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Combination of Shuxuetong and aspirin protects against cerebral ischemia/reperfusion injury through ameliorating coagulation and fibrinolysis system

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chinese herbal medicines 2018年第2期10卷 191-198页

作者： Yong-mei Wu Ya-dong Zhai Yu-ting Zhou Shi-min Tang Xin-yue Li Li-fu Jia Xiang-baoMeng Hui Zhang Gui-bo Sun Xiao-bo Sun Institute of Medicinal Plant Development Peking Union Medical College and Chinese Academy of Medical SciencesZhongguancun Open Laboratory of the Research and Development of Natural Medicine and Health ProductsKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal MedicineMinistry of EducationBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine(Natural Medicine)and Translational MedicineBeijing 100193China Department of Pharmacology Changchun University of Chinese MedicineChangchun 130117China North Minzu University Yinchuan 750021China YouBo Pharmaceutical Co. LtdMudanjiang 157013China

Objective：To explore the influence of the combination of Shuxuetong（SXT）and aspirin on coagulation and fibrinolytic system of ***：Suture method was applied to establish focal cerebral ischemia-reperfusion injury models in *** rats were randomly divided into sham group,middle cerebral artery occlusion/reperfusion（MCAO/R）group,aspirin group,SXT group,and SXT＋aspirin group（S＆A）.The neurological deficits were assessed according to Longa’s grade 5 scoring *** cerebral edema was detected by measuring the content of water in brain *** volume of cerebral infarction was observed by 2,3,5-Triphenyltetrazolium chloride（TTC）*** plasma was collected by abdominal aortic method to test maximum platelet aggregation rate and four blood ***61,CD62p,6-keto prostaglandin F1αantithrombinⅢ（AT-Ⅲ）,D-dimer,plasminogen activator inhibitor-1（PAI-1）,tissue factor（TF）,tissue plasminogen activator（t-PA）,platelet thromboxaneand von Willebrand factor（v WF）content in rat plasma were detected by ***：SXT combined with aspirin could improve the neurological deficits,alleviate cerebral edema,and decrease the cerebral infarct *** with the sham operation group,fibrinogen（FIB）,6-AT-III,and t-PA in model group were significantly decreased;Compared with the model group,the above-mentioned indexes in SXT and aspirin treatment group were significantly *** prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,D-dimer,PAI-1,TF,TXB2,and v WF of the model group were significantly increased;The above-mentioned indexes in blood SXT＋aspirin treated group were significantly *** was a significant difference between the combined group and SXT *** maximum concentration of plateletsin aspirin treated rats was significantly decreased,however,MPAR was reversed in SXT＋aspirin treated ***：SXT combined with aspirin can effectively inhibit platelet activation,regulate the maximum concentra

关键词： aspirin blood coagulation fibrinolysis system Shuxuetong

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Protective effects of combination of Xuesaitong and aspirin on cerebral ischemia and reperfusion injury in rats

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chinese herbal medicines 2018年第2期10卷 223-230页

作者： Na-na Zhao Shi-min Tang Xin-yue Li Yong-mei Wu Yu-ting Zhou Jin-feng Shen Song Fang Xiang-bao Meng Gui-bo Sun Xiao-bo Sun Institute of Medicinal Plant Development Peking Union Medical College and Chinese Academy of Medical SciencesZhongguancun Open Laboratory of the Research and Development of Natural Medicine and Health ProductsKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal MedicineMinistry of EducationBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine(Natural Medicine)and Translational MedicineBeijing 100193China Heilongdiang University of chinese medicine Harbin 150040China Changchun University of chinese medicine Changchun 130117China North Minzu University Yinchuan 750021China China resources Kunming Shenghuo Pharmaceutical Co. Ltd.Kunming 650217China

Objective：To investigate the protective effects of the combination of Xuesaitong（XST）and aspirin on cerebral ischemia and reperfusion injury（CIRI）in rats,and further explore the underlying ***：A total of 150 male Sprague-Dawley（SD）rats were randomly divided into five groups with 30rats in each group：sham group,middle cerebral artery occlusion/reperfusion（MCAO/R）model group,XST group,aspirin group,and XST＋aspirin *** were pretreated with XST,aspirin,or XST＋aspirin for7 *** hour after the last administration,a model of CIRI was induced by MCAO/*** deficits were assessed using Longa’s five-point *** edema was detected by the measurement of brain water *** volume of cerebral infarction was determined by 2,3,5-triphenyltetrazolium chloride（TTC）*** activities of superoxide dismutase（SOD）,catalase（CAT）,and glutathione peroxidase（GSH-Px）,as well as levels of malonaldehyde（MDA）were detected by commercial ***-linked immunosorbent assay（ELISA）was used to determine the levels of interleukin-1（）,interleukin-4（IL-4）,interleukin-6（IL-6）,interleukin-10（IL-10）,tumor necrosis factor-alphamonocyte chemotactic protein 1（MCP-1）,and kynurenine in serum,cerebral cortex,and hippocampus of MCAO/R *** protein expression of nuclear factor erythroid 2-related factor（Nrf2）,heme oxygenase-1（HO-1）,I-kappa B alpha（IκBα）,and nuclear factor kappa B（B）/p65 in the cortex were analyzed by western ***：Treatment of XST,aspirin,and XST＋aspirin significantly alleviated the neurological deficits,cerebral edema,and cerebral infarct volume induced by MCAO/*** of XST,aspirin,and XST＋aspirin also reduced MDA,,MCP-1,and kynurenine levels,and increased SOD,CAT,GSH-Px,IL-4,and IL-10 levels in serum,cerebral cortex,and hippocampus of MCAO/R ***,treatment of XST,aspirin,and XST＋aspirin decreased the expression of nuclearB/p65 and increased the expression of IκBα,nuclear Nrf2,and ***,the combinat

关键词： aspirin cerebral ischemia and reperfusion injury inflammation oxidative stress Xuesaitong(XST)

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Perilla frutescens:A traditional medicine and food homologous plant

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chinese herbal medicines 2023年第3期15卷 369-375页

作者： Xinling Wu Shuting Dong Hongyu Chen Miaoxian Guo Zhiying Sun Hongmei Luo College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China key Lab of chinese medicine resources Conservation State Administration of Traditional Chinese Medicine of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Engineering Research Center of chinese medicine Resource Ministry of EducationBeijing 100193China

Perilla frutescens,an annual herb of the Labiatae family,has been cultivated in China for more than 2000 *** is the one of the first medicinal and edible plant published by the ministry of *** leaves,stems and seeds can be used as medicine and edible *** of the abundant nutrients and bioactive components in this plant,*** has been studied extensively in medicine,food,health care and chemical fields with great prospects for *** paper reviews the cultivation history,chemical compositions and pharmacological activities of ***,which provides a reference for the development and utilization of *** resources.

关键词： bioactive compounds medicine and food homology Perilla frutescens(L.)Britt pharmacological activities

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A chromosome-level genome assembly for Dracaena cochinchinensis reveals the molecular basis of its longevity and formation of dragon’s blood

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Plant Communications 2022年第6期3卷 89-103页

作者： Yanhong Xu Kaijian Zhang Zhonglian Zhang Yang Liu Feifei Lv Peiwen Sun Shixi Gao Qiuling Wang Cuicui Yu Jiemei Jiang Chuangjun Li Meifang Song Zhihui Gao Chun Sui Haitao Li Yue Jin Xinwei Guo Jianhe Wei key laboratory of bioactive substances and resources utilization of chinese herbal medicine Ministry of Education&National Engineering Laboratory for Breeding of Endangered Medicinal MaterialsInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Hainan Branch of the Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeHaikou 570311China Yunnan key laboratory of Southern medicine utilization Yunnan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeJinghong 666100China Novogene Bioinformatics Institute Beijing 100083China Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Dracaena,a remarkably long-lived and slowly maturing species of plant,is world famous for its ability to produce dragon’s blood,a precious traditional medicine used by different cultures since ancient ***,there is no detailed and high-quality genome available for this species at present;thus,the molecular mechanisms that underlie its important traits are largely *** factors seriously limit the protection and regeneration of this rare and endangered plant ***,we sequenced and assembled the genome of Dracaena cochinchinensis at the chromosome *** *** genome covers 1.21 Gb with a scaffold N50 of 50.06 Mb and encodes 31619 predicted protein-coding *** showed that *** has undergone two whole-genome duplications and two bursts of long terminal repeat *** expansion of two gene classes,cis-zeatin O-glucosyltransferase and small auxin upregulated RNA,were found to account for its longevity and slow *** transcription factors(bHLH and MYB)were found to be core regulators of the flavonoid biosynthesis pathway,and reactive oxygen species were identified as the specific signaling molecules responsible for the injuryinduced formation of dragon’s *** study provides high-quality genomic information relating to *** and significant insight into the molecular mechanisms responsible for its longevity and formation of dragon’s *** findings will facilitate resource protection and sustainable utilization of Dracaena.

关键词： genome Dracaena cochinchinensis dragon’s blood longevity flavonoid biosynthesis ROS

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Flavonoids isolated from Sinopodophylli Fructus and their bioactivities against human breast cancer cells

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chinese Journal of Natural medicines 2017年第3期15卷 225-233页

作者： WANG Qing-Hui GUO Shuai YANG Xue-Yan ZHANG Yi-Fan SHANG Ming-Ying SHANG Ying-Hui XIAO Jun-Jun CAI Shao-Qing Department of Natural medicine School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China Department of Cell Biology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Four prenylated flavonoids compounds 1-4,named sinopodophyllines A-D,and a flavonoid glycoside(compound 13),sinopodophylliside A,together with 19 known compounds(compounds 5-12 and 14-24) were isolated from the fruits of Sinopodophyllum *** structures of new compounds were elucidated by extensive spectroscopic analysis,including HRESIMS,1D and 2D *** 1-6,9-11,and 14-17 were tested for their cytotoxicity against human breast-cancer T47 D,MCF-7 and MDA-MB-231 cells in vitro,and compounds 2,5,6,10 and 11 showed significant cytotoxicity(IC50 values < 10 μmol·L^(-1))against T47 D cells.

关键词： Sinopodophylli Fructus Prenylated flavonoids Flavonoid glycosides Breast-cancer cell lines

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