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Dendrobium officinale polysaccharide attenuates type 2 diabetes in mice model by modulating gut microbiota and alleviating intestinal mucosal barrier damage

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food Science and Human Wellness 2024年

作者： Xiaoxia Chen Chun Chen Changyang Ma Wenyi Kang Junlin Wu Xiong Fu Guangzhou Wondfo Health Science and Technology Co.， Ltd. National R&D Center for Edible Fungus processing Technology， Henan University Guangdong Province key laboratory for Green processing of Natural Products and Product Safety Guangzhou Institute of Modern Industrial Technology 4. Overseas Expertise Introduction Center for Discipline Innovation of food Nutrition and Human Health (111 Center) SCUT-Zhuhai Institute of Modern Industrial Innovation， School of food Science and Engineering， South China University of Technology

The purpose of this study was to investigate the hypoglycemic effect and mechanism of Dendrobium officinale polysaccharide (DOP) on type 2 diabetes mellitus (T2DM) mice established by high-fat diet and streptozotocin. The results showed that DOP improved glycolipid metabolism and serum inflammation levels， and inhibited intestinal-derived lipopolysaccharide (LPS) translocation， suggesting that inhibiting LPS-mediated intestinal barrier damage may be a key target for DOP to alleviate T2DM. Interestingly， the study found that DOP reduced intestinal inflammation and oxidative stress levels， significantly up-regulated the mRNA expression of tight junction proteins Claudin-1， Occludin and Zonula occluden-1 (ZO-1)， and ameliorated intestinal epithelial damage. In addition， DOP strongly inhibited the intestinal pathogenic bacteria and LPS-producing bacteria Helicobacter， Enterococcus and Desulfovibrio with a reduction rate of 95%， 73% and 9%， respectively， and promoted the proliferation of anti-inflammatory bacteria Bifidobacterium and Lactobacillus by 139% and 8%， respectively. Taken together， the hypoglycemic effect of DOP was related to the protection of intestinal mucosal barrier， and its underlying mechanism lied in its excellent anti-inflammatory and gut microbiota-modulatory effects， providing a theoretical basis for developing DOP as a novel prebiotic in functional food for diabetes.

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A highly linear stretchable MXene-based biocompatible hydrogel-elastomer hybrid with tissue-level softness

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Science China Materials 2024年第10期67卷 3368-3378页

作者： Shu Wan Haizhou Huang Zisheng He Yizhou Ye Shen Li Shi Su Jiaxin Shen Longxiang Han Peng Wan Xu Ran Li Chen Xuefeng He Litao Sun Hengchang Bi key laboratory of Optoelectronic Technology and Systems Ministry of EducationKey Disciplines Laboratory of Novel Micro-Nano Devices and System TechnologySchool of Optoelectronics EngineeringChongqing UniversityChongqing 400044China College of Photonic and Electronic Engineering Fujian Normal UniversityFuzhou 350117China School of Aeronautical Engineering Nanjing Vocational University of Industry TechnologyNanjing 210023China SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of EducationCollaborative Innovation Center for Micro/Nano FabricationDevice and SystemSoutheast UniversityNanjing 210096China The Shanghai key laboratory of Multidimensional Information processing School of Communication and Electronic EngineeringEast China Normal UniversityShanghai 200241China

Maintaining low modulus while endowing the wide-range linear stretchability to wearable or implantable devices is crucial for these devices to reduce the mechanical mismatch between the devices and human skin/tissue ***,improving linear stretchability often results in an increased modulus of stretchable electronic materials,which hinders their conformability in long-term quantifiable monitoring of ***,we develop a hybrid structure involving interlocking low-modulus porous elastomers(Ecoflex-0030)and MXene-based hydrogels with crosslinking networks of polyvinyl alcohol,sodium alginate,and *** hydrogel–elastomer structure exhibits superior performance compared with previous reports,with a wide linear stretchability strain range from 0 to 1000%and maintaining a low modulus of 6.4 ***,the hydrogel–elastomer hybrids can be utilized as highly sensitive strain sensors with remarkable characteristics,including high sensitivity(gauge factor~3.52),a linear correlation between the resistance and strain(0–200%),rapid response(0.18 s)and recovery times(0.21 s),and excellent electrical reproducibility(1000 loading–unloading cycles).Those electrical and mechanical properties allow the sensor to act as a suitable quantifiable equipment in organ monitoring,human activities detecting,and human–machine interactions.

关键词： linear stretchability low modulus MXene hydrogel-elastomer hybrid

UAV-Assisted Dynamic Avatar Task Migration for Vehicular Metaverse Services: A Multi-Agent Deep Reinforcement Learning Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 430-445页

作者： Jiawen Kang Junlong Chen Minrui Xu Zehui Xiong Yutao Jiao Luchao Han Dusit Niyato Yongju Tong Shengli Xie IEEE School of Automation Guangdong University of TechnologyGuangzhou 510006China 111 Center for Intelligent Batch Manufacturing based on IoT Technology Guangzhou 510006China key laboratory of Intelligent Information processing and System Integration of IoT Ministry of EducationGuangzhou 510006China School of Computer Science and Engineering Nanyang Technological UniversitySingaporeSingapore Pillar of Information Systems Technology and Design Singapore University of Technology and DesignSingaporeSingapore College of Communication Engineering Army Engineering University of PLANanjing 210007China National Natural Science Foundation of China Beijing 100085China key laboratory of Intelligent Detection and IoT in Manufacturing Ministry of EducationGuangzhou 510006China Guangdong key laboratory of IoT Information Technology Guangzhou 510006China

Avatars, as promising digital representations and service assistants of users in Metaverses, can enable drivers and passengers to immerse themselves in 3D virtual services and spaces of UAV-assisted vehicular Metaverses. However, avatar tasks include a multitude of human-to-avatar and avatar-to-avatar interactive applications, e.g., augmented reality navigation,which consumes intensive computing resources. It is inefficient and impractical for vehicles to process avatar tasks locally. Fortunately, migrating avatar tasks to the nearest roadside units(RSU)or unmanned aerial vehicles(UAV) for execution is a promising solution to decrease computation overhead and reduce task processing latency, while the high mobility of vehicles brings challenges for vehicles to independently perform avatar migration decisions depending on current and future vehicle status. To address these challenges, in this paper, we propose a novel avatar task migration system based on multi-agent deep reinforcement learning(MADRL) to execute immersive vehicular avatar tasks dynamically. Specifically, we first formulate the problem of avatar task migration from vehicles to RSUs/UAVs as a partially observable Markov decision process that can be solved by MADRL algorithms. We then design the multi-agent proximal policy optimization(MAPPO) approach as the MADRL algorithm for the avatar task migration problem. To overcome slow convergence resulting from the curse of dimensionality and non-stationary issues caused by shared parameters in MAPPO, we further propose a transformer-based MAPPO approach via sequential decision-making models for the efficient representation of relationships among agents. Finally, to motivate terrestrial or non-terrestrial edge servers(e.g., RSUs or UAVs) to share computation resources and ensure traceability of the sharing records, we apply smart contracts and blockchain technologies to achieve secure sharing management. Numerical results demonstrate that the proposed approach

关键词： Avatar blockchain metaverses multi-agent deep reinforcement learning transformer UAVs

Credible and Facile Fluorometric Detection of Soybean Trypsin Inhibitor Activity with a Water-Soluble Poly(diphenylacetylene) Derivative

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Transactions of Tianjin University 2024年第4期30卷 305-313页

作者： Jiao Tang Xiao Tang Jiaxiang Tang Wei Qi Qianwei Pan Jinhong Zeng Housheng Xia Jianping Zhou Zhongyi Sheng Junfeng Niu Zhejiang Tiantai Xianghe Industrial Co. Ltd.Taizhou 317200China Zhejiang Xianghe Track Fastener Research Institute Taizhou 317200China Shaoxing Institute for food and Drug Control Shaoxing 312000China key laboratory of Chemical and Biological processing Technology for Farm Products of Zhejiang Province School of Biological and Chemical EngineeringZhejiang University of Science and TechnologyHangzhou 310023China

Herein,a novel method for fl uorometric detection of soybean trypsin inhibitor(SBTI)activity based on a water-soluble poly(diphenylacetylene)derivative was *** quenching of the polymer via p-nitroaniline,produced from the trypsin-catalyzed decomposition of N-benzoyl-DL-arginine-4-nitroanilide hydrochloride(L-BAPA),was well described using the Stern-Volmer *** activity was quantitatively assessed based on changes in the fl uorescence intensity of the *** strategy has several advantages,such as high sensitivity and ease of ***,its applicability to other biochemical analyses is promising.

关键词： Fluorometric detection Soybean trypsin inhibitor Inhibition activity Fluorescence quenching

A functionalized activated carbon adsorbent prepared from waste amidoxime resin by modifying with H_(3)PO_(4) and ZnCl_(2) and its excellent Cr(Ⅵ)adsorption

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 585-598页

作者： Chunlin He Yun Liu Mingwei Qi Zunzhang Liu Yuezhou Wei Toyohisa Fujita Guifang Wang Shaojian Ma Wenchao Yang School of resources Environment and MaterialsGuangxi UniversityNanning 530004China State key laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi UniversityNanning 530004China School of Nuclear Science and Technology University of South ChinaHengyang 421000China School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China key laboratory of New Low-carbon Green Chemical Technology Education Department of Guangxi Zhuang Autonomous RegionNanning 530004China

With the application of resins in various fields, numerous waste resins that are difficult to treat have been produced. The industrial wastewater containing Cr(Ⅵ) has severely polluted soil and groundwater environments, thereby endangering human health. Therefore, in this paper, a novel functionalized mesoporous adsorbent PPR-Z was synthesized from waste amidoxime resin for adsorbing Cr(Ⅵ). The waste amidoxime resin was first modified with H3PO4 and ZnCl_(2), and subsequently, it was carbonized through slow thermal decomposition. The static adsorption of PPR-Z conforms to the pseudo-second-order kinetic model and Langmuir isotherm, indicating that the Cr(Ⅵ) adsorption by PPR-Z is mostly chemical adsorption and exhibits single-layer adsorption. The saturated adsorption capacity of the adsorbent for Cr(Ⅵ) could reach 255.86 mg/g. The adsorbent could effectively reduce Cr(Ⅵ) to Cr(Ⅲ) and decrease the toxicity of Cr(Ⅵ) during adsorption. PPR-Z exhibited Cr(Ⅵ) selectivity in electroplating wastewater. The main mechanisms involved in the Cr(Ⅵ) adsorption are the chemical reduction of Cr(Ⅵ) into Cr(Ⅲ) and electrostatic and coordination interactions. Preparation of PPR-Z not only solves the problem of waste resin treatment but also effectively controls Cr(Ⅵ) pollution and realizes the concept of “treating waste with waste”.

关键词： waste amidoxime resin mesoporous adsorbent H_(3)PO_(4)and ZnCl_(2)processing Cr(VI)adsorption electroplating wastewater

Intelligent design and construction of novel APN-based theranostic probe driven by advanced computational methods

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Chinese Chemical Letters 2024年第2期35卷 352-357页

作者： Yingli Zhu Jie Qian Kunqian Yu Jing Hou Yeshuo Ma Fei Chen Jie Dong Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410083China National Engineering Research Center of Rice and Byproduct Deep processing School of Food Science and EngineeringCentral South University of Forestry and TechnologyChangsha 410004China State key laboratory of Drug Research Drug Discovery and Design CenterShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Geriatrics Third Xiangya HospitalCentral South UniversityChangsha 410013China

Multifunctional molecules with both optical signal and pharmacological activity play an important role in drug development,disease diagnosis,and basic theoretical *** N(APN),as a representative tumor biomarker with anti-tumor potential,still lacks a high-precision theranostic probe specifically targeting *** this study,a novel quaternity design strategy for APN theranostic probe was *** proposed strategy utilizes advanced machine learning and molecular dynamics simulations,and cleverly employs the strategy of conformation-induced fluorescence recovery to achieve multi-objective optimization and integration of functional *** this strategy,a unique“Off-On”theranostic probe,ABTP-DPTB,was ingeniously constructed to light up APN through fluorescence restoration,relying on conformation-induced effects and solvent *** from the common diagnostic probes,the intelligent design with non-substrated linkage makes ABTP-DPTB for long-term in-situ *** fabricated probe was used for detecting and inhibiting APN in various environments,with a better in vitro inhibitory than golden-standard drug bestatin.

关键词： Theranostic probe Artificial intelligence Conformational restriction Fluorescence restoration Design strategy

Chemical composition,pharmacological activity and development strategies of Rubus chingii:A review

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Chinese Herbal Medicines 2024年第3期16卷 313-326页

作者： Xiangmei Xiong Zheng Liu Xiance Che Xuemin Zhang Xia Li Wenyuan Gao Tianjin University of Traditional Chinese Medicine Tianjin 301600China Tianjin key laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyFaculty of MedicineTianjin UniversityTianjin 300110China key laboratory of Advanced Chinese Medicine resources Research Enterprises Tianjin 300402China

Raspberries are used for both food and medicine,but it has not yet attracted widespread *** this paper,the chemical constituen of the original plant *** is one of the new“Zhe Bawei”medicinal materials selected in 2017.“Zhe Bawei”refers to eight kinds of genuine medicinal materials in Zhejiang *** chemical constituents,pharmacological effects,processing,and application of Rubus chingii Hu were reviewed to provide a reference for its further *** literature in recent years was collected in databases such as China Knowledge Network,Web of Science,Elsevier,PubMed,and X-Mol,using“raspberry”,“Rubus chingii”,“traditional use”,“chemical composition”,“pharmacology”,*** keywords individually or in *** summary of pharmacological activities shows that the relationship between the pharmacological activities of raspberry is still not deep *** in-depth research should be carried out in this direction to explore the mechanism of action of its active ingredients and provide effective reference for the further development of the raspberry *** the future,with the participation of more researchers,it is expected to develop innovative drugs based on raspberry for the treatment of diseases.

关键词： applications chemical compositions processing pharmacological effects Rubus chingii Hu

A process insight into production of ethyl levulinate via a stepwise fractionation

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Journal of Bioresources and Bioproducts 2024年第2期9卷 233-242页

作者： Yan Ma Hongxiao Wang Ziyang Wu Weihong Tan Guodong Feng Jianchun Jiang Institute of Chemical Industry of Forest Products Chinese Academy of ForestryNanjing 210042China Jiangsu Province key Lab.of Biomass Energy and Material Nanjing 210042China National Engineering Lab.for Biomass Chemical Utilization Nanjing 210042China Co-Innovation Center of Efficient processing and Utilization of Forest resources Nanjing Forestry UniversityNanjing 210037China

Ethyl levulinate(EL)is a key biomass-derived compounds due to its socio-economic benefits for the synthesis of commodity ***,we proposed an efficient one-step bamboo conversion to EL in ethanol,and a novel stepwise fractionation to purify EL and lignocellulose degradation products.A proton acid,due to its high catalytic efficiency,yielded 26.65%EL in 120 min at 200℃.The productions of ethyl glucoside and 5-ethoxymethylfurfural were analyzed in terms of by-products *** the best of our knowledge,there is no single report on catalyst for one step synthesis of EL directly from bamboo,as well as a stepwise fractionation to purify *** to similar physiochemical properties in each fraction,the platform molecules could broaden a new paradigm of bamboo biomass utilization for renewable energy and value-added *** addition,glucose,ethyl glucoside,corn starch,and microcrystalline cellulose were also investigated as substrates,so that the reaction intermediates of this one-pot procedure were identified and a possible reaction mechanism was proposed.

关键词： Ethyl levulinate Liquefaction Biomass Ethanol By-products

Insights into the enhancement of food flavor perception:strategies,mechanism and emulsion applications

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food Science and Human Wellness 2024年第5期13卷 2410-2424页

作者： Luyao Huang Yujie Dai Fan Zhang Longtao Zhang Baodong Zheng Yi Zhang Engineering Research Centre of Fujian-Taiwan Special Marine food processing and Nutrition Ministry of EducationFuzhou 350002China College of food Science Fujian Agriculture and Forestry UniversityFuzhou 350002China

The core drivers of the modern food industry are meeting consumer demand for tasty and healthy *** application of food flavor perception enhancement can help to achieve the goals of salt-and sugar-reduction,without compromising the sensory quality of the original food,and this has attracted increasing research *** analysis of bibliometric results from 2002 to 2022 reveals that present flavor perception enhancement strategies(changing ingredient formulations,adding salt/sugar substitutes,emulsion delivery systems)are mainly carry out based on sweetness,saltiness and *** systems is becoming a novel research foci and development trends of international food flavor perception-enhancement *** structured design of food emulsions,by using interface engineering technology,can effectively control,or enhance the release of flavor ***,this review systematically summarizes strategies,the application of emulsion systems and the mechanisms of action of food flavor perception-enhancement technologies,based on odor-taste cross-modal interaction(OTCMI),to provide insights into the further structural design and application of emulsion systems in this field.

关键词： food flavor perception Emulsion Mechanism Bibliometric