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Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field

Zoological Research 2024年第3期45卷 478-490页

作者： Han-Xiao Chen Xin-Yu Wang Biao Yu Chuan-Lin Feng Guo-Feng Cheng Lei Zhang Jun-Jun Wang Ying Wang Ruo-Wen Guo Xin-Miao Ji Wen-Jing Xie Wei-Li Chen Chao Song Xin Zhang CAS key laboratory of high magnetic field and ion beam physical biology High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230026China Institutes of physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China

Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in Europe.The predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late stage.In the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery stage.During the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte proliferation.Moreover,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially declines.Overall,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP overdose.Of note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.

关键词： Acetaminophen Acute liver injury Static magnetic fields Oxidative stress DNA synthesis

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Solid-state NMR reveals that oxygen tri-clusters make glass highly crackresistant

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magnetic Resonance Letters 2024年第2期4卷 77-78页

作者： Zhiwu Yu high magnetic field laboratory CAS Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China

In a recent paper,advanced solid-state nuclear magnetic resonance(SSNMR)technology was employed to reveal the underlying mechanism contributing to the high hardness and exceptional resistance to fragmentation observed in certain special glasses[1].This study utilized SSNMR to analyze the atomic-scale internal structure of glass,enabling the quantification of the fraction of three-coordinated oxygen([^((3))O]).The research findings demonstrate a quantitative relationship between[^((3))O]and the resistance of glass to crack initiation.

关键词： crack resistance glass

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Enhanced conductivity and weakened magnetism in Pb-doped Sr2IrO4

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Chinese Physics B 2024年第1期33卷 696-701页

作者：岳智来甄伟立牛瑞焦珂珂朱文卡皮雳张昌锦 high magnetic field laboratory Hefei Institutes of Physical ScienceChinese Academy of Sciences Science Island Branch of Graduate School University of Science and Technology of China Collaborative Innovation Center of Advanced Microstructures Nanjing University

Group IV element Pb has been selected as the dopant to dope at the Sr site of Sr2IrO4. It is exciting to find that the single-phase crystal structure could be maintained with a high Pb doping level of up to x=0.3 in Sr2-xPbxIrO4. The mapping data obtained from energy-dispersive x-ray spectroscopy analyses give solid evidence that the Pb ions are uniformly distributed in the Sr2IrO4matrix. The incorporation of Pb leads to a moderate depression of the canted antiferromagnetic ordering state. The electrical conductivity could be greatly enhanced when the Pb doping content is higher than x=0.2.The present results give a fresh material base to explore new physics in doped Sr2IrO4systems.

关键词： conductivity doping iridates magnetism

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Pressure-induced magnetic phase and structural transition in SmSb2

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Chinese Physics B 2024年第6期33卷 484-489页

作者：李涛王舒阳陈绪亮陈春华房勇杨昭荣 Science Island Branch of Graduate School University of Science and Technology of China Anhui key laboratory of Low-Energy Quantum Materials and Devices High Magnetic Field LaboratoryHFIPS Chinese Academy of Sciences Jiangsu laboratory of Advanced Functional Materials Department of Physics Changshu Institute of Technology Institutes of physical Science and Information Technology Anhui University Collaborative Innovation Center of Advanced Microstructures

Motivated by the recent discovery of unconventional superconductivity around a magnetic quantum critical point in pressurized CeSb2,here we present a high-pressure study of an isostructural antiferromagnetic（AFM） SmSb2through electrical transport and synchrotron x-ray diffraction measurements.At PC～2.5 GPa,we found a pressure-induced magnetic phase transition accompanied by a Cmca→P4/nmm structural phase transition.In the pristine AFM phase below PC,the AFM transition temperature of SmSb2is insensitive to pressure;in the emergent magnetic phase above PC,however,the magnetic critical temperature increases rapidly with increasing pressure.In addition,at ambient pressure,the magnetoresistivity（MR） of SmSb2increases suddenly upon cooling below the AFM transition temperature and presents linear nonsaturating behavior under high field at 2 K.With increasing pressure above PC,the MR behavior remains similar to that observed at ambient pressure,both in terms of temperature-and field-dependent MR.This leads us to argue an AFM-like state for SmSb2above PC.Within the investigated pressure of up to 45.3 GPa and the temperature of down to 1.8 K,we found no signature of superconductivity in SmSb2.

关键词： antiferromagnet high pressure magnetoresistivity structural transition

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Revisit of the anisotropic vortex states of 2H-NbSe_(2) towards the zero-field limit

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Chinese Physics B 2024年第6期33卷 80-86页

作者：张凡侯兴元姜宇轩张宗源涂玉兵朱相德陈根富单磊 Beijing National laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of physical Sciences University of Chinese Academy of SciencesBeijing 100190China Center of Free Electron Laser and high magnetic field Anhui UniversityHefei 230601China Information Materials and Intelligent Sensing laboratory of Anhui Province Institutes of Physical Science and Information TechnologyAnhui UniversityHefei 230601China key laboratory of Structure and Functional Regulation of Hybrid Materials in Anhui University Ministry of EducationHefei 230601China School of Physics and Materials Science Anhui UniversityHefei 230601China Anhui key laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryHFIPSAnhuiChinese Academy of Sciencesand University of Science and Technology of ChinaHefei 230031China Hefei National laboratory Hefei 230088China

We revisited the vortex states of 2H-NbSe_(2) towards zero fields by a low-temperature scanning tunneling microscope.Fine structures of the anisotropic vortex states were distinguished, one is a spatially non-splitting zero bias peak, and the other is an in-gap conductance anomaly resembling evolved crossing features around the center of the three nearest vortices.Both of them distribute solely along the next nearest neighboring direction of the vortex lattice and become unresolved in much higher magnetic fields, implying an important role played by the vortex–vortex interactions. To clarify these issues,we have studied the intrinsic vortex states of the isolated trapped vortex in zero fields at 0.45 K. It is concluded that the anisotropic zero bias peak is attributed to the superconducting gap anisotropy, and the spatially evolved crossing features are related to the vortex–vortex interaction. The vortex core size under the zero-field limit is determined. These results provide a paradigm for studying the inherent vortex states of type-II superconductors especially based on an isolated vortex.

关键词： vortex states zero-bias conductance peak scanning tunneling microscopy

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Scalable synthesis of lipid nanoparticles for nucleic acid drug delivery using an isometric channel-size enlarging strategy

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Nano Research 2024年第4期17卷 2899-2907页

作者： Zesen Ma Haiyang Tong Sijin Lin Li Zhou Demeng Sun Baoqing Li Changlin Tian Jiaru Chu Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230027China key laboratory of Precision Scientific Instrumentation of Anhui higher Education Institutes University of Science and Technology of ChinaHefei 230027China Science Island Branch Graduate SchoolUniversity of Science and Technology of ChinaHefei 230026China Anhui Provincial key laboratory of high field magnetic Resonance Imaging High Magnetic Field LaboratoryHefei Institute of Physical ScienceChinese Academy of SciencesHefei 230031China Anhui Provincial Engineering laboratory of Peptide Drugs University of Science and Technology of ChinaHefei 230027China School of Biomedical Engineering Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaSuzhou 215127China

Lipid nanoparticles(LNPs)have emerged as highly effective delivery systems for nucleic acid-based therapeutics.However,the broad clinical translation of LNP-based drugs is hampered by the lack of robust and scalable synthesis techniques that can consistently produce formulations from early development to clinical application.In this work,we proposed a method to achieve scalable synthesis of LNPs by scaling inertial microfluidic mixers isometrically in three dimensions.Moreover,a theoretical predictive method,which controls the mixing time to be equal across different chips,is developed to ensure consistent particle size and size distribution of the synthesized LNPs.LNPs loaded with small interfering RNA(siRNA)were synthesized at different flow rates,exhibiting consistent physical properties,including particle size,size distribution and encapsulation efficiency.This work provides a practical approach for scalable synthesis of LNPs consistently,offering the potential to accelerate the transition of nucleic acid drug development into clinical application.

关键词： lipid nanoparticles nucleic acid delivery microfluidics scalable synthesis consistent particle size

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Screening-current-induced magnetic fields and strains in a compact REBCO coil in self field and background field

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Superconductivity 2024年第1期9卷 35-49页

作者： Yufan Yan Donghui Jiang Peng Song Jeonghwan Park Seungyong Hahn Yunfei Tan Timing Qu Department of Electrical and Computer Engineering Seoul National UniversitySeoul 08826Republic of Korea State key laboratory of Clean and Efficient Turbomachinery Power Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China high magnetic field laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Wuhan National high magnetic field Center Huazhong University of Science and TechnologyWuhan 430074China

REBa_(2)Cu_(3)O_(7−x)(REBCO)coated conductors,owing to its high tensile strength and current‐carrying ability in a background field,are widely regarded a promising candidate in high‐field applications.Despite the great potentials,recent studies have highlighted the challenges posed by screening currents,which are featured by a highly nonuniform current distribution in the superconducting layer.In this paper,we report a comprehensive study on the behaviors of screening currents in a compact REBCO coil,specifically the screeningcurrent‐induced magnetic fields and strains.Experiments were carried out in the self‐generated magnetic field and a background field,respectively.In the self‐field condition,the full hysteresis of the magnetic field was obtained by applying current sweeps with repeatedly reversed polarity,as the nominal center field reached 9.17 T with a maximum peak current of 350 A.In a background field of 23.15 T,the insert coil generated a center field of 4.17 T with an applied current of 170 A.Ultimately,a total center field of 32.58 T was achieved before quench.Both the sequential model and the coupled model considering the perpendicular field modification due to conductor deformation are applied.The comparative study shows that,for this coil,the electromagnetic–mechanical coupling plays a trivial role in self‐field conditions up to 9 T.In contrast,with a high axial field dominated by the background field,the coupling effect has a stronger influence on the predicted current and strain distributions.Further discussions regarding the role of background field on the strains in the insert suggest potential design strategies to maximize the total center field.

关键词： Electromagnetic-mechanical analysis high‐field insert coil REBCO coated conductor Screening‐current‐induced magnetic field Screening‐current‐induced stress

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General synthesis of transition metal nitride arrays by ultrafast flash Joule heating within 500 ms

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Science China Chemistry 2024年第6期67卷 1976-1982页

作者： Peiqi Shen Jiahui Zhao Yanan Gao Yunxiang Lin Yuchen Han Kun Xu School of Chemistry and Chemical Engineering Key Laboratory of Functional Inorganic Material Chemistry of Anhui ProvinceAnhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized MaterialsKey Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationAnhui UniversityHefei230601China Institutes of physical Science and Information Technology Center of Free Electron Laser&High Magnetic FieldLeibniz International Joint Research Center of Materials Sciences of Anhui ProvinceAnhui UniversityHefei230601China

Transition metal nitrides(TMNs)are considered as viable alternatives to noble metal catalysts owing to their versatile electronic structure and favorable catalytic performance.However,the conventional synthetic processes for TMNs suffer from high energy consumption and low production yield.In this study,a range of TMNs and their hetero-composite arrays were successfully synthesized via an ultrafast flash Joule heating technology within 0.5 s.As a proof concept,the nitrides and hetero-composites were applied for the electrocatalytic hydrazine oxidation reaction(HzOR),in which the Co_(4)N/Mo_(16)N_(7)arrays shows the best performance with a geometric current density of 100 mA cm^(-2)at 23 mV(vs.reversible hydrogen electrode(RHE)).This work paves a new way for the ultrafast synthesis of TMNs which could meet the ever-increased energy crisis.

关键词： flash Joule heating rapid synthesis transition metal nitrides hydrazine oxidation reaction electrocatalysts

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Crystalline-amorphization-recrystallization structural transition and emergent superconductivity in van der Waals semiconductor SiP under compression

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 115-122页

作者： Chunhua Chen Zhenyu Ding Yonghui Zhou Yifang Yuan Nixian Qian Jing Wang Shuyang Wang Ying Zhou Chao An Min Zhang Xuliang Chen Xiaoping Yang Mingliang Tian Zhaorong Yang Anhui key laboratory of Low-Energy Quantum Materials and Devices High Magnetic Field LaboratoryHFIPSChinese Academy of SciencesHefei 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefei 230026China key laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityHefei 230601China Institutes of physical Science and Information Technology Anhui UniversityZhengzhou 450001China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

van der Waals(vdW)semiconductors have gained significant attention due to their unique physical properties and promising applications,which are embedded within distinct crystallographic symmetries.Here,we report a pressure-induced crystallineamorphization-recrystallization transition under compression in binary vdW semiconductor SiP.Upon compression to 52 GPa,bulk SiP undergoes a consecutive phase transition from pristine crystalline to amorphous phase,ultimately to recrystallized phase.By employing synchrotron X-ray diffraction experiments in conjunction with high-pressure crystal structure searching techniques,we reveal that the recrystallized Si P hosts a tetragonal structure(space group I4mm)and further transforms partially into a cubic phase(space group Fm3m).Consistently,electrical transport and alternating-current magnetic susceptibility measurements indicate the presence of three superconducting phases,which are embedded in separate crystallographic symmetries—the amorphous,tetragonal,and cubic structures.Furthermore,a high superconducting transition temperature of 12.3 K is observed in its recovered tetragonal phase during decompression.Our findings uncover a novel phase evolution path and elucidate a pressure-engineered structure-property relationship in vdW semiconductor SiP.These results not only offer a new platform to explore the transformation between different structures and functionalities,but also provide new opportunities for the design and exploration of advanced devices based on vdW materials.

关键词： recrystallization transition amorphous

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Absence of metallicity and bias-dependent resistivity in low-carrier-density EuCd_(2)As_(2)

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 119-125页

作者： Yuxiang Wang Jianwen Ma Jian Yuan Wenbin Wu Yong Zhang Yicheng Mou Jiaming Gu Peihong Cheng Wu Shi Xiang Yuan Jinglei Zhang Yanfeng Guo Cheng Zhang State key laboratory of Surface Physics and Institute for Nanoelectronic Devices and Quantum Computing Fudan UniversityShanghai 200433China School of physical Science and Technology ShanghaiTech UniversityShanghai 201210China State key laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China Anhui Province key laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory of the Chinese Academy of SciencesHefei 230031China School of Physics and Electronic Science East China Normal UniversityShanghai 200241China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China ShanghaiTech laboratory for Topological Physics Shanghai 201210China

EuCd_(2)As_(2)was theoretically predicted to be a minimal model of Weyl semimetals with a single pair of Weyl points in the ferromagnet state.However,the heavily p-doped Eu Cd_(2)As_(2)crystals in previous experiments prevent direct identification of the semimetal hypothesis.Here,we present a comprehensive magneto-transport study of high-quality Eu Cd_(2)As_(2)crystals with ultralow bulk carrier density(10^(13)cm^(-3)).In contrast to the general expectation of a Weyl semimetal phase,Eu Cd_(2)As_(2)shows insulating behavior in both antiferromagnetic and ferromagnetic states as well as surface-dominated conduction from band bending.Moreover,the application of a dc bias current can dramatically modulate the resistance by over one order of magnitude,and induce a periodic resistance oscillation due to the geometric resonance.Such nonlinear transport results from the high nonequilibrium state induced by an electrical field near the band edge.Our results suggest an insulating phase in Eu Cd_(2)As_(2)and put a strong constraint on the underlying mechanism of anomalous transport properties in this system.

关键词： magnetic Weyl semimetal quantum transport Hall effect nonlinear resistivity

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