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Immunovirological Discordance and Associated factors among People Living with HIV under Antiretroviral Treatment at Hôpital de Jour de Donka, Guinea

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Open Journal of Medical Microbiology 2024年第2期14卷 93-104页

作者： Mariama Sadjo Diallo Djiba Kaba Charles Tchibinda Delicat Issiaga Diallo Boh fanta Diane Doufin Traore Ousmane Niabaly Oumar Mouctar Diallo Ouo-Ouo Yaramon Kolie Aly Patrice Kamano Pascal Koivogui Ahmed Sékou Keita Mohamed Macire Soumah Thierno Mamadou Tounkara Mohamed Cisse facult des Sciences et Techniques de la Sant Universit Gamal Abdel Nasser de Conakry Conakry Guine Laboratoire de Biologie Molculaire Nestor Bangoura/Helene Labrousse Hpital de Jour Donka CHU Donka Conakry Guine Centre dExcellence Africain Pour la Prvention et le Contrle des Maladies Transmissibles Conakry Guine Service de dermatologie-Vnrologie CHU Donka Conakry Guine

The antiretroviral treatment (ArT) has significantly reduced the number of new HIV/AIDS infections and related deaths. However, cases of immunovirological discordance (IVD) are found in various locations. The objective of this study was to determine the profile of People living with HIV (PLHIV) with IVD and to identify associated factors. We conducted a cross-sectional study based on the records of PLHIV under ArT for at least 6 months, followed at Hpital de Jour Donka from 2015 to 2017, and having both viral load (CV) and CD4 T-cell count. Prevalence of IVD was 34.57%, with 23.87% for immunological discordance (ID) and 10.7% for virological discordance (VD). females were predominant (66.26%), and male gender influenced IVD with a statistically significant difference (p = 0.006) and was associated with VD (p = 0.007). The average age was 38.77 11.30 years. PLHIV were classified at WHO stages 3 and 4 (86.01%). The median initial haemoglobin level was 11.5 g/L [3.2 - 12]. The mean initial CD4 T-cell count was 272.84 cells/mm3 201.6. The median initial viral load (VL) was 147,337 copies/mL [1092 - 31,675,000]. The initial CD4 T-cell count 3 was associated with IVD with a statistically significant difference (p = 0.0009) and correlated with ID (p = 0.000). Prurigo was associated with IVD with a statistically significant difference (p = 0.003). Cerebral toxoplasmosis was not associated with IVD but was associated with ID (p = 0.04). This study allowed us to describe the profile of PLHIV with IVD. The main associated factors were male gender, initial CD4 T-cell count 3, toxoplasmosis, prurigo, and herpes zoster.

关键词： HIV Antiretroviral Treatment (ArT) Immunovirological Discordance Donka Guinea

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伴眼部受累的坏死性黄色肉芽肿的长期病程

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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 53-54页

作者： Meyer S. Landthaler M. Hohenleutner S. 罗素菊徐波 klinik und Poliklinik fü r dermatologie Universitt 93042 RegensburgDr.

The clinical features of necrobiotic xanthogranuloma (NX)have been presented in a series of case reports, but there are hardly any reports on the clinical long- term course of this rare and usually chronic entity. Therapeutic recommendations are mostly based on individual observations, lacking general therapeutic guidelines. To illustrate a typical chronic and progressive course of NX, we report the case of a 64- year- old woman with periorbital NX, ocular involvement and IgG paraproteinemia. Diagnosed with NX for the first time in 1993, the patient was already presented in this journal in 1995. Since then a series of therapeutic options including medication with dapsone, chlorambucil, interferon- alpha, clofazimine, melphalan, fumaric acid esters, surgical treatment and other physical therapies such as radiation, plasmapheresis, and photodynamic therapy have been applied. None of these therapeutic approaches, however, showed a satisfying long- term effect. At present the patient is undergoing cyclophosphamide- dexamethasone pulse therapy.

关键词：黄色肉芽肿坏死性异常蛋白血症苯丙氨酸氮芥 α-干扰素光动力疗法反丁烯二酸苯丁酸氮芥塞米

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A strategy for uncovering germline variants altering anti-tumor CD8 T cell response

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Journal of Genetics and Genomics 2023年第5期50卷 353-361页

作者： Vijay Kumar Ulaganathan Martina H.Vasileva klinik fur dermatologie&Allergology Universitatsmedizin GottingenGottingen 37075Germany Institut fuir Multiple Sklerose forschung NeuroimmunologieUniversitatsmedizin GottingenGottingen 37075Germany University of Lorraine NGERE UnitFaculte de Medecine9 Avenue de La Foret de HayeVandoeuvre-les-Nancy 54505France

Among many factors known to alter the outcomes of T cell receptor(TCr)-induced proximal signaling,the role of human germline variants in dictating the individuality of the anti-tumor CD8 T cell response has remained challenging to ***,we describe a convenient strategy for molecular and functional characterization of phosphotyrosine-altering non-synonymous single nucleotide variations(pTyr-SNVs)that directly impact TCr-induced proximal phosphotyrosine motif-based signaling *** devise an experimental co-cultivation set-up comprising a C57BL/6 mouse-derived metastatic melanoma cell line engineered to constitutively present ovalbumin(OVA)antigens and retrovirally engineered syngeneic major histocompatibility complex(MHC)Class I restricted OVA TCr-transgenic CD8 T cells(OT-I).Using the synthetic version of pTyr-SNV rs1178800678-G/T-encoding integrin alpha 4(ITGA4)p.S1027I variant as a prototype,we show that under identical TCr stimulation conditions,genetically determined membrane-proximal immunoreceptor tyrosin activation motif(ITAM)results in increased tyrosine phosphorylation of 70 kDa zeta-chain-associated protein(ZAP70)and the levels of cytotoxic effector molecule granzyme B(GZMB),which in turn result in enhanced cytotoxic activity against metastatic melanoma cell *** strategy paves the way for rapid molecular and functional characterization of anti-tumor immune response-linked germline pTyr-SNVs so as to improve our understanding of the genetic basis of individual-to-individual differences in anti-tumor CD8 T cell response.

关键词： Non-synonymous single nucleotide variants(nsSNVs) Membrane-proximal phosphotyrosine signalling motifs Phosphotyrosine-altering non-synonymous single nucleotide variants(pTyr-SNVs) Immunoreceptor tyrosine activation motif(ITAM) CD8 T cells Melanoma B16-f10

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慢性创伤患者的接触性变态反应:1999—2004年研究结果(德语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 51-52页

作者： Lehnen M. Kohaus S. Krber A. J. Dissemond 周少娜 klinik für dermatologie Venerologie und Allergologie Universittsklinikum Essen Hufelandstraβe 55 45122 Essen Dr.

Patients with chronic wounds frequently acquire clinically relevant contact sensitization. We examined the results of the skin patch tests in patients with chronic wounds, who were treated between 1999-2004 in the Department of Dermatology, University School of Medicine, Essen, Germany. Altogether 105 patients with chronic wounds underwent patch testing. In 68 individuals, contact sensitization to at least one substance was detected. The most frequent contact allergens were to balsam of Peru, Amerchol L-101, fragrance mix, wool wax alcohols and rosins. Contact sensitization to wound dressing materials was also identified in 4 patients. Our results demonstrate the current spectrum of contact sensitization of patients with chronic wounds. Our results show the importance of paying attention to the ingredients in wound dressings and performing patch testing if there is any clinical suggestion of allergic contact dermatitis.

关键词：接触性过敏反应创伤患者慢性变态反应皮肤斑贴试验变应性接触性皮炎德语治疗相关伤口敷料芳香混合物

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松香致敏导致对水状胶体敷料产生变应性接触性皮炎(德语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 50-51页

作者： Krber A. Kohaus S. Geisheimer M. J. Dissemond 周少娜 klinik und Poliklinik für dermatologie Venerologie und Allergologie Universittsklinikum Hufelandstraβe 55 45122 Essen Dr.

A 62-year-old female patient with a venous leg ulcer developed massive eczema during wound bed preparation with the hydrocolloid dressing Varihesive. The patch testing confirmed a pronounced sensitization to the hydrocolloid dressing apart from the sensitization to colophony. After review of the current literature we found several case reports from the last 10 years about sensitization to hydrocolloids which were identical but distributed under different brand names in different countries. These dressings contain the pentaerythritol ester of hydrogenated rosin as the tackifying agent which is the substance retaining the sensitizing potential of colophony. Especially patients with chronic wounds frequently tend to contact sensitizations, and colophony currently represents the 4th most frequent allergen in Germany. Therefore, highly potent allergens such as colophony should be strictly avoided as a content material of modern wound dressings.

关键词：创伤敷料潜在致敏性变应性接触性皮炎松香胶体接触性过敏反应下肢静脉性溃疡水德语女性患者

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毛发脱色剂引起的过敏反应

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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 51-52页

作者： Babilas P. Landthaler M. Szeimies r.- M. 罗素菊徐波 klinik und Poliklinik fü r dermatologie Universittsklinik Regensburg Franz- Josef- Strauss- Allee 11 93042 Regensburg GermanyDr.

Ammonium persulphate is a potent bleach and oxidizing agent that is commonly present in hair bleaches. Because bleaching is so commonly performed, hairdressers often develop allergic contact dermatitis to ammonium persulphate. In addition to this delayed reaction, asthma and rhinitismay develop as immediate reactions in those exposed to the fumes. Severe anaphylactic reactions are rare. We report a 24- year- old woman who acquired dermatitis following contact with bleaching substances while working as a hairdresser. After changing her profession, the dermatitis disappeared. following the private use of a hairdressing bleach containing ammonium persulphate, she suffered a severe anaphylactic reaction with unconsciousness. The patient also developed an anaphylactic reaction three hours following patch testing with the hairdresser battery. The rub test with ammonium persulphate (2.5% ) in a 1:100 solutionwas positive.

关键词：迟发性反应摩擦试验

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镀银衣物治疗特应性湿疹的功效研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 2-3页

作者： Gauger A fischer S Mempel M 冯义国 klinik und Poliklinik fü r dermatologie und Allergologie am Biederstein TU Mü nchen Biedersteiner Str. 29 D- 80802 MunichGermany

Background: Microbial skin colonization with Staphylococcus aureus is known to play an important role in atopic eczema (AE). recently, an antibacterial effect of silver-coated textiles on S. aureus colonization has been demonstrated. Objectives: To investigate clinical efficacy and functionality of silver-coated textiles in AE, a multicentre, double-blind, placebo-controlled trial was conducted. Patients/methods: from November 2001 to August 2002, 68 consecutive outpatients clinically diagnosed with generalized AE were included in the study. Inclusion criteria were the clinical diagnosis of AE with amoderate severity as measured by the scoring of atopic dermatitis (SCOrAD) index with at least 20. Patients were instructed to wear either silvercoated (verum, 35 patients + 2 dropouts) or cotton garments (placebo, 22 patients + 9 dropouts) directly on the skin for 2 weeks. Only basic skin care and ongoing therapy with topical steroids or oral antihistamines was permitted. Clinical severity was assessed using the ‘ SCOrAD’ before, during and at the end of study. Quality of life (QOL), wearing comfort (WC) and functionality (fU) of study clothes were measured in parallel. Patients documented their subjective and objective symptoms daily. results: In the verum group, eczema improved significantly after 1 week with further enhancement until the end of study (P = 0.03 and P r-coated textiles were comparable to cotton inWC and fU. Pruritus and self-assigned skin condition improved significantly more than with placebo (P r coated textiles are able to improve objective and subjective symptoms of AE significantly within 2 weeks, showing a good wearing comfort and functionality comparable to cotton.

关键词：特应性皮炎衣物镀银湿疹治疗功效对照临床试验金黄色葡萄球菌

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多系统萎缩中部分排汗功能紊乱(德国)

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 3-4页

作者： Saft C. Andrich J. Mü ller T. M. Stü cker 刘安 Dr. klinik fü r dermatologie und Allergologie Ruhr- Universitt Bochum St. Josef Hospital Gudrunstrafle 56 44791 Bochum Germany

There are many different causes of anhidrosis. Sweat glands can be absent, atrophic or blocked; sympathetic innervation may be disturbed, or central nervous system damage may prevent perspiration. We present a patient with multiple system atrophy (MSA) who presented with unilateral anhidrosis of the trunk. MSA is a sporadic neurodegenerative disorder of adults involving the pyramidal, extrapyramidal, cerebellar and/or autonomic system. The findings in our patient could be explained by a depletion of catecholaminergic sympathetic neurons of the thoracic spinal neurons.

关键词：多系统萎缩排汗神经变性疾病无汗症神经元缺失锥体外系自主神经系统神经紊乱儿茶酚

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HIV相关皮肤和可见粘膜症状与疾病

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德国医学 1998年第3期15卷 158-159页

作者： B.-r.Balda 江文 klinik für dermatologie und Allergologie Zentralklinikum Augsburg Stenglinstr.2 D-86156 AugsburgGermany 同济医科大学附属同济医院

在HIV感染的各期中或多或少地在皮肤和可见粘膜出现非常明显的症状,仅少数病期例外。当然,单独一种症状不一定具有疾病特征性。相反,它们反映了较宽的皮肤病学疾病病状谱。具备三联征“异常的部位、非典型的病程和不相称的年龄”,它们... 详细信息

在HIV感染的各期中或多或少地在皮肤和可见粘膜出现非常明显的症状,仅少数病期例外。当然,单独一种症状不一定具有疾病特征性。相反,它们反映了较宽的皮肤病学疾病病状谱。具备三联征“异常的部位、非典型的病程和不相称的年龄”,它们才有诊断意义。为了正确的诊断及判断预后,每个医生必须熟悉以下一些疾病特征。

关键词：艾滋病皮肤粘膜临床表现

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高嗜酸性粒细胞增多性皮炎:一个被忽略的诊断?

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世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 54-55页

作者： Kemmler N. Peitsch W.K. Glorer E. Goerdt S. 李政霄 klinik fü r dermatologie Venerologie und Allergologie Klinikum Mannheim gGmbH Ruprecht- Karls- Universit t Heidelberg Theodor- Kutzer- Ufer 1- 3 68135 Mannheim GermanyDr.

Background. The idiopathic hypereosinophilic syndrome is a rare systemic disease characterized by blood and tissue eosinophilia of unknown etiology, in which multiple organs may be affected. In hypereosinophilic dermatitis the only affected organ besides the blood is the skin. Patients. We present a series of seven patients with hypereosinophilic dermatitis who were treated in our hospital between 2002 and 2003. results. All patients initially showed characteristic, therapy- resistant, polymorphic skin lesions, presenting with a combination of erythematous, pruritic and urticarial papules and plaques. All had blood eosinophilia without evidence of allergic, parasitic or other causes. The histology showed tissue eosinophilia only in half of the cases; the other histological findings were non- specific. We observed a good response to therapy with systemic corticosteroids, dapsone and light therapy, applied as UVA- 1 irradiation or as shower photochemotherapy. Conclusions. The diagnosis “ hypereosinophilic dermatitis” should be based primarily on the characteristic clinical picture together with “ idiopathic” peripheral eosinophilia, whereas the histological findings are not always indicative. Because of the multiplicity of possible differential diagnoses and the often non- revealing histology,we assume that the diagnosis “ hypereosinophilic dermatitis” is often overlooked.

关键词：特应性组织学检查光疗法多器官受累多形性系统性疾病光化学疗法非特异性改变氨苯砜抵抗性

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