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Biomedical and Environmental Sciences 2017年第7期30卷 508-516页

作者： DU Yang GAO Yan Hui FENG Zhuo Ying MENG Fan Gang FAN Li Jun SUN Dian Jun Center for Endemic disease control Chinese Center for Disease Control and PreventionHarbin Medical UniversityKey Lab of Etiology and EpidemiologyNational Health and Family Planning Commission(23618504) Heilongjiang Land Reclamation Bureau General Hospital

Objective To evaluate the usefulness of the thyroglobulin （Tg） level in adults as a nutritiona biomarker of iodine status and to identify the factors related to the serum Tg level. Methods A cross-sectional study was conducted in adult populations of areas differing in iodine nutrition from three provinces （Autonomous Region） in China. Serum levels of thyroid hormones and Tg as well as thyroid autoantibodies were measured. The thyroid volume and nodule were measured by ultrasound. A multivariate linear regression analysis was used to assess iodine intake and other indeterminate factors associated with the serum Tg level. Results A total of 573 adults were recruited for this study. The serum Tg levels differed significantly among the three groups （22.27 ~g/L, 9.73 pg/L and 15.77 pg/L in the excess, more-than-adequate, and deficient groups, respectively）. The results of multivariate linear regression analysis indicate that excess and deficient iodine intake, goiter, thyroid nodule, hypothyroidism are significantly related with higher Tg level, and TgAb positivity is significantly related with lower serum Tg. Conclusion The serum Tg level reflects abnormal thyroid function and is a sensitive functiona biomarker of iodine nutrition status.

关键词： High iodine Iodine deficiency Thyroglobulin

Estimating the prevalence of schistosomiasis japonica in China:a serological approach

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Infectious diseases of Poverty 2018年第1期7卷 601-610页

作者： Xin-Yao Wang Jing Xu Song Zhao Wei Li Jian-Feng Zhang Jian He Ashley M.Swing Kun Yang Jiangsu Institute of parasitic diseases Yangxiang117#MeiyuanWuxi 214064JiangsuChina key laboratory on Technology for parasitic disease prevention and control Ministry of HealthJiangsu Provincial Key Laboratory on the Molecular Biology of ParasitesYangxiang117#MeiyuanWuxi 214064JiangsuChina Public health Research Center Jiangnan UniversityJiangsuShengChina national Institute of parasitic diseases Chinese Center for Disease Control and PreventionShanghaiChina

Background:The prevalence of schistosomiasis japonica has decreased significantly,and the responses changing from control to elimination in Jiangsu Province,*** to estimate the change in prevalence of schistosomiasis using only serological data will be important and ***:We collected serum samples from 2011 to 2015 to build a serum bank from Dantu County of Jiangsu,*** samples were detected by enzyme-linked immunosorbent assay(ELISA),the positive rate and optical density(OD)value were *** Bayesian model including the prior information of sensitivity and specificity of ELISA was established,and the estimated infection rates were obtained for different years,genders and age ***:There was no significant difference in the mean OD between different years and genders,but there was a significant difference between the different age *** were statistically significant differences in the positive rate for different years and age groups,but no significant difference at different *** estimated infection rate for the five years was 1.288,1.456,1.032,1.485 and 1.358%,*** was no significant difference between different years and between genders,but a significant difference between different age ***:The risk of schistosomiasis transmission in this area still exists,and risk monitoring of schistosomiasis should be strengthened.

关键词： Enzyme-linked immunosorbent assay(ELISA) Bayesian statistics Schistosomiasis japonica Sensitivity Specificity Estimated infection rate

ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016

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Science China(Life Sciences) 2017年第12期60卷 1364-1371页

作者： Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang State key laboratory of Infectious disease prevention and control national Institute for Viral disease control and prevention Chinese Center for Disease Control and PreventionBeijing 102206China Collaborative Innovation Center for Diagnosis and Treatment of Infectious diseases Hangzhou 310058China Qingdao University Qingdao 266071China Shandong Provincial Research Center for Bioinformatic Engineering and Technique School of Life SciencesShandong University of TechnologyZibo 255049China national Institute of parasitic diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMinistry of HealthWHO Collaborating Centre for Tropical DieasesShanghai 200025China Center for disease control and prevention of Shenyang Command Shenyang 110034China Guizhou Province Center for disease control and prevention Guiyang 550004China

A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens *** ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue.

关键词： arbovirus surveillance mosquito-borne arbovirus Japanese encephalitis virus Zika virus

A brief history of artemisinin:Modes of action and mechanisms of resistance

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Chinese Journal of Natural Medicines 2019年第5期17卷 331-336页

作者： LU Feng HE Xin-Long Richard Culleton CAO Jun Institute of Translational Medicine Medical College Yangzhou University key laboratory of national health commission on parasitic disease control and prevention Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology Jiangsu Institute of Parasitic Diseases Jiangsu key laboratory of integrated traditional Chinese and Western Medicine for prevention and treatment of Senile diseases Yangzhou University Jiangsu Co-Innovation Center for the prevention and control of Important Animal Infectious diseases and Zoonoses College of Veterinary Medicine Yangzhou University Malaria Unit Institute of Tropical Medicine Nagasaki University Center for Global health School of Public Health Nanjing Medical University Public health Research Center Jiangnan University

The cornerstone of antimalarial treatment, artemisinin, has reduced malaria associated morbidity and mortality worldwide. However, Plasmodium falciparum parasites with reduced sensitivity to artemisinin have emerged, and this threatens malaria control and elimination efforts. In this minireview, we describe the initial development of artemisinin as an antimalarial drug,its use both historically and currently, and our current understanding of its mode of action and the mechanisms by which malaria parasites achieve resistance.

关键词： Artemisinin Resistance Malaria

Increasing Trends and Species Diversity of Nontuberculous Mycobacteria in A Coastal Migrant City−Shenzhen, China

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Biomedical and Environmental Sciences 2022年第2期35卷 146-150页

作者： JI Le Cai CHEN Shuai PIAO Wei HONG Chuang Yue LI Jin Li JIANG Qi Department of Tuberculosis control Institute of Laboratory ResearchShenzhen Center for Chronic Disease ControlShenzhen 518020GuangdongChina School of Public health Wuhan UniversityWuhan 430071HubeiChina national Institute for Nutrition and health Chinese Center for Disease Control and PreventionKey Laboratory of Trace Element Nutrition of National Health CommissionBeijing 100050China

Nontuberculous mycobacteria(NTM)are opportunistic pathogens of environmental origin that can cause human infections in a wide variety of tissues[1].Lung involvement is the most common manifestation of NTM infection[1].The symptoms and radiographic signs are similar to those of patients with pulmonary tuberculosis(TB)who are infected with Mycobacterium tuberculosis complex(MTBC)[1].Most NTM species are naturally resistant to first-line anti-TB drugs and have different resistance profiles,thus misdiagnosis leads to inappropriate treatment and increases the risk of poor prognosis for patients with an NTM infection,and even wider spread through person-to-person contact[2].

关键词： involvement tuberculosis drugs

Surveillance and Response to Imported Malaria During the COVID-19 Epidemic—Anhui Province,China,2019–2021

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China CDC weekly 2022年第28期4卷 622-625页

作者： Tao Zhang Jingjing Jiang Xiaofeng Lyu Xian Xu Shuqi Wang Zijian Liu Jianhai Yin Weidong Li Anhui Provincial Center for disease control and prevention HefeiAnhui ProvinceChina national Institute of parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)National Health Commission Key Laboratory of Parasite and Vector BiologyWHO Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina.

Summary What is already known about this topic?China was certified malaria-free on June 30,***,imported malaria continuously threatens the effort to prevent re-establishment of malaria in *** is added by this report?Measures such as international travel restrictions,entry quarantine,and screening in fever clinics during the coronavirus disease 2019(COVID-19)period were associated with a significant decrease of imported malaria cases in Anhui Province,a higher proportion of non-Plasmodium falciparum(***)malaria reported infections,and a higher proportion of cases requiring medical attention at their initial *** are the implications for public health practices?It is necessary to be vigilant about imported malaria during the COVID-19 epidemic,especially for *** infections which are more difficult to detect,and to promote research,development,and introduction of more sensitive and specific point-ofcare detection methods for *** species.

关键词： Anhui travel imported

Plasmodium vivax in the Elimination Phase—China,2013–2020

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China CDC weekly 2022年第28期4卷 609-613,I0002,I0003页

作者： Li Zhang Boyu Yi Zhigui Xia Fang Huang national Institute of parasitic diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Center for Tropical DiseasesNational Centre for International Research on Tropical DiseasesNHC Key Laboratory of Parasite and Vector Biology(National Institute of Parasitic DiseasesChinese Center for Disease Control and Prevention)ShanghaiChina.

Summary What is already known about this topic?Plasmodium vivax(***)was the most widely distributed and major human malaria parasite in China,considered the last parasite to be *** is added by this report?The last domestic *** case was reported in 2016,while hundreds of imported cases were reported annually from 2013–2020,predominantly from Southeast *** are the implications for public health practice?In the post-elimination phase,adaptive and practical strategies focusing on imported *** cases should be updated and adopted to prevent malaria resurgence.

关键词： vivax Plasmodium parasite

Molecular Epidemiology of Echovirus 18 Circulating in China's Mainland from 2015 to 2016

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Virologica Sinica 2019年第1期34卷 50-58页

作者： Xiangpeng Chen Tianjiao Ji Jiayun Guo Wei Wang Wenbo Xu Zhengde Xie key laboratory of Major diseases in Children Ministry of EducationNational Clinical Research Center for Respiratory DiseasesBeijing Key Laboratory of Pediatric Respiratory Infection DiseasesVirology LaboratoryBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health WHO WPRO Regional Polio Reference laboratory and key laboratory of Medical Virology and Viral diseases National Health and Family Planning Commission of ChinaNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention

Echovirus 18(E18), a serotype of Enterovirus B(EV-B) species, is an important pathogen in aseptic meningitis. E18 had rarely been detected in China's Mainland, but became the predominant pathogen associated with viral encephalitis(VE) and meningitis in Hebei province for the first time in 2015. To investigate the molecular epidemiology and genetic characteristics of E18 in China's Mainland, sixteen E18 strains from patient throat swabs with hand, foot, and mouth disease(HFMD) in six provinces in China collected between 2015 and 2016, and four E18 strains isolated from 18 patient cerebrospinal fluid specimens with VE in Hebei Province in 2015 were obtained and sequenced. Combined with the sequences from the GenBank database, we performed an extensive genetic analysis. Phylogenetic analysis of VP1 gene sequences revealed that all E18 strains from China's Mainland after 2015 belonged to subgenotype C2. There were no obvious specific differences in phylogenetic and variation analyses of E18 genome sequences between HFMD and VE/meningitis strains. Potential multiple recombination may have occurred in the 50-untranslated region and in the P2 and P3 nonstructural protein-encoding regions of E18 strains from China. The current E18 strains were potential multiplerecombinant viruses. Overall, these findings supported that E18 caused HFMD, VE, and meningitis, although there were no significant associations between clinical features and viral genomic characteristics.

关键词： Genetic characteristics Echovirus 18 (E18) Genome Enterovirus Recombination

Genomic surveillance of coxsackievirus A10 reveals genetic features and recent appearance of genogroup D in Shanghai,China,2016–2020

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Virologica Sinica 2022年第2期37卷 177-186页

作者： Jiayu Wang Jiajing Liu Fanghao Fang Jiajin Wu Tianjiao Ji Yuying Yang Ling Liu Chongshan Li Wanju Zhang Xi Zhang Zheng Teng Microbiology Department Shanghai Municipal Center for Disease Control and PreventionShanghai200336China Microbiology Department Songjiang District Center for Disease Control and PreventionShanghai201620China WHO WPRO Regional Polio Reference laboratory NHC Key Laboratory for BiosafetyNHC Key Laboratory for Medical VirologyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China

Coxsackievirus A10(CVA10)is one of the major causative agents of hand,foot and mouth disease(HFMD).To investigate the epidemiological characteristics as well as genetic features of CVA10 currently circulating in Shanghai,China,we collected a total of 9,952 sporadic HFMD cases from January 2016 to December *** the past five years,CVA10 was the fourth prevalent causatives associated with HFMD in Shanghai and the overall positive rate was 2.78%.The annual distribution experienced significant fluctuations over the past five *** addition to entire VP1 sequencing,complete genome sequencing and recombination analysis of CVA10 isolates in Shanghai were further performed.A total of 64 near complete genomes and 11 entire VP1 sequences in this study combined with reference sequences publicly available were integrated into phylogenetic *** CVA10sequences in this study mainly belonged to genogroup C and presented 91%-100%nucleotide identity with other Chinese isolates based on VP1 *** the first time,our study reported the appearance of CVA10 genogroup D in Chinese mainland,which had led to large-scale outbreaks in Europe *** recombination analysis showed the recombination break point located between 5,100 nt and 6,700 nt,which suggesting intertypic recombination with CVA16 genogroup *** conclusion,CVA10 genogroup C was the predominant genogroup in Shanghai during ***10 recombinant genogroup D was firstly reported in circulating in Chinese *** surveillance is needed to better understand the evolution relationships and transmission pathways of CVA10 to help to guide disease control and prevention.

关键词： Coxsackievirus A10(CVA10) Genogroup D Intertypic recombination Hand foot and mouth disease(HFMD)

单个蝙蝠病毒组分析揭示了蝙蝠间的共感染和溢出以及病毒的人畜共患潜力

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中华实验和临床病毒学杂志 2024年第4期38卷 480-480页

作者：王娟(编译) State key laboratory for Biocontrol School of Medicine Shenzhen Campus of Sun Yat-sen University Sun Yat-sen University Shenzhen China Shenzhen key laboratory for Systems Medicine in Inflammatory diseases Shenzhen Campus of Sun Yat-sen University Sun Yat-sen University Shenzhen China Guangzhou national laboratory Guangzhou International Bio-Island Guangzhou Guangdong Province China Ministry of Education key laboratory of Biodiversity Science and Ecological Engineering School of Life Sciences Fudan University Shanghai China Department of Viral and Rickettsial disease control Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention Yunnan Institute of Endemic Disease Control and Prevention Dali Yunnan China School of Public health (Shenzhen) Shenzhen Campus of Sun Yat-sen University Sun Yat-sen University Shenzhen China Yunnan key laboratory of Plant Reproductive Adaptation and Evolutionary Ecology and Centre for Invasion Biology School of Ecology and Environmental Science Yunnan University Kunming Yunnan China Molecular Imaging Center Central Laboratory The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai 519000 Guangdong China State key laboratory of Infectious disease prevention and control National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Department of Infectious diseases and Public health Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong Hong Kong China Sydney Institute for Infectious diseases School of Medical Sciences The University of Sydney Sydney NSW 2006 Australia

蝙蝠是许多人畜共患病病毒的储备宿主。但是关于个体蝙蝠内病毒的多样性和丰度的了解还较少,因此它们之间病毒共感染和溢出的频率也不清楚。我们用无偏的元转录组学方法,对中国云南省采样的149只个体蝙蝠中携带的哺乳动物相关病毒进行... 详细信息

蝙蝠是许多人畜共患病病毒的储备宿主。但是关于个体蝙蝠内病毒的多样性和丰度的了解还较少,因此它们之间病毒共感染和溢出的频率也不清楚。我们用无偏的元转录组学方法,对中国云南省采样的149只个体蝙蝠中携带的哺乳动物相关病毒进行了表征。结果显示研究的动物中病毒的高频共感染(即蝙蝠个体同时感染多种病毒物种)和溢出,这可能进一步促进病毒的重组和再组合。

关键词：人畜共患病共感染病毒组蝙蝠溢出多样性云南省