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Status of Serum Uric Acid and Hyperuricemia among Adults in China:China Nutrition and health Surveillance(2015)

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Biomedical and Environmental Sciences 2022年第10期35卷 911-920页

作者： PIAO Wei BO Ya Cong ZHAO Li Yun YU Dong Mei key laboratory of Trace Element Nutrition of national health commission National Institute of Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000HenanChina

Objective The purpose of this study was to determine the serum uric acid levels and the prevalence of hyperuricemia among Chinese adults in 2015 and compare the differences between urban and rural areas,as well as the differences between eastern,central,and western *** A national representative sample of 180,208 participants were included using a stratified,multistage,and random sampling *** demographic characteristics and blood samples were collected to determine the serum uric acid levels and prevalence of hyperuricemia among subgroups using complicated sampling weight.A t-test or ANOVA was used for normally-distributed *** Kruskal-Wallis rank test was used for skewed-distributed *** Mantel-Haenszel chi-square test was used to compare the difference in categorical *** The weighted mean uric acid level in Chinese adults was 310.4μmol/L(317.5μmol/L in urban areas and 302.9μmol/L in rural areas).The weighted average values of uric acid in eastern,central,and western China were 315.5μmol/L,303.5μmol/L,and 310.4μmol/L,*** weighted prevalence of hyperuricemia in Chinese adults was 14.6%,with a prevalence of 16.5%in urban areas and12.5%in rural *** weighted prevalence of hyperuricemia in eastern,central,and western China was 16.0%,12.5%,and 14.8%,*** The uric acid level in Chinese adults is relatively *** actions are warranted to improve this metabolic abnormality.

关键词： Uric acid Hyperuricemia Adults China

Serological Study of An Imported Case of Middle East Respiratory Syndrome and His Close Contacts in China, 2015

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Biomedical and Environmental Sciences 2016年第3期29卷 219-223页

作者： WANG Wen Ling WANG Hui Juan DENG Yao SONG Tie LAN Jia Ming WU Gui Zhen KE Chang Wen TAN Wen Jie key laboratory of Medical Virology and Virus disease National Health and Family Planning Commission of the People's Republic of China，National Institute for Viral Disease Control and Prevention Chinese Center for Disease Controland Prevention Beijing 102206 China Guangdong Provincial Center for disease control and prevention Guangzhou 511430 Guangdong China

The first imported Middle East respiratory syndrome （MERS） case in China was identified in May 2015. We determined the kinetics of antibody （IgG and IgM） and neutralizing antibodies against MERS-coronavirus （MERS-CoV） in this case before discharge. Moreover, no seroconversion was found among 53 close contacts by anti-MERS IgG antibody enzyme-linked immunosorbent assay （ELISA） of paired serum samples. These findings suggest that neither community nor nosocomial transmission of MERS-CoV occurred in China.

关键词： Serological Study of An Imported Case of Middle East Respiratory Syndrome and His Close Contacts in China Co Figure ELISA Ig

Genome sequencing and phylogenetic analysis of Banna virus(genus Seadornavirus,family Reoviridae)isolated from Culicoides

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Science China(Life Sciences) 2017年第12期60卷 1372-1382页

作者： Song Song Yuanyuan Li Shihong Fu Wenwen Lei Xiaofang Guo Yun Feng Xiaoyan Gao Xiaolong Li Zhonghua Yang Ziqian Xu Ying He Huanyu Wang Hongning Zhou Bin Wang Xiaoqing Lu Guodong Liang School of Public health Qingdao UniversityQingdao 266071China State key laboratory of lnfectious disease prevention and control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Collaborative Innovation Center for Diagnosis and Treatment of Infectious diseases Hangzhou 310058China yunnan Institute of parasitic diseases Pu'er 665000China Yunnan Institute of Endemic disease control and prevention Dali 671000China

In an investigation of blood-sucking insects and arboviruses, a virus(YN12243) was isolated from Culicoides samples collected in the Sino-Burmese border region of Yunnan Province, China. The virus caused cytopathic effect(CPE) in C6/36 cells and passaged stably. Polyacrylamide gel analysis showed that the genome of YN12243 was composed of 12 segments of double-stranded RNA(dsRNA), with a distribution pattern of 6-6. The nucleotide and amino acid sequences of the coding region(1.12 segments) were17,803 bp and 5,925 amino acids in length, respectively. The phylogenetic analysis of VP1 protein(RdRp) revealed that YN12243 belonged to genus Seadornavirus of family Reoviridae, and further analysis indicated that YN12243 belongs to the Banna virus(BAV) genotype A2. Additionally, YN12243 was located in the same evolutionary cluster as BAV strains isolated from different mosquito species, suggesting that the BAV isolated from Culicoides does not have species barriers. These results indicate that Culicoides can also be a vector for BAV. In view of the hematophagous habits of Culicoides on cattle, horses, deer, and other large animals, as well as the possibility of spreading and causing a variety of animal arboviral diseases, it is important to improve infection detection and monitor the BAV in large livestock.

关键词： Banna virus Seadornavirus Reoviridae mosquito Culicoides

Application of Auto-regressive Linear Model in Understanding the Effect of Climate on Malaria Vectors Dynamics in the Three Gorges Reservoir

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Biomedical and Environmental Sciences 2014年第10期27卷 811-814页

作者： WANG Duo Quan GU Zheng Cheng ZHENG Xiang GUO Yun TANG Lin Hua national Institute of parasitic diseases Chinese Center for Disease Control and Prevention WHO Collaborating Centre for Malaria Schistosomiasis and Filariasis key laboratory of Parasite and Vector Biology Ministry of Health

It is important to understand the dynamics of malaria vectors in implementing malaria control strategies. Six villages were selected from different sections in the Three Gorges Reservoir fc,r exploring the relationship between the climatic ｜：actors and its malaria vector density from 1997 to 2007 using the auto-regressive linear model regressi^n method. The result indicated that both temperature and precipitation were better modeled as quadratic rather than linearly related to the density of Anopheles sinensis.

关键词： Application of Auto-regressive Linear Model in Understanding the Effect of Climate on Malaria Vectors Dynamics in the Three Gorges Reservoir Auto

Intake of Vitamin A,Thiamine,Riboflavin,Vitamin C,and Niacin Among Children Aged 6−11 Years Old—China,2016−2017

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China CDC weekly 2021年第11期3卷 237-241页

作者： Wei Piao Lahong Ju Hongyun Fang Qiya Guo Shuya Cai Xiaoli Xu Shujuan Li Xue Cheng Liyun Zhao Dongmei Yu national Institute for Nutrition and health Chinese Center for Disease Control and PreventionKey Laboratory of Trace Element NutritionNational Health Commission of the People's Republic of ChinaBeijingChina.

Summary What is already known on this topic?Insufficient intake of vitamins is one of the major nutritional problems in children aged 6-11 years old in China,and the problem is particularly severe for rural *** is add... 详细信息

关键词： vitamin intake Vitamin

Publication output of the new integrated strategy for schistosomiasis japonica control in China: a PubMed-based bibliometric assessment

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Global health Journal 2019年第1期3卷 4-8页

作者： Yao Deng Wei Wang Yili Qian Hongru Zhu Yousheng Liang key laboratory of national health commission on parasitic disease control and prevention Wuxi214064China Jiangsu Provincial key laboratory on Parasites and Vector control Technology Wuxi214064China Jiangsu Institute of parasitic diseases Wuxi214064China

Background:Although sustainable control since 1950s has achieved great successes,schistosomiasis japonica remains a major public health problem in *** 2004,a new integrated strategy was developed aiming to control the transmission of Schistosoma japonicum through the implementation of a package of *** date,no systematic review or meta-analysis assessing the effectiveness of this new integrated strategy for schistosomiasis control in China has been *** performed a PubMed-based bibliometric assessment of publications on the new integrated strategy for schistosomiasis japonica control in China,to understand the global transmissibility and sharing of the new integrated ***:An in-depth bibliometric analysis of all publications on the new integrated strategy for schistosomiasis japonica control in China was performed through a PubMed search using the terms 'schistosomiasis' and 'China,'from January 1,2004 to August 31,*** titles and abstracts were read carefully,and the publications reporting the effectiveness,experiences,lessons,or problems of the new integrated strategy were included in the bibliometric ***:Overall,2,361 titles were screened,and 70 eligible publications were accessed for analyses,including 23 studies in English,published in 15 international journals,and 47 studies in Chinese with abstracts in English,published in 3 national *** Journal of Schistosomiasis control (Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi) published 60% of the research output,Research articles (48.6%) and short reports (37.1%) were the dominant manuscript ***,471 contributing authors from 277 affiliations across 9 countries produced these 70 ***:This is the first PubMed-based quantitative analysis of the research output of the new integrated strategy,and our data indicate a low global transmissibility of Chinese new integrated *** therefore call for more research outputs o

关键词： schistosomiasis japonica integrated strategy publication output bibliometric analysis PubMed

Epidemiological Characteristics of Echinococcosis in Non-Endemic PLADs—China,2017–2020

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China CDC weekly 2021年第51期3卷 1084-1088页

作者： Yan Kui Baixue Liu Xu Wang Cuizhao Xue Jingbo Xue Yalan Zhang Benguang Zhang Yang Dai Shuai Han Weiping Wu national Institute of parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)National Health Commission Key Laboratory of Parasite and Vector BiologyWorld Health Organization Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Henan Provincial Center for disease control and prevention ZhengzhouHenanChina Shandong Institute of parasitic diseases JiningShandongChina Jiangsu Institute of parasitic diseases WuxiJiangsuChina.

Summary What is already known about this topic?Echinococcosis,also known as hydatid disease,is a zoonotic parasitic disease caused by the larvae of Echinococcus *** China has one of the most severe epidemics *** is endemic in 370 counties of 9 provincial-level administrative divisions(PLADs)including Inner Mongolia,Sichuan,Yunnan,Tibet,Shaanxi,Gansu,Qinghai,Ningxia,Xinjiang and Xinjiang Production and Construction Corps(XPCC).

关键词： Xinjiang Ningxia Ech

Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (Sf9 cells) in adult recipients of inactivated vaccines

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1165-1173页

作者： Wenxin Luo Jiadi Gan Zhu Luo Shuangqing Li Zhoufeng Wang Jiaxuan Wu Huohuo Zhang Jinghong Xian Ruixin Cheng Xiumei Tang Yi Liu Ling Yang Qianqian Mou Xue Zhang Yi Chen Weiwen Wang Yantong Wang Lin Bai Xuan Wei Rui Zhang Lan Yang Yaxin Chen Li Yang Yalun Li Dan Liu Weimin Li Lei Chen Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduChina Institute of Respiratory health Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengduChina Precision Medicine Center Precision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina State key laboratory of Respiratory health and Multimorbidity West China HospitalChengduChina Institute of Respiratory health and Multimorbidity West China HospitalSichuan UniversityChengduChina Clinical Trial Center West China HospitalSichuan UniversityChengduChina General Practice Medical Center West China HospitalSichuan UniversityChengduChina Fangcao Community health Service Center of Chengdu High-tech Zone ChengduChina The Research Units of West China Chinese Academy of Medical SciencesWest China HospitalChengduChina West China School of Nursing Sichuan UniversityChengduChina Department of Infection control West China HospitalSichuan UniversityChengduChina Department of Pathology West China HospitalSichuan UniversityChengduChina Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology West China HospitalSichuan UniversityChengduChina

Vaccines have proven effective in protecting populations against COVID-19,including the recombinant COVID-19 vaccine(Sf9 cells),the first approved recombinant protein vaccine in *** this positive-controlled trial with 85 adult participants(Sf9 cells group:n=44;CoronaVac group:n=41),we evaluated the safety,immunogenicity,and protective effectiveness of a heterologous boost with the Sf9 cells vaccine in adults who had been vaccinated with the inactivated vaccine,and found a post-booster adverse events rate of 20.45%in the Sf9 cells group and 31.71%in the CoronaVac group(p=0.279),within 28 days after booster *** group reported any severe adverse *** the Sf9 cells vaccine booster,the geometric mean titer(GMT)of binding antibodies to the receptor-binding domain of prototype SARS-CoV-2 on day 28 post-booster was significantly higher than that induced by the CoronaVac vaccine booster(100,683.37 vs.9,451.69,p<0.001).In the Sf9 cells group,GMTs of neutralizing antibodies against pseudo SARS-CoV-2 viruses(prototype and diverse variants of concern[VOCs])increased by 22.23–75.93 folds from baseline to day 28 post-booster,while the CoronaVac group showed increases of only 3.29–10.70 ***,neutralizing antibodies against live SARS-CoV-2 viruses(prototype and diverse VOCs)increased by 68.18–192.67 folds on day 14 post-booster compared with the baseline level,significantly greater than the CoronaVac group(19.67–37.67 folds).A more robust Th1 cellular response was observed with the Sf9 cells booster on day 14 post-booster(mean IFN-γ+spot-forming cells per 2×105 peripheral blood mononuclear cells:26.66 vs.13.59).Protective effectiveness against symptomatic COVID-19 was approximately twice as high in the Sf9 cells group compared to the CoronaVac group(68.18%vs.36.59%,p=0.004).Our study findings support the high protective effectiveness of heterologous boosting with the recombinant COVID-19 vaccine(Sf9 cells)against symptomatic COVID-19 of dive

关键词： protective vaccine boost

Dissemination of Antibiotic Resistance Genes Among Patients with Diarrhea — Freetown, Sierra Leone, 2018

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China CDC weekly 2022年第49期4卷 1093-1096页

作者： Xia Chen Enmin Zhang Michael K Abdulai Alie Brima Tia Esther Debora Ngegba Jianhai Yin Songtao Xu Lili Wang Xiaoping Dong Doris Harding Biao Kan State key laboratory of Infectious disease prevention and control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing MunicipalityChina Sierra Leone-China Friendship Biological Safety laboratory Chinese Center for Disease Control and PreventionFreetownSierra Leone and Beijing MunicipalityChina national Institute of parasitic diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchShanghai MunicipalityChina national Institute for Viral disease control and prevention Chinese Center for Disease Control and PreventionBeijing MunicipalityChina Center for Global Public health Chinese Center for Disease Control and PreventionBeijing MunicipalityChina Ministry of health and Sanitation FreetownSierra Leone.

What is already known about this topic?Antibiotic resistance(AR)is a serious public health threat ***,the AR and antibiotic resistance genes(ARGs)data from West Africa,especially from Sierra Leone,are *** is added by this report?The study revealed ARGs’common dissemination,and multiplex antibiotic resistance genes in one *** blaNDM and blaOXA-48-like were first discovered in Sierra *** are the implications for public health practice?Basic information is provided for AR research and surveillance and highlights that effective AR surveillance among diarrhea patients is necessary for Sierra Leone and West Africa.

关键词： Antibiotic diarrhea Patients