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Prevention and management of adverse events following COVID-19 vaccination using traditional korean medicine:An online survey of public health doctors

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World Journal of Clinical Cases 2022年第28期10卷 10053-10065页

作者： Byungsoo Kang Hongmin Chu Bo-Young Youn Jungtae Leem College of korean medicine Dongshin UniversityNaju-si 58245South Korea Daecheong Public Health Subcenter Ongjin Public HealthcenterIncheon 23105IncheonSouth Korea Department of Preventive medicine College of Korean MedicineKyung Hee UniversitySeoul 02447South Korea College of korean medicine Wonkwang UniversityIksan 54538Jeollabuk-doSouth Korea

BACKGROUND Since February 2021,vaccination against coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2 has started in *** To perform a questionnaire survey about the prevention and management of adverse events of COVID-19 vaccination among public health doctors of korean medicine(PHKMDs).METHODS An online questionnaire was developed,comprising categories about adverse events of vaccination(AEVs)and perception of using korean medicine(KM)in managing vaccine adverse events(AEs)among ***’experience of AEVs,usage of korean medicine for AEVs,and perception and attitude in using KM for AEVs were *** survey web-link was emailed to the association of *** links were sent through Survey Monkey to all PHKMDs in *** A total of 143 participants were recruited for this study;65%of participants were vaccinated at the same of the survey(n=93).Although most participants did not take any medication for prevention of the adverse events,62%(n=58)of participants had taken herbal medicine to treat the adverse events(n=52).Approximately 35%of participants(n=33)said that they would recommend taking herbal medicine to prevent any *** various KM interventions,the participants strongly recommended taking an herbal medicine(n=69,74.19%)to treat AEs,and the second-highest was acupuncture treatment(n=19,20.43%).CONCLUSION Overall,this research demonstrated a high prevalence of KM usage by the ***,this study’s results may serve as fundamental evidence for health professionals to consider using KM treatments when treating or preventing AEVs in the near future.

关键词： COVID-19 Vaccination Adverse events Herbal medicine korean medicine

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Recognition of Association Between Blood Stasis Syndrome and Traumatic Injury among Doctors of korean medicine:A Cross-Sectional Observation Study

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Chinese Journal of Integrative medicine 2018年第4期24卷 254-259页

作者： Jeeyoun Jung Mi Mi Ko Ju Ah Lee Myeong Soo Lee korean medicine Fundamental Research Division Korea Institute of Oriental Medicine Clinical Research Division Korea Institute of Oriental Medicine

Objective： To investigate the diagnostic indicators and herbal treatments for blood stasis syndrome（BSS） patients with traumatic injuries and to identify the association between BSS and traumatic injury in Korea. Methods： Two-hundred and four patients with traumatic injury were recruited from the Gangnam and Daejeon branches of Jaseng Hospital of Oriental medicine between June 2014 and December 2014. Two independent doctors of korean medicine（DKMs） determined the diagnosis of BSS or non-BSS based on the subjects＇ signs and symptoms. The scores assigned to BSS symptoms and DKMs＇ reasons for diagnosing BSS in patients with traumatic injury were investigated. Both medication and herbal prescription records from a 3-month period were collected for all patients diagnosed with BSS by both DKMs. Results： A total of 169 of 204（82.8%） patients received consistent diagnosis related to BSS by two DKMs. Among them, 54.4%（92 cases） were diagnosed with BSS, and 45.6%（77 cases） were not diagnosed with BSS. DKMs most frequently cited symptoms of recent traumatic injury as justifications for BSS diagnoses, and also selected pain-related indicators such as abdominal pain, sharp pain and nocturnal pain as important reasons in diagnosing BSS. In addition, an inconsistency in the pattern identification theory with respect to traumatic injury was observed. Although only 92 cases（54.4%） of patients were diagnosed with BSS, 77.6% of them were prescribed decoctions for BSS. Conclusions： DKMs considered traumatic injury could cause BSS, and utilized decoction for BSS in patients with traumatic injury without confirming a diagnosis of BSS because they assumed the main symptoms or pathologies of traumatic injury to be closely related to BSS.

关键词： blood stasis syndrome korean medicine traumatic injury herbal medicine diagnosis pattern identification

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Inter-observer Reliability of Indicators and Decision of Pattern Identification Using Diagnostic Flowchart with Traditional korean medicine

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Chinese Journal of Integrative medicine 2017年第5期23卷 338-344页

作者： Ju Ah Lee Jeeyoun Jung Mi Mi Ko Myeong Soo Lee korean medicine Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 305-811 Republic of Korea Clinical Research Division Korea Institute of Oriental Medicine Daejeon 305-811 Republic of Korea

Objective： To evaluate the consistency of patterns and pattern identification（PI）, and the improvement in the diagnosis of blood stasis after the standard operating procedures（SOPs） were enhanced by using a diagnostic flowchart. Methods： A total of 358 subjects who were admitted by the Jaseng Hospital of korean medicine between June 2013 and December 2014 were included in the study. Each patient was independently diagnosed by two experts from the same department. In 2014, the SOPs included the use of a diagnostic flowchart for each indicator. Inter-observer consistency was assessed by simple percent agreement and by the kappa and AC1 statistics. Results： The improvements in inter-observer agreement for the indicators（for al patients） and PI were greater in 2014 than in 2013. In 2013, the j-value measure of agreement between the two experts ranged from ＂poor＂（κ=–0.051） to ＂good＂（κ=0.968）. The AC1 measure of agreement between the experts was generally high for the indicators and ranged from –0.010 to 0.978. In most cases, agreement was considerably lower when it was assessed by the j-values compared with the AC1 values. In 2014, the j-value measure of agreement on the indicators（for the subjects） general y ranged from poor to good, with the values ranging from –0.007 to 0.994. Moreover, the AC1 measure of agreement between the experts was general y high for al of the indicators and ranged from ＂moderate＂（AC1=0.408） to ＂excel ent＂（AC1=0.996）. Conclusions： In four examinations, there was moderate agreement between the clinicians on the PI indicators of blood stasis. To improve clinician consistency（e.g., in the diagnostic criteria used）, it is necessary to analyse the reasons for inconsistency and to improve clinician training.（Trial registration No. KCT0000916）

关键词： blood stasis inter-observer reliability pattern identification traditional Chinese medicine traditional korean medicine

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Clean-DM1, a korean Polyherbal Formula, Improves High Fat Diet-Induced Diabetic Symptoms in Mice by Regulating IRS/PI3K/AKT and AMPK Expressionsin Pancreas and Liver Tissues

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Chinese Journal of Integrative medicine 2024年第2期30卷 125-134页

作者： Piao Wang Yi Liu Seok Yong Kang Chenzi Lyu Xiang Han Tianjun Ho Kyung Jae Lee Xianglong Meng Yong-Ki Park Hyo Won Jung Department of Herbology College of Korean MedicineDongguk UniversityGyeongju 38066Korea College of Pharmacy&Graduate School of Pharmaceutical Sciences Ewha Womans UniversitySeoul 03760Korea korean medicine R&D Center Dongguk UniversityGyeongju 38066Korea Shanxi Key Laboratory of Traditional Herbal medicines Processing Shanxi University of Chinese MedicineJinzhong(030619)ShanxiProvinceChina

Objective:To investigate the effects of Clean-DM1(C-DM1),a polyherbal formulation of Radix Scrophulariae,Radix Astragali,Rhizoma Atractylodis,and Radix Salviae Miltiorrhizae,on high-fat diet(HFD)-induced diabetes ***:The information about active components of C-DM1 extract and molecular mechanism was obtained from network pharmacology *** compounds of C-DM1 extract by high performance liquid chromatography-mass spectrometry(HPLC-MS)analysis were conducted for quality *** in vivo study,mice were induced diabetes by HFD for 12 *** mice in the normal group(Nor)were maintained with a regular diet and treated with saline by *** HFD model mice were randomly divided into 3 groups,including a HFD diabetic model group,a C-DM1 extract-administered group(C-DM1,500 mg/kg),and metformin-administered groups(Met,500 mg/kg),8 mice in each *** intake,body weight(BW),and fasting blood glucose(FBG)levels were recorded weekly for 4 *** 4 weeks of treatment,alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood glucose,low-density lipoprotein cholesterol(LDL-C)were determined using an automated clinical chemistry analyzer,and homeostatic model for assessing insulin resistance(HOMA-IR)levels and oral glucose tolerance test(OGTT)were *** histopathological changes of liver and pancreatic tissues were observed by hematoxylin-eosin *** receptor substrate(IRS)/phosphatidylinositol 3 kinase(PI3K)/protein kinase B(AKT)and adenosine 5'-monophosphate-activated protein kinase(AMPK)expressions in liver and pancreas tissues were detected by Western blot ***:HPLC-MS identified dihydroisotanshinone,dihydroisotanshinone I,cryptotanshinone,harpagoside,and atractyloside A in C-DM1 *** administration of C-DM1 extract significantly decreased body weight,calorie intake,and the levels of blood glucose and insulin in the diabetic mice(P<0.05 or P<0.01).The C-DM1 extract administration improved the im

关键词： high-fat diet type 2 diabetes mellitus herbal formulation insulin receptor substrate/phosphatidylinositol 3 kinase/protein kinase B adenosine 5'-monophosphate-activated protein kinase network pharmacology high performance liquid chromatography-mass spectrometry analysis

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Capsosiphon fulvescens suppresses LPS-stimulated inflammatory responses by suppressing TLR4/NF-κB activation in RAW264.7 murine macrophages

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 115-126页

作者： Seon Yeong Ji EunJin Bang Hyun Hwangbo Min Yeong Kim Da Hye Kim Su Hyun Hong Shin-Hyung Park Chang-Young Kwon Gi-Young Kim You-Jin Jeon Suengmok Cho Yung Hyun Choi Department of Biochemistry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center Dong-eui UniversityBusan 47227Republic of Korea Department of Pathology Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Department of Food Science and Technology/Institute of Food Science Pukyong National UniversityBusan 48513Republic of Korea

Objective:To evaluate the effects of Capsosiphon fulvescens(***)ethanolic extract on inflammation in lipopolysaccharide(LPS)-induced RAW296.7 ***:The protective effects of *** ethanolic extract on LPS-induced inflammation in RAW264.7 macrophages were assessed using biochemical analysis,including enzyme-linked immunosorbent assay,quantitative reverse transcription-polymerase chain reaction,and Western blot *** examine reactive oxygen species(ROS)production,flow cytometry analysis,and immunofluorescence staining were ***,the modulatory effect of *** ethanolic extract on NF-κB activation was ***:*** ethanolic extract significantly attenuated LPS-induced levels of pro-inflammatory cytokines and notably reduced the secretion and mRNA levels of LPS-mediated matrix *** addition,*** ethanolic extract decreased ROS production and suppressed the TLR4/NF-κB signaling ***:*** ethanolic extract alleviates inflammation as well as oxidative stress by modulating the TLR4/NF-κB signaling in LPS-induced RAW264.7 *** can be used as a potential therapeutic agent to suppress inflammation and oxidative stress-associated diseases.

关键词： Capsosiphon fulvescens Inflammation Oxidative stress NF-κB Nrf2 TLR4

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Analysis of Herbal medicine Prescriptions for Patients in An Academic korean Medical Hospital:A Cross Sectional Study of Electronic Medical Records(2010–2013)

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Chinese Journal of Integrative medicine 2018年第6期24卷 467-473页

作者： Byung-Wook Lee Hyeon-Yeop Lee Kwang-Ho Heo Hyun-Woo Cho Man-Suk Hwang In Heo Byung-Cheul Shin Eui-Hyoung Hwang Department of Classics and Medical History College of Korean MedicineDongguk University Dongje Medical Co. Ltd. Department of korean medicine Yeongam Public Health Center Department of Third Green Oriental HospitalBu-cheon (14582)Republic of Korea Department of korean Medical Science School of Korean MedicinePusan National University Department of Rehabilitation medicine of korean medicine Dae-Jeon Korean Medicine HospitalDae-Jeon University Department of Rehabilitation medicine of korean medicine Korean Medicine HospitalPusan National University

Objective： To obtain fundamental information for the standardization of herbal medicine in Korea. Methods： We analyzed the herbal medicine prescription data of patients at the Pusan National University korean medicine Hospital from March 2010 to February 2013. We used the Dongui-Bogam （Dong Yi Bao Jian） to classify prescribed herbal medicines. Results： The study revealed that the most frequently prescribed herbal medicine was ‘Liuwei Dihuang Pill （LWDHP, 六味地黄丸）＇ which was used for invigorating ‘Shen （Kidndy）-yin＇. ‘LWDHP＇ was most frequently prescribed to male patients aged 50-59, 60-69, 70-79 and 80-89 years, and ‘Xionggui Tiaoxue Decoction （XGTXD, 芎归调血饮）＇ was most frequently prescribed to female patients aged 30-39 and 40-49 years. According to the International Classification of Diseases （ICD） codes,‘Diseases of the musculoskeletal system and connective tissue＇ showed the highest prevalence. ‘LWDHP＇ and ＇XGTXD＇ was the most frequently prescribed in categories 5 and 3, respectively. Based on the percentage of prescriptions for each sex, ‘Ziyin Jianghuo Decoction （滋阴降火汤）＇ was prescribed to mainly male patients, and ‘XGTXD＇ with ‘Guima Geban Decoction （桂麻各半汤）＇ were prescribed to mainly female patients. Conclusion： This study analysis successfully determined the frequency of a variety of herbal medicines, and many restorative herbal medicines were identified and frequently administered.

关键词： herbal medicine herbal medicine prescription traditional korean medicine Chinese medicine electronic medical record Dongui-Bogam

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Discourse analysis of knowledge-based live streaming:a case study of East Buy streamer Dong Yuhui

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Language and Semiotic Studies 2024年第2期10卷 222-244页

作者： Yehui Song Junhua Mo korean Department Soochow UniversitySuzhou215006China English Department Soochow UniversitySuzhouChina

Live streaming e-commerce is not only an important part of China’s digital economy but also the preferred way of purchase for many Chinese,especially the *** 2022,a new model initiated by East Buy has emerged,quickly becoming known as knowledge-based live *** most famous streamer from this novel type of live streaming is Dong Yuhui,a former English teacher of the New Oriental *** a top Internet influencer with millions of followers,Dong Yuhui has become a conspicuous social sign of the rising China that is undergoing fast technological,economic,and cultural *** study thus takes Dong Yuhui as an example to examine the typical discourses of the knowledge-based live *** a triangulation of case study,discourse analysis,and sentiment analysis,it finds that Dong Yuhui mainly employs the strategies of disseminating encyclopedic knowledge,telling intriguing stories,and using poetic language in his live streaming *** unique discourse has the main function of fulfilling customers’intellectual,emotional,and psychological *** such,it is warmly received by customers,whose comments are centered on the talents of the streamer rather than the attributes of the commodity.

关键词： knowledge-based live streaming Dong Yuhui typical discourses major strategies main functions customer comments

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The variety of intestinal flora in korean medicine Sasang people

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TMR Integrative medicine 2020年第21期4卷 1-11页

作者： Xiao-Ou Wang Li-Na Jin Xian-Bo Wu Yanbian Hospital of Traditional Chinese medicine Yanji City Hospital of Traditional Chinese MedicineYanji 133000China School of Sports medicine and Health Chengdu Sport UniversityChengdu 610041China

Background:To confirm that the four constitutions of the korean medicine is closely related to the intestinal flora,and explore the influence of specific intestinal microbes on these four ***:We collect stool samples of four different physiques of the Taeeum,Soeum,Taeyang,and *** on 16S rDNA amplicon sequencing,SPSS 18.0 statistical software and GraphPad Prism 8.0 mapping software,the body weight,body mass index,cholesterol and intestinal microcommunity composition of the four groups were analyzed and ***:The results found that the body weight and body mass index of the Taeeum group were significantly higher than the Shaoyang group and the Soeum group,the body weight,cholesterol and body mass index of the Taeyang group were significantly higher than the Soeum *** the analysis of gut microbiota,the richness and diversity of intestinal microorganisms and the abundance ratio of posterior firmicutes to bacteroides were all different in the four populations,and there were 24 gut microbiota with significant differences(P<0.05).Among them,the abundance of[Eubacterium]coprostanoligenes group of Taeyang people,Taeeum people,Shaoyang people,and Soeum people were 3.71,9.62,9.36 and 9.33,***:[Eubacterium]coprostanoligenes group may be related to the differences in cholesterol content of the four ***,the firmicutes/bacteroidetes abundance ratio may also be related to the differences in body weight,blood glucose and blood lipid among the four groups.

关键词： korean medicine Sasang people Intestinal flora Variety

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korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission

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Chinese Journal of Natural medicines 2024年第7期22卷 599-607页

作者： HONG Geum-Lan KIM Kyung-Hyun CHO Sung-Pil LEE Hui-Ju KIM Yae-Ji JUNG Ju-Young Department of Veterinary medicine&Institute of Veterinary Science Chungnam National UniversityDaejeon 34134Korea Department of Anatomy College of MedicineKonyang UniversityDaejeon 35365Korea

Panax ginseng(***.)has been traditionally employed in Korea and China to alleviate fatigue and digestive *** particular,korean red ginseng(KRG),derived from streamed and dried ***,is known for its anti-aging and anti-inflammatory ***,its effects on benign prostatic hyperplasia(BPH),a representative aging-related disease,and the underlying mechanisms remain *** study aims to elucidate the therapeutic effects of KRG on BPH,with a particular focus on mitochondrial dynamics,including fission and fusion *** effects of KRG on cell proliferation,apoptosis,and mitochondrial dynamics and morphology were evaluated in a rat model of testosterone propionate(TP)-induced BPH and TP-treated LNCaP cells,with mdivi-1 as a *** results revealed that KRG treatment reduced the levels of androgen receptors(AR)and prostate-specific antigens in the BPH *** inhibited cell proliferation by downregulating cyclin D and proliferating cell nuclear antigen(PCNA)levels,and it promoted apoptosis by increasing the ratio of B-cell lymphoma protein 2(Bcl-2)-associated X protein(Bax)to Bcl-2 ***,KRG treatment enhanced the phosphorylation of dynamin-related protein 1(DRP-1,serine 637)compared with that in the BPH group,which inhibited mitochondrial fission and led to mitochondrial *** modulation of mitochondrial dynamics was associated with decreased cell proliferation and increased *** dysregulating AR signaling and inhibiting mitochondrial fission through enhanced DRP-1(ser637)phosphorylation,KRG effectively reduced cell proliferation and induced *** findings suggest that KRG’s regulation of mitochondrial dynamics offers a promising clinical approach for the treatment of BPH.

关键词： Androgen Benign prostatic hyperplasia Fission korean red ginseng Mitochondria

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Neuroprotective Effects of the Biologically Active Components From Traditional korean medicine on the Brain Ischemia in Rats

Neuroprotective Effects of the Biologically Active Component...

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第十五届国际药理学大会

作者： Daehee Lee Miyeon Kim Jinhee Jung Seongmi Choi Hocheol Kim Dep.of Herbal Pharmacology College of Oriental MedicineKyung Hee Univ.SeoulKorea. Korea Institute of Science and Technology for Eastern Medicien （KISTEM） NeuMed Co. Korea Institute of Science and Technology for Eastern Medicien （KISTEM） NeuMed Co. Korea Institute of Science and Technology for Eastern Medicien （KISTEM） NeuMed Co. Dep.of Herbal Pharmacology College of Oriental MedicineKyung Hee Univ.SeoulKorea.

＜正＞ The purpose of the study is to observe the neuroprotective components of herbs which have been used to treat stroke in traditional korean medicine. For global cerebral ischemia,male wister rats weighing 180 ± 10 g were used and common carotid arteries and vertebral arteries were occluded for 10 min. For focal cerebral ischemia,male SD rats weighing 300 ± 10 g were used and the right middle cerebral artery were occluded for 2 hrs. As the results,decursin （10 mg/kg） showed 36.46% , gomisin A. （30 mg/kg） showed 41.18% of neurorprotection in global cerebral ischemia. Nodakenin （30 mg/kg）. wogonin （30 mg/kg） showed 61. 33% and 42.67% of neuroprotection effect compared with control,respectively. Gomisin A showed the highest effect as 64.67 % of neuroprotection in focal cerebral ischemia. In conclusion,it could be suggested that gomisin A in Schizandra chinensis. decursin and nodakenin in Angelica gigas. wogonin and baicalein in Scutellaria baicalensis are effective components for the treatment of stroke.

关键词： Scutellaria Schizandra Angelica brain ischemia stroke

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