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Copper homeostasis and neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi Li Kaifei Xu Guoqing Wang Feng Zhang International Research laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo key laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina key laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

Preparation and Characterization of Organic/Inorganic Hybrid Nanofibers

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Journal of Donghua University(English Edition) 2006年第5期23卷 20-23页

作者：吴宁魏取福李琪徐文正 key laboratory of eco-textile SouthernYangtze University

A new class of nanocomposites based on organic and inorganic species integrated at a nanoscale has obtained more attention these years. Organic-inorganic hybrids have both the advantages of organic materials, such as light weight, flexibility and good moldability, and inorganic materials, such as high strength, heat stability and chemical resistance. In this work, PVAc/TiO2 organicinorganic hybrid was prepared by sol-gel process. Eiectrospinning technique was used to fabricate PVAc/TiO2 hybrid nanofibers. The structures and properties of the hybrid nanofibers were characterized by Scanning Electron Microscopy （SEM）, Atomic Force Microscope （AFM）, Differential Scanning Calorimeter （DSC） and Fouriertransform infrared （FTIR） spectra. SEM and AFM were employed to study the topography of the hybrid nanofibers. The chemical structure of the hybrid nanofibers were examined by FTIR. The DSC scans revealed the second order transition temperature of the hybrid materials were higher than PVAc.

关键词： hybrid nano f ibers PVAc / TiO2 characterization

Effects of transparent inorganic pigment on spectral properties of spectrum-fingerprint anti-counterfeiting fiber containing rare earths

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Journal of Rare Earths 2012年第9期30卷 952-957页

作者：张技术葛明桥 key laboratory of eco-textile Ministry of EducationCollege of Textiles and ClothingJiangnan University

Transparent inorganic pigment is the color-filler material for manufacturing spectrum-fingerprint anti-counterfeiting fiber, and has great effects on the emission spectral characteristics of the fiber. In order to explain the change mechanism of the emission spectral character- istics of spectrum-fingerprint anti-counterfeiting fiber and to promote the development of the fiber, several kinds of spectrum-fingerprint fiber samples were prepared by using rare-earth strontium aluminate and polyethylene terephthalate （PET） as raw materials and by adding different kinds of transparent inorganic pigments respectively in this research. The effect of transparent inorganic pigment on the spectral characteristics of the fiber was analyzed in detail by means of scanning electron microscopy （SEM）, X-ray diffraction （XRD） and fluorescence spectrometer. The results showed that transparent inorganic pigment had no effect on the dispersion state and phase structure of rare-earth luminescent mate- rial in spectrum-fingerprint fiber and the microscopic morphology of the fiber. However, transparent inorganic pigment did affect the excitation and emission process of spectrum-fingerprint fiber so as to decrease its excitation and emission efficiency. The change of both the type and content of transparent inorganic pigment exerted great effects on the excitation and emission spectra of the fiber. Therefore, it was a feasible way to control the emission spectrum of spectrum-fingerprint fiber through changing the type and content of transparent inorganic pigment.

关键词： luminescence pigments strontium aluminate fibers rare earths

Effect of light conversion agent on luminous properties of a new down-converting material SrAl_2O_4:Eu^(2+),Dy^(3+)/light conversion agent

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Journal of Rare Earths 2016年第5期34卷 483-488页

作者：朱亚楠逄增媛王建葛明桥孙思瑾胡泽华翟佳鹤高佳欣姜伏生 key laboratory of eco-textile Ministry of EducationCollege of Textiles and ClothingJiangnan University

A new luminous material SrAl2O4：Eu^2＋,Dy^3＋/light conversion agent that can emit red light in the darkness after being excited was fabricated by combining light conversion agent on to SrAl2O4：Eu^2＋,Dy^3＋ particles through *** morphology of the luminous materials was analyzed by scan electron microscopy（SEM）.The emission behavior was evaluated by fluorescence spectrophotometric analysis and the results demonstrated that the emission spectra of samples had a redshift compared to SrAl2O4：Eu^2＋,Dy^3＋ and the emission intensity rose dramatically at first and then decreased when the ratio of light conversion agent doping was over 1.4 wt.%.And the emission color of SrAl2O4：Eu^2＋,Dy^3＋/light conversion agent was tuned from green（SrAl2O4：Eu^2＋,Dy^3＋）to ***,the afterglow property was also investigated,and the results indicated that the afterglow brightness reached 6.5 cd/m^2,and as the light conversion agent concentration increased the brightness intensity decreased.

关键词： SrAl2O4 Eu^2+ Dy^3+/light conversion agent emission afterglow brightness afterglow time rare earths

Preparation and properties of rare earth luminous fiber containing red organic fluorescent pigment

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Journal of Rare Earths 2013年第11期31卷 1043-1048页

作者：朱亚楠葛明桥陈志 key laboratory of eco-textile Ministry of Education College of Textiles and Clothing Jiangnan University

Rare earth luminous fiber was prepared by method of melt spinning. X-ray diffraction （XRD）, scanning electron micros-copy （SEM）, and fluorescence spectrophotometer as well as afterglow brightness tester were used to characterize the resulting sam-ples. Results from XRD and SEM demonstrated that the phase of SrA12O4：Eu2＋,Dy3＋in the fiber was not destroyed in the manufac-turing process and the as-formed luminous fiber consisted of irregular particles. Under ultraviolet excitation, the luminous fiber exhib-ited a yellow-green and orange-red emission band with a maximum at 520 nm and around 600 nm originating from SrAl2O4：Eu2＋, Dy3＋and red organic fluorescent pigments. The energy transfer process was further studied. Furthermore, the emission colors of lu-minous fibers could be tuned from yellow-green to orange-red easily by doping red organic fluorescent pigment, making the materials have potential application in many areas.

关键词： rare earth luminous fiber SrAl2O4:Eu^2+,Dy^3+ red organic fluorescent pigment emission color

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第01期 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie State key laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State key laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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Factors affecting afterglow properties of red-emitting phosphor MgSiO_3:Mn^(2+),Nd^(3+) for luminescent fiber

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Journal of Rare Earths 2013年第7期31卷 660-664页

作者：朱亚楠葛明桥 key laboratory of eco-textile of Ministry of Education College of Textiles and ClothingJiangnan University

With stable physical properties, the rare-earth silicate phosphor of MgSiO3：Mn2＋,Nd3＋ is one of the suitable luminescent materials used in preparing functional fibers. In order to promote the afterglow properties of red-emitting phosphors, we prepared it by means of solid-state reaction, and the effect of manufacturing elements including H3BO3 and environmental factor of calcining temperature, type of flux on its luminescence property were investigated through evaluating their afterglow properties. The results showed that with the concentration of Nd3＋ increasing, the amounts of H3BO3 doping and calcining temperature, the afterglow time and initial brightness of the rare-earth silicate phosphor increased and then decreased gradually. The afterglow properties of different flux concentration were different from one to another as： H3BO3〉Na＋〉K＋〉No flux.

关键词： MgSiO3:Mn2+,Nd3+ red-emitting afterglow properties rare earths

Researches on preparation and properties of polypropylene nonwovens containing rare earth luminous materials

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Journal of Rare Earths 2014年第12期32卷 1196-1200页

作者：余媛王建朱亚楠葛明桥 key laboratory of eco-textile of Ministry of Education College of Textiles and Clothing Jiangnan University

Polypropylene composite nonwovens containing rare-earth strontium aluminates Sr Al2O4：Eu2＋,Dy3＋ and functional additives were fabricated by the spun-bonded *** optical properties, morphology and mechanical properties of the samples were *** from scanning electron microscopy photographs（SEM） indicated that the surface of the fiber was destroyed by the addition of rare earth luminescent materials lightly but the thickness of the fiber was *** scanning calorimetry results showed that pure polypropylene has the double crystallization peak at 162.3 and 165.1 °*** from X-ray diffraction showed that the nonwoven prepared with the luminescent materials contained the α-monoclinic crystal and β crystalline ***, the afterglow properties were tested, which showed that the afterglow curve of the luminous nonwoven was similar to that of strontium aluminate, and the intensity was more intensive than luminous nonwoven at the *** nonwoven fabricated with the luminescent material did not affect the crystal lattice of the polymer making the materials have potential applications in fluorescent lamps and field emission displays（FEDs）.

关键词： luminescent material spun-bonded technique nonwoven characteristics rare earths