检索结果-南通市图书馆

Metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： Mohammad M Khan Zaw Ali Khan Mohsin Ali Khan Laboratory of Translational Neurology and Molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s Lucknow Medical college and hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications Metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

Lung imaging characteristics in a patient infected with Elizabethkingia miricola following cerebral hemorrhage surgery: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第1期12卷 169-175页

作者： Ping-Qiang Qi Yi-Jun Zeng Wei Peng Juan Kuai Department of Neurosurgery The Third Affiliated Hospital of Chengdu Medical College Pidu District People’s HospitalChengdu 611730Sichuan ProvinceChina

BACKGROUND Elizabethkingia miricola is a non-fermenting gram-negative bacterium,which was first isolated from the condensate of the Russian peace space station in *** studies on this bacterium have been carried out in the laboratory,and clinical case studies are *** date,a total of 6 clinical cases have been reported *** sUMMARY We present the first case of postoperative pulmonary infection in a patient with intracerebral hemorrhage due to Elizabethkingia *** imaging character-istics of pulmonary infection were identified and the formulation and selection of the clinical treatment plan for this patient are *** Elizabethkingia miricola infection is *** pulmonary infection occurs,computed tomography imaging may show diffuse distribution of a ground glass density shadow in both lungs,the air containing bronchial sign in local areas,thickening of bronchial vascular bundle,and pleural effusion.

关键词： Elizabethkingia miricola Cerebral hemorrhage surgery Postoperative pulmonary infection Imaging features Case report

Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第4期15卷 724-734页

作者： Gu-Lao Zhang Yuan Liu Yan-Feng Liu Xian-Tao Huang Yu Tao Zhen-Huan Chen Heng-Li Lai Department of Cardiology Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330000Jiangxi ProvinceChina

BACKGROUND Diabetic cardiomyopathy(DCM),which is a complication of diabetes,poses a great threat to public *** studies have confirmed the role of NLRP3(NOD-like receptor protein 3)activation in DCM development through the inflammatory *** is an oral hypoglycemic dipeptidyl peptidase-IV inhibitor used to treat *** has recently been reported to have anti-inflammatory and protective effects on myocardial *** To examine the therapeutic effects of teneligliptin on DCM in diabetic *** streptozotocin was administered to induce diabetes in mice,followed by treatment with 30 mg/kg *** Marked increases in cardiomyocyte area and cardiac hypertrophy indicator heart weight/tibia length reductions in fractional shortening,ejection fraction,and heart rate;increases in creatine kinase-MB(CK-MB),aspartate transaminase(AsT),and lactate dehydrogenase(LDH)levels;and upregulated NADPH oxidase 4 were observed in diabetic mice,all of which were significantly reversed by ***,NLRP3 inflammasome activation and increased release of interleukin-1βin diabetic mice were inhibited by *** mouse cardiomyocytes were treated with high glucose(30 mmol/L)with or without teneligliptin(2.5 or 5μM)for 24 ***3 inflammasome *** in CKMB,AsT,and LDH levels in glucose-stimulated cardiomyocytes were markedly inhibited by teneligliptin,and AMP(p-adenosine 5‘-monophosphate)-p-AMPK(activated protein kinase)levels were ***,the beneficial effects of teneligliptin on hyperglycaemia-induced cardiomyocytes were abolished by the AMPK signaling inhibitor compound *** Overall,teneligliptin mitigated DCM by mitigating activation of the NLRP3 inflammasome.

关键词： Diabetic cardiomyopathy Teneligliptin NLRP3 AMPK Interleukin-1β

Non-contact wide-field viewing system-assisted scleral buckling surgery for retinal detachment in silicone oilfilled eyes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第4期17卷 761-766页

作者： su-Lan Wu Yi-Qi Chen Li-Jun shen Jian-Bo Mao Li Lin Ji-Wei Tao Huan Chen shi-An Zhang Jia-Feng Yu Chen-Xi Wang Center for Rehabilitation Medicine Department of OphthalmologyZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina The Affiliated Eye hospital of Wenzhou Medical University in Hangzhou Hangzhou 310000Zhejiang ProvinceChina

AIM:To evaluate scleral buckling(sB)surgery using a noncontact wide-field viewing system and 23-gauge intraocular illumination for the treatment of rhegmatogenous retinal detachment in silicone oil(sO)-filled ***:Totally 9 patients(9 eyes)with retinal detachment in sO-filled eyes were retrospectively *** patients underwent non-contact wide-field viewing system-assisted buckling surgery with 23-gauge intraocular *** was removed at an appropriate time based on *** patients were followed up for at least 3mo after sO *** reattachment,complications,visual acuity and intraocular pressure(IOP)before and after surgery were ***:Patients were followed up for a mean of 8.22mo(3-22mo)after sO *** patients had retinal *** the final follow-up,visual acuity showed improvement for 8 patients,and no change for 1 *** IOP was high in 3 patients before surgery,but it stabilized after treatment;it was not affected in the other *** of the patients had infections,hemorrhage,anterior ischemia,or any other ***:This new non-contact wide-field viewing system-assisted sB surgery with 23-gauge intraocular illumination is effective and safe for retinal detachment in sO-filled eyes.

关键词： non-contact wide-field viewing system scleral buckling silicone oil-filled retinal detachment

Anesthesia,Anesthetics,and Postoperative Cognitive Dysfunction in Elderly Patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical science 2024年第2期44卷 291-297页

作者： Hong-yu ZHU Jian-li YAN Min ZHANG Tian-yun XU Chen CHEN Zhi-lin WU Department of Anesthesiology Linhe District People's HospitalBayannur 015000China Department of Neurosurgery Xinzhou District People's HospitalWuhan 430408China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Postoperative cognitive dysfunction(POCD)remains a major issue that worsens the prognosis of elderly surgery *** article reviews the current research on the effect of different anesthesia methods and commonly utilized anesthetics on the incidence of POCD in elderly patients,aiming to provide an understanding of the underlying mechanisms contributing to this condition and facilitate the development of more reasonable anesthesia protocols,ultimately reducing the incidence of POCD in elderly surgery patients.

关键词： anesthesia anesthetics postoperative cognitive dysfunction elderly patients

Epinephrine promotes tumor progression and M2 polarization of tumor-associated macrophages by regulating the TRIM2-NF-kB pathway in colorectal cancer cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 141-144页

作者： Zhengyi Liu Chenxing Jian Wenzheng Yuan Guiqing jia Donghui cheng Yanzhuo Liu Yanling Zhang Bin Zhang Zili Zhou Gaoping Zhao Department of Breast surgery Henan Provincial People's HospitalThe People's Hospital of Zhengzhou UniversityThe People's Hospital of Henan UniversityZhengzhouHenan 450003China Microbiome Laboratory Henan Provincia People's Hospital Zhengzhou University People's HospitalZhengzhouHenan 450000China Department of Gastrointestinal surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Gastrointestinal surgeryll Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Gastrointestinal surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Hepatobiliary surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China

Tumor-associated inflammation is an important component of the tumor microenvironment,and an important factor affecting tumor *** the tumor microenvironment,tumor-associated macrophages(TAMs)receive different stimuli and can be polarized into classically activated M1 macrophages and alternatively activated M2 *** studies have indicated that the polarization of TAMs is closely related to tumor progression.

关键词： nephrin tumor inflammation

Electric tuning of plasmonic resonances in ultrathin gold nanoribbon arrays

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonics Research 2024年第08期12卷 1750-1759页

作者： ZHENXIN WANG ALEXEY V.KRAsAVIN CHENXINYU PAN JUNsHENG ZHENG ZHIYONG LI XIN GUO ANATOLY V.ZAYATs LIMIN TONG PAN WANG state Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and Engineering Zhejiang University Department of Physics and London Centre for Nanotechnology King's College London Jiaxing Key Laboratory of Photonic sensing & Intelligent Imaging Intelligent Optics & Photonics Research Center Jiaxing Research Institute Zhejiang University

Ultrathin plasmonic nanostructures offer an unparalleled opportunity for the study of light–matter interactions at the nanoscale and realization of compact nanophotonic devices. In this study, we introduce an ultrathin gold nanoribbon array and demonstrate an electric approach to actively tuning its plasmonic resonance, which leveraging the extreme light confinement capability in the ultrathin plasmonic nanostructure and a robust nanoscale electro-optical effect in indium tin oxide. Optimizing the design(to a total thickness as small as 12 nm for a 2-nmthick gold nanoribbon array), we numerically demonstrate a spectral shift in the plasmonic resonance up to 36 nm along with an approximately 16% change in the transmission at a gate voltage below 1.7 V at the wavelength of1.47 μm. This work presents progress towards electric tuning of plasmonic resonances in ultrathin metallic nanostructures for various applications including surface-enhanced spectroscopy, spontaneous emission enhancement,and optical modulation.

关键词： Chemical sensors Diffraction limit Electrooptical effects Indium tin oxide Light matter interactions Nanostructures

RoGRUT: A Hybrid Deep Learning Model for Detecting Power Trapping in smart Grids

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第5期79卷 3175-3192页

作者： Farah Mohammad saad Al-Ahmadi Jalal Al-Muhtadi Center of Excellence in Information Assurance(CoEIA) King Saud UniversityRiyadh11543Saudi Arabia college of Computer&Information sciences King Saud UniversityRiyadh11543Saudi Arabia

Electricity theft is a widespread non-technical issue that has a negative impact on both power grids and electricity *** hinders the economic growth of utility companies,poses electrical risks,and impacts the high energy costs borne by *** development of smart grids is crucial for the identification of power theft since these systems create enormous amounts of data,including information on client consumption,which may be used to identify electricity theft using machine learning and deep learning ***,there also exist different solutions such as hardware-based solutions to detect electricity theft that may require human resources and expensive ***-based solutions are presented in the literature to identify electricity theft but due to the dimensionality curse,class imbalance issue and improper hyper-parameter tuning of such models lead to poor *** this research,a hybrid deep learning model abbreviated as RoGRUT is proposed to detect electricity theft as amalicious and non-malicious *** key steps of the RoGRUT are data preprocessing that covers the problem of class imbalance,feature extraction and final theft *** advanced-level models like RoBERTa is used to address the curse of dimensionality issue,the near miss for class imbalance,and transfer learning for *** effectiveness of the RoGRUTis evaluated using the dataset fromactual smartmeters.A significant number of simulations demonstrate that,when compared to its competitors,the RoGRUT achieves the best classification *** performance evaluation of the proposed model revealed exemplary results across *** accuracy achieved was 88%,with precision at an impressive 86%and recall reaching 84%.The F1-score,a measure of overall performance,stood at 85%.Furthermore,themodel exhibited a noteworthyMatthew correlation coefficient of 78%and excelled with an area under the curve of 91%.

关键词： Electricity theft smart grid RoBERTa GRU transfer learning

Distribution and correlation of refractive parameters in children with different corneal curvatures in southeast China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第4期17卷 713-720页

作者： si-Yuan He Ting He Meng-Yue Xu Ying-Jie Ni Chao-Yang Hong Ting shen The second Clinical college Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Ophthalmology Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Eye Center the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

AIM:To analyze the distribution of refractive status in school-age children with different corneal curvatures(CC)and the correlation between CC and refractive ***:A total of 2214 school-aged children of grade 4 in Hangzhou who were screened for school myopia were *** distance visual acuity(UCDVA),non-cycloplegic refraction,axial length(AL),horizontal and vertical corneal curvature(K1,K2)were measured and spherical equivalent(sE),corneal curvature radius(CCR)and axial length/corneal radius of curvature ratio(AL/CR)were ***sE≤-0.50 D were classified as school-screening *** to the different CCRs,the patients were divided into the lower corneal curvature(LCC)group(CCR≥7.92)and the higher corneal curvature(HCC)group(CCRs further divided into the normal AL subgroup and the long AL *** refractive parameters were compared to identify any differences between the two ***:Both sE and AL were greater in the LCC group(P=0.013,Ps 38% in the LCC group and 44% in the HCC group(Pscreening myopia was higher in the LCC group(62%)than in the HCC group(56%).Among these children without screening myopia,the proportion of long AL in the LCC group(24%)was significantly higher than that in the HCC group(0.012%;PsE in the LCC group was less affected by the increase of AL than that in the HCC ***:school-aged children in the LCC group have a lower incidence of screening myopia and longer *** CC can mask sE reduction and AL growth to some extent,and the change of AL growth change more in children with low CC than high *** the onset of myopia,its growth rate is even faster than that after the onset of myopia.

关键词： school-aged children corneal curvature axial length spherical equivalent myopia screening