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Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction

Chinese Journal of Natural Medicines 2024年第5期22卷 402-415页

作者： XIU Ye WANG Sihao ZHANG Ping LI Chengwei WU Zhixin WEN Jincai XU Yingjie LV Guiji ZHAO Xiaomei DONG Xu CHEN Yichong LI Junjie WANG Yan ZOU Liang XIAO Xiaohe BAI Zhaofang School of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China China Military Institute of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Pharmacy Medical Supplies Center of PLA General HospitalBeijing 100039China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China National Key Laboratory of kidney diseases Chinese PLA General HospitalBeijing 100039China

In the realm of autoimmune and inflammatory diseases,the cyclic GMP-AMP synthase(cGAS)stimulator of interferon genes(STING)signaling pathway has been thoroughly investigated and established.Despite this,the clinical approval of drugs targeting the cGAS-STING pathway has been limited.The Total glucosides of paeony(TGP)is highly anti-inflammatory and is commonly used in the treatment of rheumatoid arthritis(RA),emerged as a subject of our study.We found that the TGP markedly reduced the activation of the cGAS-STING signaling pathway,triggered by various cGAS-STING agonists,in mouse bone marrow-derived macrophages(BMDMs)and Tohoku Hospital Pediatrics-1(THP-1)cells.This inhibition was noted alongside the suppression of interferon regulatory factor 3(IRF3)phosphorylation and the expression of interferon-beta(IFN-β),C-X-C motif chemokine ligand 10(CXCL10),and inflammatory mediators such as tumor necrosis factor-alpha(TNF-α)and interleukin-6(IL-6).The mechanism of action appeared to involve the TGP’s attenuation of the STING-IRF3 interaction,without affecting STING oligomerization,thereby inhibiting the activation of downstream signaling pathways.In vivo,the TGP hindered the initiation of the cGAS-STING pathway by the STING agonist dimethylxanthenone-4-acetic acid(DMXAA)and exhibited promising therapeutic effects in a model of acute liver injury induced by lipopolysaccharide(LPS)and D-galactosamine(D-GalN).Our findings underscore the potential of the TGP as an effective inhibitor of the cGAS-STING pathway,offering a new treatment avenue for inflammatory and autoimmune diseases mediated by this pathway.

关键词： Total glucosides of gaeony cGAS-STING pathway Inflammation LPS/D-GalN STING inhibitor

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Epidemiology and current management of cardiovascular disease in China

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Journal of Geriatric Cardiology 2024年第4期21卷 387-406页

作者： Sheng-Shou HU the Writing Committee of the Report on Cardiovascular Health and dis-eases in China Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The Annual Report on Cardiovascular Health and diseases in China(2022) intricate landscape of cardiovascular health in China. This is the fourth section of the report with a specific focus on epidemiology and current management of cardiovascular disease(CVD) in China. This section of the report highlights the epidemiological trends of CVD in China. It reveal a concerning rise in prevalence, with approximately 330 million affected individuals, including significant numbers with stroke, coronary artery disease(CAD), heart failure, and other conditions. CVD stands as the primary cause of mortality among both urban and rural populations, accounting for nearly half of all deaths in 2020. Mortality rates are notably higher in rural areas compared to urban centers since 2009. While age-standardized mortality rates have decreased, the absolute number of CVD deaths has increased, primarily due to population aging. Ischemic heart disease, hemorrhagic and ischemic strokes are the leading causes of CVD-related deaths. Notably, the burden of atherosclerotic cardiovascular disease has risen substantially, with atherosclerotic cardiovascular disease-related deaths increasing from 1990 to 2016. The incidence of ischemic stroke and ischemic heart disease has shown similar increasing trends over the past three decades. CAD mortality, particularly acute myocardial infarction, has been on the rise, with higher mortality rates observed in rural areas since 2016. The prevalence of CAD has increased significantly, with over 11 million patients identified in 2013. Studies assessing hospital performance in managing acute coronary syndrome reveal gaps in adherence to guideline-recommended strategies, with disparities in care quality across hospitals. However, initiatives like the China Patient-centered Evaluative Assessment of Cardiac Events(PEACE)-Retrospective AMI Study and the Improving Care for Cardiovascular disease in China-Acute Coronary Syndrome(CCC-ACS) project aim to improve patient outcomes through enhanced care protocols. More

关键词： epidemiology landscape deaths

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Clinical efficacy and prognosis analysis of different treatment regimens in patients with uncomplicated brucellosis

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 24-25页

作者：袁关敏 Dept Infect dis Natl Infect Dis Med CenterShanghai Key Lab Infect Dis&Biosafety Emerg ResponseHuashan HospFudan UnivShanghai 200040

Objective To analyze the efficacy and prognosis of different treatment regimens in patients with uncomplicated brucellosis,and to provide guidance for clinical treatment.Methods The patients diagnosed with brucellosis... 详细信息

关键词： regimen patients prognosis

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 25-26页

作者：崔坤平 Infect dis center West China HospSichuan UnivChengdu 610041

Objective To explore the risk factors related to death in patients with tuberculosis complicated with sepsis in an intensive care unit,in order to provide reference for the clinical treatment of patients with tuberculosis complicated with sepsis.Methods A retrospective case-control study was conducted to collect the general clinical data of 384 patients with tuberculosis complicated with sepsis in intensive care unit of Public Health Clinical center of Chengdu from March 2020 to November 2022.

关键词： tuberculosis complicated patients

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A cohort study of HIV infection in club drug abusers among men who have sex with men in Qingdao

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 23-24页

作者：李培龙 Div Epidemiol Natl AIDS/STD Contr&Prev CenterChin Dis Contr&Prev CenterBeijing 102206

Objective To understand and analyze the incidence of HIV infection in club drug abusers among men who have sex with men (MSM) in Qingdao and provide a reference for the prevention and intervention of this population.Methods From March 2017 to July 2022,club drug abusers among MSM who were HIV-negative were recruited by snowball sampling of MSM social organizations in Qingdao.

关键词： prevention drug among HIV

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Risk analysis of gastrointestinal bleeding in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 35-36页

作者：叶明 Coronary Artery dis center Div CardiolBeijing Anzhen HospCapital Med UnivBeijing 100029

Objective To investigate the in-hospital incidence,associated outcomes,and predictors of UGIB after STEMI.Methods In this retrospective study,we analyzed the records of 2 791 patients with acute STEMI admitted to Beij... 详细信息

关键词： admitted patients acute

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Lattice Boltzmann simulation study of anode degradation in solid oxide fuel cells during the initial aging process

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 405-411页

作者： Shixue Liu Zhijing Liu Shuxing Zhang Hao Wu Hydrogen Energy Industrial Technology Innovation center China Nuclear Power Technology Research InstituteShenzhen 518031China Shenzhen Engineering Research center for Hydrogen Safety Shenzhen 518031China

For present solid oxide fuel cells(SOFCs),rapid performance degradation is observed in the initial aging process,and the dis-cussion of the degradation mechanism necessitates quantitative analysis.Herein,focused ion beam-scanning electron microscopy was em-ployed to characterize and reconstruct the ceramic microstructures of SOFC anodes.The lattice Boltzmann method(LBM)simulation of multiphysical and electrochemical processes in the reconstructed models was performed.Two samples collected from industrial-size cells were characterized,including a reduced reference cell and a cell with an initial aging process.Statistical parameters of the reconstructed microstructures revealed a significant decrease in the active triple-phase boundary and Ni connectivity in the aged cell compared with the reference cell.The LBM simulation revealed that activity degradation is dominant compared with microstructural degradation during the initial aging process,and the electrochemical reactions spread to the support layer in the aged cell.The microstructural and activity de-gradations are attributed to Ni migration and coarsening.

关键词： solid oxide fuel cell anode degradation focused ion beam-scanning electron microscopy lattice Boltzmann method

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Efficacy and feasibility of catheter-based adrenal ablation on Cushing's syndrome associated hypertension

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 37-38页

作者：闫振成 Dept Hypertens&Endocrinol Hypertens&Cardiometab Dis CenterDaping HospArmy Med UnivChongqing Hypertens InstitChongqing 400042

Objective To explore the value of catheter-based adrenal ablation in treating Cushing’s syndrome (CS)-associated hypertension.Methods A clinical study was conducted in patients with CS,who received catheterbased adrenal ablation between March 2018 and July2023 in Daping Hospital.Parameters monitored were blood pressure (outpatient and 24-hour ambulatory).

关键词： Cushing adrenal hypertension

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Zunyou Wu(1963–2023)Chief Epidemiologist,China CDC

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China CDC weekly 2024年第3期6卷 60-60页

作者： Wu, Zunyou Chinese Ctr dis Control & Prevent Beijing Peoples R China

Born in Huangshan city,Anhui Province in June 1963,Zunyou Wu passed away on October 27,2023,in Beijing at the age of 60.Dr.Wu is the Chief Epidemiologist at China CDC,and served as the former director and researcher of the National center for acquired immunodeficiency syndrome/sexually transmitted diseases(AIDS/STD)Control and Prevention(NCAIDS)at China CDC.Additionally,he was a member of the 14th National Committee of the Chinese People’s Political Consultative Conference(CPPCC),and a member of the 15th Central Standing Committee of the China Association for Promoting Democracy(CAPD).Dr.Wu earned a medical degree in 1985 and a master’s degree in epidemiology in 1988 from Anhui Medical University,China.

关键词： Anhui logist earned

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Cardiovascular Risk Factors in China

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Journal of Geriatric Cardiology 2024年第2期21卷 153-199页

作者： Sheng-Shou HU the Writing Committee of the Report on Cardiovascular Health and diseases in China Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina 不详

The Annual Report on Cardiovascular Health and diseases in China(2022) intricate landscape of cardiovascular health in China. This section dissects cardiovascular risk factors in China which including hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease, metabolic syndrome and air pollution. Hypertension prevalence has steadily increased in China,with efforts to control it facing challenges in achieving optimal rates, especially in rural areas. Interventions like salt substitutes and intensive blood pressure control show promise but need improvement. Abnormal lipid levels, indicative of dyslipidemia,have risen significantly, posing a risk for cardiovascular diseases. Despite efforts, many patients struggle to achieve target lipid levels, necessitating improved treatment strategies. Both type 1 and type 2 diabetes mellitus affect millions of adults in China,with long-term complications adding to the disease burden. Early intervention and effective management are crucial to mitigate its impact. Prevalent among older adults, chronic kidney disease is associated with diabetes mellitus, hypertension, and cardiovascular diseases, necessitating comprehensive management approaches. The prevalence of metabolic syndrome, characterized by a cluster of risk factors, has increased in both adults and adolescents, calling for lifestyle modifications and public health interventions. Ambient and household air pollution remain significant environmental risk factors, despite some improvements in air quality. Continued efforts to reduce emissions are essential for mitigating associated health risks. Addressing these risk factors requires a multifaceted approach, including public health initiatives, policy interventions, and individual-level strategies to promote healthy lifestyles and reduce environmental exposures. Surveillance and research efforts are crucial for monitoring trends and developing effective strategies to lessen the burden of cardiovascular diseases in China.

关键词： landscape adding spite

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