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EZH2-dependent myelination following sciatic nerve injury

Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li Mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang laboratory(Zhejiang laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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Electrodeposition of aluminum and aluminum-magnesium alloys at room temperature

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Journal of Central South University 2015年第10期22卷 3689-3697页

作者：阚洪敏祝跚珊张宁王晓阳 key laboratory of Advanced Materials Technology of liaoning province Shenyang University

Electrodeposition of aluminum from benzene-tetrahydrofuran-Al Cl3-Li Al H4 was studied at room temperature. Galvanostatic electrolysis was used to investigate the effect of various parameters on deposit morphology and crystal size, including current density, temperature, molar ratio of benzene/tetrahydrofuran and stirring speed. The deposit microstructure was adjusted by changing the parameters, and the optimum operating conditions were determined. Dense, bright and adherent aluminum coatings were obtained over a wide range of current densities(10-25 m A/cm2), molar ratio of benzene and tetrahydrofuran(4:1 to 7:8) and stirring speeds(200-500 r/min). Smaller grain sizes and well-adhered deposits were obtained at lower temperatures. Aluminum-magnesium alloys could potentially be used as hydrogen storage materials. A novel method for Al-Mg deposition was proposed by using pure Mg anodes in the organic solvents system benzene-tetrahydrofuran-Al Cl3-Li Al H4. XRD shows that the aluminum-magnesium alloys are mainly Al3Mg2 and Al12Mg17.

关键词： electrodeposition aluminum coating aluminum-magnesium(Al-Mg) coating organic solvent system

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Optimization of flow uniformity control device for six-stream continuous casting tundish

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Journal of Iron and Steel Research International 2020年第9期27卷 1035-1044页

作者： Xin-gang Ai Dong Han Sheng-li Li Hong-bo Zeng Hui-ya Li key laboratory of Chemical Metallurgy Engineering liaoning province University of Science and Technology LiaoningAnshan 114051LiaoningChina

For a multistream tundish,the uniformity among the streams plays a significant role in the quality of molten *** to analyze the uniformity quantitatively and optimize structures of a multistream tundish is an important research content for a multistream tundish.A new approach was proposed to quantify the uniformity among the *** a physical study and a numerical study were carried out to optimize the structure of the diversion hole based on the prototype of a six-stream tundish in a steel *** the basis of average residence time,the uniformity of each flow was considered fully and then the optimal structure of the diversion hole was obtained by means of the comprehensive analysis of temperature field and velocity *** results show that the optimum structural parameters adopted for diversion holes are height of 20 mm,angle of 15°and diameter of 80 mm.

关键词： Multistream tundish Uniformity Diversion hole Physical simulation Numerical simulation

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Food web structure and trophic levels in polyculture ricecrab fields

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Chinese Journal of Oceanology and Limnology 2015年第3期33卷 735-740页

作者：郭凯赵文李文宽赵苑淞张鹏张晨 key laboratory of Hydrobiology in liaoning province Dalian Ocean University Freshwater Fisheries Science Institute of liaoning province

Stable carbon and nitrogen isotopes were used to investigate nutrient pathways and trophic relationships from the rice-crab system in Panjin, liaoning province, China. Values of 313C ranged from -27.38%±0.44%o to -18.34%±0.26%o and δ^15N ranged from 1.10%o4-0.88%o to 9.33%±0.57%. Pseudorasbora parva （Stone moroko） had the highest δ^13C and 8tSN values. The lowest δ^13C values were obtained for the macrophytes and the lowest δ^15N value was found in sediments. Stable carbon and nitrogen isotopes were used to determine the contribution of different food items to the diets of crabs. The δ^13C results indicated that the Pseudorasbora parva made the greatest contribution to the diet of Eriocheir sinensis （Chinese mitten crab）, while the δ^15N results indicated that most food items contributed more than 10% to the diet of the crab. There were three trophic levels identified in the system （Levels 0-2）. The crab Eriocheir sinensis, fish Pseudorasbora parva and Misgurnus anguillicaudatus （Oriental weatherfish）, and the oligochaete Limnodrilus hoffmeisteri （Limnodrilus worm）, were at the second level, zooplankton were at the first level and suspended particulate matter and macrophytes were at trophic position 0.

关键词： rice-crab culture Eriocheir sinens stable carbon isotope stable nitrogen isotope trophic level

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Design and simulation of blue/violet sensitive photodetectors in silicon-on-insulator

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Journal of Semiconductors 2009年第10期30卷 59-62页

作者：韩志涛褚金奎孟凡涛金仁成 key laboratory for Micro/Nano Technology and System of liaoning province Dalian University of Technology key laboratory for Microsystem and Microfabrication of the Education Department of liaoning province Dalian University of Technology

According to Lambert’s law,a novel structure of photodetectors,namely photodetectors in siliconon-insulator,is *** choosing a certain thickness value for the SOI layer,the photodetector can absorb blue/violet light effectively and affect the responsivity of the long wavelength in the visible and near-infrared region,making a blue/violet filter *** material of the SOI layer is high-resistivity floating-zone silicon which can cause the neutral N type SOI layer to become fully depleted after doping with a P type *** can improve the collection efficiency of short-wavelength photogenerated *** device structure was optimized through numerical simulation,and the results show that the photodiode is a kind of high performance photodetector in the blue/violet region.

关键词： photodetectors silicon-on-insulator quantum efficiency resonant cavity enhancement

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Synthesis, Structure and Biological Activity of 2-[2-(4-Fluorobenzylidene)hydrazinyl]-4-(1-methyl-1H-indol-3-yl)thieno[3,2-d]pyrimidine

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Chinese Journal of Structural Chemistry 2019年第9期38卷 1530-1536页

作者： SHI Jian-Tao GONG Yi-Lin LI Jun WANG Yang CHEN Ye DING Shi LIU Ju College of Pharmacy of liaoning University Key Laboratory of New Drug Research and Development of Liaoning Province

The title compound 2-[2-(4-fluorobenzylidene)hydrazinyl]-4-(1-methyl-1 H-indol-3-yl)thieno[3,2-d] pyrimidine(8) was synthesized by the condensation of 4-fluorobenzaldehyde(7) with 2-hydrazinyl-4-(1-methyl-1 H-indol-3-yl)thieno[3,2-d]pyrimidine(6). This intermediate was prepared from methyl 3-aminothiophene-2-carboxylate(1) by the condensation with urea, chlorination with phosphorus oxychloride and then condensation with hydrazine hydrate. The crystal of 8 belongs to monoclinic system, space group P21/c with a = 14.0453(18), b = 17.436(2), c = 18.0982(17) ? and β = 122.969(7)°. In addition, 8 possesses marked inhibition against the proliferation of human colon cancer cell line HT-29(IC50 = 6.09 μM) and human gastric cancer cell line MKN45(IC50 = 3.04 μM), displaying promising anticancer activity.

关键词： thieno[3,2-d] pyrimidine synthesis X-ray diffraction antitumor activity

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Dissolution rate determination of alumina in molten cryolite-based aluminum electrolyte

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Journal of Central South University 2012年第4期19卷 897-902页

作者：阚洪敏张宁王晓阳 key laboratory of Advanced Materials Technology of liaoning province Shenyang University

Determination of dissolution rate of alumina is one of the classical problems in aluminum electrolysis. A novel method which can measure the dissolution rate of alumina was presented. Effect of factors on dissolution rate of alumina was studied intuitively and roundly using transparent quartz electrobath and image analysis techniques. Images about dissolution process of alumina were taken at an interval of fixed time from transparent quartz electrobath of double rooms. Gabor wavelet transforms were used for extracting and describing the texture features of each image. After subsampling several times, the dissolution rate of alumina was computed using these texture features in local neighborhood of samples. Regression equation of the dissolution rate of alumina was obtained using these dissolution rates. Experiments show that the regression equation of the dissolution rate of alumina is y=-0.000 5x^3＋0.024 0x^2-0.287 3x＋ 1.276 7 for Na3AIF6-AIF3-Al2O3-CaF2-LiF- MgF2 system at 920 ℃.

关键词： aluminum electrolyte dissolution rate image analysis alumina Gabor wavelet transform

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Compound heterozygous mutation of MUSK causing fetal akinesia deformation sequence syndrome: A case report

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World Journal of Clinical Cases 2019年第21期7卷 3655-3661页

作者： Na Li Chong Qiao Yuan Lv Tian Yang Hao Liu Wen-Qian Yu Cai-Xia Liu Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina key laboratory of Maternal-Fetal Medicine of liaoning province Key Laboratory of Obstetrics and Gynecology of Higher Education of Liaoning ProvinceShenyang 110004Liaoning ProvinceChina

BACKGROUND Fetal akinesia deformation sequence(FADS)is a broad spectrum disorder with absent fetal movements as the unifying *** etiology of FADS is heterogeneous and mostly still unknown.A prenatal diagnosis of FADS relies on clinical features obtained by ultrasound and fetal muscle ***,the recent advances of next-generation sequencing(NGS)can effectively provide a definitive molecular *** SUMMARY A fetus presented after 24 wk and 6 d of gestation with absent fetal movements and multiple abnormal ultrasonographic *** mother had had a previous abortion due to a similarly affected fetus a year before.A clinical diagnosis of FADS was *** parents refused cord blood examination and chose abortion.A molecular diagnosis of fetal muscle using NGS of genes found a compound heterozygous mutation in the MUSK gene:c.220C>T(chr9:113449410 p.R74W)and c.421delC(chr9:113457745 p.P141fs).CONCLUSION To our knowledge,this is the first report in China showing that a mutation in MUSK is associated with *** supports previous finding that a lethal mutation of MUSK will cause FADS.A precise molecular diagnosis for genetic counseling and options for a prenatal diagnosis of FADS are very important,especially for recurrent FADS;this may also provide evidence for both prenatal and preimplantation genetic diagnoses.

关键词： MUSK gene Fetal akinesia deformation sequence Joint contractures Casereport

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A size-dependent composite laminated skew plate model based on a new modified couple stress theory

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Acta Mechanica Solida Sinica 2017年第1期30卷 75-86页

作者： Dan He Wanli Yang Wanji Chen key laboratory of liaoning province for Composite Structural Analysis of Aerocraft and Simulation Shenyang Aerospace University

In this study, a size-dependent composite laminated skew Mindlin plate model is proposed based on a new modified couple stress theory. This plate model can be viewed as a simplified couple stress theory in engineering mechanics. Governing equations and related boundary conditions are derived based on the principle of minimum potential energy. The Rayleigh–Ritz method is employed to obtain the numerical solutions of the center deflections of simply supported plates with different ply orientations. Numerical results show that the normalized center deflections obtained by the proposed model are always smaller than those obtained by the classical one, i.e. the present model can capture the scale effects of microstructures. Moreover, a phenomenon reveals that the ply orientation would make a significant influence on the magnitude of scale effects of composite laminated plates at micro scale. Additionally, the present model of thick skew plate can be degenerated to the model of Kirchhoff plate based on the modified couple stress theory by adopting the assumptions in Bernoulli–Euler beam and material isotropy.

关键词： Modified couple stress theory Composite laminated plates Scale effects Ply orientation Rayleigh-Ritz method

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