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Fast Blood Oxygenation through Hemocompatible Asymmetric Polymer of Intrinsic Microporosity Membranes

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Research 2024年第1期2023卷 261-270页

作者： Xinxi Huang Junping Huang Pengcheng Su Wanbin Li guangdong key laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou 511443China

Membrane technology has attracted considerable attention for chemical and medical applications,among *** organs play important roles in medical science.A membrane oxygenator,also known as artificial lung,can replenish O_(2) and remove CO_(2) of blood to maintain the metabolism of patients with cardiopulmonary ***,the membrane,a key component,is subjected to inferior gas transport property,leakage propensity,and insufficient *** this study,we report efficient blood oxygenation by using an asymmetric nanoporous membrane that is fabricated using the classic nonsolvent-induced phase separation method for polymer of intrinsic *** intrinsic superhydrophobic nanopores and asymmetric configuration endow the membrane with water impermeability and gas ultrapermeability,up to 3,500 and 1,100 gas permeation units for CO_(2) and O_(2),***,the rational hydrophobic–hydrophilic nature,electronegativity,and smoothness of the surface enable the substantially restricted protein adsorption,platelet adhesion and activation,hemolysis,and thrombosis for the ***,during blood oxygenation,the asymmetric nanoporous membrane shows no thrombus formation and plasma leakage and exhibits fast O_(2) and CO_(2) transport processes with exchange rates of 20 to 60 and 100 to 350 ml m^(−2) min^(−1),respectively,which are 2 to 6 times higher than those of conventional *** concepts reported here offer an alternative route to fabricate high-performance membranes and expand the possibilities of nanoporous materials for membrane-based artificial organs.

关键词： porosity asymmetric Oxygen

Investigation of Maxima Assumptions in Modelling Tropical Cyclone- Induced Hazards in the South China Sea

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China Ocean Engineering 2024年第3期38卷 491-504页

作者： WEN Ze-guo WANG Fu-ming WAN Jing YANG Fan School of Civil Engineering Sun Yat-sen University&Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China guangdong Academy of Safety Science and Technology Guangzhou 510060China guangdong key laboratory of Oceanic Civil Engineering Guangzhou 510275China Advanced Energy Science and Technology guangdong laboratory(Yangjiang Offshore Wind Energy laboratory) Yangjiang 529500China

The present study aims to examine the suitability of two commonly used assumptions that simplify modelling metoceanconditions for designing offshore wind turbines in the South China Sea (SCS). The first assumption assumes thatjoint N-year extreme wind and wave events can be independently estimated and subsequently combined. The secondone assumes peak wind and waves can be modelled as occurring simultaneously during a tropical cyclone (TC) *** better understand the potential TC activity, a set of 10000 years synthetic TC events are generated. The wind fieldmodel and the Mike 21 spectral wave model are employed to model the TC-induced hazards. Subsequently, theeffect of the assumptions is evaluated by analyzing the peak structural response of both monopile and semisubmersibleoffshore wind turbines during TC events. The results demonstrate that the examined assumptions are generally *** assessing the implications of these assumptions, valuable insights are obtained, which can inform andimprove the modelling of TC-induced hazards in the SCS region.

关键词： tropical cyclone numerical wave modelling hazards offshore wind turbines structural response

Brain Transcriptome Analysis Reveals Metabolic Changes Adapting to Hyperhaline or Hypohaline Environments in Spotted Scat(Scatophagus argus)

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Journal of Ocean University of China 2024年第3期23卷 755-765页

作者： LIN Ting ZHAI Yi TIAN Changxu JIANG Dongneng SHI Hongjuan JIANG Mouyan LI Guangli DENG Siping Fisheries College Guangdong Ocean UniversityZhanjiang 524088China guangdong Research Center on Reproductive Control and Breeding Technology of Indigenous Valuable Fish Species Zhanjiang 524088China guangdong Provincial key laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic animals Zhanjiang 524088China

The fish brain is crucial for adjusting to environmental *** changes play a vital role in the adaptation to salinity change in aquatic ***,few studies have evaluated the responses of the fish brain to salinity *** evaluate the response to various salinities,spotted scat(Scatophagus argus)was cultured in water with salinity levels of 5(low salinity:LS),25(control group:Ctrl),and 35(high salinity group:HS)for 22 *** brain transcriptome was *** total,1698 differentially expressed genes(DEGs)were identified between the HS and Ctrl groups,and 841 DEGs were identified between the LS and Ctrl *** analysis showed that the DEGs in the HS *** comparison were involved in steroid biosynthesis,terpenoid backbone biosynthesis,fatty acid biosynthesis,ascorbate and aldarate metabolism,other types of O-glycan biosynthesis,and fatty acid *** and dicarboxylate metabolism,one carbon pool by folate,steroid biosynthesis,and cysteine and methionine metabolism were significantly enriched in the LS *** ***,the genes related to metabolism(acc,fas,hmgcr,hmgcs1,mvd,soat1,nsdhl,sqle,cel,fdft1,dnmt3a and mtr)were significantly up-regulated in the HS *** *** genes related to metabolism(lipa,sqle,acc,fas,bhmt,mpst,dnmt3a,mtr,hao2,LOC111225351 and hmgcs1)were significantly up-regulated,while hmgcr and soat1 were significantly down-regulated in the LS *** *** results suggest that salinity stress affects signaling pathways and genes’expressions involved in metabolic processes in the brain,and the differences in metabolism play an important role in adaptation to hyperhaline or hypohaline environments in spotted *** research provides a comprehensive overview of transcriptional changes in the brain under hyperhaline or hypohaline conditions,which is helpful to understand the mechanisms underlying salinity adaptation in euryhaline fishes.

关键词： Scatophagus argus brain salinity transcriptome analysis

Volatiles in the mantle transition zone and their effects on big mantle wedge systems

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National Science Review 2024年第6期11卷 15-18页

作者： Yu Wang Yi-Gang Xu State key laboratory of Isotope Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Southern Marine Science and Engineering guangdong laboratory (Guangzhou)

The mantle transition zone (MTZ), located between the upper and lower mantle, is characterized by sudden seismicvelocity discontinuities at depths of 410 and 660 km where significant change in mineralogical composition occurs. As a link between the upper and lower mantle,the MTZ is a layer of special significance in Earth’s deep structure, and a critical interface in geodynamics and material circulation.

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Mode-dependent dynamic gain of all-fiber FM-EDFA under various pump manipulation

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Chinese Optics Letters 2024年第2期22卷 128-134页

作者：方翼鸿张心怡黄锡恒曾研许鸥李建平付松年秦玉文 Institute of Advanced Photonics Technology School of Information EngineeringGuangdong University of TechnologyGuangzhou 510006China guangdong Provincial key laboratory of Information Photonics Technology Guangdong University of TechnologyGuangzhou 510006China key laboratory of Photonic Technology for Integrated Sensing and Communication Ministry of EducationGuangdong University of TechnologyGuangzhou 510006China

The dynamic gain of a few-mode erbium-doped fiber amplifier(FM-EDFA)is vital for the long-haul mode division multiplexing(MDM)***,we investigate the mode-dependent dynamic gain of an FM-EDFA under various manipulations of the pump ***,we numerically calculate the gain variation with respect to the input signal power,where a modedependent saturation input power occurs under different pump *** under the fixed intensity profile of the pump laser,the saturation input power of each spatial mode is ***,high-order mode pumping leads to a compression of the linear amplification region,even though it is beneficial for the mitigation of the differential modal gain(DMG)arising in all guided ***,we develop an all-fiber 3-mode EDFA,where the fundamental mode of the pump laser can be efficiently converted to the LP_(11)mode using the all-fiber mode-selective coupler(MSC).In comparison with the traditional LP_(01)pumping scheme,the DMG at 1550 nm can be mitigated from 1.61 dB to 0.97 dB under the LP_(11)mode pumping,while both an average gain of 19.93 dB and a DMG of less than 1 dB can be achieved from 1530 nm to 1560 ***,the corresponding signal input saturation powers are reduced by 0.3 dB for the LP_(01)mode and 1.6 dB for the LP_(11)mode,*** theoretical and experimental results indicate that a trade-off occurs between the DMG mitigation and the extension of the linear amplification range when the intensity profile of pump laser is manipulated.

关键词： few-mode erbium-doped fiber amplifier differential modal gain saturation input power

Enhanced bioethanol production from sugarcane bagasse:combination of liquid hot water and deep eutectic solvent pretreatment for optimized enzymatic saccharification

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Frontiers of Chemical Science and Engineering 2024年第8期18卷 1-13页

作者： Xiaoling Xian Biying Li Shiyong Feng Jiale Huang Xinyuan Fu Ting Wu Xiaoqing Lin School of Chemical Engineering and Light Industry Guangdong Provincial Key Laboratory of Plant Resources BiorefineryGuangdong University of TechnologyGuangzhou 510006China

In the present study,a sustainable pretreatment methodology combining liquid hot water and deep eutectic solvent is proposed for the efficient fractionation of hemicellulose,cellulose,and lignin from sugarcane bagasse,thereby facilitating the comprehensive utilization of both C5 and C6 *** application of this combined pretreatment strategy to sugarcane bagasse led to notable enhancements in enzymatic saccharification and subsequent *** results demonstrate that liquid hot water-deep eutectic solvent pretreatment yielded 85.05±0.66 g·L^(-1)of total fermentable sugar(glucose:60.96±0.21 g·L^(-1),xylose:24.09±0.87 g·L^(-1))through enzymatic saccharification of sugarcane ***,fermentation of the pretreated sugarcane bagasse hydrolysate yielded 34.33±3.15 g·L^(-1)of *** findings confirm the effectiveness of liquid hot water-deep eutectic solvent pretreatment in separating lignocellulosic components,thus presenting a sustainable and promising pretreatment method for maximizing the valuable utilization of biomass resources.

关键词： sugar cane bagasse synergistic pretreatment enzymatic saccharification ethanol

J-family genes redundantly regulate flowering time and increase yield in soybean

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The Crop Journal 2024年第3期12卷 944-949页

作者： Haiyang Li Zheng Chen Fan Wang Hongli Xiang Shuangrong Liu Chuanjie Gou Chao Fang Liyu Chen Tiantian Bu Fanjiang Kong Xiaohui Zhao Baohui Liu Xiaoya Lin guangdong key laboratory of Plant Adaptation and Molecular Design/Guangzhou key laboratory of Crop Gene Editing/Innovative Center of Molecular Genetics and Evolution School of Life SciencesGuangzhou UniversityGuangzhou 510006GuangdongChina

Soybean(Glycine max)is a short-day crop whose flowering time is regulated by *** longjuvenile trait extends its vegetative phase and increases yield under short-day *** variation in J,the major locus controlling this trait,modulates flowering *** report that the three J-family genes influence soybean flowering time,with the triple mutant Guangzhou Mammoth-2 flowering late under short days by inhibiting transcription of E1-family genes.J-family genes offer promising allelic combinations for breeding.

关键词： Soybean Flowering time Yield J-family genes

Arbuscular mycorrhizal fungi inoculation and exogenous indole-3-acetic acid application induce antioxidant defense response to alleviate cadmium toxicity in Broussonetia papyrifera

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Pedosphere 2024年第2期34卷 447-459页

作者： Xue LI Jingwei LIANG Hongjian WEI Yuxuan KUANG Hui CHEN Ming TANG Wentao HU State key laboratory of Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory for Lingnan Modern AgricultureGuangdong Key Laboratory for Innovative Development and Utilization of Forest Plant GermplasmCollege of Forestry and Landscape ArchitectureSouth China Agricultural UniversityGuangzhou 510642China

Cadmium(Cd)contamination in soil poses a huge threat to plants even at low concentrations;Broussonetia papyrifera has great potential in remediation of soil heavy metal ***,whether exogenous indole-3-acetic acid(IAA)application and arbuscular mycorrhizal fungi(AMF)have synergistic effects on Cd tolerance of *** remains *** investigate the effects of AMF inoculation and IAA application on the tolerance of *** to Cd stress,two experiments were conducted:the first to investigate the effect of AMF(Rhizophagus irregularis)inoculation on the tolerance of *** to Cd stress and the second to investigate the combined effects of AMF inoculation and IAA application on the tolerance of *** to Cd *** including endogenous hormone concentration,antioxidant defense response,malondialdehyde(MDA)content,and gene expression related to antioxidant enzyme system and hormone were *** results indicated that AMF alleviated Cd toxicity of *** by reducing MDA content and improving antioxidant enzyme activities and Cd absorption ***,the combination of AMF inoculation and IAA application had a synergetic effect on the tolerance of *** to Cd stress through upregulating BpAUX1 and BpAUX2,which might contribute to root growth and root xylem synthesis,and by upregulating BpSOD2 and BpPOD34 to enhance the antioxidant enzyme *** work provides a new insight into the application of IAA in the remediation of soil Cd pollution by mycorrhizal plants.

关键词： enzyme activity geneexpression heavy metal phytoremediation remediation Rhizophagus irregularis soil cadmium pollution stress tolerance

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3467-3482页

作者： Zhan-Li Chen Chen Xie Wei Zeng Rui-Qi Huang Jin-E Yang Jin-Yu Liu Ya-Jing Chen Shi-Mei Zhuang MOE key laboratory of Gene Function and Regulation Guangdong Province Key Laboratory of Pharmaceutical Functional GenesSchool of Life SciencesState Key Laboratory of Oncology in Southern ChinaSun Yat-sen UniversityGuangzhouPR China key laboratory of Liver Disease of guangdong Province The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630PR China

Mitotic catastrophe(MC),which occurs under dysregulated mitosis,represents a fascinating tactic to specifically eradicate tumor *** pyroptosis can be a death form of MC remains ***-mediated protein degradation is crucial for ***(BTZ),which inhibits the 20S catalytic particle of proteasome,is approved to treat multiple myeloma and mantle cell lymphoma,but not solid tumors due to primary *** date,whether and how proteasome inhibitor affected the fates of cells in M-phase remains ***,we show that BTZ treatment,or silencing of PSMC5,a subunit of 19S regulatory particle of proteasome,causes G2-and M-phase arrest,multi-polar spindle formation,and consequent caspase-3/GSDME-mediated pyroptosis in M-phase(designated as mitotic pyroptosis).Further investigations reveal that inhibitor of WEE1/PKMYT1(PD0166285),but not inhibitor of ATR,CHK1 or CHK2,abrogates the BTZ-induced G2-phase arrest,thus exacerbates the BTZ-induced mitotic arrest and *** BTZ and PD0166285 treatment(named BP-Combo)selectively kills various types of solid tumor cells,and significantly lessens the IC50 of both BTZ and PD0166285 compared to BTZ or PD0166285 *** using various mouse models show that BP-Combo has much stronger inhibition on tumor growth and metastasis than BTZ or PD0166285 monotreatment,and no obvious toxicity is observed in BP-Combo-treated *** findings disclose the effect of proteasome inhibitors in inducing pyroptosis in M-phase,characterize pyroptosis as a new death form of mitotic catastrophe,and identify dual inhibition of proteasome and WEE family kinases as a promising anti-cancer strategy to selectively kill solid tumor cells.

关键词： proteasome inhibiting catastrophe