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Mice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection

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Virologica Sinica 2024年第2期39卷 251-263页

作者： Wei Yang Chong-Yang Tang Dong-Ying Fan Yi-Song Wang Pei-Gang Wang Jing An Guo-Ming Luan Beijing Key Laboratory of Epilepsy Sanbo Brain HospitalCapital Medical UniversityBeijing100093China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing100093China Department of Neurosurgery Epilepsy CenterSanbo Brain HospitalCapital Medical UniversityBeijing100093China Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing100069China Chinese Institute for Brain Research Beijing102206China

Viral encephalitis continues to be a significant public health *** our previous study,we discovered a lower expression of antiviral factors,such as IFN-β,STING and IFI16,in the brain tissues of patients with Rasmussen's encephalitis(RE),a rare chronic neurological disorder often occurred in children,characterized by unihemispheric brain ***,a higher cumulative viral score of human herpes viruses(HHVs)was also found to have a significant positive correlation with the unihemispheric atrophy in *** I IFNs(IFN-I)signaling is essential for innate anti-infection response by binding to IFN-α/βreceptor(IFNAR).In this study,we infected WT mice and IFNAR-deficient A6 mice with herpes simplex virus 1(HSV-1)via periocular injection to investigate the relationship between IFN-I signaling and HHVs-induced brain *** all mice exhibited typical viral encephalitis lesions in their brains,HSV-induced epilepsy was only observed in A6 *** gene expression matrix,functional enrichment analysis and protein-protein interaction network revealed four gene models that were positively related with HSV-induced ***,ten key genes with the highest scores were *** together,these findings indicate that intact IFN-I signaling can effectively limit HHVs induced neural symptoms and brain lesions,thereby confirming the positive correlation between IFN-I signaling repression and brain atrophy in RE and other HHVs encephalitis.

关键词： IFN-I signaling Human herpes viruses(HHVs) Rasmussen's encephalitis(RE)

Plasmodesmatal Dynamics in Both Woody Poplar and Herbaceous Winter Wheat Under Controlled Short Day and in Field Winter Period

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Acta Botanica Sinica 2004年第2期46卷 230-235页

作者： JIANLing-Cheng WANGHong keylaboratoryofphotosynthesisbeijing100093 China

Electron microscopic observation revealed that poplar (Populus deltoides Marsh.) and winterwheat ( Triticum aestivum L. cv. Seward 80004) plasmodesmatal structures significantly changed undershort day (SD, 8 h light) and in winter period, and such changes differed also noticeably between these twowoody and herbaceous plants. Under long day (LD, 16 h light), many plasmodesmata with strong stainappeared in the cell wall of both poplar apical buds and winter wheat young leaf tissues, and connections ofcytoplasmic endoplasmic reticulum (ER) with the ER in some plasmodesmata were observed. In addition,the typical “neck type” plasmodesmata were observed in winter wheat young leaf tissues, and their centraldesmotubules (appressed-ER) could be clearly identified. Under SD, many poplar plasmodesmata showedonly a partial structure in the cell wall and appeared to be discontinued; some plasmodesmata swelled in themid-wall, forming the cavity, and no appressed-ER appeared, in winter wheat, however, no noticeablealterations of plasmodesmata occurred, and the plasmodesmatal structure essentially remained the sameas it was under LD. In winter period, poplar plasmodesmata had a similar morphology as those observedunder SD, however, winter wheat manifested at least two types of significant plasmodesmatal alterations:one plugged by electron-dense materials and the other of reduced neck region compared to those underLD. The above dynamic difference of the two species plasmodesmata under SD and winter period revealedthe difference of their dormancy development under those environmental conditions.

关键词：杨树冬小麦大分子胞间运输植物休眠胞间连丝

Alternation in Lipid Composition of Wheat Leaves Induced by Phosphate Deficiency Is Related to Both Lipid Biosynthesis and Phosphatidylglycerol Degradation

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Acta Botanica Sinica 2004年第2期46卷 211-215页

作者： YANGWen FENGFu-Ying HOUHai-Tong JIANGGui-Zhen XUYi-Nong KUANGTing-Yun keylaboratoryofphotosynthesisbeijing100093 China

In this study, the causes of the changes in lipid composition induced by different phosphatenutrient levels were investigated. Wheat plants were grown in phosphate-deficient and phosphate-suffcient conditions, respectively, and lipid compositions in the leaves of 9-day-old and 16-day-old plants wereanalyzed. We found that phosphate deficiency induced a dramatic change at the lipid levels in photosyntheticmembranes of wheat leaves and the extent of changes in lipid composition depended on the leaf *** deficiency induced a gradual decrease in PG and MGDG and a concomitant increase in DGDGand SQDG from the first leaf to the second and the third leaf on 16-day-old plants. In addition, as comparedto leaves grown under phosphate sufficient solution, PG content in the first leaf of 16-day-old plants wassignificantly lower than that of 9-day-old leaf with 2.5 mol% versus 5.5 mol% when these plants were grownunder phosphate deficient condition. From these results, it is suggested that the alternation in lipidcomposition in wheat leaves induced by phosphate deficiency is related to both lipid biosynthesis and PGdegradation. PG decrease in younger leaves is mainly due to insufficient phosphate supply for PG biosynthesis,while PG degradation mainly resulted in the PG decrease in older leaves.

关键词：磷脂酰甘油降解脂合成磷转移磷缺失小麦叶片

Publication-level analysis of Journal of Plant Ecology during 2018-2022

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Journal of Plant Ecology 2024年第4期17卷 197-201页

作者： Yu Liao Pu Wang Lijuan Liu Wen-Hao Zhang National Science Library Chinese Academy of SciencesBeijing 100190China Center for Documentation and Information Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China

Journal of Plant Ecology(JPE)was established in 2008 and is sponsored by the Botanical Society of China and the Institute of Botany,Chinese Academy of *** by Oxford University Press,UK,JPE encompasses a wide range of article types within the expansive field of plant *** of July 2021,JPE has transitioned to fully Open Access,ensuring unrestricted access to the full text for both readers and *** shift enhances the journal’s role as a crucial platform for plant ecologists worldwide to disseminate their research findings.

关键词： Open Plant Access

MMCo:using multimodal deep learning to detect malicious traffic with noisy labels

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Frontiers of Computer Science 2024年第1期18卷 239-241页

作者： Qingjun YUAN Gaopeng GOU Yuefei ZHU Yongjuan WANG Strategic Support Force Information Engineering University Zhengzhou 450001China Institute of Information Engineering Chinese Academy of SciencesBeijing 100093China

1 Introduction The success of a deep learning-based network intrusion detection systems(NIDS)relies on large-scale,labeled,realistic traffic[1,2].However,automated labeling of realistic traffic,such as by sandbox and rule-based approaches,is prone to errors[3],which in turn affects deep learning-based *** effective schemes for learning with noisy labels(LNL)have been proposed,among which the use of parallel networks for sample selection during training has been shown to be *** is argued that parallel networks can discriminate samples from different perspectives,thus adding additional information to the training *** centerpiece is maintaining disagreement of networks.

关键词： network networks modal

Carbon preservation in sedimentary deposits: Beyond mineral protection

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The Innovation 2024年第2期5卷 5-6页

作者： Yunpeng Zhao Juan Jia Chengzhu Liu Xiaojuan Feng State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

The deposition and preservation of organic carbon(OC)in sedimentary environments(including soils and sediments)play major roles in mediating the global carbon *** than 90%of OC burial in the ocean occurs in continental margin sediments,which contributes to the evolution of the Earth’s atmosphere,such as oxygen content,over geological timescales.1 However,how OC escapes mineralization and persists in such sedimentary deposits has long been a *** protection through physicochemical associations of organic matter with minerals and cations is considered to be one of the primary mechanisms contributing to the environmental persistence of sedimentary OC.

关键词： sedimentary mineralization environments

Reproductive height determines the loss of clonal grasses with nitrogen enrichment in a temperate grassland

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Plant Diversity 2024年第2期46卷 256-264页

作者： Xu Chen Haining Lu Zhengru Ren Yuqiu Zhang Ruoxuan Liu Yunhai Zhang Xingguo Han State Key Laboratory of Vegetation and Environmental Change Institute of Botanythe Chinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Yuquan RoadBeijing 100049China

Tall clonal grasses commonly display competitive advantages with nitrogen(N)***,it is currently unknown whether the height is derived from the vegetative or reproductive ***,it is unclear whether the height of the vegetative or reproductive system regulates the probability of extinction and colonization,and determines species *** this study,the impacts on clonal grasses were studied in a field experiment employing two frequencies(twice a year ***)crossing with nine N addition rates in a temperate grassland,*** found that the N addition decreased species frequency and increased extinction probability,but did not change the species colonization probability.A low frequency of N addition decreased species frequency and colonization probability,but increased extinction ***,we found that species reproductive height was the best index to predict the extinction probability of clonal grasses in N-enriched *** low frequency of N addition may overestimate the negative effect from N deposition on clonal grass diversity,suggesting that a higher frequency of N addition is more suitable in assessing the ecological effects of N ***,this study illustrates that reproductive height was associated with the clonal species extinction probability under N-enriched environment.

关键词： ANPP Biodiversity Clonal grass Colonization Extinction Nitrogen addition frequency

Rosemary extract improves egg quality by altering gut barrier function,intestinal microbiota and oviductal gene expressions in late-phase laying hens

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Journal of Animal Science and Biotechnology 2024年第1期15卷 295-312页

作者： Lianhua Zhang Junwei Ge Fei Gao Min Yang Hui Li Fei Xia Hongtong Bai Xiangshu Piao Zhiying Sun Lei Shi Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background Rosemary extract(RE)has been reported to exert antioxidant ***,the application of RE in late-phase laying hens on egg quality,intestinal barrier and microbiota,and oviductal function has not been systematically *** study was investigated to detect the potential effects of RE on performance,egg quality,serum parameters,intestinal heath,cecal microbiota and metabolism,and oviductal gene expressions in late-phase laying hens.A total of 21065-week-old“Jing Tint 6”laying hens were randomly allocated into five treatments with six replicates and seven birds per replicate and fed basal diet(CON)or basal diet supplemented with chlortetracycline at 50 mg/kg(CTC)or RE at 50 mg/kg(RE50),100 mg/kg(RE100),and 200 mg/kg(RE200).Results Our results showed that RE200 improved(P<0.05)Haugh unit and n-6/n-3 of egg yolk,serum superoxide dismutase(SOD)compared with *** significant differences were observed for Haugh unit and n-6/n-3 of egg yolk among CTC,RE50,RE100 and RE200 *** with CTC and RE50 groups,RE200 increased serum SOD activity on d 28 and *** with CON,RE supplementation decreased(P<0.05)total cholesterol(TC)***,RE100 and RE200 decreased(P<0.05)serum interleukin-6(IL-6)content compared with *** and RE200 increased jejunal m RNA expression of ZO-1 and Occludin compared with *** biomarkers of cecal microbiota and metabolite induced by RE 200,including Firmicutes,Eisenbergiella,Paraprevotella,Papillibacter,and butyrate,were closely associated with Haugh unit,n-6/n-3,SOD,IL-6,and ***2 analysis indicated that RE altered carbohydrate and amino acid metabolism of cecal microbiota and increased butyrate synthesizing enzymes,including 3-oxoacid Co A-transferase and butyrate-acetoacetate Co ***,transcriptomic analysis revealed that RE200 improved gene expressions and functional pathways related to immunity and albumen formation in the oviductal *** Dietary supplementation with 2

关键词： Intestinal health Laying hens Microbiota Oviductal function Phytochemicals Production

pyIFPNI:A package for querying and downloading plant fossil data from the IFPNI

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Plant Diversity 2024年第2期46卷 280-282页

作者： Bailong Zhao State Key Laboratory of Plant Diversity and Specialty Crops Institute of BotanyChinese Academy of SciencesBeijing100093China University of Chinese Academy of Sciences Beijing100049China

The International Fossil Plant Names Index(IFPNI,2014-onwards)not only serves as an online gateway to the fossil plant name registry for the global scientific community,but also serves as a comprehensive and dynamic archive of fossil plants(Doweld,2016,2022).Since its establishment in 2014,the IFPNI has accumulated more than 80,000 entries of fossil plant names,along with information on over 10,000 documents and over 6000 paleobotanists,all supported by exhaustive data,demonstrating the scope of the IFPNI's work(IFPNI,2014-onwards).

关键词： plant fossil