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A Macaca mulatta model of fulminant hepatic failure

World Journal of Gastroenterology 2012年第5期18卷 435-444页

作者： Ping Zhou Jie Xia Gang Guo Zi-Xing Huang Qiang Lu Li Li Hong-Xia Li Yu-Jun Shi Hong Bu Department of Pathology West ChinaHospital Sichuan University Chengdu 610041 Sichuan Prov-ince China key Labo-ratory of Transplant Engineering and Immunology Ministryof Health West China Hospital Sichuan University Chengdu610041 Sichuan Province China Department of Radiology West China HospitalSichuan University Chengdu 610041 Sichuan Province China Department of Ultrasound West China Hospital Si-chuan University Chengdu 610041 Sichuan Province China National Chengdu Center for Safety Evalua-tion of Drugs West China Hospital Sichuan University Chengdu610041 Sichuan Province China

AIM:To establish an appropriate primate model of fulminant hepatic failure (FHF).METHODS:We have,for the first time,established a large animal model of FHF in Macaca mulatta by intraperitoneal infusion of amatoxin and *** features,biochemical indexes,histopathology and iconography were examined to dynamically investigate the progress and outcome of the animal ***:Our results showed that the enzymes and serum bilirubin were markedly increased and the enzyme-bilirubin segregation emerged 36 h after toxin *** activity was significantly *** deteriorated parenchymal abnormality was detected by magnetic resonance imaging (MRI) and ultrasonography at 48 *** liver biopsy showed marked hepatocyte steatosis and massive parenchymal necrosis at 36 h and 49 h,*** autopsy showed typical yellow atrophy of the *** encephalopathy of the models was also confirmed by hepatic coma,MRI and pathological changes of cerebral *** lethal effects of the extrahepatic organ dysfunction were ruled out by their biochemical indices,imaging and ***:We have established an appropriate large primate model of FHF,which is closely similar to clinic cases,and can be used for investigation of the mechanism of FHF and for evaluation of potential medical therapies.

关键词： Fulminant hepatic failure Macaca mulatta Biochemistry Imaging Pathology

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The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

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Psychoradiology 2022年第1期2卷 32-42页

作者： Xiao Chen Bin Lu Hui-Xian Li Xue-Ying Li Yu-Wei Wang Francisco Xavier Castellanos Li-Ping Cao Ning-Xuan Chen Wei Chen Yu-Qi Cheng Shi-Xian Cui Zhao-Yu Deng Yi-Ru Fang Qi-Yong Gong Wen-Bin Guo Zheng-Jia-Yi Hu Li Kuang Bao-Juan Li Le Li Tao Li Tao Lian Yi-Fan Liao Yan-Song Liu Zhe-Ning Liu Jian-Ping Lu Qing-Hua Luo Hua-Qing Meng Dai-Hui Peng Jiang Qiu Yue-Di Shen Tian-Mei Si Yan-Qing Tang Chuan-Yue Wang Fei Wang Hua-Ning Wang Kai Wang Xiang Wang Ying Wang Zi-Han Wang Xiao-Ping Wu Chun-Ming Xie Guang-Rong Xie Peng Xie Xiu-Feng Xu Hong Yang Jian Yang Shu-Qiao Yao Yong-Qiang Yu Yong-Gui Yuan Ke-Rang Zhang Wei Zhang Zhi-Jun Zhang Jun-Juan Zhu Xi-Nian Zuo Jing-Ping Zhao Yu-Feng Zang the DIRECT consortium Chao-Gan Yan CAS key laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA Nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal University Beijing 100089China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China Department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Xijing Hospital of Air Force Military Medical University Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of

Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging

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Correction to:Vascular Endothelial Growth Factor‑Recruiting Nanofiber Bandages Promote Multifunctional Skin Regeneration via Improved Angiogenesis and Immunomodulation

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Advanced Fiber Materials 2023年第2期5卷 694-694页

作者： Yi Chen Zhengchao Yuan Weiyan Sun Muhammad Shafiq Jun Zhu Jiafei Chen Hai Tang Ling Hu Weikang Lin Yanxi Zeng Long Wang Lei Zhang Yunlang She Hui Zheng Guofang Zhao Dong Xie Xiumei Mo Chang Chen Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji UniversityShanghai 200092China Shanghai Engineering Research Center of Lung Transplantation Shanghai 200433China State key laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Center for Life Science Tsinghua UniversityBeijing 100084China State key laboratory of Medical neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200433China Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu UniversityFukuoka 819‑0395Japan Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092China Department of Biotechnology Faculty of Science and TechnologyUniversity of Central Punjab(UCP)Lahore 54000Pakistan Department of Cardiothoracic Surgery Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315000China Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo 315000China

Correction to:Advanced Fiber Materials https://***/10.1007/s42765-022-00226-8 In this article the author name Muhammad Shafiq was incorrectly written as Shafiq *** original article has been corrected.

关键词： Skin Regeneration Vascular

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Science:研究鉴定出导致脑细胞死亡的罪魁祸首

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现代生物医学进展 2017年第4期17卷 I0001-I0001页

作者： Yingfei Wang Ran An George K Umanah Hyejin Park Kalyani Nambiar Stephen M Eacker BongWoo Kim Lei Bao Maged M Harraz Calvin Chang Rong Chen Jennifer E Wang TaeIn Kam Jun Seop Jeong Zhi Xie Stewart Neifert Jiang Qian Shaida A Andrabi Seth Blackshaw Heng Zhu Hongjun Song GuoLi Ming Valina L Dawson Ted M Dawson Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. tdawson@jhmi.edu vdawson1@jhmi.edu yingfei.wang@utsouthwestern.edu. Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Pathology University of Texas Southwestern Medical Center Dallas TX 75390 USA. Department of Neurology and Neurotherapeutics University of Texas Southwestern Medical Center Dallas TX 75390 USA. Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Neurology of Huashan Hospital State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China. Adrienne Helis Malvin Medical Research Foundation New Orleans LA 70130-2685 USA. Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Center for High-Throughput Biology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Ophthalmology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Physiology Johns Hopkins University School of Medicine Baltimore MD 21205 USA.

尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋... 详细信息

尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋白。即一种通过切割细胞的DNA给予致命性打击的蛋白。他们说，这一发现潜在地为开发预防、阻止或削弱这一过程的药物打开新的大门。相关研究结果发表在Science期刊上。

关键词：细胞死亡脑损伤神经退行性疾病鉴定阿尔茨海默病分子事件研究人员致命性

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*** Endocytic Adaptor Protein Numb Functions in Müller Glia to Maintain Retinal Polarity and Photoreceptor Survival through the Polarity Determinant Crumbs

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Annals of Eye Science 2019年第1期 221-221页

作者： Maude Vinette Marie-Claude Bélanger Christine Jolicoeur Mina Gabraie Pierre Lachapelle Michel Cayouette Cellular neurobiology Research Unit Institut de recherches cliniques de Montréal(IRCM)MontrealQCCanada Integrated Program in Neuroscience McGill UniversityMontrealQCCanada Division of Experimental Medicine McGill UniversityMontrealQCCanada Department of Ophthalmology Research Institute of the McGill University Health CentreMontrealQCCanada Department of Neurology and Neurosurgery McGill UniversityMontrealQCCanada Department of Medicine Universitéde MontréalMontrealQCCanada

Background:The loss of cell polarity plays a key part in retinal dystrophies such as retinitis pigmentosa(RP)and Leber congenital amaurosis(LCA),resulting in photoreceptor(PR)degeneration and vision *** not knowing the direct genotype-to-phenotype correlation,many disease-causing mutations in the polarity determinant Crumbs(Crb1),have been ***,the loss of Crb1 in mice was shown to cause PR death,due to the loss of adhesions between PR and Müller cells at the apical surface of the ***,although the role of Crb1 in neuron polarity and survival is well established,little is known about how its intracellular trafficking is *** future treatments for retinal degenerative diseases in mind,the goal of this project is to understand the mechanism by which Crb1 is regulated and how it maintains retinal *** work in our laboratory showed that Numb,an endocytic adaptor protein,is an important regulator of protein trafficking in retinal *** therefore hypothesized that Numb might function as regulator of Crb1 in Müller ***:To study Numb function in Müller cells,we generated a conditional knockout(cKO)mouse line to inactivate Numb specifically in Müller cells by crossing a Glast-CreERT2 mouse line with a Numb-floxed *** 30 days,mice were administered tamoxifen to trigger inactivation of Numb and retinas were then collected at time points varying from 2 weeks to 17 months for ***,we studied the retinal morphology and outer limiting membrane integrity by histology and *** electron microscopy(EM),adhesions between Müller glia and photoreceptors were analysed and retinal function was assayed in live mice by electroretinography(ERG).To detect protein expression levels,protein extracts were prepared from cKO and control retinas for *** test for the presence of a biochemical interaction,Hek-293 cells were transfected with Numb and Crb1 vectors,and protein ext

关键词： Degeneration retinal polarity Crumbs-related dystrophies(Crb1-related dystrophies)

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Signaling pathways for germ cell death in adult cynomolgus monkeys（Macaca fascicularis） induced by mild testicular hyperthermia and exol enous testosterone treatment

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南京医科大学学报（自然科学版） 2007年第10期27卷 1142-1142页

作者： Jia, Y. Hikim, A.P.S. Lue,Y.H. Swerdloff, R.S. Vera,Y. Zhang,X. S. Hu, Z. Y. Li, Y. C. Liu, Y. X. Wang, C Univ Calif Los Angeles Med Ctr David Geffen Sch Med Div Endocrinol Torrance CA 90509 USA. Univ Calif Los Angeles Med Ctr David Geffen Sch Med Dept Med Torrance CA 90509 USA. Los Angeles Biomed Res Inst Torrance CA 90509 USA. Chinese Acad Sci Inst Zool State Key Lab Reprod Biol Beijing 100080 Peoples R China. Nanjing Med Univ Affiliated Hosp 1 Dept Endocrinol Nanjing 210029 Peoples R China

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