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Crosstalk between RNA m^(6)A modification and epigenetic factors in plant gene regulation

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Plant Communications 2024年第10期5卷 45-58页

作者： Jianzhong Hu Tao Xu Hunseung Kang Guangdong Provincial Key Laboratory for Plant Epigenetics Longhua Bioindustry and Innovation Research InstituteCollege of Life Sciences and OceanographyShenzhen UniversityShenzhenGuangdong 518060China Jiangsu Key Laboratory of Genomics School of Life SciencesJiangsu Normal UniversityXuzhouJiangsu Province 221116China Department of Applied Biology College of Agriculture and Life SciencesChonnam National UniversityGwangju 61186Korea

N^(6)-methyladenosine(m^(6)A)is the most abundant modification observed in eukaryotic *** in transcriptome-wide m^(6)A mapping and sequencing technologies have enabled the identification of several conserved motifs in plants,including the RRACH(R=A/G and H=A/C/U)and UGUAW(W=U or A)***,the mechanisms underlying deposition of m^(6)A marks at specific positions in the conserved motifs of individual transcripts remain to be *** from plant and animal studies suggests that m^(6)A writer or eraser components are recruited to specific genomic loci through interactions with particular transcription factors,5-methylcytosine DNA methylation marks,and histone *** addition,recent studies in animal cells have shown that microRNAs play a role in depositing m^(6)A marks at specific sites in transcripts through a base-pairing mechanism.m^(6)A also affects the biogenesis and function of chromatin-associated regulatory RNAs and long noncoding *** we have less of an understanding of the link between m^(6)A modification and epigenetic factors in plants than in animals,recent progress in identifying the proteins that interact with m^(6)A writer or eraser components has provided insights into the crosstalk between m^(6)A modification and epigenetic factors,which plays a crucial role in transcript-specific methylation and regulation of m^(6)A in plants.

关键词： RNA methylation DNA methylation histone modification epigenetics microRNA long noncoding RNA

Longitudinal trajectories of physical activity in women using latent class growth analysis:The WIN Study

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Journal of sport and Health science 2016年第4期5卷 410-416页

作者： Youngdeok Kim Minsoo Kang Anna M.Tacón James R.Morrow Jr Department of Kinesiology and sport Management Texas Tech University Department of Health and Human Performance Middle Tennessee State University Department of Kinesiology Health Promotionand RecreationUniversity of North Texas

Purpose：This study aimed（1） to examine the longitudinal trajectories in objectively measured physical activity（PA）;（2） to identify unknown（i.e.,latent） subgroups with distinct trajectories;and（3） to examine the correlates of latent subgroups among community dwelling ***：The study sample included a total of 669 women from the Women＇s Injury Study,a 5-year prospective cohort study conducted from2007 in the Southwest Central region of the ***-based step-count data across 18 consecutive months were fitte to a latent growth model（LGM） and a latent class growth model（LCGM）.Baseline characteristics were regressed on latent class ***：The longitudinal change in PA was best fi to a piecewise LGM with seasonal *** y increased and decreased levels of PA were observed during the spring,fall,and winter,respectively（p〈0.001）.Three latent subgroups with distinct PA trajectories were identifie（low-active（46.8%）,somewhat-active（41.3%）,and active（11.9%））.Age and body fat percentage at the baseline significant y explained the likelihoods of being in low-active ***：Seasonal variations in PA among women were observed but may not be practically significant A relatively large portion of the sample showed low levels of PA for long *** strategies should be considered for women who are overweight or obese,and aged 〉40 years old to promote PA during the life course.

关键词： Female Pedometer Prospective cohort Season Step-count

Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients:A systematic review and meta-analysis of randomized controlled trials

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Journal of sport and Health science 2023年第2期12卷 147-157页

作者： Antonio García-Hermoso Robinson Ramírez-Vélez Javier Díez Arantxa González Mikel Izquierdo Navarrabiomed Public University of Navarra(UPNA)Health Research Institute of Navarra(IdiSNA)University Hospital of NavarraPamplona 310008Spain CIBER of Frailty and Healthy Aging(CIBERFES) Carlos Ⅲ Institute of HealthMadrid 28029Spain institute for Health Research of Navarra(IDISNA) Pamplona 31008Spain Program of Cardiovascular Diseases Center for Applied Medical ResearchUniversity of NavarraPamplona 31008Spain Centre for Biomedical Research in Cardiovascular Disease Network Carlos Ⅲ Institute of HealthMadrid 28029Spain Departments of Nephrology and Cardiology University of Navarra ClinicPamplona 31008Spain

Background:This study investigates the effects of exercise training on exerkines in patients with type 2 diabetes mellitus to determine the optimal exercise ***:A systematic search for relevant studies was performed in 3 *** controlled trials investigating the effects of exercise training on at least one of the following exerkines were included:adiponectin,apelin,brain-derived neurotrophic factor,fetuin-A,fibroblast growth factor-21,follistatin,ghrelin,interleukin(IL)-6,IL-8,IL-10,IL-15,IL-18,leptin,myostatin,omentin,resistin,retinol-binding protein 4,tumor necrosis factor-α,and ***:Forty randomized controlled trials were selected for data extraction(n=2160).Exercise training induces changes in adiponectin,fetuin-A,fibroblast growth factor-21,IL-6,IL-10,leptin,resistin,and tumor necrosis factor-a levels but has no significant effects on apelin,IL-18,and ghrelin compared to *** exercise training favored large and positive changes in pooled exerkines(i.e.,an overall effect size calculated from several exerkine s)(Hedge’s g=1.02,95%confidence interval(95%CI):0.76-1.28),which in turn were related to changes in glycated hemoglobin(mean difference(MD)=-0.81%,95%CI:-0.95%to-0.67%),fasting glucose(MD=-23.43 mg/dL,95%CI:-30.07 mg/dL to-16.80 mg/dL),waist circumference(MD=-3.04 cm,95%CI:-4.02 cm to-2.07 cm),and body mass(MD=-1.93 kg,95%CI:-2.00 kg to-1.86 kg).Slightly stronger effects were observed with aerobic,resistance,or high-intensity interval protocols at moderate-to vigorous-intensity and with programs longer than 24 weeks that comprise at least 3 sessions per week and more than 60 min per ***:Exercise training represents an anti-inflammatory therapy and metabolism-improving strategy with minimal side effects for patients with type 2 diabetes mellitus.

关键词： Adipokines Exercise training Hepatokines Myokines

Properties of three seismic events in September 2017 in the northern korean Peninsula from moment tensor inversion

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science Bulletin 2017年第23期62卷 1569-1571页

作者： Libo Han Zhongliang Wu Changsheng Jiang Jie Liu institute of Geophysics China Earthquake Administration Beijing 100081 China China Earthquake Networks Center Beijing 100036 China

In September 2017 three noticeable seismic events occurred in the northern korean Peninsula （Fig. 1; Table 1）. Democratic People＇s Republic of korea （DPRK） authorities announced that the first M6.3 event on September 3rd was a ＂successfully conducted hydrogen-bomb test＂. The M4.6 event, some 8 min followed, was regarded as an implosion.

关键词： Properties of three seismic moment tensor inversion

Hydrothermal Synthesis of Molybdenum Disulfide for Lithium Ion Battery Applications

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Chinese Journal of Chemical Engineering 2010年第6期18卷 910-913页

作者： WANG Shiquan LI Guohua DU Guodong JIANG Xueya FENG Chuanqi GUO Zaiping KIM Seung-Joo Institue of NT-IT Fusion Technology Ajou University Suwon 443-749 Korea Department of Chemistry Hubei University Wuhan 430062 China State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology Zhejiang University of Technol-ogy Hangzhou 310032 China institute for Superconducting and Electronic Materials University of Wollongong Northfield Avenue Wollon-gong NSW 2522 Australia Division of Energy Systems Research Ajou University Suwon 443-749 Korea

Molybdenum disulfide nanoflakes were synthesized by a simple hydrothermal process using sodium molybdate and thiourea as reactants at a relatively low temperature. X-ray diffraction(XRD) and transmission elec-tron microscopy(TEM) indicate that the samples have the structure of 2H-MoS2 and the morphology of nanoflakes with the average thickness around 5-10 nm. The results of electrochemical properties indicate that the morphology and size of MoS2 particles have effects on their capacity when they are used as the anode for lithium ion battery. The as-prepared MoS2 samples have high reversible discharge capacity up to 994.6 mA·h·g-1 for the MoS2-1 elec-trode and 930.1 mA·h·g-1 for the MoS2-2 electrode and show excellent cycling performances. The MoS2-1 electrode has a better cycling stability than the MoS2-2 electrode due to their difference in the uniformity of the samples.

关键词： molybdenum disulfide chemical synthesis electrochemical property electrode material

Correction to:Arduino-based low-cost electrical load tracking system with a long-range mesh network

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Advances in Manufacturing 2021年第4期9卷 592-592页

作者： Xinlin Wang Bora Ha Frank Andrew Manongi Woo-Kyun Jung Yusufu Abeid Chande Jande Sung-Hoon Ahn Department of Mechanical and Aerospace Engineering Seoul National UniversitySeoulSouth Korea School of Materials Energy Water and Environment and Environmental sciences Nelson Mandela African Institution of Science and TechnologyArushaTanzania Water Infrastructure and Sustainable Energy Futures Centre Nelson Mandela African Institution of Science and TechnologyArushaTanzania institute of Advanced Machinery and Design Seoul National UniversitySeoulSouth Korea

Correction to:***://***/10.1007/s40436-020-00310-5 In the original publication the first author name is published incorrectly as "Xin-Lin Wang".The correct author name should be read as "Xinlin Wang".Also,the correct fund note in the acknowledgement section should be "This research was supported in part by the International S&T Cooperation Program through the National Research Foundation of korea(NRF)funded by the Ministry of science,ICT&Future Planning(MSIP)(Grant ***-2017K1A3A9A04013801),and by the Basic Research Lab Program through NRF funded by the MSIT(Grant No.2018R1A4A1059976)".The correct author name and correct fund note is available in this correction.

关键词： cost Arduino Basic

The recent progress on the bioactive compounds from algal biomass for human health applications

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Food Bioscience 2023年第1期51卷 90-108页

作者： Yang Yang Sedky HAHassan Mukesh Kumar Awasthi Babu Gajendran Monika Sharma Min-Kyu Ji El-Sayed Salama Department of Occupational and Environmental Health School of Public HealthLanzhou UniversityLanzhou City730000Gansu ProvincePR China Department of Biology College of ScienceSultan Qaboos UniversityMuscat123Oman Botany&Microbiology Department Faculty of ScienceNew Valley UniversityEl-Kharga72511Egypt College of Natural Resources and Environment Northwest A&F UniversityTaicheng Road 3#YanglingShaanxi712100PR China School of Pharmaceutical sciences Guizhou Medical UniversityGuiyangGuizhou Province550025PR China Environmental Assessment Group Korea Environment InstituteYeongi-gun30147South Korea

The secondary metabolites produced by algae(including macroalgae and microalgae)possess several human health *** bioactive compounds in algae have potential to be used in the medical and pharmaceutical industries for drug *** rapid development of genetic tools and omics approaches has extended the understanding of algal metabolism along with enhanced productivity and improving the properties of bioactive ***,the focus of this review is to discuss the molecular progress on algae for bioactive compound production which includes genomics,transcriptomics,proteomics,and *** comprehensive discussion on multi-omics approaches provides the potential knowledge for future *** structural and functional genomics,application of genetic tools,molecular mechanisms of bioactive compound synthesis,protein modification,and the omics performance of algae at various levels under abiotic stress are *** annotation and identification of key functions are the basis of genomics which provides the comprehensive overview of genetic *** recent development of molecular modifications and their application in algae to produce high-yield bioactive compounds that meet human needs through the optimization of algal target strains are also *** exploration of the molecular mechanisms of bioactive compounds under abiotic stress is of great practical significance to guide the optimization of culture conditions.

关键词： Macroalgae Microalgae Bioactive compounds Omics Abiotic stress

The antioxidant methyl gallate inhibits fungal growth and deoxynivalenol production in Fusarium graminearum

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Food Production, Processing and Nutrition 2021年第1期3卷 326-334页

作者： Xin Liu Xin Fang Shuang Wang Deliang Wu Tao Gao Yin-Won Lee Sherif Ramzy Mohamed Fang Ji Jianhong Xu Jianrong Shi Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base Ministry of Science and Technology/Key Laboratory for Control Technology and Standard for Agro-product Safety and QualityMinistry of Agriculture and Rural Affairs/Key Laboratory for Agro-product Safety Risk Evaluation(Nanjing)Ministry of Agriculture and Rural Affairs/Collaborative Innovation Center for Modern Grain Circulation and Safety/Institute of Food Safety and NutritionJiangsu Academy of Agricultural SciencesNanjing 210014JiangsuChina School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina School of Agricultural Biotechnology Seoul National UniversitySeoul 08826Republic of Korea Department of Food Toxicology and Contaminant National Research Centre of EgyptGiza 12411Egypt

Production of the Fusarium toxin deoxynivalenol(DON)is associated with oxidative stress and has been indicated to be part of an adaptive response to oxidative stress in the important wheat fungus Fusarium *** this study,we found that the antioxidant methyl gallate(MG)displays inhibitory effects against mycelial growth,conidial formation and germination,and DON biosynthesis in *** in a dose-dependent *** with 0.05%(w/v)MG resulted in an abnormal swollen conidial *** expression of the TRI genes involved in DON biosynthesis was significantly reduced,and the induction of Tri1-GFP green fluorescence signals in the spherical and crescent-shaped toxisomes was abolished in the MG-treated ***-Seq analysis of MG-treated *** showed that 0.5%(w/v)MG inhibited DON production by possibly altering membrane functions and oxidoreductase *** with the observations that MG treatment decreases catalase,POD and SOD activity in *** results of this study indicated that MG displays antifungal activity against DON production by modulating its oxidative *** together,the current study revealed the potential of MG in inhibiting mycotoxins in ***.

关键词： Fusarium graminearum Antioxidant methyl gallate Deoxynivalenol production Mechanism of action

Apalutamide for metastatic castration-sensitive prostate cancer:final analysis of the Asian subpopulation in the TITAN trial

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Asian Journal of Andrology 2023年第6期25卷 653-661页

作者： Byung Ha Chung Jian Huang Hiroji Uemura Young Deuk Choi Zhang-Qun Ye Hiroyoshi Suzuki Taek Won Kang Da-Lin He Jae Young Joung Sabine D Brookman-May Sharon McCarthy Amitabha Bhaumik Anildeep Singh Suneel Mundle Simon Chowdhury Neeraj Agarwal Ding-Wei Ye Kim N Chi Hirotsugu Uemura Gangnam Severance Hospital Yonsei University College of MedicineSeoul 06273South Korea Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhou 510123China Yokohama City University Medical Center Minami-kuYokohamaKanagwa 232-0024Japan Severance Hospital Yonsei University College of MedicineSeoul 03722South Korea Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Toho University Sakura Medical Center Chiba 285-0841Japan Chonnam National University Hospital and Medical School Gwangju 61469South Korea Department of Urology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Prostate Cancer Center National Cancer CenterGoyang 10408South Korea Janssen Research and Development Spring HousePA 19002USA Ludwig Maximilians University Munich 80539Germany Janssen Research and Development RaritanNJ 08869USA Janssen Medical Affairs Asia PacificSingapore 118222Singapore Guy’s and St Thomas’NHS Foundation Trust London SE14YBUK University of Utah Huntsman Cancer institute Salt Lake CityUT 84112USA Fudan University Shanghai Cancer Center Shanghai 200032China Vancouver Prostate Centre University of British ColumbiaVancouverBritish Columbia V6H 3Z6Canada Kindai University Faculty of MedicineOsaka-Sayama 589-8511Japan

The final analysis of the phase 3 Targeted Investigational Treatment Analysis of Novel Anti-androgen(TITAN)trial showed improvement in overall survival(OS)and other efficacy endpoints with apalutamide plus androgen deprivation therapy(ADT)versus ADT alone in patients with metastatic castration-sensitive prostate cancer(mCSPC).As ethnicity and regional differences may affect treatment outcomes in advanced prostate cancer,a post hoc final analysis was conducted to assess the efficacy and safety of apalutamide in the Asian ***-driven endpoints were OS,and time from randomization to initiation of castration resistance,prostate-specific antigen(PSA)progression,and second progression-free survival(PFS2)on first subsequent therapy or *** endpoints were assessed using the Kaplan–Meier method and Cox proportional-hazards models without formal statistical testing and adjustment for *** Asian patients received once-daily apalutamide 240 mg(n=111)or placebo(n=110)plus *** a median follow-up of 42.5 months and despite crossover of 47 placebo recipients to open-label apalutamide,apalutamide reduced the risk of death by 32%(hazard ratio[HR]:0.68;95%confidence interval[CI]:0.42–1.13),risk of castration resistance by 69%(HR:0.31;95%CI:0.21–0.46),PSA progression by 79%(HR:0.21;95%CI:0.13–0.35)and PFS2 by 24%(HR:0.76;95%CI:0.44–1.29)relative to *** outcomes were comparable between subgroups with low-and high-volume disease at *** new safety issues were *** provides valuable clinical benefits to Asian patients with mCSPC,with an efficacy and safety profile consistent with that in the overall patient population.

关键词： apalutamide Asia event-driven analysis metastatic castration-sensitive prostate cancer overall survival