检索结果-南通市图书馆

Pediatric Head Injury: The Incidence of Multiple Injuries

Journal of Behavioral and Brain Science 2016年第6期6卷 254-267页

作者： Thomas Kapapa Melanie Kapapa Carsten Posovszky Joachim Gülke ralph König Dieter Woischneck Christian rainer Wirtz Andrej Pala Neurochirurgische klinik Universitatsklinikum Ulm Ulm Germany Sektion Kinderchirurgie Universitatsklinikum Ulm Ulm Germany klinik für Kinder-und Jugendmedizin Universitatsklinikum Ulm Ulm Germany klinik für Unfall- Hand-und Plastische und Wiederherstellungschirurgie Universitatsklinikum Ulm Ulm Germany Neurochirurgische klinik Klinikum Landshut Landshut Germany

Objectives: Concomitant injuries play an important role when it comes to clinical management of traumatic brain injury (TBI). We examined the incidence of concomitant injuries and their relevance with respect to hospitalization. Methods: Children aged between 0 - 18 years hospitalized for treatment of TBI (ICD 10;S06.0 - 9) during 2010-2011 were included. The data relating to concomitant injuries and the course of treatment were evaluated. Statistical analysis included multivariate regressions at a level of significance of p ≤ 0.05. results: 794 children were treated for head injury in our hospital. Head injury with other associated injuries had been sustained by 158 (19.9%) children. The face and the extremities were the areas of the body most often affected (p = 0.001). Boys represent the majority within the cohort of multiple injured children (p = 0.0001). The older the child, the higher the percentage of children with concomitant injuries (r = 0.27;p = 0.034). There was a significant correlation between the severity of the head injury and the occurrence of concomitant injuries (r = 0.19;p = 0.046). Children with concomitant injuries were found to suffer significantly more falls (N = 82;51.9%) than road traffic accidents (N = 68;43%) (p = 0.0001). A comparison of different variables revealed that age (7 to 10 years), severity of head injury (mild TBI), and trauma mechanism (fall) were most influential (KB = ?1.55;p = 0.023) for concomitant injuries. Children with concomitant injuries have a significant longer stay in hospital than those without: mean stay 2.5 to 4.5 days (p = 0.0001). Conclusion: Concomitant injuries are hints for more severe head injuries and children should be examined with special care.

关键词： Isolated Traumatic Brain Injury Concomitant Injury facial Injury Length of Hospitalization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肾癌转移的放疗效果

引用

放射学实践 1990年第3期5卷 121-124页

作者： L.Schertel r.Mohring I.Brameyer 管竟贤 klinik und poliklinik für Strahlentherapie Münster 同济医科大学附属同济医院

肾癌主要发生在中老年人,能获早期诊断者少见。典型症状是血尿(常是首发症状),肾区疼痛并可触及肿块。这些症状只有在实质性肿块较大或侵犯肾盂时才出现,由于病期晚,常提示预后不良。肾癌的诊断常常是在已经出现了转移才得出的。转移多... 详细信息

肾癌主要发生在中老年人,能获早期诊断者少见。典型症状是血尿(常是首发症状),肾区疼痛并可触及肿块。这些症状只有在实质性肿块较大或侵犯肾盂时才出现,由于病期晚,常提示预后不良。肾癌的诊断常常是在已经出现了转移才得出的。转移多数发生在治疗后的第一年内。肾癌转移的根治性治疗效果至今仍不令人满意。

关键词：肾癌转移放疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

运用开放式高场1.0T MrI行Mr引导肝脏肿瘤消融作为影像引导近距离治疗

引用

国际医学放射学杂志 2010年第5期 507-508页

作者： J.ricke M.Thormann M.Ludewig K.Jungnickel O.Grosser C.Wybranski 吴海军 klinik für radiologie und nuklearmedizin Universit tsklinikum Magdeburg ARMagdeburgGermany

关键词： Mr介入治疗肝脏恶性肿瘤近距离治疗微创肿瘤学

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Electroencephalogram response in premature infants to different odors: a feasibility study

引用

World Journal of Pediatrics 2022年第12期18卷 845-848页

作者： Janine Gellrich Sandy Schlage Veronika Messer Valentin A.Schriever Abteilung Neuropädiatrie Medizinische fakultät Carl Gustav Carus Technische UniversitätDresdenGermany klinik und poliklinik für Kinder-und Jugendmedizin Medizinische Fakultät Carl Gustav CarusTechnische Universität DresdenFetscherstrasse 7401307DresdenGermany Center for Chronically Sick Children(Sozialpädiatrisches Zentrum SPZ)Charité-Universitätsmedizin BerlinBerlinGermany Department of Pediatric Neurology Charité-Universitätsmedizin BerlinBerlinGermany

The importance of olfaction for newborns,especially for mother-associated odors is well *** receptor neurons were found in preterm infants as early as 24–27 weeks of gestation[1].Therefore,it can be assumed that the olfactory sense is functioning in preterm infants[2],but only very little is known about olfactory processing at this *** studies dealing with the processing of olfactory stimuli have been conducted on mature ***,in 2001 a research group demonstrated,using near-infrared spectroscopy,that a change in blood oxygenation of premature infants could be detected in the orbitofrontal cortex after olfactory stimulation with disinfectant and detergent[3].Electroencephalogram(EEG)techniques have broadly been used to measure central odor processing in adults and children[4,5,6].

关键词： mother stimulation cortex

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer

引用

World Journal of Gastroenterology 2008年第1期14卷 1-14页

作者： Michael Hpfner Detlef Schuppan Hans Scherübl Institute of Physiology Charité-Universittsmedizin Berlin Campus Benjamin Franklin Berlin 12200 Germany Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 United States klinik für Innere Medizin Gastroenterologie und Gastrointestinale Onkologie Klinikum am Urban Vivantes Netzwerk für Gesundheit Berlin 10967 Germany

Growth factors and their corresponding receptors are commonly overexpressed and/or dysregulated in many cancers including hepatocellular cancer （HCC）. Clinical trials indicate that growth factor receptors and their related signalling pathways play important roles in HCC cancer etiology and progression, thus providing rational targets for innovative cancer therapies. A number of strategies including monoclonal antibodies, tyrosine kinase inhibitors （＂small molecule inhibitors＂） and antisense oligonucleotides have already been evaluated for their potency to inhibit the activity and downstream signalling cascades of these receptors in HCC. first clinical trials have also shown that multi-kinase inhibition is an effective novel treatment strategy in HCC. In this respect sorafenib, an inhibitor of raf-, VEGf- and PDGf-signalling, is the first multi-kinase inhibitor that has been approved by the fDA for the treatment of advanced HCC. Moreover, the serine-threonine kinase of mammalian target of rapamycin （mTOr） upon which the signalling of several growth factor receptors converge plays a central role in cancer cell proliferation, roTOr inhibition of HCC is currently also being studied in preclinical trials. As HCCs represent hypervascularized neoplasms, inhibition of tumour vessel formation via interfering with the VEGf/VEGfr system is another promising approach in HCC treatment. This review will summarize the current status of the various growth factor receptor-based treatment strategies and in view of the multitude of novel targeted approaches, the rationale for combination therapies for advanced HCC treatment will also be taken into account.

关键词： Growth factor receptor Hepatocellular cancer Small molecule inhibitor Monoclonal antibody Innovative cancer treatment Sorafenib Bevacizumab Erlotinib

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Considerations on the role of environmental toxins in idiopathic Parkinson’s disease pathophysiology

引用

Translational Neurodegeneration 2014年第1期3卷 67-79页

作者： francisco Pan-Montojo Heinz reichmann Neurologische klinik Klinikum der Ludwig-Maximilians-Universität MünchenMarchioninistr.1581377 MunichGermany Munich Cluster for Systems Neurology(SyNergy) Adolf-Butenandt-Institut Ludwig-Maximilians-Universität MünchenSchillerstr.4480336 MunichGermany klinik und poliklinik für Neurologie Carl Gustav Carus University HospitalTU-DresdenFetscherstr.7401307 DresdenGermany

Neurodegenerative diseases are characterized by a progressive dysfunction of the nervous *** associated with atrophy of the affected central or peripheral nervous structures,they include diseases such as Parkinson’s Disease(PD),Alzheimer’s Disease and other dementias,Genetic Brain Disorders,Amyotrophic Lateral Sclerosis(ALS or Lou Gehrig’s Disease),Huntington’s Disease,Prion Diseases,and *** prevalence of neurodegenerative diseases has increased over the last *** has had a major impact both on patients and their families and has exponentially increased the medical bill by hundreds of billions of ***,understanding the role of environmental and genetic factors in the pathogenesis of PD is crucial to develop preventive *** some authors believe that PD is mainly genetic and that the aging of the society is the principal cause for this increase,different studies suggest that PD may be due to an increased exposure to environmental *** this article we review epidemiological,sociological and experimental studies to determine which hypothesis is more *** conclusion is that,at least in idiopathic PD(iPD),the exposure to toxic environmental substances could play an important role in its aetiology.

关键词： Idiopathic Parkinson’s disease Environmental toxins Gene-environment interactions Braak’s staging and pathology progression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Die　selektive　Sklerosierung　der　Vena　coronaria　ventriculi　─eine　neuartige　Therapie　der　Osophagusvarizenblutung

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 1996年第1期16卷 36-40页

作者：叶启发戴植本裘法祖刘效恭 Abteilung für Chirurgie Tongji Klinik Tongji Medizinische Universität Wuhan Chirurgische klinik Medizinische Universität Xian China

Patienten beiderlei Geschlechts mit portaler Hypertension bei Leberzirrhose wurden nach erfolgloser endoskopischer Behandlung einer akuten sophagusvarizenblutung operiert. 134 flle waren als posthepatitische, 62 als schistosomatische und 25 als bilire Leberzirrhosen diagnostiziert. Das wichtigste bei unserem Operationsverfahren ist: Darstellung der V. coronaria ventriculi in der Mitte der kleinen Kurvatur und Kanlierung der beiden Venensegmente. Nach Setzen von Klemmen 5 cm pr- und 5 cm postkardial und in der Korpusmitte Sklerosierung des kranialen V. coronaria-Segmentes mit α-Octyl-Cyanoacrylat und Venenligatur; Messung des portalvensen Druckes im kaudalen Segment. Die selektive Sklerosierung der V. coronaria ventriculi (SSVCV) wurde bei 18 fllen als prophylaktischer, bei 106 fllen als notfallmβiger und bei 98 fllen als elektiver Eingriff durchgefhrt, und bei allen Patienten konnte die Varizenblutung gestillt werden. 219 Patienten berlebten , 3 Patienten verstarben an Leberversagen 24 Stunden postoperativ. Bei 189 operierten Patienten der Gruppe zeigte sich bei der Durchleuchtung, rntgenkontrastfllung und Endoskopie, daβ die sophagusvarizen 3-6 Monate nach der SSVCV eine offensichtliche Verbesserung aufwiesen. Die postoperative Untersuchung nach 1 bis 2 Jahren zeigte, daβ die sophagusvarizen nicht mehr ezistierten. Bei 182 operierten Patienten hat sich beim follow-up im Zeitraum von 6 1/2 Jahren bis 7 1/2 Jahren ergeben, daβ nach der Operation keine Blutung mehr aufgetreten ist.

关键词： sophagusvarizenblutung selektive Sklerosierung Vena coronaria ventriculi α-Octyl-Cyano-acrylat

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

肿瘤病人的随诊检查

引用

放射学实践 1991年第1期6卷 39-43页

作者： L.Schertel r.Mohring f.Lambertz 余力生 klinik und poliklinik fr Strahlentherapie-radioonkologie Universitt Mnster 同济医科大学附属同济医院

肿瘤病人的随诊与初诊治疗一样,同属于治疗范畴,早期发现复发和/或转移以及安排各项检查尤其是放射学检查的程序,只有能从它引出适当的措施时才有意义。

关键词：肿瘤放疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Case report: Bilateral Pneumothoraces due to Targeted Tumor Therapy with regorafenib in a Young Woman with Metastatic Colorectal Cancer

引用

Case reports in Clinical Medicine 2022年第5期11卷 139-145页

作者： Tobias rachow Tim Sandhaus Thomas Ernst Helmut Schiffl Susanne M. Lang klinik für Innere Medizin II Universit&auml tsklinikum Jena Jena Germany klinik für Innere Medizin V Universit&auml tsklinikum Jena Jena Germany klinik für Herz- und Thoraxchirurgie Universit&auml tsklinikum Jena Jena Germany Medizinische klinik IV LMU München München Germany

Background: Colorectal cancer is one of the most common cancer types, frequently metastasizing into the lungs. Treatment options have been vastly improved over the last years. With the increasing use of targeted therapies, novel and rare adverse effects can be seen. Case Presentation: A 43-year-old woman presented in our oncology department with chest pain and dyspnea. The patient was diagnosed with colorectal cancer seven years earlier and had received chemoradiation, surgery, and multiple chemotherapies before she was started on regorafenib because of progressive pulmonary metastases. Computed tomography scans demonstrated cavitation of former nodular bilateral pulmonary metastases. After drainage and resolution of the right-sided pneumothorax, the patient returned eleven days later with recurrent symptoms caused by left-sided tension pneumothorax. Video-assisted thoracoscopy and bilateral pleurodeses were performed. Persistent air leaks with severe pain and pulmonary infiltrates led to the death of the patient. Conclusions: This case demonstrates the efficacy of oral antiangiogenetic therapy in advanced metastatic colorectal cancer. Nevertheless, it also depicts an important potential side effect by transforming multiple solid lung metastases into cavitations which led to recurrent pneumothoraces. Special attention should be paid to this phenomenon as treatment of these complications can be challenging.

关键词： regorafenib Pneumothorax Pulmonary Metastases Colorectal Cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Artificial sweetener sucralose: a possible modulator of autoimmune diseases

引用

Signal Transduction and Targeted Therapy 2023年第11期8卷 5123-5125页

作者： Nicolle Kränkel Ursula rauch-Kroehnert Deutsches Herzzentrum der Charité Klinik für KardiologieAngiologie und IntensivmedizinCampus Benjamin-Franklin(CBF)12203BerlinGermany DZHK(German Centre for Cardiovascular research) Partner site BerlinBerlinGermany friede Springer—Centre of Cardiovascular Prevention@Charité Charité—University Medicine BerlinBerlinGermany

In their research article in Nature in March 2023,fabio Zani and colleagues reported that high concentrations of the zero-calorie artificial sweetener sucralose affected the proliferation and differentiation of T cells toward interferon-γ-producing subsets,with no effect observed for B cells and myeloid cells.1 The publication has raised high hopes in the lay press on a widely available cure for patients suffering from autoimmune diseases.

关键词： autoimmune interferon diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：