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Adherence to Advisory Committee on Immunization Practices in diabetes mellitus patients in saudi Arabia:A multicenter retrospective study

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World Journal of Diabetes 2024年第3期15卷 440-454页

作者： Saleh Fahad Alqifari Aya K Esmail Dalal M Alarifi Ghalya Y Alsuliman Maram M Alhati May R Mutlaq Mohammed Aldhaeefi Shaden A Alshuaibi Palanisamy Amirthalingam Abrar Abdallah Afaf S Wasel Heba R Hamad Shoroq Alamin Tasneem H Atia Tariq Alqahtani Department of Pharmacy Practice University of TabukTabuk 71491Saudi Arabia Department of Clinical sciences Sulaiman Alrajhi UniversityQassim 52726Saudi Arabia Department of Family Medicine International Medical CenterJeddah 23214Saudi Arabia Clinical and Administrative Pharmacy sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Department of Pharmacology King Saud Bin Abdulaziz University for Health SciencesKing Abdullah International Medical Research CenterRiyadh 11481Saudi Arabia

BACKGROUND Patients with diabetes mellitus(DM)are predisposed to an increased risk of infection signifying the importance of vaccination to protect against its potentially severe *** centers for Disease Control and Prevention/Advisory Committee on Immunization Practices(CDC/ACIP)issued immunization recommendations to protect this patient *** To assess the adherence of patients with DM to the CDC/ACIP immunization recommendations in saudi Arabia and to identify the factors associated with the vaccine adherence *** An observational retrospective study conducted in 2023 was used to collect data on the vaccination records from 13 diabetes care centers in saudi Arabia with 1000 eligible patients in phase I with data collected through chart review and 709 patients in phase II through online *** Among participants,10.01%(n=71)had never received any vaccine,while 85.89%(n=609)received at least one dose of the coronavirus disease 2019(COVID-19)vaccine,and 34.83%(n=247)had received the annual influenza *** 2.96%(n=21),2.11%(n=15),and 1.12%(n=8)received herpes zoster,tetanus,diphtheria,and pertussis(Tdap),and human papillomavirus(HPV)vaccines,*** patients with DM in saudi Arabia,the rate of vaccination for annual influenza and COVID-19 vaccines was higher compared to other vaccinations such as herpes zoster,Tdap,pneumococcal,and *** such as vaccine recommendations provided by family physicians or specialists,site of care,income level,DM-related hospitalization history,residency site,hemoglobin A1c(HbA1c)level,and health sector type can significantly influence the vaccination rate in patients with *** non-vaccinated patients with DM,the most reported barriers were lack of knowledge and fear of side *** signifies the need for large-scale research in this area to identify additional factors that might facilitate adherence to CDC/ACIP vaccine recommendations in patients with *** In S

关键词： Diabetes mellitus Vaccine recommendation COVID-19 vaccine Influenza vaccine Pneumococcal vaccine Immunization Retrospective study

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Spinal dural arteriovenous fistula:a comprehensive review of the history,classification systems,management,and prognosis

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Chinese Neurosurgical Journal 2024年第1期10卷 48-56页

作者： Ali Alkhaibary Ahoud Alharbi Nada Alnefaie Hajar Alammar Alshaymaa M.Arishy Noor Alghanim Yazeed M.Aldhfyan Arwa Albaiahy Yahya H.Khormi Wael Alshaya Saad AlQahatani Ahmed Aloraidi Ahmed Alkhani Sami Khairy College of Medicine King Saud Bin Abdulaziz University for Health SciencesRiyadhSaudi Arabia king abdullah international medical research center RiyadhSaudi Arabia Division of Neurosurgery Department of SurgeryKing Abdulaziz Medical CityMinistry of National Guard-Health AffairsRiyadhSaudi Arabia Department of Neurosurgery National Neurosciences InstituteKing Fahad Medical CityRiyadhSaudi Arabia College of Medicine Jazan UniversityJazanSaudi Arabia Department of Neurosurgery King Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia Department of Surgery Faculty of MedicineJazan UniversityJazanSaudi Arabia

Spinal dural arteriovenous fistulas account for the majority of spinal vascular *** are typically located in the thoracolumbar region and are diagnosed in the middle-aged and elderly *** spinal dural arteriovenous fistulas have been postulated to be acquired,their exact development remains ***,the arteriovenous shunt is situated close to the spinal nerve root,inside the dura mater,where the blood from the radiculomeningeal artery and radicular vein *** history,there have been multiple classification systems of spinal arteriovenous shunts since *** were mainly based on the evolution of diagnostic studies as well as the treatment of these *** classification systems have undergone significant changes over the *** intracranial dural arteriovenous fistula,spinal dural arteriovenous fistula is progressive in *** neurological manifestations,due to venous congestion,tend to be insidious as well as *** include sensory deficits,such as paresthesia,bilateral and/or unilateral radicular pain affecting the lower limbs,and gait *** dural arteriovenous fistulas can be suspected on magnetic resonance imaging/magnetic resonance angiography and confirmed by digital subtraction angiography(DSA).The management includes surgery,endovascular therapy,and in selected cases,*** treatment goal of spinal dural arteriovenous fistula is to halt the progression of the *** prognosis depends on both the duration of symptoms as well as the clinical condition prior to *** present article comprehensively reviews the pathophysiology,changes in classification systems,natural history,clinical manifestations,radiological features,management,and prognosis.

关键词： Connection Endovascular Myelopathy Vascular

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Autosomal recessive cerebellar ataxia with spasticity due to a rare mutation in GBA2 gene in a large consanguineous saudi family

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Genes & Diseases 2021年第1期8卷 110-114页

作者： Hussein Algahtani Bader Shirah Ikram Ullah Mohammad H.Al-Qahtani Angham Abdulrahman Abdulkareem Muhammad Imran Naseer king abdulaziz medical City King Saud bin Abdulaziz University for Health SciencesJeddahSaudi Arabia king abdullah international medical research center King Saud bin Abdulaziz University for Health SciencesJeddahSaudi Arabia Sulaiman bin abdullah Aba Al-Khail Centre for Interdisciplinary research in Basic sciences International Islamic UniversityIslamabadPakistan center of Excellence in Genomic Medicine research King Abdulaziz UniversityJeddahSaudi Arabia Department of medical Laboratory Technology Faculty of Applied Medical SciencesKing Abdulaziz UniversityJeddahSaudi Arabia

The nonlysosomal glucosylceramidase b2(GBA2)gene encode an enzyme that catalyzes the hydrolysis of glucosylceramide to glucose and *** in the GBA2 gene have been reported to cause hereditary spastic paraplegia,autosomal recessive cerebellar ataxia with spasticity,and Marinescu-Sjogren-Like *** this study,we report the clinical features and genetic diagnosis of autosomal recessive cerebellar ataxia with spasticity due to a rare mutation in GBA2 gene in a large consanguineous saudi *** included a large consanguineous saudi family with a presumptive clinical diagnosis of ataxia at king abdulaziz medical City in Jeddah,saudi *** family included six affected individuals and four unaffected in addition to the *** exome sequencing(WES)was performed for the probandⅣ-5,and Sanger sequencing was used to confirm the variant in other family *** study was performed using DNA from the parents and siblings of the *** analysis identified a homozygous variant c.2618G>A,p.(Arg873His)in GBA2 *** homozygous variant was identified in affected members of the family while the parents and the other four siblings were heterozygous carriers of the *** sibling was not available for genetic *** variant identified in our patients is classified as pathogenic considering the current evidence of the *** recessive cerebellar ataxia with spasticity is an extremely rare genetic disorder with very few cases reported in the *** conclude that the c.2617G>A mutation in GBA2 gene causes the loss of function with abolishment of the enzymatic activity that causes the *** report adds further evidence to support the pathogenicity of this *** patients had the classical clinical phenotype of cerebellar ataxia and spasticity consistent with previous reports in the literature.

关键词： Ataxia with spasticity Autosomal recessive GBA2 Novel mutation saudi Arabia

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Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients

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World Journal of Gastroenterology 2012年第1期18卷 55-63页

作者： Abdulrahman A Aljumah Mohamed A Saeed Ahmed I Al Flaiw Ibrahim H Al Traif Abduljaleel M Al Alwan Salem H Al Qurashi Ghormallah A Al Ghamdi Fayez F Al Hejaili Mohammed A Al Balwi Abdulla A Al Sayyari Division of Hepatology Department of Hepatobiliary Sciences and Liver Transplantation King Abdulaziz Medical City and King Saud bin Abdulaziz University for Health Sciences National Guard Health Affairs Division of Nephrology and Renal Transplantation Department of Medicine King Abdulaziz Medical City and King Saud bin Abdulaziz University for Health Sciences National Guard Health Affairs Division of Molecular Pathology and Genetics King Abdulaziz Medical City and King Saud bin Abdulaziz University for Health Sciences National Guard Health Affairs

AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (ALT) levels at baseline, 78.9% had their ALT normalized (including the virological non responders). ALT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. All patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in su

关键词： Allograft rejection Hepatitis C Pegylated interferon Ribavirin Renal transplant

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Free fatty acids receptors 2 and 3 control cell proliferation by regulating cellular glucose uptake

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World Journal of Gastrointestinal Oncology 2020年第5期12卷 514-525页

作者： Saeed Al Mahri Amal Al Ghamdi Maaged Akiel Monira Al Aujan Sameer Mohammad Mohammad Azhar Aziz king abdullah international medical research center Riyadh 11426Saudi Arabia king saud bin abdulaziz university for health sciences Riyadh 11426Saudi Arabia Ministry of the National Guard-health Affairs Riyadh 11426Saudi Arabia Department of Experimental Medicine King Abdullah International Medical Research CenterRiyadh 11426Saudi Arabia Colorectal Cancer research Program King Abdullah International Medical Research CenterRiyadh 11426Saudi Arabia Department of Clinical Laboratory sciences College of Applied Medical SciencesKing Saud bin Abdulaziz University for Health SciencesRiyadh 11426Saudi Arabia Department of medical Genomics King Abdullah International Medical Research CenterRiyadh 11426Saudi Arabia Department of Human and Molecular Genetics Virginia Commonwealth UniversityRichmondVA 23284United States

BACKGROUND Colorectal cancer(CRC)is a worldwide problem,which has been associated with changes in diet and lifestyle *** a result of colonic fermentation of dietary fibres,short chain free fatty acids are generated which activate free fatty acid receptors(FFAR)2 and ***2 and FFAR3 genes are abundantly expressed in colonic epithelium and play an important role in the metabolic homeostasis of colonic epithelial *** studies point to the involvement of FFAR2 in colorectal *** To understand the role of short chain FFARs in *** Transcriptome analysis console software was used to analyse microarray data from CRC patients and cell *** employed short-hairpin RNA mediated down regulation of FFAR2 and FFAR3 genes,which was validated using quantitative real time polymerase chain *** for glucose uptake and cyclic adenosine monophosphate(cAMP)generation was done along with immunofluorescence studies to study the effects of FFAR2/FFAR3 *** measuring cell proliferation,we employed real time electrical impedancebased assay available from *** Microarray data analysis of CRC patient samples showed a significant down regulation of FFAR2 gene *** prompted us to study the FFAR2 in ***,FFAR3 shares significant structural and functional homology with FFAR2,we knocked down both these receptors in CRC cell line HCT *** modified cell lines exhibited higher proliferation rate and were found to have increased glucose uptake as well as increased level of glucose transporter ***,FFAR2 and FFAR3 signal through G protein subunit(Gαi),knockdown of these receptors was associated with increased *** of protein kinase A(PKA)did not alter the growth and proliferation of these cells indicating a mechanism independent of cAMP/PKA *** Our results suggest role of FFAR2/FFAR3 genes in increased proliferation of colon cancer cells via enhanced glucose uptake and exclude t

关键词： Cell proliferation Glucose transporter 1 Colorectal cancer Free fatty acids receptor 2 Free fatty acids receptor 3 Glucose uptake

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Visual resolution under photopic and mesopic conditions in patients with Sjogren's syndrome

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国际眼科杂志:英文版 2023年第10期16卷 1662-1669页

作者： Mosaad Alhassan Amal Aldarwesh Issa Alessa Rafif Alhijji Reema Alduhayan Ali Almustanyir Department of Optometry College of Applied Medical SciencesKing Saud UniversityRiyadh 11433Saudi Arabia Imaging research Department King Abdullah International Medical Research CenterKing Saud bin Abdelaziz University for Health SciencesRiyadh 11481Saudi Arabia

AIM:To focus on different visual resolution tasks under photopic and mesopic conditions in Sjogren’s syndrome patients compared to age-matched healthy ***:The visual resolution measurements included high and low visual acuities and contrast sensitivity *** tests were conducted under photopic and then mesopic ***-one Sjögren’s syndrome patients and 21 aged-matched healthy volunteers completed all the measurements in this ***:Sjogren’s syndrome patients have greater impairment in contrast sensitivity than standardized visual *** reduction was significant under the mesopic ***,Sjogren’s syndrome patients treated with pilocarpine suffer more than patients without pilocarpine treatment under low light ***:Sjogren’s syndrome patients shows greater impairment in different visual resolution tasks due to dry eye symptoms.

关键词： Sjogren’s syndrome dry eye visual acuity contrast sensitivity mesopic night vision

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Incidence of ocular manifestations in patients with graft versus host disease after allogeneic stem cell transplant in Riyadh, saudi Arabia

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international Journal of Ophthalmology(English edition) 2022年第7期15卷 1149-1156页

作者： Tariq Aldebasi Rabia Bashir Shiji Gangadharan Naila AShaheen Basil Alhussain Tariq Almudhaiyan Bader Alahmari Department of Ophthalmology King Abdulaziz Medical CityNational Guard Health AffairsRiyadh 11426Saudi Arabia king abdullah international medical research center(KAIMRC) Riyadh 11426Saudi Arabia king saud bin abdulaziz university for health sciences Riyadh 11426Saudi Arabia Divisions of Adult Hematology and SCT King Abdulaziz Medical CityNational Guard Health AffairsRiyadh 11426Saudi Arabia

AIM: To evaluate the incidence and severity of ocular graft versus host disease(o GVHD) in patients who underwent allogeneic stem cell transplant(SCT) in king Abdul-Aziz medical City, saudi ***: This is a retrospective cohort study conducted in king Abdul Aziz medical City on patients who underwent allogeneic hematopoietic cell transplant(allo-HCT) from 2010 to 2017. The ocular examination findings including visual acuity, meibomian gland dysfunction, corneal and conjunctival staining with severity, corneal scarring, tear film meniscus and breakup time, anterior and posterior segment examination findings, intraocular pressure, treatment given, punctual plugs used or not, and follow up response were ***: The five years cumulative incidence of o GVHD among post-transplant patients was 56.98%(95%CI 38.6%-71.7%). The potential risk factors assessed for developing ocular manifestation were age, gender, donor’s age, donor gender mismatch CD3 and CD34 infusion, while none of the correlates were identified as statistically significant risk factors of developing ocular manifestation. However, the incidence was statistically significantly different betweenpatients diagnosed with acute myelocytic leukemia and acute lymphocytic leukemia(P=0.038). The mean latent period to develop ocular symptoms was 20.5 mo. All patients had variable degree of dry eyes. None of the patients developed any posterior segment ***: The incidence of o GVHD is low in king Abdul-Aziz medical City. This can be attributed to the preconditioning and immunosuppressive regime.

关键词： graft versus host disease allogenic stem cell transplant dry eye

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Opinions and attitudes toward targeted temperature management in the emergency department and intensive care unit in a developing country: a survey study

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World Journal of Emergency Medicine 2023年第2期14卷 138-142页

作者： abdullah Bakhsh Hadeel Alotaibi Sara Alothman Abdulrahman Alothman Rahaf Alothman Abdulrahman Alsulami Malak Alamoudi Ali Alothman Ali Al-Shareef Department of Emergency Medicine the King Abdulaziz UniversityJeddah 21589Saudi Arabia Faculty of Medicine the King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Anesthesia Intensive Care Unitthe King Abdulaziz UniversityJeddah 21589Saudi Arabia College of Medicine King Saud Bin Abdulaziz University for Health SciencesCollege of MedicineJeddah 21589Saudi Arabia king abdulaziz medical City Jeddah 21589Saudi Arabia king abdullah international medical research center Jeddah 21589Saudi Arabia

INTRODUCTION The past two decades have witnessed one of the most contentious scientific debates in the field of temperature management after cardiac arrest in *** started in 2002,following the publication of two groundbreaking trials showing lower mortality rates and improved neurologic recovery with the use of active cooling.[1,2]international recommendations advocate active cooling in the range of 32–34℃for comatose survivors of out-of-hospital cardiac arrest (OHCA).[3,4]The year2013 marked the tipping point with the release of the TTM 1 trial.

关键词： breaking release showing

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Therapeutic benefits of zinc sulfate on neonatal hyperbilirubinemia

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World Journal of Pediatrics 2022年第4期18卷 300-304页

作者： Abdulrahman Al-Matary abdullah AlGhamdi Bandar Alenaze Rasha abdulaziz Mandili Dhuha abdulaziz Alhawsawi Duha Magzoub Ahmed Abu-Zaid Department of Neonatology King Fahad Medical CityRiyadhSaudi Arabia Department of Pediatrics King Abdullah Specialized Children HospitalKing Abdulaziz Medical CityMinistry of National GuardHealth AffairsRiyadhSaudi Arabia king abdullah international research medical research center RiyadhSaudi Arabia king saud bin abdulaziz university for health sciences RiyadhSaudi Arabia College of Medicine Umm Al-Qura UniversityMeccaSaudi Arabia School of Public health University of MemphisMemphisTNUSA Department of Pharmacology College of Graduate Health SciencesUniversity of Tennessee Health Science CenterMemphisTN 38163USA College of Medicine Alfaisal UniversityRiyadhSaudi Arabia

Neonatal hyperbilirubinemia is a common phenomenon shortly after birth and a frequent cause of prolonged hospitalization[1].Increased enterohepatic circulation of indirect bilirubin is one of the elucidated mechanisms implicated in the pathophysiology of neonatal hyperbilirubinemia[2,3].According to various in vitro and in vivo evidence from animal[3]and human[2]trials,zinc salts have been depicted to reduce bilirubin levels.

关键词： neonatal hepatic Therapeutic

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Delayed atomoxetine or fluoxetine treatment coupled with limited voluntary running promotes motor recovery in mice after ischemic stroke

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Neural Regeneration research 2021年第7期16卷 1244-1251页

作者： Faisal F.Alamri abdullah Al Shoyaib Nausheen Syeara Anisha Paul Srinidhi Jayaraman Serob T.Karamyan Thiruma V.Arumugam Vardan T.Karamyan Department of Pharmaceutical sciences School of PharmacyTexas Tech University Health Sciences CenterAmarilloTXUSA Department of Pharmacology Faculty of PharmacyYerevan State Medical UniversityYerevanArmenia Department of Physiology Anatomy and MicrobiologySchool of Life SciencesLa Trobe UniversityMelbourneAustralia center for Blood Brain Barrier research School of PharmacyTexas Tech University Health Sciences CenterAmarilloTXUSA College of sciences and health Profession King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research CenterJeddahSaudi Arabia

Currently, there is an unmet need for treatments promoting post-stroke functional *** aim of this study was to evaluate and compare the dose-dependent effect of delayed atomoxetine or fluoxetine therapy(starting on post-stroke day 5), coupled with limited physical exercise(2 hours daily voluntary wheel running;post-stroke days 9 to 42), on motor recovery of adult male mice after photothrombotic *** drugs are selective norepinephrine or serotonin reuptake inhibitors indicated for disorders unrelated to *** predetermined primary end-point for this study was motor function measured in two tasks of spontaneous motor behaviors in grid-walking and cylinder ***, we quantified the running distance and speed throughout the study, the number of parvalbumin-positive neurons in the medial agranular cortex and infarct *** sensorimotor tests revealed that neither limited physical exercise nor a drug treatment alone significantly facilitated motor recovery in mice after ***, combination of physical exercise with either of the drugs promoted restoration of motor function by day 42 post-stroke, with atomoxetine being a more potent *** was accompanied by a significant decrease in parvalbumin-positive inhibitory interneurons in the ipsilateral medial agranular cortex of mice with recovering motor function, while infarct volumes were comparable among experimental *** further validated in larger studies, our observations suggest that add-on atomoxetine or fluoxetine therapy coupled with limited, structured physical rehabilitation could offer therapeutic modality for stroke survivors who have difficulty to engage in early, high-intensity ***, in light of the recently completed Assessment o F Fluoxet INe In s Troke recover Y(AFFINITY) and Efficacy o F Fluoxetine-a randomis Ed Controlled Trial in Stroke(EFFECTS) trials, our observations call for newly designed studies where fluoxetine or atomoxeti

关键词： drug repurposing neural repair physical exercise physiotherapy post-stroke recovery pre-clinical trial FLAME trial selective norepinephrine reuptake inhibitor selective serotonin reuptake inhibitor stroke pharmacotherapy

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