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Agrocybe cylindracea Polysaccharides repair the intestinal mucosal barrier in DSS-induced colitis by modulating the gut microbiota -macrophage axis

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Food Science and Human Wellness 2025年

作者： Zaoxuan Wu Shujian Wu Xiuying Liu Shuze Chen Senbao Xu Yunying Gong Qiujuan Ye Xuefeng Gao Ye Chen Department of Gastroenterology， Guangdong Provincial key Laboratory of Gastroenterology， State key Laboratory of Organ Failure research， Nanfang Hospital， Southern Medical University The First School of clinical Medicine， Southern Medical University Integrative Microecology clinical Center， Shenzhen key Laboratory of Gastrointestinal Microbiota and Disease Integrative clinical Microecology Center， Shenzhen key Laboratory of Gastrointestinal Microbiota and Disease， Shenzhen clinical research Center for Digestive Disease， Shenzhen Technology research Center of Gut Microbiota Transplantation， Shenzhen Hospital， Southern Medical University

The Agrocybe cylindracea polysaccharides (ACP) have been shown to possess various health benefits. However， the anti-inflammatory effects of ACP and the mechanisms underlying these effects remain poorly understood. In this study， we delved into the potential of ACP in mitigating colitis induced by dextrose sodium sulfate (DSS) in C57BL/6J mice and explored the associated mechanisms. ACP demonstrated notable anti-inflammatory effects in the intestines， as evidenced by the restoration of various indicators such as increased body weight and colon length， decreased DAI score， and alleviation of pathological damage in the colon. Additionally， ACP upregulated the expression of ZO-1， Occludin， and Muc2， suggesting a restoration of the mechanical and mucus barriers of the intestinal mucosa. Furthermore， ACP facilitated the polarization of M2 macrophages and preserved intestinal immune balance. The impact of ACP on the biological barrier was further scrutinized. ACP ameliorated disruptions in the gut microbiota， particularly by enhancing the relative abundance of bacteria that produce short-chain fatty acids (Anaerostipes， Romboutsia， and Butyricicoccus). Remarkably， the ameliorative effects of ACP on colitis were compromised upon the removal of the microbial community， but were restored post fecal microbiota transplantation， indicating that the efficacy of ACP in alleviating colitis is dependent on the gut microbiota. Intriguingly， the regulatory influence of ACP on macrophages also hinged on the gut microbiota. In essence， ACP exhibits the potential to modulate the composition of the gut microbiota， fostering the growth of beneficial bacteria， which in turn promotes the polarization of colonic M2 macrophages and facilitates the repair of the intestinal mucosal barrier in DSS-induced colitis. These findings underscore the capacity of ACP to enhance the intestinal mucosal barrier and ameliorate colitis by modulating the gut microbiota-macrophage axis， suggesting that ACP cou

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Integrating artificial intelligence into radiological cancer imaging: from diagnosis and treatment response to prognosis

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Cancer Biology & Medicine 2025年第1期22卷 6-13页

作者： Sunyi Zheng Xiaonan Cui Zhaoxiang Ye Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Key Laboratory of Digestive Cancer Key Laboratory of Cancer Prevention and Therapy Department of Radiology

Cancer poses a serious threat to human health worldwide and is a leading cause of death1. The analysis of radiological imaging is crucial in early detection, accurate diagnosis, effective treatment planning, and ongoing monitoring of patients with cancer. However, several challenges impede the effectiveness of cancer imaging analysis in clinical practice.

关键词： intelligence prognosis imaging cancer from artificial diagnosis integrating into radiological

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Internal transcribed spacer sequencing to explore the intrinsic composition of fungal communities in fungal esophagitis

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World Journal of Gastroenterology 2025年第7期31卷 26-38页

作者： Yi-Kang Song Lin Zheng Ai-Xin Liu Jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000Hebei ProvinceChina

BACKGROUND Fungal esophagitis(FE)is caused by fungal invasion of the esophageal *** endoscopy,the esophageal mucosa shows edema,congestion,erosion,and ulceration,and bleeds easily when touched,and the surface of the mucosa is covered with small white spots like"bean curd residue".clinical cases showing typical FE under endoscopic imaging but negative esophageal mucosal brush(referred to as suspected FE)have increased the difficulty and challenge of clinical diagnosis and *** present,the esophageal fungal flora of suspected case has not been thoroughly *** To characterize the fungal flora in FE,suspected FE,and the esophageal normal controls(NCs),and to identify marker species to improve detection of *** This was a case-control study.A total of 19 patients with FE,16 with suspected FE,and 10 NCs were selected by *** esophageal cell brush samples of each group were sequenced by internal transcribed spacer(ITS)1 and analyzed by *** In FE and suspected FE patients,species richness,species diversity and species evenness,as measured by the Chao1 index,Shannon index and Pielou index,were lower than in the NCs,and the comparison between the FE and NCs was the most significant(Punity was similar in the F

关键词： Fungal microbiota Esophagitis Candida Yarrowia Biomarker

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina key Laboratory for research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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Biomaterial‑based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration

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Military Medical research 2025年第1期12卷 96-120页

作者： Ying-Ying Li Shuai-Fei Ji Xiao-Bing Fu Yu-Feng Jiang Xiao-Yan Sun research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation research Department Chinese PLA General Hospital and PLA Medical CollegePLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin InjuryRepair and RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048China research unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048China 2Department of Tissue Regeneration and Wound RepairChinese PLA General HospitalBeijing 100853China

Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages,ultimately impairing its normal physiological *** evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration,promoting scarless repair by influencing the extracellular microenvironment and driving the phenotypic *** field of skin repair and skin appendage regeneration has witnessed remarkable advancements in the utilization of biomaterials with distinct physical ***,a comprehensive understanding of the underlying mechanisms remains somewhat elusive,limiting the broader application of these *** this review,we present two promising biomaterial-based mechanical approaches aimed at bolstering the regenerative capacity of compromised *** first approach involves leveraging biomaterials with specific biophysical properties to create an optimal scarless environment that supports cellular activities essential for *** second approach centers on harnessing mechanical forces exerted by biomaterials to enhance cellular plasticity,facilitating efficient cellular reprogramming and,consequently,promoting the regeneration of skin *** summary,the manipulation of mechanical cues using biomaterial-based strategies holds significant promise as a supplementary approach for achieving scarless wound healing,coupled with the restoration of multiple skin appendage functions.

关键词： Scarless Wound healing Biomaterials Mechanical cues Skin appendages

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Tandem asymmetric dearomatized functionalization reaction of phenols with Evans-ynamides enabled by divergent electrophiles

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Science China Chemistry 2025年第2期68卷 649-660页

作者： Ying-Qi Zhang Gan-Lu Qian Yun Liu Jia-Hui Li Xin Hong Zhou Xu Bo Zhou Long-Wu Ye State key Laboratory of Physical Chemistry of Solid Surfaces Key Laboratory of Chemical Biology of Fujian Provinceand College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Center of Chemistry for Frontier Technologies Department of ChemistryState Key Laboratory of Clean Energy UtilizationZhejiang UniversityHangzhou 310027China Jiangsu key Laboratory of New Drug research and clinical Pharmacy School of PharmacyXuzhou Medical UniversityXuzhou 221004China State key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China State key Laboratory of Organometallic Chemistry Chinese Academy of SciencesShanghai 200032China

Herein,we disclose a highly regio-/chemoselective tandem asymmetric dearomatized halofunctionalization reaction of phenoltethered ynamides with diverse electrophilic halogenation sources in a catalyst-free manner for the practical and rapid assembly of a series of halogenated spirocyclic ***,the related dearomatized selenation and protonation are also achieved,affording the corresponding selenated and protonated spirocycles in high ***,the enantioselectivities of these products can be perfectly induced by Evans auxiliaries(99%ees).Significantly,this protocol not only represents the first tandem asymmetric halofunctionalization reaction of phenol derivatives,but also constitutes the first asymmetric halogenation/selenation of *** calculations indicate a remote induction model of Evans chiral auxiliary-attached keteniminium.

关键词： alkynes cyclization dearomatization Evans chiral auxiliary spirocycles

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 144-154页

作者： Nan Chen Jie Zhang Lin Wang Qian Yang Ai-Wen Wu key Laboratory of Carcinogenesis and Translational research(Ministry of Education/Beijing) Gastrointestinal CenterUnit IIIPeking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND Stoma creation is a common procedure in colorectal cancer surgery,however,stoma-related complications remain a significant *** To investigate the incidence,types,and risk factors of stoma-related complications in colorectal cancer patients who underwent stoma *** Patients with stoma was prospectively recorded in the established stoma *** was collected from this stoma management system from November 2021 through May *** rates of stoma-related complications were assessed,and potential risk factors were analyzed using univariate and multivariate logistic regression *** A total of 734 patients were included in the *** results showed that 12.3%of patients experienced stoma-related complications,with mucocutaneous separation,edema,and skin excoriation being the most common *** majority(90%)of complications were classified as grade 2 according to the Clavien-Dindo *** factors,such as blood loss volume greater than 500 mL and open surgery,were significantly associated with stoma ***,stoma features like location,shape,color,height,and edema were important factors in the association with *** mass index over 30 kg/m²was also found to be a significant risk *** These findings highlight the need for a holistic approach to preventing and managing stoma complications,considering both patient-related and surgical factors.

关键词： Stoma Complication Colorectal Registry Prospective

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Advances in basic and translational research into nasopharyngeal carcinoma

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Oncology and Translational Medicine 2025年第1期11卷 10-16页

作者： Zhe Li Yupei Chen Jun Ma Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina

According to the International Cancer research Institute of the World Health Organization data,nasopharyngeal carcinoma(NPC)remains a significant health concern,particularly in regions such as Southeast Asia and southern ***,substantial progress has been made in the field of basic and translational research on NPC,enhancing our understanding of the molecular mechanisms underlying the disease and paving the way for precise therapeutic *** review summarizes the advances in NPC research,focusing on key areas that include radiotherapy and chemotherapy resistance and tumor metastasis,microenvironment,metabolism,microbiome,and ***,future research directions in NPC are discussed to provide valuable insights to advance the field further.

关键词： Nasopharyngeal carcinoma Treatment resistance Tumor biomarkers Tumor microenvironment

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Screening optimal target populations with symptomatic bradyarrhythmia for pharmacotherapy:a discriminant analysis pilot study

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Journal of Traditional Chinese Medicine 2025年第1期45卷 160-166页

作者： ZHANG Wantong YI Danhui LU Fang YANG Qiaoning SHI Shuai LI Qiuyan WENG Weiliang WANG Xujie ZHU Baochen Institute of clinical pharmacology Xiyuan HospitalChina Academy of Chinese Medical Sciences NMPA key Laboratory for clinical research and Evaluation of Traditional Chinese Medicine National clinical research Center for Chinese Medicine Cardiology Xiyuan HospitalChina Academy of Chinese Medical Sciences School of Statistics Renmin University of China Department of General Medicine Guanganmen HospitalChina Academy of Chinese Medical Sciences Department of Pharmacy Dongzhimen HospitalBeijing University of Chinese Medicine

OBJECTIVE: To screen the target population with symptomatic bradyarrhythmia for pharmacotherapy. METHODS: This study use database from clinical trial that use Yuanjiang decoction(元姜方), a traditional Chinese medicinal prescription. Eligible participants were recruited and treated with Yuanjiang decoction(composed of 6 Chinese herbal medicines), 200 m L twice daily. Cross-contingency analysis, logistic regression analysis, interaction analysis, discriminant analysis and 10-fold cross validation methods were used to establish discriminant model. RESULTS: This study concluded that the clinical treatment of bradyarrhythmia has a clear effect. Low minimum heart rate, high maximum heart rate are risk factors that affect the efficacy. Patients with only one comorbid disease did not significantly affect the efficacy, but patient with two or more diseases of coronary heart disease, hypertension, paroxysmal atrial fibrillation, premature ventricular contraction and premature atrial contraction at the same time did not have a good effect. Using the discriminant analysis method to establish a efficacy prediction model, y = 0.07X1 + 0.16X2-0.65X3-1.12X4-0.71X5-0.75X6-0.91X7(X1 = 24 h mean heart rate, X2 = minimum heart rate, X3 = coronary heart disease, X4 = paroxysmal atrial fibrillation, X5 = premature ventricular contraction, X6= sinus block, X7 = atrioventricular block). CONCLUSION: Our model based on the clinical features of patients with bradyarrhythmia. Should be useful aid for predicting pharmacotherapy response and could screen the optimal pharmacotherapy target.

关键词： bradycardia discriminant analysis drug therapy health services needs and demand medicine, Chinese traditional

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Integrating machine learning and human use experience to identify personalized pharmacotherapy in Traditional Chinese Medicine:a case study on resistant hypertension

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Journal of Traditional Chinese Medicine 2025年第1期45卷 192-200页

作者： CHE Qianzi LIU Dasheng XIANG Xinghua TIAN Yaxin XIE Feibiao XU Wenyuan LIU Jian WANG Xuejie WANG Liying BAI Weiguo HAN Xuejie YANG Wei Department of Medical Statistics Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences Department of Science and Education Medical Statistics Teaching and Research OfficeInstitute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences Computer Department Xiyuan Hospital of the China Academy of Chinese Medical Sciences Traditional Chinese Medicine Standards research Center Medical Statistics Teaching and Research OfficeInstitute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences

OBJECTIVE: To enhance the understanding of identifying personalized pharmacotherapy options in Traditional Chinese Medicine(TCM), and further support the registration of new TCM drugs. METHODS: Generalized Boosted Models and XGBoost were employed to construct a classification model to identify the bad prognosis factors in resistant hypertension(RH) patients. Furthermore, we used association analysis to explore the rules of "symptomsyndrome" and "symptom-herb" for the major influencing factors, in order to summarize prescription pattern and applicable patients of TCM. RESULTS: Patients with major adverse cardiac events mostly have complex symptoms of phlegm, stasis, deficiency and fire intermingled with each other, and finally summarized the human experience of using Chinese herbal medicine to precisely intervene in some symptoms of RH patients on the basis of conventional Western medical treatment. CONCLUSIONS: Machine learning algorithms can make full use of human use experience and evidence to save clinical trial resources and accelerate the development of TCM varieties.

关键词： human clinical experience machine learning new drugs registration personalized pharmacotherapy

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