toβ-adrenergic stimulation,and caused only limited changes in gene expression patterns,such as those for electrical ***,following ischemia and reperfusion,KO heart sections exhibited significantly fewer apoptotic nuclei than WT *** These studies indicate that cardiac-specific loss of NBCe1 does not impair cardiovascular performance,causes only minimal changes in gene expression patterns,and protects against IR injury in vivo.

关键词： Deep sequencing Ischemic Apoptosis Slc4a4 NBCe1

流行的评估和在有稳定的长期的心失败的病人的疼痛的严厉

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World Journal of cardiology 2012年第8期4卷 250-255页

作者： Dioma U Udeoji Ankit B Shah Parag Bharadwaj Peter Katsiyianis Ernst R Schwarz Heart institute of Southern California TemeculaCA 92592United State Cedars-Sinai Medical Center Los AngelesCA 90048United States University of California Los Angeles Los AngelesCA 90095United States Heart institute of Southern California TemeculaCA 92592United State Dioma U Udeoji

AIM:To evaluate the prevalence and severity of pain in patients with chronic stable heart failure(HF) in an outpatient clinic ***:This is a cross-sectional study evaluating symptoms of generalized or specific pain in patients with chronic stable heart failure.A standardized questionnaire(Edmonton Symptom Assessment System) was administered during a routine outpatient clinic *** severity of pain and other symptoms were assessed on a 10 point scale with 10 being the worst and 0 representing no ***:Sixty-two patients [age 56 ± 13 years,51 males,11 females,mean ejection fraction(EF) 33% ± 17%] completed the ***-two patients(52%) reported any pain of various character and location such as chest,back,abdomen or the extremities,with a mean pain score of 2.5 ± *** with an EF less than 40%(n = 45,73%) reported higher pain scores than patients with an EF greater than 40%(n = 17,27%),scores were 3.1 ± 3.3 vs 1.2 ± 1.9,P < *** frequent symptoms were tiredness(in 75% of patients),decreased wellbeing(84%),shortness of breath(SOB,76%),and drowsiness(70%).The most severe symptom was tiredness with a score of 4.0 ± 2.8,followed by decreased wellbeing(3.7 ± 2.7),SOB(3.6 ± 2.8),and drowsiness(2.8 ± 2.8).CONCLUSION:Pain appears to be prevalent and significantly affects quality of life in HF *** pain assessment and management should be an integral part of chronic heart failure management.

关键词： Heart failure Pain Symptoms Therapy Palliative care

脑卒中并发急性A型主动脉夹层时实施紧急手术修复是否安全

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世界核心医学期刊文摘(心脏病学分册) 2007年第5期 61-61页

作者： Estrera A.L. Garami Z. Miller C.C. 黄浙勇 Department of Cardiothoracic and Vascular Surgery The University of Texas-Houston Medical School Memorial Hermann Heart and Vascular InstituteHouston Tex United States

目的:脑卒中并发急性A型主动脉夹层是否进行紧急手术干预尚存在争议;因在这种情况下脑再灌注可能加重神经系统症状。本研究旨在报道和分析关于脑卒中并发急性A型主动脉夹层的经验。方法:1999年9月至2005年3月间共有151例急性A型主动脉... 详细信息

目的:脑卒中并发急性A型主动脉夹层是否进行紧急手术干预尚存在争议;因在这种情况下脑再灌注可能加重神经系统症状。本研究旨在报道和分析关于脑卒中并发急性A型主动脉夹层的经验。方法:1999年9月至2005年3月间共有151例急性A型主动脉夹层患

关键词：主动脉夹层手术修复脑卒中

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女性运动能力列线图的预测价值

世界核心医学期刊文摘(心脏病学分册) 2006年第3期 25-25页

作者： Gulati M. Black H.R. Shaw L.J. 姜朝晖 Northwestern University Bluhm Cardiovascular institute 201 E. Huron St. Chicago IL 60611 United States Dr.

BACKGROUND: Recent studies have demonstrated that exercise capacity is an independent predictor of mortality in women. Normative values of exercise capacity for age in women have not been well established. Our objectives were to construct a nomogram to permit determination of predicted exercise capacity for age in women and to assess the predictive value of the nomogram with respect to survival. METHODS: A total of 5721 asymptomatic women underwent a symptom-limited, maximal stress test. Exercise capacity was measured in metabolic equivalents(MET). Linear regression was used to estimate the mean MET achieved for age. A nomogram was established to allow the percentage of predicted exercise capacity to be estimated on the basis of age and the exercise capacity achieved. The nomogram was then used to determine the percentage of predicted exercise capacity for both the original cohort and a referral population of 4471 women with cardiovascular symptoms who underwent a symptom-limited stress test. Survival data were obtained for both cohorts, and Cox survival analysis was used to estimate the rates of death from any cause and from cardiac causes in each group. RESULTS: The linear regression equation for predicted exercise capacity(in MET) on the basis of age in the cohort of asymptomatic women was as follows: predicted MET=14.7-(0.13× age). The risk of death among asymptomatic women whose exercise capacity was less than 85 percent of the predicted value for age was twice that among women whose exercise capacity was at least 85 percent of the age-predicted value(P< 0.001). Results were similar in the cohort of symptomatic women. CONCLUSIONS: We have established a nomogram for predicted exercise capacity on the basis of age that is predictive of survival among both asymptomatic and symptomatic women. These findings could be incorporated into the interpretation of exercise stress tests, providing additional prognostic information for risk stratification.

关键词：列线图运动能力预测值数值分析预测价值女性运动