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Gut microbiota-mediated modulation of lipid metabolism by punicic acid in diet-induced hepatic steatosis

Food Science and Human Wellness 2024年

作者： Liping Chen Yifan Lei Hengqian Lu Yongzhong Wang School of Life Sciences， anhui University anhui key laboratory of modern biomanufacturing key laboratory of Human Microenvironment and Precision Medicine of anhui Higher Education Institutes， anhui University

Pomegranate seed oil (PSO) mainly consisted of punicic acid (PunA)， has gained attention due to rich conjugated linolenic acids and potential application in the improvement of various diseases. The aim of this study was to explore the ability of PunA to modulate lipid metabolism associated with non-alcoholic fatty liver disease (NAFLD) and explore the emerging role of the gut microbiota in modulating hepatic lipid metabolism. In this regard， PunA’s capacity was evaluated through C57BL/6J fed with a choline and L-amino acid defined， high fat diet (CDAHFD). Mice were randomly divided into four groups: NC group， MC group， PSO group and Cur group. Collected results indicated that supplement of PunA improved hepatic lipid profile. PunA administration also ameliorated hepatic steatosis and lipid accumulation. mRNA analysis showed that PunA exerted ameliorative e?ect on hepatic lipid accumulation by downregulating the mRNA expression of Dgat1， Scd-1， Srebp-1c， but increasing expression level of Cpt-1α. Metagenomic analysis discovered that PunA increased species diversity and richness of intestinal microbiota， promoted proliferation of beneficial commensals and restraining the endotoxin-producing microorganisms in cecum of CDAHFD-administrated mice. Furthermore， PunA suppressed lipid accumulation and lipid droplet formation in a cell NAFLD model in vitro. Overall， PunA exhibited anti-lipogenic and lipid-lowering effects， improvement of intestinal flora. In summary， PunA could be a candidate for the exploitation of functional foods or nutraceuticals aiming NAFLD.

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The cluster digging behavior of larvae confers trophic benefits to fitness in insects

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Insect Science 2024年第3期31卷 870-884页

作者： Yujie Wu Qiang Wang Weikang Yang Sheng Zhang Chuan-Xi Mao Nana He Shaojie Zhou Chuanming Zhou Wei Liu School of Plant Protection Anhui Agricultural UniversityAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Province Engineering Laboratory for Green Pesticide Development and ApplicationHefeiChina College of Plant Protection Nanjing Agricultural UniversityNanjingChina School of Teacher Education Nanjng Xiaozhuang UniversityNanjingChina State key laboratory of Biocatalysis and Enzyme engineering Hubei Province Key Laboratory of Biotechnology of Chinese Traditional MedicineNational&Local Joint Engineering Research Center of High-throughput Drug Screening TechnologySchool of Life ScienceHubei UniversityWuhanChina

Collective behaviors efficiently impart benefits to a diversity of species ranging from bacteria to *** larvae tend to cluster and form coordinated digging groups under crowded conditions,yet understanding the rules governing this behavior is in its *** primarily took advantage of the Drosophila model to investigate cooperative foraging ***,we report that Drosophila-related species and the black soldier fly have evolved a conserved strategy of cluster digging in food ***,we investigated relative factors,including larval stage,population density,and food stiffness and quality,that affect the cluster digging ***,oxygen supply through the posterior breathing spiracles is necessary for the organization of digging *** importantly,we theoretically devise a mathematical model to accurately calculate how the cluster digging behavior expands food resources by diving depth,cross-section area,and food *** found that cluster digging behavior approximately increases 2.2 fold depth,1.7-fold cross-section area,and 1.9 fold volume than control groups,*** of food sources significantly facilitates survival,larval development,and reproductive success of Drosophila challenged with competition for limited food resources,thereby conferring trophic benefits to fitness in ***,our findings highlight that the cluster digging behavior is a pivotal behavior for their adaptation to food scarcity,advancing a better understanding of how this cooperative behavior confers fitness benefits in the animal kingdom.

关键词： cluster digging determinant development fecundity larvae mathematical model

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Hybrid Network Model Based on Data Enhancement for Short-term Power Prediction of New PV Plants

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Journal of modern Power Systems and Clean Energy 2024年第1期12卷 77-88页

作者： Shangpeng Zhong Xiaoming Wang Bin Xu Hongbin Wu Ming Ding the anhui province key laboratory of Renewable Energy Utilization and Energy Saving Hefei University of TechnologyHefei 230009China the State Grid anhui Electric Power Research Institute Hefei 230061China

This study proposes a hybrid network model based on data enhancement to address the problem of low accuracy in photovoltaic(PV)power prediction that arises due to insuffi cient data samples for new PV ***,a time-series gener ative adversarial network(TimeGAN)is used to learn the distri bution law of the original PV data samples and the temporal correlations between their features,and these are then used to generate new samples to enhance the training ***,a hybrid network model that fuses bi-directional long-short term memory(BiLSTM)network with attention mechanism(AM)in the framework of deep&cross network(DCN)is con structed to effectively extract deep information from the origi nal features while enhancing the impact of important informa tion on the prediction ***,the hyperparameters in the hybrid network model are optimized using the whale optimi zation algorithm(WOA),which prevents the network model from falling into a local optimum and gives the best prediction *** simulation results show that after data enhance ment by TimeGAN,the hybrid prediction model proposed in this paper can effectively improve the accuracy of short-term PV power prediction and has wide applicability.

关键词： New photovoltaic(PV)plant short-term predic tion time-series generative adversarial network(TimeGAN) hy brid network hyperparameter

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Bioinspired polysaccharide-based nanocomposite membranes with robust wet mechanical properties for guided bone regeneration

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National Science Review 2024年第3期11卷 215-226页

作者： Jian-Hong Xiao Zhen-Bang Zhang JiaHao Li Si-Ming Chen Huai-Ling Gao YinXiu Liao Lu Chen ZiShuo Wang YiFan Lu YuanZhen Hou HengAn Wu DuoHong Zou Shu-Hong Yu Department of Chemistry New Cornerstone Science Laboratory Institute of Biomimetic Materials&Chemistry Anhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Department of Dental Implant Center Stomatologic Hospital and College Key Laboratory of Oral Diseases Research of Anhui Province Anhui Medical University CAS key laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics CAS Center for Excellence in Complex System Mechanics University of Science and Technology of China Department of Oral Surgery College of Stomatology National Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Institute of Innovative Materials(I2M) Department of Chemistry Department of Materials Science and Engineering Southern University of Science and Technology

Polysaccharide-based membranes with excellent mechanical properties are highly desired. However, severe mechanical deterioration under wet conditions limits their biomedical applications. Here, inspired by the structural heterogeneity of strong yet hydrated biological materials, we propose a strategy based on heterogeneous crosslink-and-hydration（HCH） of a molecule/nano dual-scale network to fabricate polysaccharide-based nanocomposites with robust wet mechanical properties. The heterogeneity lies in that the crosslink-and-hydration occurs in the molecule-network while the stress-bearing nanofiber-network remains unaffected. As one demonstration, a membrane assembled by bacterial cellulose nanofiber-network and Ca2+-crosslinked and hydrated sodium alginate molecule-network is designed. Studies show that the crosslinked-and-hydrated molecule-network restricts water invasion and boosts stress transfer of the nanofiber-network by serving as interfibrous bridge. Overall, the molecule-network makes the membrane hydrated and flexible; the nanofiber-network as stress-bearing component provides strength and *** HCH dual-scale network featuring a cooperative effect stimulates the design of advanced biomaterials applied under wet conditions such as guided bone regeneration membranes.

关键词： bioinspiration heterogeneous crosslink-and-hydration dual-scale network nanocomposite membrane wet mechanical properties guided bone regeneration

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Green light mediates atypical photomorphogenesis by dual modulation of Arabidopsis phytochromes B and A

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Journal of Integrative Plant Biology 2024年第9期66卷 1915-1933页

作者： Miqi Xu Yi‐Yuan Wang Yujie Wu Xiuhong Zhou Ziyan Shan Kunying Tao Kaiqiang Qian Xuncheng Wang Jian Li Qingqing Wu Xing Wang Deng Jun‐Jie Ling National engineering laboratory of Crop Stress Resistance Breeding School of Life SciencesAnhui Agricultural UniversityHefei 230036China province key laboratory of Resource Insect Biology and Innovative Utilization School of Life SciencesAnhui Agricultural UniversityHefei 230036China biotechnology Center State Key Laboratory of Tea Plant Biology and UtilizationSchool of Tea and Food Sciences and TechnologyAnhui Agricultural UniversityHefei 230036China Beijing key laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Institute of Plant and Environment ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China College of Life Sciences Nanjing Normal UniversityNanjing 210023China State key laboratory of Protein and Plant Gene Research Peking–Tsinghua Center for Life SciencesSchool of Advanced Agriculture Sciencesand School of Life SciencesPeking UniversityBeijing 100871China State key laboratory of Wheat Improvement Shandong Laboratory of Advanced Agricultural Sciences at WeifangPeking University Institute of Advanced Agricultural SciencesWeifang 261000China

Although green light(GL)is located in the middle of the visible light spectrum and regulates a series of plant developmental processes,the mechanism by which it regulates seedling development is largely *** this study,we demonstrated that GL promotes atypical photomorphogenesis in Arabidopsis thaliana via the dual regulations of phytochrome B(phyB)and *** the Pr-to-Pfr conversion rates of phyB and phyA under GL were lower than those under red light(RL)in a fluence rate-dependent and time-dependent manner,long-term treatment with GL induced high Pfr/Pr ratios of phyB and ***,GL induced the formation of numerous small phyB photobodies in the nucleus,resulting in atypical photomorphogenesis,with smaller cotyledon opening angles and longer hypocotyls in seedlings compared to *** abundance of phyA significantly decreased after short-and long-term GL *** determined that four major PHYTOCHROME-INTERACTING FACTORs(PIFs:PIF1,PIF3,PIF4,and PIF5)act downstream of phyB in GL-mediated cotyledon *** addition,GL plays opposite roles in regulating different *** example,under continuous GL,the protein levels of all PIFs decreased,whereas the transcript levels of PIF4 and PIF5 strongly increased compared with dark *** together,our work provides a detailed molecular framework for understanding the role of the antagonistic regulations of phyB and phyA in GL-mediated atypical photomorphogenesis.

关键词： cotyledon development green light photobody phytochrome PIF3

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Role of 5-hydroxytryptamine type 3 receptors in the regulation of anxiety reactions

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2024年第1期25卷 23-37页

作者： Yinan DU Zhiwei LI Yukui ZHAO Jing HAN Weiping HU Zhiqiang LIU MOE key laboratory of modern Teaching Technology Shaanxi Normal UniversityXi’an710062China

5-Hydroxytryptamine(5-HT)type 3 receptor(5-HT_(3)R)is the only type of ligand-gated ion channel in the 5-HT receptor *** the high permeability of Na+,K+,and Ca2+and activation of subsequent voltage-gated calcium channels(VGCCs),5-HT_(3)R induces a rapid increase of neuronal excitability or the release of neurotransmitters from axon terminals in the central nervous system(CNS).5-HT_(3)Rs are widely expressed in the medial prefrontal cortex(mPFC),amygdala(AMYG),hippocampus(HIP),periaqueductal gray(PAG),and other brain regions closely associated with anxiety *** have a bidirectional regulatory effect on anxiety reactions by acting on different types of cells in different brain regions.5-HT_(3)Rs mediate the activation of the cholecystokinin(CCK)system in the AMYG,and theγ-aminobutyric acid(GABA)“disinhibition”mechanism in the prelimbic area of the mPFC promotes anxiety by the activation of GABAergic intermediate inhibitory neurons(IINs).In contrast,a 5-HT_(3)R-induced GABA“disinhibition”mechanism in the infralimbic area of the mPFC and the ventral HIP produces anxiolytic effects.5-HT_(2)R-mediated regulation of anxiety reactions are also activated by 5-HT_(3)R-activated 5-HT release in the HIP and *** provides a theoretical basis for the treatment of anxiety disorders or the production of anxiolytic drugs by targeting 5-HT_(3)***,given the circuit specific modulation of 5-HT_(3)Rs on emotion,systemic use of 5-HT_(3)R agonism or antagonism alone seems unlikely to remedy anxiety,which deeply hinders the current clinical application of 5-HT_(3)R ***,the exploitation of circuit targeting methods or a combined drug strategy might be a useful developmental approach in the future.

关键词： 5-Hydroxytryptamine type 3 receptor(5-HT_(3)R) Anxiety Medial prefrontal cortex Amygdala Hippocampus Periaqueductal gray

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Electrochemical construction of 2,5-diaryloxazoles via N–H and C(sp_(3))-H functionalization

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Chinese Chemical Letters 2024年第4期35卷 340-345页

作者： Tong Li Leping Pan Yan Zhang Jihu Su Kai Li Kuiliang Li Hu Chen Qi Sun Zhiyong Wang Hefei National Center for Physical Sciences at Microscale Key Laboratory of Precision and Intelligent ChemistrySchool of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China anhui University of Science and Technology Huainan 232001China CAS key laboratory of Microscale Magnetic Resonance Department of Modern PhysicsUniversity of Science and Technology of ChinaHefei 230026China

An efficient N–H and C(sp~3)-H functionalization of aryl ketones with benzylamines/amino acids was developed under mild conditions by virtue of anodic oxidation. A variety of functionalized 2,5-diaryloxazoles were obtained with good to excellent yields. Moreover, some important natural products can be prepared by this method. The reaction features a broad substrate scope, scalability, metal-free and chemical oxidant-free.

关键词： Electrochemical Metal-free Oxazole Oxidant-free

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Comparison-embedded evidence-CNN model for fuzzy assessment of wear severity using multi-dimensional surface images

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Friction 2024年第6期12卷 1098-1118页

作者： Tao SHAO Shuo WANG Qinghua WANG Tonghai WU Zhifu HUANG key laboratory of Education Ministry for modern Design and Rotor-Bearing System Xi’an Jiaotong UniversityXi’an 710049China State key laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China

Wear topography is a significant indicator of tribological behavior for the inspection of machine health *** intelligent in-suit wear assessment method for random topography is here ***-dimension(3D)topography is employed to address the uncertainties in wear ***,3D topography reconstruction from a worn surface is accomplished with photometric stereo vision(PSV).Then,the wear features are identified by a contrastive learning-based extraction network(WSFE-Net)including the relative and temporal prior knowledge of wear ***,the typical wear degrees including mild,moderate,and severe are evaluated by a wear severity assessment network(WSA-Net)for the probability and its associated uncertainty based on subjective *** integrating the evidence information from 2D and 3D-damage surfaces with Dempster–Shafer(D–S)evidence,the uncertainty of severity assessment results is further *** proposed model could constrain the uncertainty below 0.066 in the wear degree evaluation of a continuous wear experiment,which reflects the high credibility of the evaluation result.

关键词： wear severity assessment contrastive learning subjective logic Dempster-Shafer(D-S)evidence theory

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Optimized Mask-RCNN model for particle chain segmentation based on improved online ferrograph sensor

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Friction 2024年第6期12卷 1194-1213页

作者： Shuo WANG Miao WAN Tonghai WU Zichen BAI Kunpeng WANG key laboratory of Education Ministry for modern Design and Rotor-Bearing System Xi’an Jiaotong UniversityXi’an 710049China

Ferrograph-based wear debris analysis(WDA)provides significant information for wear fault analysis of mechanical *** decades of offline application,this conventional technology is being driven by the online ferrograph sensor for real-time wear state ***,online ferrography has been greatly limited by the low imaging quality and segmentation accuracy of particle chains when analyzing degraded lubricant oils in practical *** address this issue,an integrated optimization method is developed that focuses on two aspects:the structural re-design of the online ferrograph sensor and the intelligent segmentation of particle *** enhancing the imaging quality of wear particles,the magnetic pole of the online ferrograph sensor is optimized to enable the imaging system directly observe wear particles without penetrating ***,a light source simulation model is established based on the light intensity distribution theory,and the LED installation parameters are determined for particle illumination uniformity in the online ferrograph *** this basis,a Mask-RCNN-based segmentation model of particle chains is constructed by specifically establishing the region of interest(ROI)generation layer and the ROI align layer for the irregular particle *** these measures,a new online ferrograph sensor is designed to enhance the image acquisition and information extraction of wear *** verification,the developed sensor is tested to collect particle images from different degraded oils,and the images are further handled with the Mask-RCNN-based model for particle feature *** results reveal that the optimized online ferrography can capture clear particle images even in highly-degraded lubricant oils,and the illumination uniformity reaches 90%in its imaging *** importantly,the statistical accuracy of wear particles has been improved from 67.2%to 94.1%.

关键词： wear particle analysis online ferrography particle image acquisition particle chain segmentation

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Functional characterization,structural basis,and protein engineering of a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3746-3759页

作者： Zilong Wang Xueqing Du Guo Ye Haotian Wang Yizhan Liu Chenrui Liu Fudong Li HansÅgren Yang Zhou Junhao Li Chao He De-An Guo Min Ye State key laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China anhui key laboratory of modern biomanufacturing and School of Life Sciences Anhui UniversityHefei 230601China National Science Center for Physical Sciences at Microscale Division of Molecular&Cell Biophysics and School of Life Sciences University of Science and Technology of ChinaHefei 230026China Department of Physics and Astronomy Uppsala UniversityUppsala SE-75120Sweden School of Pharmacy Jinan UniversityGuangzhou 510632China Shanghai Research Center for modernization of Traditional Chinese Medicine Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Glycosylation is an important post-modification reaction in plant secondary metabolism,and contributes to structural diversity of bioactive natural *** plants,glycosylation is usually catalyzed by *** 2′-O-glycosides are rare ***,no UGTs have been reported,thus far,to specifically catalyze 2′-O-glycosylation of *** this work,UGT71AP2 was identified from the medicinal plant Scutellaria baicalensis as the first flavonoid 2′-*** could preferentially transfer a glycosyl moiety to 2′-hydroxy of at least nine flavonoids to yield six new *** of the 2′-O-glycosides showed noticeable inhibitory activities against cyclooxygenase *** crystal structure of UGT71AP2(2.15Å)was solved,and mechanisms of its regio-selectivity was interpreted by pKa calculations,molecular docking,MD simulation,MM/GBSA binding free energy,QM/MM,and hydrogen‒deuterium exchange mass spectrometry *** structure-guided rational design,we obtained the L138T/V179D/M180T mutant with remarkably enhanced regio-selectivity(the ratio of 7-O-glycosylation byproducts decreased from 48%to 4%)and catalytic efficiency of 2′-O-glycosylation(kcat/Km,0.23 L/(s·μmol),12-fold higher than the native).Moreover,UGT71AP2 also possesses moderate UDP-dependent de-glycosylation activity,and is a dual function *** work provides an efficient biocatalyst and sets a good example for protein engineering to optimize enzyme catalytic features through rational design.

关键词： Glycosyltransferase Regio-selectivity Crystal structure De-glycosylation Catalytic mechanisms

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