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nuclear Science and Techniques 2019年第3期30卷 9-14页

作者： Bao-Lu Yang Qiang Zhou Jing Zhang Shuai-Mo Yao Ze-Shu Li Wen-Hong Li Fei Tuo key laboratory of radiological protection and nuclear emergency National Institute for Radiological ProtectionChinese Center for Disease Control and Prevention

This study reports the performances of efficiency calibrations for high-purity-germanium gamma-ray spectrometry using the source-, laboratory Sourceless Object Calibration Software(LabSOCS)-and ANGLE-based methods in an inter-comparison exercise. Although the results of LabSOCS and ANGLE for ^(241)Am emitting lowenergy gamma rays were not very satisfactory, all of the three efficiency calibration methods passed acceptance criteria. The results confirmed the reliability of the calculation codes ANGLE and LabSOCS as alternative efficiency calibration methods in high-purity-germanium gamma spectrometry. This study is likely to promote the further application of the ANGLE and LabSOCS calculation codes in radioactivity measurements.

关键词： Efficiency calibration ANGLE laboratory Sourceless Object Calibration Software (LabSOCS) Gamma-ray spectrometry

Facile Synthesis of the Magnetic Metal Organic Framework Fe_3O_4@UiO-66-NH_2 for Separation of Strontium

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Biomedical and Environmental Sciences 2018年第6期31卷 483-488页

作者： YIN Liang Liang KONG Xiang Yin ZHANG Yao JI Yan Qin key laboratory of radiological protection and nuclear emergency National Institute for Radiological ProtectionChinese Center for Disease Control and Prevention

A magnetic metal organic framework（MMOF） was synthesized and used to separate Sr^2＋ in aqueous solution. The shape and structure of prepared Fe3O4@UiO-66-NH2 were characterized, and the absorbed concentration of strontium was determined through inductively coupled plasma mass spectrometry. The results indicated that Fe3O4 and UiO-66-NH2 combined through chemical bonding. The experimental adsorption results for separation of Sr^2＋ in aqueous solution indicated that the adsorption of Sr^2＋ to Fe3O4@UiO-66-NH2 increased drastically from pH 11 to pH 13. The adsorption isotherm model indicated that the adsorption of Sr^2＋ conformed to the Freundlich isotherm model（R2 = 0.9919）. The MMOF thus inherited the superior qualities of magnetic composites and metal organic frameworks, and can easily be separated under an external magnetic field. This MMOF thus has potential applications as a magnetic adsorbent for low level radionuclide （90）Sr.

关键词： Magnetic metal organic framework(MMOF) Fe3O4@UiO-66-NH2 Radioactivity Strontium Adsorbents

Synthesis of TBP-coated magnetic Pst-DVB particles for uranium separation

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nuclear Science and Techniques 2014年第3期25卷 22-26页

作者：王欢邵宪章田青吉艳琴 China CDC key laboratory of radiological protection and nuclear emergency National Institute for Radiological ProtectionChinese Center for Disease Control and Prevention

Magnetically assisted chemical separation process is an efficient method used widely in separating radionuclides and heavy metals in environmental samples. It is simple, compact and cost-effective, with less secondary waste streams. Tributyl phosphate(TBP)-coated magnetic poly(styrene-divinylbenzene)(Pst-DVB)nano-particles were synthesized and characterized by transmission electron microscopy, scanning electron microscopy, vibrating sample magnetometer, thermogravimetry and Fourier transform infrared spectrometry. The application of TBP-coated magnetic Pst-DVB particles in separating low concentration of uranium from aqueous media was evaluated, and the equilibrium adsorption isotherm was investigated. Our results indicate that the TBP-coated magnetic Pst-DVB particles may be of potential application for uranium separation.

关键词：分离方法 B粒子合成傅里叶变换红外光谱法透射电子显微镜振动样品磁强计铀纳米颗粒

Monte Carlo simulation of indoor external exposure due to gamma-emitting radionuclides in building materials

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Chinese Physics C 2014年第10期38卷 126-130页

作者：邓君曹磊苏旭 key laboratory of radiological protection and nuclear emergency Chinese Center for Disease Control and PreventionNational Institute for Radiological ProtectionChinese Center for Disease Control and Prevention

The use of building materials containing naturally occurring radionuclides such as^40K,^238U,^232Th and their progeny, could lead to external exposures to the residents of such buildings. In this paper, a set of models are constructed to calculate the specific effective dose rates（the effective dose rate per Bq/kg of ^40K, the ^238U series,and the ^232Th series） imposed on residents by building materials with the MCNPX code. The effect of chemical composition, position concerned in the room and thickness as well as density of material is analyzed. In order to facilitate more precise assessment of indoor external dose due to gamma-emitting radionuclides in building materials,three regressive expressions are proposed and validated by measured data to calculate specific effective rates for40 K,the238U series and the232 Th series, respectively.

关键词： Monte Carlo specific effective dose rate building materials

Connexin43 Modulates X-Ray-Induced Pyroptosis in Human Umbilical Vein Endothelial Cells

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Biomedical and Environmental Sciences 2019年第3期32卷 177-188页

作者： LI Chen TIAN Mei GOU Qiao JIA Yong Rui SU Xu China CDC key laboratory of radiological protection and nuclear emergency National Institute for Radiological Protection Chinese Center for Disease Control and Prevention Medical and Health Analysis Center Peking University

Objective Pyroptosis is an inflammatory form of programmed cell death. This phenomenon has been recently reported to play an important role in radiation-induced normal tissue injury. Connexin43(Cx43) is a gap junction protein that regulates cell growth and apoptosis. In this study, we investigated the effect of Cx43 on X-ray-induced pyroptosis in the human umbilical vein endothelial cells(HUVECs). Methods HUVECs, Cx43 overexpression, and Cx43 knockdown strains were irradiated with 10 Gy. Proteins were detected using western blot analysis. Cell pyroptosis was evaluated using the fluorescence-labeled inhibitor of caspase assay(FLICA) and propidium iodide staining through flow cytometry and confocal microscopy. Cell morphology and cytotoxicity were detected by scanning electron microscopy and lactate dehydrogenase release assay, respectively. Results Irradiation with 10 Gy X-ray induced pyroptosis in the HUVECs and reduced Cx43 expression. The pyroptosis in the HUVECs was significantly attenuated by overexpression of Cx43 as it decreased the level of active caspase-1. However, interference of Cx43 expression with si RNA significantly promoted pyroptosis by increasing the active caspase-1 level. Pannexin1(Panx1), a gap junction protein regulates pyroptosis, and its cleaved form is used to evaluate channel opening and active state. The level of cleaved Panx1 in the HUVECs and Cx43 knockdown strains increased in the presence of X-ray, but decreased in the Cx43 overexpression strains. Furthermore, interference of Panx1 with si RNA alleviated the upregulation of pyroptosis caused by Cx43 knockdown. Conclusion Results suggest that single high-dose X-ray irradiation induces pyroptosis in the HUVECs. In addition, Cx43 regulates pyroptosis directly by activating caspase-1 or indirectly by cleaving Panx1.

关键词： X-ray Connexin43 HUVECs Pyroptosis

Identification and Validation of Candidate Radiation-responsive Genes for Human Biodosimetry

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Biomedical and Environmental Sciences 2017年第11期30卷 834-840页

作者： LI Shuang LU Xue FENG Jiang Bin TIAN Mei LIU Qing Jie China CDC key laboratory of radiological protection and nuclear emergency National Institute for Radiological ProtectionChinese Center for Disease Control and PreventionBeijing 200088China

The aim of the present study is to analyze the global research trend of radiation-responsive genes and identify the highly reproducible radiation-responsive genes. Bibliometric methods were applied to analyze the global research trend of radiation-responsive genes. We found 79 publications on radiation-responsive genes from 2000 to 2017. A total of 35 highly reproducible radiation-responsive genes were identified. Most genes are involved in response to DNA damage, cell proliferation, cell cycle regulation, and DNA *** p53 signal pathway was the top enriched pathway. The expression levels of 18 genes in human B lymphoblastoid cell line（AHH-1） cells were significantly up-regulated in a dose-dependent manner at 24 h after exposure to 0-5 Gy ^60 Coγ-ray irradiation. Our results indicate that developing a gene expression panel with the 35 high reproducibility radiation-responsive genes may be necessary for qualitative and quantitative assessment after exposure.

关键词： Identification Validation of Candidate Radiation-responsive Genes Human Biodosimetry

Tacrolimus may play a role in dermatitis and radiation-induced skin injury through cellular senescence

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Radiation Medicine and protection 2024年第3期5卷 161-164页

作者： Jie Chen Ling Gao China CDC key laboratory of radiological protection and nuclear emergency National Institute for Radiological ProtectionChinese Center for Disease Control and PreventionBeijing 100088China

Skin Exposure of skin to ionizing radiation can induce acute or chronic biological effects,resulting in radiation-induced skin injury(RSI).Premature cellular senescence,caused by oxidative stress and/or DNA damage from chemical or physical agents,leads to the decrease of cellular proliferation and physiological *** DNA damage and accumulation of senescent cells are associated with the progression of radiation-induced *** dermatitis and RSI have similar inflammatory *** treatment of tacrolimus(TAC)in atopic dermatitis may be associated with premature cellular *** can prevent the onset of cellular senes-cence by inactivating the p38 mitogen-activated protein kinase(p38 MAPK).The activation of p38 MAPK can induce the senescence-associated secretory phenotype(SASP)by enhancing the transcriptional activity of nuclear factor kappa-B(NF-κB),which ultimately leads to premature cellular ***506 binding protein 51(FKBP51)exhibits resistance to ionizing radiation,but the mechanism of TAC regulation of ionizing radiation-induced premature senescence still needs further *** review discusses the mechanism of cellular senes-cence in RSI and the role of TAC in both dermatitis and RSI.

关键词： Tacrolimus Premature cellular senescence Radiation-induced skin injury p38 MAPK NF-κB

Role of bioinformatics databases and tools in radiation biology

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Radiation Medicine and protection 2024年第3期5卷 165-169页

作者： Yizhe Gao Qingjie Liu China CDC key laboratory of radiological protection and nuclear emergency National Institute for Radiological ProtectionChinese Center for Disease Control and PreventionBeijing100088China

Bioinformatics has become increasingly integral to radiation biology,also known as radiobiology,providing substantial support through data storage,conversion,visualization,and *** review aims to deepen understanding of bioinformatics application in radiobiology by introducing key databases and analytical tools in radiobiology,including general bioinformatics databases,radiobiology-specific databases,data processing tools,and statistical analysis tools for differentially expressed genes(DEGs)and LC/MS *** review also discusses bioinformatics applications in radiobiological fields,such as radioresistance and immune cell *** these advances,challenges such as data interoperability *** and projects to address these issues,such as GeCo and GMQL,are also examined.

关键词： Radiobiology Bioinformatics Radioresistance Immune cell enrichment

Analysis and Monitoring of Indoor Radon Concentrations of 37 Kindergartens — Beijing Municipality, China, 2023

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China CDC weekly 2024年第13期6卷 272-276页

作者： Meinan Yao Kuke Ding Xiaozhe Tang Yunyun Wu Yanchao Song Shuyuan Liu Bin Bai Li Zhang Yongzhong Ma Institute for Radiation Hygiene protection Beijing Center for Disease Prevention and ControlBeijingChina Chinese Center for Disease Control and Prevention BeijingChina key laboratory of radiological protection and nuclear emergency&National Institute for radiological protection Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Radon(222Rn or 222radon)is a radioactive gas emitted from building materials,foundations,and *** are especially susceptible to radon exposure,underscoring the need to assess indoor radon levels in *** study monitored radon concentrations in 37 Beijing kindergartens from June to October ***:A random sample of 37 kindergartens was selected from 18 administrative districts in *** indoor radon concentration was measured using the solid track accumulation method,with radon detectors continuously monitored over a 3-month ***:The mean indoor radon level in 37 kindergartens,observed at 252 monitoring points,was 84.3 Bq/m^(3),with values varying from 12.9 to 263.5 Bq/m^(3).About 20.2%of points showed radon levels between 100.0 and 200.0 Bq/m^(3),while 2.4%exceeded 200.0 Bq/m^(3).Notably,radon levels were significantly elevated on the ground floor compared to the upper ***:Indoor radon levels in 37 kindergartens remained below the national standard limit of 300.0 Bq/m^(3) for buildings(GB/T 16146-2015).Nonetheless,18.9%of the kindergartens exceeded the 100.0 Bq/m^(3) limit set for new *** is advised to improve radon monitoring in kindergartens and consider developing a national standard for maximum permissible radon levels in such facilities.

关键词： Radon limit floor

Indoor Radon Survey in 31 Provincial Capital Cities and Estimation of Lung Cancer Risk in Urban Areas of China

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Biomedical and Environmental Sciences 2024年第11期37卷 1294-1302页

作者： Xiaoxiang Miao Yinping Su Changsong Hou Yanchao Song Bowei Ding Hongxing Cui Yunyun Wu Quanfu Sun key laboratory of radiological protection and nuclear emergency China CDCNational Institute for Radiological ProtectionChinese Center for Disease Control and PreventionBeijing 100088China

Objective We aimed to analyze the current indoor radon level and estimate the population risk of radon-induced lung cancer in urban areas of *** Using the passive monitoring method,a new survey on indoor radon concentrations was conducted in 2,875 dwellings across 31 provincial capital cities in Chinese mainland from 2018 to *** attributable risk of lung cancer induced by indoor radon exposure was estimated based on the risk assessment *** The arithmetic mean(AM)and geometric mean(GM)of indoor radon concentrations were 65 Bq/m^(3)and 55 Bq/m^(3),respectively,with 13.6%of measured dwellings exceeding 100 Bq/m^(3)and 0.6%exceeding 300 Bq/m^(3).The estimated number of lung cancer deaths induced by indoor radon exposure was 150,795,accounting for 20.30%(95%CI:20.21%-20.49%)of the lung cancer death *** This study provided the most recent data on national indoor radon levels in urban areas and the attributable risk of lung *** results served as an important foundation for further research on the disease burden of indoor radon exposure and radon mitigation efforts.

关键词： Indoor radon Urban Attributable risk Lung cancer