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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)key laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina guangdong Provincial Center for Quality control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3273-3286页

作者： Shiming Li Jianfeng Li Guoliang Chen Tao Lin Penghui Zhang Kuileung Tong Ningning Chen Shaoyu Liu Shenzhen key laboratory of Bone Tissue Repair and Translational Research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu key laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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Distributed event triggering control for six-rotor UAV systems with asymmetric time-varying output constraints

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Science China(Information Sciences) 2021年第7期64卷 193-208页

作者： Liang CAO Hongru REN Wei MENG Hongyi LI Renquan LU guangdong province key laboratory of Intelligent Decision and Cooperative control Guangdong University of Technology

Inspired by the practical operability and safety of unmanned aerial vehicles(UAVs) in confined areas, this paper investigates adaptive trajectory tracking control problems in multiple six-rotor UAV systems with asymmetric time-varying output constraints and input saturation. Under model and disturbance uncertainties, six-rotor UAV systems are modeled as two non-strict-feedback systems, including attitude(inner-loop) and position(outer-loop) regulation systems. For the inner-loop design, the neural-based distributed adaptive attitude consensus control protocol is employed to realize the leader-follower *** first-order sliding mode differentiators and an auxiliary dynamic system are introduced to address the "explosion of complexity" and saturation nonlinearity issues, respectively. Then, an event-triggered condition is predefined to alleviate the communication loads and reduce the number of messages to be transmitted from the controller to actuator. In addition, a class of asymmetric time-varying barrier Lyapunov functions are constructed for preventing the violation of time-varying output constraints. Accordingly, the proposed double-loop control strategies guarantee that all signals of UAV systems are semi-globally and uniformly bounded. Simulation results demonstrate that the proposed control method is effective.

关键词： adaptive neural control asymmetric time-varying output constraints event triggering mechanism input saturation six-rotor UAV systems

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Accelerated Evolution of H7N9 Subtype Influenza Virus under Vaccination Pressure

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Virologica Sinica 2021年第5期36卷 1124-1132页

作者： Yifan Wu Jingkai Hu Xuanjiang Jin Xiao Li Jinfeng Wang Mengmeng Zhang Jianglin Chen Shumin Xie Wenbao Qi Ming Liao Weixin Jia National Avian Influenza Para-Reference laboratory(Guangzhou) College of Veterinary MedicineSouth China Agricultural UniversityGuangzhou 510642China key laboratory of zoonosis Key Laboratory of Animal Vaccine DevelopmentMinistry of Agriculture and Rural AffairsGuangzhou 510642China guangdong laboratory for Lingnan Modern Agriculture Guangzhou 510642China National and Regional Joint Engineering laboratory for Medicament of zoonosis prevention and control Guangzhou 510642China key laboratory of Zoonoses prevention and control of guangdong province Guangzhou 510642China

No avian H7 N9 outbreaks have occurred since the introduction of H7 N9 inactivated vaccine in the fall of ***,H7 N9 is still prevalent in *** surveil the prevalence,genetic characteristics,and antigenic changes of H7 N9,over7000 oropharyngeal and cloaca swab specimens were collected from live poultry markets and farms in 15 provinces of China from 2017 to 2019.A total of 85 influenza virus subtype H7 N9 strains were isolated and 20 representative strains were selected for genetic analysis and antigenicity *** indicated the decreased prevalence of low-pathogenic H7 N9 strains while highly-pathogenic H7 N9 strains became dominated since the introduction of *** analysis showed that strains from 2019 formed an independent small branch and were genetically distant to strains isolated in 2013–*** of key amino acid sites showed that the virus strains may adapt to the host environment evolutionally through *** analysis predicted additional potential glycosylation sites for HA and NA genes in the 2019 *** analysis of HA gene in strains isolated from 2018 to 2019 showed that there were an increased nucleotide substitution rate and an increased mutation rate in the first and second nucleotides of coding codons within the open reading *** hemagglutination inhibition(HI)assay showed that H7-Re1 and H7-Re2 exhibited a lower HI titer for isolates from 2019,while H7-Re3 and r LN79 showed a high HI *** protective effect of the vaccine decreased after15 months of ***,under vaccination pressure,the evolution of influenza virus subtype H7 N9 has accelerated.

关键词： H7N9 Genetic evolution Epidemiological investigation Hemagglutination inhibition assay Vaccination pressure

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Machine learning driven rational design of dual atom catalysts on graphene for carbon dioxide electroreduction

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Nano Research 2025年第1期18卷 186-194页

作者： Dongxu Jiao Xinyi Li Mingzi Sun Lin Liu Jinchang Fan Jingxiang Zhao Bolong Huang Xiaoqiang Cui State key laboratory of Automotive Simulation and control School of Materials Science and Engineeringand Key Laboratory of Automobile Materials of MOEJilin UniversityChangchun 130012China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina College of Chemistry and Chemical Engineering and Key Laboratory of Photonic and Electronic Bandgap MaterialsMinistry of EducationHarbin Normal UniversityHarbin 150025China

The development of high-performance atomiccatalysts for the carbon dioxide reduction reaction(CO_(2)RR)is atime-consuming process due to the complexity of the reactionmechanism and the uncertainty of the active ***,wehave proposed combining density functional theory(DFT)andmachine learning(ML)to investigate the potential of topologicalgraphene-based dual-atom catalysts(DACs)as CO_(2)*** analyzing the ML results,we identify thenumber of d-orbital electrons in the active site as a key factorinfluencing the CO_(2)RR catalytic ***,wepropose a simple descriptor to measure the CO_(2)RR activity ofthese *** findings provide plausible explanations for thesynergistic interactions between bimetallic atoms in CO_(2)RR andallow us to screen the homogeneous Ni-Ni pair as the mostpromising dual-atom *** work offers a fast MLapproach based on limited DFT calculations to predict the mostelectroactive and stable DACs on carbon support for CO_(2)RR,facilitating rapid screening of high-performance dual-atomcatalysts.

关键词： CO_(2)reaction reduction dual-atom catalysts density functional theory machine learning

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The Associated Factors of SARS-CoV-2 Reinfection by Omicron Variant—guangdong province,China,December 2022 to January 2023

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China CDC weekly 2023年第18期5卷 391-396页

作者： Chunsheng Cai Yihong Li Ting Hu Rongwei Liang Kaibin Wang Congrui Guo Yan Li Meng Zhang Min Kang guangdong Field Epidemiology Training Program Guangzhou CityGuangdong ProvinceChina Zhongshan Center for Disease control and prevention Zhongshan CityGuangdong ProvinceChina guangdong Provincial Center for Disease control and prevention Guangzhou CityGuangdong ProvinceChina Huaiji County Center for Disease control and prevention Zhaoqing CityGuangdong ProvinceChina Tianhe District Center for Disease control and prevention Guangzhou CityGuangdong ProvinceChina Futian District Center for Disease control and prevention Shenzhen CityGuangdong ProvinceChina

Summary What is already known about this topic?Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)reinfection by variants is being reported commonly and has caused waves of epidemic in many *** of dynamic zero policy,the SARSCoV-2 reinfection was less reported in *** is added by this report?SARS-CoV-2 reinfections were observed in guangdong province between December 2022 and January *** study estimated that the reinfection incidence was 50.0%for the original strain primary infections,35.2%for the Alpha or Delta variants,and 18.4%for the Omicron variant;The reinfection incidence within 3-6 months after primary infection by Omicron variant was 4.0%.Besides,96.2%reinfection cases were symptomatic while only 7.7%sought medical *** are the implications for public health practice?These findings suggest a reduced likelihood of an Omicron-driven epidemic resurgence in the short term but emphasize the importance of maintaining vigilant surveillance of emerging SARS-CoV-2 variants and conducting population-based antibody level surveys to inform response preparedness.

关键词： policy guangdong conducting

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Observer-based adaptive consensus control for nonlinear multi-agent systems with time-delay

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Science China(Information Sciences) 2020年第3期63卷 195-211页

作者： Wenbin XIAO Liang CAO Hongyi LI Renquan LU School of Automation and guangdong province key laboratory of Intelligent Decision and Cooperative control Guangdong University of Technology

In this paper, we consider the observer-based adaptive consensus tracking problem for a class of nonlinear time-delay multi-agent systems in the presence of input saturation. Under the assumption that the communication topology is directed and connected, a distributed adaptive consensus controller is developed based on the dynamic surface control technique. By constructing the nonlinear observer, the unmeasurable agents dynamics can be estimated. Input saturation problem is solved by a smooth function combined with an auxiliary variable. With the help of prescribed performance functions, the synchronization errors converge to the prescribed sets, which are characterized as a neighborhood of zero. According to Lyapunov stability theory, it is shown that with the proposed distributed consensus tracking approach, the consensus errors are cooperatively semi-globally uniformly ultimately bounded. Finally, a simulation example is provided to show the effectiveness of the proposed algorithm.

关键词： adaptive consensus control multi-agent systems prescribed performance time-delay unmeasurable states

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Near-perfect replication on amorphous alloys through active force modulation based on machine learning/neural network parameter prediction

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 181-191页

作者： Senkuan Meng Zheng Wang Ruisong Zhu Ruijie Liu Jiang Ma Lina Hu Weihua Wang key laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and Engineering Shandong University College of Mechatronics and control Engineering Shenzhen University Songshan Lake Materials laboratory Institute of Physics Chinese Academy of Sciences

As a microforming technique, micro/nano-structural replication possesses advantages of high precision and efficiency. With the remarkable superplasticity in the supercooled liquid region, amorphous alloys or metallic glasses(MGs) are regarded as ideal materials for miniature fabrication. However, due to the intrinsic metastable nature of supercooled liquids, the design of imprinting processes for MGs poses a challenge. In the past, process parameters have largely relied on trial-and-error *** this work, a low-frequency active force modulation system is employed to apply a stable, precise, and real-time feedback stress field for imprinting of MG samples. Low-frequency vibrations can facilitate the filling of microstructures on the template surface by reducing the effective viscosity of the supercooled liquid. With the dataset composed of orthogonal experiments, a machine learning strategy based on back-propagation(BP) neural networks was utilized to construct a 3D parameter space for temperature, stress, and time, and to predict the corresponding filling ratio. Furthermore, the optimal combination of imprinting process parameters was identified, and its filling ratio was experimentally validated to reach as high as 0.94. The near-perfect replication of microstructures confirms the superiority of the active force modulation system and the data-driven strategy of machine learning-assisted parameter design. At the same time, this one-step microforming process provides a new approach to addressing the accuracy-cost trade-off dilemma in precision manufacturing.

关键词： metallic glass amorphous alloy microforming imprinting machine learning

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Effectiveness of COVID-19 Vaccination Against SARS-CoV-2 Omicron Variant Infection and Symptoms—China,December 2022–February 2023

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China CDC weekly 2023年第17期5卷 369-373,I0001-I0005页

作者： Di Fu Guanhao He Huanlong Li Haomin Tan Xiaohui Ji Ziqiang Lin Jianxiong Hu Tao Liu Jianpeng Xiao Xiaofeng Liang Wenjun Ma Department of Public Health and Preventive Medicine School of MedicineJinan UniversityGuangzhou CityGuangdong ProvinceChina Disease control and prevention Institute Jinan UniversityGuangzhou CityGuangdong ProvinceChina key laboratory of Ministry of Education for Viral Pathogenesis&Infection prevention and control Jinan UniversityGuangzhou CityGuangdong ProvinceChina Fuyang District Center for Disease control and prevention Hangzhou CityZhejiang Province guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina

Summary What is already known about this topic?A considerable percentage of the population has received both primary and booster vaccinations,which could potentially provide protection against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron infections and related *** is added by this report?The self-reported infection rate,as determined from an online survey,reached its peak(15.5%)between December 19 and 21,2022,with an estimated 82.4%of individuals in China being infected as of February 7,*** the epidemic,the effectiveness of booster vaccinations against SARS-CoV-2 Omicron infection was found to be 49.0%within three months of vaccination and 37.9%between 3 and 6 months following ***,the vaccine effectiveness of the booster vaccination in relation to symptom prevention varied from 48.7%to 83.2%within three months and from 25.9%to 69.0%between 3 and 6 months post-booster vaccination.

关键词： vaccination prevention acute

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