Background:Skin,being a vital organ that regulates physiological responses in the human body,is prone to injury from external environmental *** full-thickness skin defects becomes especially challenging when infection...
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Background:Skin,being a vital organ that regulates physiological responses in the human body,is prone to injury from external environmental *** full-thickness skin defects becomes especially challenging when infections and vascular injuries are *** wound dressings with single functions,such as antibacterial or angiogenic properties,fall short in achieving rapid wound *** address this,there is a need to develop wound dressing materials that possess both effective antibacterial and angiogenic ***:In this study,we utilized electrospinning technology to fabricate hyaluronic acid-cellulose acetate fibrous membrane dressings,incorporating poly(ionic liquid)as an antibacterial polymer and deferoxamine as an angiogenic ***:The resulting fibrous membrane dressing contained poly(ionic liquid)and deferoxamin showcased a microporous structure,drug-releasing capabilities,and excellent air *** not only demonstrated highly effective antibacterial properties but also exhibited remarkable angiogenesis,thereby promoting the healing of full-thickness skin defect wounds in both in vitro and in vivo ***:These findings highlight the immense potential of this wound dressing material for future clinical applications.
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