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The effect of pregnancy on paternal skin allograft survival

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Science China(Life Sciences) 2009年第11期52卷 1011-1015页

作者： SHOU ZhangFei1,2,3, XU YiFang2, XIAO HuaYing2, ZHOU Qin2, CAI JieRu2, YANG Yi1, JIANG Hong2, ZHANG WenJie3 & CHEN JiangHua1,2 1 Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China 2 key laboratory of Multi-organ Combined Transplantation, Ministry of Health, Hangzhou 310003, China 3 key laboratory of Xinjiang endemic and ethnic diseases, Ministry of Education, School of Medicine, Shihezi University 832003, China Kidney Disease Center First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China key laboratory of Multi-organ Combined Transplantation Ministry of Health Hangzhou China key laboratory of Xinjiang endemic and ethnic diseases Ministry of Education School of Medicine Shihezi University Shihezi China

Elucidation of maternal-fetal tolerance mechanisms clarifies the role of regulatory T cells (Treg) in transplant tolerance. This study aim to investigate the effect of pregnancy on paternal skin allograft survival. Flow cytometry techniques, mixed lymphocytes reaction (MLR), PCR, real-time PCR and skin transplantation were key methods. Treg increased significantly from 4.2% before pregnancy to peak at 6.8% day 8 after pregnancy. Both heme oxygenase-1 (HO-1) and indoleamine 2,3-dioxygenase (IDO) mRNA express high in placenta while low in spleen (P<0.05). Although Treg increased during pregnancy, and splenocytes from the pregnant mice showed lower MLR response toward the paternal stimulator, single time pregnancy showed no significant protective effect on paternal skin allograft survival in the tested condition.

关键词： regulatory T cells pregnancy maternal-fetal tolerance transplant tolerance survival MLR paternal skin allograft mice

THE EFFECT ON PROTEOGLYCAN METABOLISM OF DEOXYNIVALENOL AND SELENIUM IN THE CULTURED HUMAN FETAL CHONDROCYTES IN VITRO

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Journal of Pharmaceutical Analysis 2005年第2期17卷 57-60页

作者：岳燕曹峻岭李思远谢龙孙健张增铁张富军师钟丽 key laboratory of Environment and Genes Related to diseases Ministry of Education key laboratory of Microelement and endemic Disease Ministry of Health Institute of endemic diseases medical school of Xi'an jiaotong University Xi'an 710061 China

Objective To investigate the effect of deoxynivalenol (DON) and selenium (Se) on the morphology of chondrocytes and the metabolism of cartilage matrix, and the expression of aggrecanase-1, 2 mRNA in monolayer cultured chondrocytes in vitro. Methods To plant human fetal chondrocytes on the BMG, the expression of Aggrecanase-1, 2 mRNA were analyzed by RT-PCR, the immunohistochemistry of NITEGE epitope was quantitativly analyzed by the image collection and analysis system. Results With the increase of the concentration of DON, the damage of cultured chondrocytes was more and more severe; the expression of NITEGE epitope showed an increasing trend and the fluorescent bands of aggrecanase-1, 2 mRNA were more and more obvious. After adding Se, the damage was relieved, and there was a decreasing trend of NITEGE epitope expressed in matrix. Conclusion DON can enhance transcription of aggrecanase gene and increase the expression of NITEGE epitope which eventually lead to the metabolic disorder of cartilage proteoglycan. It suggested that Se can partially alleviate the damage of DON on cartilage, but can not completely prevent the occurrence of these changes.

关键词： kashin-beck disease (KBD) bone matrix gelatin (BMG) deoxynivalenol (DON) selenium(Se) NITEGE epitope aggrecanase

Synthesis of 3-acylindoles via decarboxylative cross-coupling reaction of free(N–H) indoles with α-oxocarboxylic acids

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Chinese Chemical Letters 2014年第1期25卷 90-92页

作者： Li-Jun Gu Ji-Yan Liu Li-Zhu Zhang Yong Xiong Rui Wang key laboratory of Chemistry in ethnic Medicinal Resources State Ethnic Affairs Commission and Ministry of EducationYunnan University of Nationalities

A convenient and general method for acylation of free （N-H） indoles via palladium-catalyzed decarboxylative cross-coupling reaction was developed. This process provided a useful method for the preparation of diverse... 详细信息

关键词： 3-Acylindoles Decarboxylative acylation α-Oxocarboxylic acids

Comparison of T-2 Toxin and HT-2 Toxin Distributed in the Skeletal System with That in Other Tissues of Rats by Acute Toxicity Test

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Biomedical and Environmental Sciences 2017年第11期30卷 851-854页

作者： YU Fang Fang LIN Xia Lu YANG Lei LIU Huan WANG Xi FANG Hua Mikko J.LAMMI GUO Xiong Institute of endemic diseases School of Public Health of Health Science Center Xi'an Jiaotong University Key Laboratory of Trace Elements and Endemic Diseases National Health and Family Planning Commission Department of Integrative Medical Biology University of Ume?

Twelve healthy rats were divided into the T-2 toxin group receiving gavage of 1 mg/kg T-2 toxin and the control group receiving gavage of normal saline. Total relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system（thighbone, knee joints, and costal cartilage） were significantly higher than those in the heart, liver, and kidneys（P 〈 0.05）. The relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system（thighbone and costal cartilage） were also significantly higher than those in the heart, liver, and kidneys. The rats administered T-2 toxin showed rapid metabolism compared with that in rats administered HT-2 toxin, and the metabolic conversion rates in the different tissues were 68.20%-90.70%.

关键词： Comparison of T-2 Toxin HT-2 Toxin Distributed in the Skeletal System That in Other Tissues of Rats by Acute Toxicity Test

Synthesis of Self-assemble pH-responsive Cyclodextrin Block Copolymer for Sustained Anticancer Drug Delivery

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Chinese Journal of Polymer Science 2017年第8期35卷 924-938页

作者： Bei-bei Lu Lu-lu Wei Gui-hua Meng Jun Hou 刘志勇 Xu-hong Guo School of Chemistry & Chemical Engineering Shihezi University/Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region/Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bingtuan Department of Immunology Shihezi University School of Medicine/Department of Pathology and Key Laboratories for Xinjiang Endemic and Ethnic DiseasesShihezi University School of Medicine State key laboratory of Chemical Engineering East China University of Science and Technology

Well-defined pH-responsive poly（e-caprolactone）-graft-β-cyclodextrin-graft-poly（2-（dimethylamino）ethyl- methacrylate）-co-poly（ethylene glycol） methacrylate amphiphilic copolymers （PCL-g-β-CD-g-P（DMAEMA-co-PEGMA）） were synthesized using a combination of atom transfer radical polymerization （ATRP）, ring opening polymerization （ROP） and ＂click＂ chemistry. Successful synthesis of polymers was confirmed by Fourier transform infrared spectroscopy （FTIR）, proton nuclear magnetic resonance （^1H-NMR）, and gel permeation chromatography （GPC）. Then, the polymers could self- assemble into micelles in aqueous solution, which was demonstrated by dynamic light scattering （DLS） and transmission electron microscopy （TEM）. The pH-responsive self-assembly behavior of these copolymers in water was investigated at different pH values of 7.4 and 5.0 for controlled doxorubicin （DOX） release, and these results revealed that the release rate of DOX could be effectively controlled by altering the pH, and the release of drug loading efficiency （DLE） was up to 88% （W/W）. CCK-8 assays showed that the copolymers had low toxicity and possessed good biodegradability and biocompatibility, whereas the DOX-loaded micelles remained with high cytotoxicity for HeLa cells. Moreover, confocal laser scanning microscopy （CLSM） images revealed that polymeric micelles could actively target the tumor site and the efficient intracellular DOX release from polymeric micelles toward the tumor cells further confirmed the anti-tumor effect. The DOX-loaded micelles could easily enter the cells and produce the desired pharmacological action and minimize the side effect of free DOX. These results successfully indicated that pH-responsive polymeric micelles could be potential hydrophobic drug delivery carriers for cancer targeting therapy with sustained release.

关键词： pH-responsive β-Cyclodextrin Self-assembly DOX Controlled release Click chemistry

Role of N4-acetylcytidine for continuously activating NLRP3 inflammosome by HMGB1 pathway in microglia

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Neural Regeneration Research 2021年第7期16卷 1427-1428页

作者： Hua Bai Qifang Zhang Department of Neurology Medical Experimental Centerthe Third Affiliated Hospital of Guizhou Medical UniversityDuyun/Department of NeurologyAffiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina key laboratory of endemic and ethnic diseases Ministry of EducationKey Laboratory of Medical Molecular BiologyGuizhou Medical UniversityGuiyangGuizhou ProvinceChina

N4-acetylcytidine(N4A) is an organic compound and a metabolite of transferrable ribonucleic *** molecular formula is C_(11)H_(15)N_3O_6.

关键词： NLRP3 HMGB1 continuously

Differential Effect of Calcium-Activated Potassium and Chloride Channels on Rat Basilar Artery Vasomotion

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2014年第4期34卷 482-490页

作者：李丽王蕊马克涛李新芝张传林刘卫东赵磊司军强 Department of Physiology Medical College of Shihezi University The key laboratory of Xinjiang endemic and ethnic diseases Medical College of Shihezi University Department of Neurobiology Tongji Medical College Huazhong University of Science and Technology Department of Physiology Wuhan University School of Basic Medical Sciences

Spontaneous, rhythmical contractions, or vasomotion, can be recorded from cerebral vessels under both normal physiological and pathophysiological conditions. We investigated the cellular mechanisms underlying vasomotion in the cerebral basilar artery （BA） of Wistar rats. Pressure myograph video microscopy was used to study the changes in cerebral artery vessel diameter. The main results of this study were as follows：（1） The diameters of BA and middle cerebral artery （MCA） were 314.5±15.7 μm （n=15） and 233.3±10.1 μm （n=12） at 10 mmHg working pressure （P〈0.05）, respectively. Pressure-induced vasomotion occurred in BA （22/28, 78.6%）, but not in MCA （4/31, 12.9%） from 0 to 70 mmHg working pressure. As is typical for vasomotion, the contractile phase of the response was more rapid than the relaxation phase; （2） The frequency of vasomotion response and the diameter were gradually increased in BA from 0 to 70 mmHg working pressure. The amplitude of the rhythmic con- tractions was relatively constant once stable conditions were achieved. The frequency of contractions was variable and the highest value was 16.7±4.7 （n=13） per 10 min at 60 mmHg working pressure; （3） The pressure-induced vasomotion of the isolated BA was attenuated by nifedipine, NFA, 181]-GA, TEA or in Ca2＋-free medium. Nifedipine, NFA, 18^-GA or Ca2＋-free medium not only dampened vasomotion, but also kept BA in relaxation state. In contrasts, TEA kept BA in contraction state. These results sug- gest that the pressure-induced vasomotion of the isolated BA results from an interaction between Ca2＋-activated C1- channels （CaCCs） currents and Kca currents. We hypothesize that vasomotion of BA depends on the depolarizing of the vascular smooth muscle cells （VSMCs） to activate CaCCs. Depolarization in turn activates voltage-dependent Ca2＋ channels, synchronizing contractions of adjacent cells through influx of extracellular calcium and the flow of calcium through gap junctions. Subsequent calcium-induced calcium r

关键词： pressure myograph vasomotion basilar artery calcium-activated ion channels vascular smooth muscle cell gap junction

PREVENTIVE EFFECT OF BORON ON DAMAGE TO CARTILAGE OF RATS WITH INTAKE EXCESSIVE FLUORIDE

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Journal of Pharmaceutical Analysis 2005年第1期17卷 36-39页

作者： Xu, Peng Guo, Xiong Cao, Hui Kang, Longli Du, Xiaoyang Zhang, Zengtie Geng, Dong Institute of endemic diseases Key Laboratory of Environment and Genes Related to Diseases Xi'an Jiaotong University Xi'an 710061 China Institute of endemic diseases Medical College of Xi'an Jiaotong University Xi'an 710061 China

Objective: To investigate and analyze the preventive effect of boron on the cartilage damage in rats with intake excessive fluoride. Methods: Fifty-ix Sprague-Dawley rats were divided into the control group (C, intake distilled water), the excessive fluoride dose group (EF, intake distilled water with 100 ppm F-) and the boron prevention group (P, intake distilled water with 100 ppm F- as well as the supplemental boron dietary). 3 to 5 months later, fluorine contents in serum, RNA contents in costal cartilage were assayed. The morphological changes in tibia growth plate cartilage (GPC) in rats were observed. Results: Although exposed to the same dose of fluoride, the fluorine contents in serum in rats of P group decreased notably compared with those of EF group, the damage of tibia GPC under optical and electron microscope lessened significantly, and RNA contents in costal cartilage increased obviously in the 3rd month. Conclusion: Boron added could decrease the fluorine level in the body and relieve the toxic symptom of excess fluoride, and thus boron has a preventive effect on skeletal fluorosis.

关键词： Boron Cartilage Fluoride Prevention Rat

A kinetic study and factor analysis of solar thermochemical membrane reactors for syngas production

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Science China Technological Sciences 2025年第1期 207-221页

作者： Jiaxin XING Chao XU Xiangyu SUN Xin XIA Fei JIN Qiongqiong JIANG Jiale GAO key laboratory of Power Station Energy Transfer Conversion and System of MOE School of Energy Power and Mechanical EngineeringNorth China Electric Power University Department of Chemistry University College London School of Chemistry and Chemical Engineering Ningxia Key Laboratory of Solar Chemical Conversion TechnologyState Ethnic Affairs CommissionNorth Minzu University

Solar thermochemical conversion technologies are promising for effectively utilizing solar energy by capturing the full spectrum of solar radiation. To overcome the challenges of low energy conversion efficiency and intermittency faced by solar thermochemical conversion, these technologies can be effectively integrated with membrane reactor technology. Although the performance of solar thermochemical membrane reactors has been experimentally tested, the chemical reactions and oxygen transport mechanisms during the energy conversion process remain poorly understood. This study introduces a resistance network model to elucidate the interactions between interfacial reactions and bulk diffusion during simultaneous oxidationreduction reactions on both sides of the membrane. We analyzed the oxygen flux of the membrane reactor under various operating conditions using this model to identify the reaction/transport-limiting side of the overall process. The most effective solar membrane reactor configuration utilizes natural gas and CO2, facilitating clean conversion of fossil fuels with significant advantages in fuel production and energy efficiency. Introducing CH4lowers the overall reaction temperature, maintains low oxygen partial pressure on the sweep side, and produces a synthesis gas with a 2:1 H2/CO molar ratio. Finally, a sensitivity analysis was used to explore the relationship between overall fuel production performance and operational parameters,highlighting the critical role of this research in enhancing the reaction and transport performance of membrane reactors and advancing the development of solar-driven thermochemical fuel production technologies.

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