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Enhancing the capabilities of biosafety laboratories through the established accreditation system:Development of the biosafety laboratory accreditation system in China

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Journal of Biosafety and Biosecurity 2019年第2期1卷 86-89页

作者： Peijun Zhai Rong Wang Yongyun Zhou Dongmei Hu Junyan li Yali Zhou China National Accreditation Service for conformity Assessment(CNAS) China

Accreditation is now widely used to attest for laboratory *** accreditation was originally used to assess products in testing laboratories and still plays an increasingly important role in international trade,it has been expanded to include laboratories in many social fields,including forensic science,medicine,and animal quarantine *** accreditation process provides basic requirements for achieving global recognition for laboratory *** paper introduces the concept of accreditation and discusses the origins and development of the accreditation system in Chinese biosafety *** study also reveals the important role of this system in national biosafety management through an examination of the 14-year development of the Chinese biosafety laboratory accreditation system.

关键词： Accreditation Management Biosafety laboratories

Analysis of rolls deflection of Sendzimir mill by 3D FEM

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中国有色金属学会会刊：英文版 2007年第3期17卷 600-605页

作者：喻海良刘相华 LEE Gyoo Taek State Key Laboratory of Rolling and Automation Northeastern University POSCO Technical Research laboratories Pohang 790-785 Korea

The deflection of rolls of Sendzimir mill with double AS-U-Roll was simulated by finite element method(FEM). The influences of rolling pressure, strip width and rolls-assignment on rolls deflection were analyzed. The results show that the work roll deflection increases with the increase of rolling pressure and the reduction of work roll radius, but the rigid displacement of work roll slightly changes; the work roll end might appear negative displacement for the narrow strip width and high rolling pressure that might cause the contact of work rolls. The research results are significant for guiding production and theoretical analysis of the rolls system of Sendzimir mill.

关键词：滚转偏度磨粉机有限元件 3D技术

Study on the Wiping Gas Jet in Continuous Galvanizing Line

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Journal of Thermal Science 2011年第3期20卷 242-247页

作者： Yong-Hun Kweon Heuy-Dong Kim POSCO Technical Research laboratories 699 Gumho-dong GwangyangJeonnam 545-090 Korea School of Mechanical Engineering Andong National UniversityAndong 760-749 Korea

In the continuous hot-dip galvanizing process, the gas-jet wiping is used to control the coating thickness of moving steel strip. The high speed gas-jet discharged from the nozzle slot impinges on the strip, and at this moment, wipes the liquid coating layer dragged by a moving strip. The coating thickness is generally influenced on the flow characteristics of wiping gas-jet such as the impinging pressure distribution, pressure gradient and shear stress distribution on the surface of strip. The flow characteristics of wiping gas-jet mentioned above depends upon considerably both the process operating conditions such as the nozzle pressure, nozzle-to-strip distance and line speed, and the geometry of gas-jet wiping apparatus such as the height of nozzle slot. In the present study, the effect of the geometry of nozzle on the coating thickness is investigated with the help of a computational fluid dynamics method. The height of nozzle slot is varied in the range of 0.6mm to 1.7mm. A finite volume method (FVM) is employed to solve two-dimensional, steady, compressible Navier-Stokes equations. Based upon the results obtained, the effect of the height of nozzle slot in the gas-jet wiping process is discussed in detail. The computational results show that for a given standoff distance between the nozzle to the strip, the effective height of nozzle slot exists in achieving thinner coating thickness.

关键词： Gas-Jet Wiping Hot-Dip Galvanizing Impact Pressure Coating Thickness

Multiple actions of lysophosphatidylcholine in human Jurkat T cells

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Acta Pharmacologica Sinica 2006年第6期27卷 700-707页

作者： Young-jinIM Yun-kyungLEE Hae-young CHUNG Dong-soon IM laboratories of Pharmacology Busan 609-735 Korea Aging Biochemistry College of Pharmacy and Research Institute for Drug DevelopmentPusan National UniversityBusan 609-735Korea

Aim:To obtain pathophysiological meanings of lysophosphatidylcholine（LPC）through the investigation of the effects of LPC in Jurkat T ***:Wemeasured ROS generation,[Ca2+]i,and mitochondrial membrane potential（MMP）by fluorescent spectrometry in Jurkat,T ***:We observed that LPCsignificantly increased the reactive oxygen species（ROS）level in human Jurkat *** structurally-related lysolipids and eleven synthetic LPCs with dif-ferent acyl chain lengths,palmitoyl LPC increased ROS to the highest level,α-Tocopherol,an antioxidant,and rottlerin PKCδ inhibitor were inhibitory effects onLPC-induced ROS *** rapidly depolarized MMP and markedly el-evated [Ca2+]iby Ca2+influx across the plasma ***,LPC-inducedROS increase seemed to not be related with LPC-induced depolarization of MMPor [Ca2+]iincrease.G2A family G protein-coupled receptors（GPCR）for lysolipidswere expressed in Jurkat T cells,however,evidence indicated that GPCR was notinvolved in LPC ***:LPC induced several cellular changes inJurkat T cells,including an increase of ROS generation in a PKCδ-dependent andGPCR-independent manner,increase of [Ca2+]ithrough Ca2+influx,and decreaseof ***-induced actions in Jurkat T cells represent novel action modes ofLPC that do not involve GPCR and multiple independent changes of intracellularsignaling molecules.

关键词： lysophosphatidylcholine reactive oxygen species calcium protein kinase C mitochondrial membrane potential

A Kinetic Study on the Control of Nitrogen in Molten Slag and Metal

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Journal of Iron and Steel Research International 2011年第S2期18卷 301-309页

作者： Seung Min HAN Dong Joon Min Technical Research laboratories POSCO Pohang 790-785 KOREA Department of Materials Science and Engineering YONSEI University Seoul 120-749 KOREA

Nitrogen can easily contaminate molten steel during the steelmaking process and due to the low nitrogen capacity in slag, it is difficult to remove entrapped nitrogen from liquid steel. Degassing is often done to the steel at secondary steelmaking to lower the nitrogen content, but the control can often be kinetically limited by the steel grade and also the slag composition. Thus, a fundamental understanding of nitrogen dissolution into molten slag and metal including the rate of nitrogen dissolution can help in controlling nitrogen content in the final *** kinetics of nitrogen dissolution in the molten calcium aluminate based slags and in molten steel with various element additions was investigated by measuring the 14N-15N isotope exchange reaction using a mass spectrometer at 1873 *** show that effect of elements on the rate constant of nitrogen dissolution such as Ni in Fe is relatively minimal similar to molybdenum. The surface rate constant of nitrogen dissolution in liquid Fe-10%Ni alloy was found to be 3.77×10-5 (mol/cm2·s·atm).The rate constant of nitrogen dissolution in the CaO-Al2O3-CaF2 slag was found to be wedge shaped, which decreased with increasing CaF2 to about 20 mol% followed by an increase through the rest of the CaF2 composition range. This was related to the effect of CaF2 on the structure of Al-O bonds for this slag.

关键词： rate constant slag structure molten steel isotope exchange technique adsorption coefficient nitrogen surface dissolution

Effects of Craddition on Charpy impact energy in austenitic 0.45C-24Mn-(0,3,6)Cr steels

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Journal of Materials Science & Technology 2020年第15期47卷 21-30页

作者： Seok Gyu Lee Bohee Kim Min Cheol Jo Kyeong-Min Kim Junghoon Lee Jinho Bae Byeong-Joo Lee Seok Su Sohn Sunghak Lee Center for Advanced Aerospace Materials Pohang University of Science and TechnologyPohang37673South Korea Steel Products Design Team Hyundai SteelDangjin31779South Korea Steel Products Research Group 1 Technical Research LaboratoriesPOSCOGwangyang57807South Korea Department of Materials Science and Engineering Korea UniversitySeoul02841South Korea

Effects of Cr addition(0,3,and 6 wt%) on Charpy impact properties of Fe-C-Mn-Cr-based steels were studied by conducting dynamic compression tests at room and cryogenic *** room temperature,deformation mechanisms of Charpy impacted specimens were observed as twinning induced plasticity(TWIP) without any transfo rmation induced plasticity(TRIP) in all the *** cryogenic temperature,many twins were populated in the Cr-added steels,but,interestingly,fine ε-martensite was found in the OCr steel,satisfying the Shoji-Nishiyama(S-N) orientation relationship,{111}γ//{0002}ε and γ//ε.Even though the cryogenic-temperature staking fault energies(SFEs) of the three steel were situated in the TWIP regime,the martensitic transformation was induced by Mn-and Cr-segregated *** the OCr steel,SFEs of low-(Mn,Cr) bands lay between the TWIP and TRIP regimes which were sensitively affected by a small change of *** dynamic compressive test results well showed the relation between segregation bands and the *** of Cr were known as not only increasing the SFE but also promoting the carbide *** order to identify the possibility of carbide formation,a precipitation kinetics simulation was conducted,and the predicted fractions of precipitated M23C6 were negligible,0.4-1.1×10-5,even at the low cooling rate of 10℃/s.

关键词： Austenitic high-Mn steels Charpy impact energy Split Hopkinson pressure bar Twinning induced plasticity(TWIP) Transformation induced plasticity(TRIP) Stacking fault energy(SFE)

Counter-balancing effects of Si on C partitioning and stacking fault energy of austenite in 10Mn quenching and partitioning steel

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Journal of Materials Science & Technology 2022年第3期98卷 248-257页

作者： Dong Hwi Kim Jee-Hyun Kang Hojun Gwon Joo Hyun Ryu Sung-Joon Kim Graduate Institute for Ferrous Technology Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Materials Science and Engineering Institute of Materials TechnologyYeungnam UniversityGyeongsan 38541Republic of Korea POSCO Technical Research laboratories POSCOGwangyang 57807Republic of Korea

Silicon is an essential alloying element in quenching and partitioning(Q&P)steels,because it is known to suppress carbide precipitation during partitioning step and promote carbon partitioning to stabilize *** 2 wt%Si was added to 10Mn-2Al-0.2C steel,the size and fraction of the carbides formed during partitioning became smaller than in the Si-free ***,the suppression of carbide formation promoted C partitioning into austenite as ***,austenite stability was always lower with Si under the equivalent partitioning condition because Si effectively decreased the stacking fault energy of *** partitioning progressed,the both yield and tensile strengths of the Si-added steel exceeded that of the Si-free steel with the similar ductility *** was because Si was an effective solid solution strengthener,and the austenite in the Si-added steel exhibited the appropriate stability to gradually transform into martensite throughout the *** resulting strengthening effect compensated for the softening caused by martensite ***,strain hardening rate decreased continuously throughout deformation,which resulted in high tensile strength and ductility.

关键词： Steels Q&P steel Silicon Austenite stability Tensile deformation Stacking fault energy Medium Mn steel

High Performance Structural Steels for Shipbuilding and Offshore Structures

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Journal of Iron and Steel Research International 2011年第S1期18卷 90-98页

作者： Choo Wung-Yong Suh In-Shik Kim Sang-ho An Gyu-Baek Lee Chang-Sun Technical Research laboratories POSCO1 Geodong-dongNam-guPohangGyungbuk790-785Korea

Recently,there have been the increase of ship size and the development of oil and gas in arctic *** trends have led to the requirements such as high strength,good toughness at low temperature and good *** high performance structural steels for shipbuilding and arctic offshore structure have been developed by our own micro-alloying and TMCP technologies.M-A constituent was precisely controlled in the both HAZ and base metal to get high toughness at low ***,the grain growth of austenite at HAZ was effectively suppressed by thermally stable TiN particles,leading to a good HAZ *** the other hand,there has been the key issue of crack arrestability in large size container *** effect of joint design on crack arrestability was investigated to prevent a catastrophic failure along the block joint of hatch side coaming.A brittle crack arrest technique was developed without block joint shift,using an arrest weld in the end of hatch side coaming weld line.

关键词： shipbuilding offshore weldability toughness micro-alloying TMCP brittle crack crack arrestability

Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning Dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai Jessica D.Eisner Li Xie Minhu Chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China Department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda Development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CI<0%)was also *** 12 weeks,endoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan