检索结果-南通市图书馆

Nrf2-mediated ferroptosis of spermatogenic cells involved in male reproductive toxicity induced by polystyrene nanoplastics in mice

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 307-323页

作者： Xufeng FU Hang HAN Hong YANG Bo XU Wenjie DAI Ling LIU Tiantian HE Xing DU Xiuying PEI Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education School of Basic Medical SciencesNingxia Medical UniversityYinchuan 750004China key laboratory of Reproduction and Genetics in Ningxia Ningxia Medical UniversityYinchuan 750004China

Microplastics(MPs)and nanoplastics(NPs)have become hazardous materials due to the massive amount of plastic waste and disposable masks,but their specific health effects remain uncertain.In this study,fluorescence-labeled polystyrene NPs(PS-NPs)were injected into the circulatory systems of mice to determine the distribution and potential toxic effects of NPs in vivo.Interestingly,whole-body imaging found that PS-NPs accumulated in the testes of mice.Therefore,the toxic effects of PS-NPs on the reproduction systems and the spermatocytes cell line of male mice,and their mechanisms,were investigated.After oral exposure to PS-NPs,their spermatogenesis was affected and the spermatogenic cells were damaged.The spermatocyte cell line GC-2 was exposed to PS-NPs and analyzed using RNA sequencing(RNA-seq)to determine the toxic mechanisms;a ferroptosis pathway was found after PS-NP exposure.The phenomena and indicators of ferroptosis were then determined and verified by ferroptosis inhibitor ferrostatin-1(Fer-1),and it was also found that nuclear factor erythroid 2-related factor 2(Nrf2)played an important role in spermatogenic cell ferroptosis induced by PS-NPs.Finally,it was confirmed in vivo that this mechanism of Nrf2 played a protective role in PS-NPs-induced male reproductive toxicity.This study demonstrated that PS-NPs induce male reproductive dysfunction in mice by causing spermatogenic cell ferroptosis dependent on Nrf2.

关键词： Polvstyrene nanoplastics(PS-NPs) Reproductive toxicity Ferroptosis Nuclear factor ervthroid 2-related factor 2(Nrf2)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第4期23卷 286-299页

作者： Xing DU Jingjing ZHANG Ling LIU Bo XU Hang HAN Wenjie DAI Xiuying PEI Xufeng FU Shaozhang HOU Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education School of Basic Medical SciencesNingxia Medical UniversityYinchuan 750004China Department of Clinical Pathology School of Basic Medical SciencesNingxia Medical UniversityYinchuan 750004China

Breast cancer is one of the most malignant tumors and is associated with high mortality rates among women.Lycium barbarum polysaccharide(LBP)is an extract from the fruits of the traditional Chinese herb,L.barbarum.LBP is a promising anticancer drug,due to its high activity and low toxicity.Although it has anticancer properties,its mechanisms of action have not been fully established.Ferroptosis,which is a novel anticancer strategy,is a cell death mechanism that relies on iron-dependent lipid reactive oxygen species(ROS)accumulation.In this study,human breast cancer cells(Michigan Cancer Foundation-7(MCF-7)and MD Anderson-Metastatic Breast-231(MDA-MB-231))were treated with LBP.LBP inhibited their viability and proliferation in association with high levels of ferroptosis.Therefore,we aimed to ascertain whether LBP reduced cell viability through ferroptosis.We found that the structure and function of mitochondria,lipid peroxidation,and expression of solute carrier family 7 member 11(SLC7 A11,also known as x CT,the light-chain subunit of cystine/glutamate antiporter system X_(c)^(-))and glutathione peroxidase 4(GPX4)were altered by LBP.Moreover,the ferroptosis inhibitor,Ferrostatin-1(Fer-1),rescued LBP-induced ferroptosis-associated events including reduced cell viability and glutathione(GSH)production,accumulation of intracellular free divalent iron ions and malondialdehyde(MDA),and down-regulation of the expression of x CT and GPX4.Erastin(x CT inhibitor)and RSL3(GPX4 inhibitor)inhibited the expression of x CT and GPX4,respectively,which was lower after the co-treatment of LBP with Erastin and RSL3.These results suggest that LBP effectively prevents breast cancer cell proliferation and promotes ferroptosis via the x CT/GPX4 pathway.Therefore,LBP exhibits novel anticancer properties by triggering ferroptosis,and may be a potential therapeutic option for breast cancer.

关键词： Lycium barbarum polysaccharide Ferroptosis Breast cancer cells xCT Glutathione peroxidase 4(GPX4)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association study of SNPs related finger bone development and digit ratio

Association study of SNPs related finger bone development an...

引用

中国解剖学会2021年年会

作者： Dang Jie Zhang Jing Lu Hong Yang Menyi Luan Pengfei Ma Zhanbin Ma Qian Wang Yanfeng Huo Zhenghao Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical University

Using bioinformatics methods,79 functional SNPs of 44 finger bone development genes potentially related to the formation of digit ratio were selected.In our study, the relationship between 2D:4D and the above SNPs genotyped by using multiple PCR method was evaluated in a Ningxia population (400 men and 408 women).L2D:4D was statistically different among different genotypes of rs3809346 (COL4A2) in whole population and female

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Association between the digit ratio(2D:4D) and body fat distribution in Ningxia population

Association between the digit ratio(2D:4D) and body fat dist...

引用

中国解剖学会2021年年会

作者： Yang Menyi Zhang Jing Ma Zhanbin Dang Jie Lu Hong Luan Pengfei Ma Qian Wang Yanfeng Huo Zhenghao Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical University

Using a bioelectrical impedance method,the body fat distribution characteristics of 808 people (400 males and 408 females) were measured,such as height,weight,body mass index,body fat mass,fat free mass,visceral fat area,soft lean mass,skeletal muscle mass,waist and hip circumference, waist-hip ratio and waist-height ratio.The mean values of 2D:4D and body fat distribution indexes of different genders were compared,

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Comparison analysis of multiple-omics data between female germline stem cells and spermatogonial stem cells

引用

Genes & Diseases 2023年第3期10卷 727-730页

作者： Geng G.Tian Jing Li Ji Wu Renji Hospital Key Laboratory for the Genetics of Developmental&Neuropsychiatric Disorders(Ministry of Education)Bio-X InstitutesSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China Department of Bioinformatics and Biostatistics School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical UniversityYinchuanNingxia 750004China

Female germline stem cells(FGSCs)and spermatogonial stem cells(SSCs)are germline stem cells that transmit the genetic material from generation to generation.Hence,it is essential to understand the similarities and differences between FGSCs and SSCs.In this study,we comprehensively compared the epigenetics of FGSCs and SSCs,including high-order chromatin organization,chromatin histone modification,and transcriptome by analyzing multiple-omics data(Hi-C,ChIP-seq,and RNA-seq).

关键词： SSCs female analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fat distribution characteristics among Hui and Han ethnic of students in Ningxia

Fat distribution characteristics among Hui and Han ethnic of...

引用

中国解剖学会2021年年会

To analyze the body fat distribution characteristics of Hui and Han college students in Ningxia.Using a bioelectrical impedance analyzer connected with computer to determine the body fat distribution of 808 college students (Hui:417,including 197 males and 220 females;Han:391,including 203 males and 188 females) in Ningxia.The differences of the mean values of related indexes of fat distribution between ethnicities and genders were compared.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Sexual difference analysis of finger bone development related SNPs of genes

Sexual difference analysis of finger bone development relate...

引用

中国解剖学会2021年年会

作者： Zhang Jing Yang Menyi Luan Pengfei Ma Qian Wang Yanfeng Ma Zhanbin Dang Jie Lu Hong Huo Zhenghao Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Basic Medical CollegeNingxia Medical University

DAVID,METASCAPE,STRING and other gene databases was used to screen the finger bone development genes that maybe related to the digit ratio;the online genomic SNP database-SNPinfo Web Server was applied to select functional SNPs;79 SNPs of 43 steroid sex hormone genes were genotyped by using multiple PCR method in a healthy Ningxia population (400 men and 408 women).

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Validation of the association between 2D:4D and SNPs of genes identified in GWAS

Validation of the association between 2D:4D and SNPs of gene...

引用

中国解剖学会2021年年会

作者： Ma Zhanbin Zhang Jing Dang Jie Lu Hong Yang Menyi Luan Pengfei Ma Qian Wang Yanfeng Huo Zhenghao Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education/Basic Medical College Ningxia Medical University

At present,11 loci have been identified in 2D:4D related GW AS,including rs4927012 (GLIS1),rs11581730 (EFNA1), rs340600 (LDAH),rs12474669 (OLA1),rs10790969 (FLI1),rs847158 (HOXD11/12),rs77640775 (GLI3),rs2332175 (SMOC1),rs6499762 (SALL1),rs1080014 (TOX3) and rs4799176 (SALL3).In our study,the relationship between 2D:4D and the above SNPs genotyped by using multiple PCR method was evaluated in a Ningxia population (400 men and 408 women).

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The second to fourth digit ratio and depression are correlated in women

The second to fourth digit ratio and depression are correlat...

引用

中国解剖学会2021年年会

作者： Zhang Jing Wang Lu Yang Menyi Ma Zhanbin Dang Jie Huo Zhenghao Lu Hong Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education/Basic Medical College Ningxia Medical University

Depression is a common mental disorder of great sex dimorphism (higher incidence in women).The intrauterine milieu exposure to sex hormones may be results in the increased vulnerability of depression.The second to fou...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Association study of SNPs related sex steroid hormone of genes and digit ratio

Association study of SNPs related sex steroid hormone of gen...

引用

中国解剖学会2021年年会

Using bioinformatics methods,44 functional SNPs of 21 steroid sex hormone genes potentially related to the formation of digit ratio were selected.In our study,the relationship between 2D:4D and the above SNPs genotype...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：