检索结果-南通市图书馆

Strengthening pharmacotherapy research for COVID-19-induced pulmonary fibrosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第5期12卷 875-879页

作者： Yan-Miao Liu Jing Zhang Jing-Jing Wu Wei-Wei Guo Fu-Shan Tang The First Clinical Institute Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina key laboratory of Clinical Pharmacy in Zunyi City Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Department of Respiratory Medicine Central Hospital in Jinchang CityJinchang 737102Gansu ProvinceChina Department of Clinical Pharmacy Key Laboratory of Basic Pharmacology of Guizhou Province and School of PharmacyZunyi Medical UniversityZunyi 563006Guizhou ProvinceChina key laboratory of basic pharmacology of Ministry of Education and Joint International Research laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

The global spread of severe acute respiratory syndrome coronavirus 2 has resulted in a significant number of individuals developing pulmonary fibrosis(PF),an irreversible lung *** condition can manifest within a short inter-val following the onset of pneumonia symptoms,sometimes even within a few *** lung transplantation is a potentially lifesaving procedure,its limited availability,high costs,intricate surgeries,and risk of immunological rejection present significant *** optimal timing of medication administration for coronavirus disease 2019(COVID-19)-induced PF remains *** this,it is crucial to explore pharmacotherapy interventions,involving early and preventative treatment as well as pharmacotherapy options for advanced-stage ***,studies have demonstrated disparities in anti-fibrotic treatment based on race and gender *** mutations may also impact therapeutic *** research efforts on pharmacotherapy interventions,while considering relevant pharmacological factors and optimizing the timing and dosage of medication administration,will lead to enhanced,personalized,and fair treatment for individuals impacted by COVID-19-related *** measures are crucial in lessening the burden of the disease on healthcare systems and improving patients'quality of life.

关键词： COVID-19 Pulmonary fibrosis Pharmacotherapy intervention Medication administration Timing Dosage

Ability of Helicobacter pylori to internalize into Candida

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第16期30卷 2281-2284页

作者： Zheng-Hong Chen Jian-Chao Sun Ting-Xiu Yang Gu-Zhen Cui key laboratory of Microbiology and Parasitology of Education Department of guizhou Guizhou Medical UniversityGuiyang 561113Guizhou ProvinceChina key laboratory of Endemic and Ethnic Diseases of Ministry of Education Guizhou Medical UniversityGuiyang 561113Guizhou ProvinceChina Joint laboratory of Helicobacter Pylori and Intestinal Microecology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550009Guizhou ProvinceChina Department of Quality Control Guizhou Provincial Center for Clinical LaboratoryGuiyang 550002Guizhou ProvinceChina Department of Hospital Infection and Management Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

The following are our views regarding the“letter to the editor”(Helicobacter is preserved in yeast vacuoles!Does Koch’s postulates confirm it?)by Alipour and Gaeini,and the response“letter to the editor”(Candida accommodates nonculturable Helicobacter pylori in its vacuole-Koch’s postulates aren’t applicable)by Siavoshi and *** and Gaeini rejected the methods,results,discussion,and conclusions summarized in a review article by Siavoshi and *** present article reviews and discusses evidence on the evolutionary adaptation of Helicobacter pylori(***)to thrive in Candida cell vacuoles and concludes that Candida could act as a Trojan horse,transporting potentially infectious *** into the stomach of humans.

关键词： Helicobacter pylori Candida yeast Intracellular presence Helicobacter pylori-specific gene Helicobacter pylori transmission

Hematopoietic aging:Cellular,molecular,and related mechanisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第11期137卷 1303-1312页

作者： Li Ye Chuan Tian Ye Li Hang Pan Jinxiu Hu Liping Shu Xinghua Pan The Stem Cells and Immune Cells Biomedical Techniques Integrated Engineering laboratory of State and Regions Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan ProvinceKunming Key Laboratory of Stem Cell and Regenerative MedicineBasic Medical Laboratory920th Hospital of Joint Logistics Support ForcePLAKunmingYunnan 650032China Department of Immunology of School of basic Medicine of guizhou Medical University National and Local Joint Engineering Laboratory of Cell Engineering Biomedical TechnologyKey Laboratory of Regenerative Medicine of Guizhou ProvinceState Key Laboratory of Efficacy and Utilization of Medicinal Plants Co-constructed by Province and MinistryKey Laboratory of Translational Research of Adult Stem Cell of Chinese Academy of Medical SciencesGuiyangGuizhou 550025China

Aging is accompanied by significant inhibition of hematopoietic and immune system function and disruption of bone marrow ***-related alterations in the inflammatory response,immunity,and stem cell niches are at the root of hematopoietic *** the molecular mechanisms underlying hematopoietic and bone marrow aging can aid the clinical treatment of aging-related *** particular,it is unknown how the niche reprograms hematopoietic stem cells(HSCs)in an age-dependent manner to maintain normal hematopoiesis in elderly ***,specific inhibitors and blood exchange methods have been shown to reshape the hematopoietic niche and reverse hematopoietic ***,we present the latest scientific discoveries related to hematopoietic aging and hematopoietic system rejuvenation,discuss the relationships between hematopoietic niche aging and HSC aging,and describe related studies on stem cell-mediated regulation of hematopoietic aging,aiming to provide new ideas for further study.

关键词： Stem cells Hematopoietic stem cell Niche Hematopoietic aging

Combined proteomic and metabolomic studies on the liver of Amur sturgeon Acipenser schrenckii under titanium dioxide nanoparticle exposure

在线全文

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2024年第3期42卷 1001-1015页

作者： Zhou ZHOU Ting LIU Jie KONG Zhenxing ZHAO Junquan ZHU key laboratory of Aquacultural Biotechnology Ministry of Educationand Key Laboratory of Marine Biotechnology of Zhejiang ProvinceCollege of Marine SciencesNingbo UniversityNingbo 315000China guizhou Fisheries Research Institute Guizhou Academy of Agriculture SciencesGuiyang 550000China

Nanomaterials,particularly titanium dioxide nanoparticles(TiO_(2)-NPs),are extensively utilized across various ***,their environmental release has raised concerns regarding their potential ecological and environmental *** reproductive toxicity of TiO_(2)-NPs in fish species has attracted considerable attention,yet conflicting research outcomes have been *** investigated the effects of TiO_(2)-NPs exposure on the liver of juvenile Amur sturgeon Acipenser schrenckii using label-free proteomic and untargeted metabolomic *** experiment included a control group and three groups exposed to different concentrations of TiO_(2)-NPs(low,TL;medium,TM;high,TH).Compared to the control group,9,19,and 25 proteins and 35,73,and 158 metabolites were differentially expressed in the TH,TM,and TL TiO_(2)-NP-exposed groups,*** differentially expressed genes(DEGs)were enriched in the Kyoto Encyclopedia for Genes and Genomes(KEGG)pathways related to glycolysis and ***,among the 126 correlated proteins,the most enriched pathways were associated with endocytosis and protein processing in the endoplasmic ***,syringic acid was significantly downregulated across all three TiO_(2)-NP-exposed *** obtain a comprehensive overview of the TiO_(2)-NP-induced expression changes,a co-regulated network of proteins and metabolites associated with TiO_(2)-NPs exposure was *** to TiO_(2)-NPs led to enrichment and alteration of pathways related to immune responses,including endocytosis,protein processing in the endoplasmic reticulum,and peroxisome proliferator-activated receptor(PPAR)*** conclusion,our findings indicate that exposure to TiO_(2)-NPs might disrupt glucose metabolism and induce immune responses,thus contributing to our understanding of the environmental impacts of nanomaterials and highlighting the need for further research and development of potential mitigation strategies.

关键词： TiO_(2)-nanoparticle exposure proteomics metabolomics glucose metabolism immune response

Biocatalytic stereoselective synthesis of methyl mandelates by engineering a cytochrome P450 hydroxylase

在线全文

学校读者我要写书评

暂无评论

Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第2期5卷 88-93页

作者： Lingzhi Xie Yun Zhang Ruyue Zhang Haibo Cui Baodong Cui Wenyong Han Nanwei Wan Zhi Li Yongzheng Chen key laboratory of Biocatalysis&Chiral Drug Synthesis of guizhou province Generic Drug Research Center of Guizhou ProvinceGreen Pharmaceuticals Engineering Research Center of Guizhou ProvinceSchool of PharmacyZunyi Medical UniversityZunyi 563000China key laboratory of basic pharmacology of Ministry of Education and Joint International Research laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563000China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4Singapore 117585Singapore

Chiral methyl mandelates are useful synthons in organic transformation and pharmaceutical *** synthesis of these valuable compounds by direct C–H activating oxidative hydroxylation has attracted keen *** herein is achieving the stereoselective and efficient bio-hydroxylation of methyl 2-phenylacetates to the chiral methyl mandelates by directed evolution of the cytochrome P450DA *** the present study,a new colorimetric high-throughput screening assay was successfully developed based on a dualenzyme cascade for the engineering of the P450DA's hydroxylation *** beneficial variants with enhanced bio-hydroxylation activity were created by combining random mutagenesis and site-saturated/directed mutagenesis ***-cell bio-hydroxylation of various methyl 2-phenylacetates using the best septupletmutant P450DA-11 yielded the corresponding chiral methyl mandelates in up to 92%isolated yields and>99%ee.

关键词： Bio-hydroxylation Directed evolution Cytochrome P450 High-throughput screening Methyl mandelates

Synthesis,phase transformation and applications of CeCO_(3)OH:A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第8期42卷 1403-1420,I0001页

作者： Zhou Zou Weihao Tian Xisong Mao Junqi Li Yuanpei Lan Chaoyi Chen Hong Yong Sohn Junshan Zhang Fengyuan Liu Department of Metallurgical Engineering College of Materials and MetallurgyGuizhou UniversityGuiyang55025China guizhou province key laboratory of Metallurgical Engineering and Process Energy Saving Guiyang550025China guizhou Provincial University key laboratory of High-Performance Battery Materials Guiyang550025China Department of Materials Science and Engineering University of UtahSalt Lake CityUT84112USA

CeCO_(3)OH has a unique crystal structure and excellent optical,electronic and catalytic properties,which has been widely investigated for many ***,ceria obtained from CeCO_(3)OH has a morphology that is similar to that of the precursor,and the CeO_(2)-based products obtained from CeCO_(3)OH exhibit outstanding properties,such as catalytic performances,owing to their designed morphology and oxygen vacancies(OVs).To introduce CeCO_(3)OH into a wider range of potential researchers,we first systematically review the physico-chemical properties,synthesis,reaction and morphology tuning mechanism of CeCO_(3)OH,and summarize the conversion behavior from CeCO_(3)OH to ***,we thoroughly survey the applications of CeCO_(3)OH and its conversion *** for further investigations of CeCO_(3)OH are also made in this *** is hoped that the exhaustive co mpilation of the valuable properties and considerable potential investigations of CeCO_(3)OH will promote further applications of CeCO_(3)OH and CeO_(2)-based functional materials.

关键词： CeCO_(3)OH Morphology tuning CeO_(2) Catalyst Lanthanide compounds Rare earths

Human brain organoid:trends,evolution,and remaining challenges

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第11期19卷 2387-2399页

作者： Minghui Li Yuhan Yuan Zongkun Hou Shilei Hao Liang Jin Bochu Wang key laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqingChina Southwest Hospital/Southwest Eye Hospital Third Military Medical University(Army Medical University)ChongqingChina School of Biology and Engineering/School of basic Medical Sciences Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and *** various studies and reviews have described developments and advancements in brain organoids,few studies have comprehensively summarized and analyzed the global trends in this area of *** identify and further facilitate the development of cerebral organoids,we utilized bibliometrics and visualization methods to analyze the global trends and evolution of brain organoids in the last 10 ***,annual publications,countries/regions,organizations,journals,authors,co-citations,and keywords relating to brain organoids were *** hotspots in this field were also systematically ***,current applications for brain organoids in neuroscience,including human neural development,neural disorders,infectious diseases,regenerative medicine,drug discovery,and toxicity assessment studies,are comprehensively *** that end,several considerations regarding the current challenges in brain organoid research and future strategies to advance neuroscience will be presented to further promote their application in neurological research.

关键词： bibliometric analysis brain organoids cerebral organoids global trends neuroscience

Ligand modulation of active center to promote lead-free Cs_(2)AgInCl_(6)photocatalytic CO_(2)reduction

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第8期95卷 660-669,I0015页

作者： Baofei Sun Wei Chen Yanyi Huang Daofu Wu Heng Luo Faguang Kuang Hongmei Ran Yichen Liu Liqin Gao Jinchen Zhou Bo Gao Qiang Huang Xiaosheng Tang key laboratory of Human Brain Bank for Functions and Diseases of Department of Education of guizhou province College of Basic MedicalGuizhou Medical UniversityGuiyang 550025GuizhouChina School of Electromechanical and Automotive Engineering Yantai UniversityYantai 264005ShandongChina State key laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina College of Optoelectronic Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China key laboratory of Optoelectronic Technology&Systems(Ministry of Education) College of Optoelectronic EngineeringChongqing UniversityChongqing 400044China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina

Metal halide perovskites(MHP)are potential candidates for the photocatalytic reduction of CO_(2)due to their long photogenerated carrier lifetime and charge diffusion ***,the conventional long-chain ligand impedes the adsorption and activation of CO_(2)molecules in practical ***,a ligand modulation technology is employed to enhance the photocatalytic CO_(2)reduction activity of lead-free Cs_(2)AgInCl_(6)microcrystals(MCs).The Cs_(2)AgInCl_(6)MCs passivated by Oleic acid(OLA)and Octanoic acid(OCA)are used for photocatalytic CO_(2)*** results show that the surface defects and electronic properties of Cs_(2)AgInCl_(6)MCs can be adjusted through ligand *** with the OLA-Cs_(2)AgInCl_(6),the OCA-Cs_(2)AgInCl_(6)catalyst demonstrated a significant improvement in the catalytic yield of CO and CH_(4).The CO and CH_(4)catalytic yields of OCA-Cs_(2)AgInCl_(6)reached 171.88 and34.15μmol g^(-1)h^(-1)which were 2.03 and 12.98 times higher than those of OLA-Cs_(2)AgInCl_(6),and the total electron consumption rate of OCA-Cs_(2)AgInCl_(6)was 615.2μmol g^(-1)h^(-1)which was 3.25 times higher than that of OLA-Cs_(2)AgInCl_(6).Furthermore,in situ diffuse reflectance infrared Fourier transform spectra revealed the enhancement of photocatalytic activity in Cs_(2)AgInCl_(6)MCs induced by ligand *** study illustrates the potential of lead-free Cs_(2)AgInCl_(6)MCs for efficient photocatalytic CO_(2)reduction and provides a ligand modulation strategy for the active promotion of MHP photocatalysts.

关键词： Surface ligand Photocatalysis CO_(2)reduction Lead-free perovskite Reactive mechanism

Na^(+)/K^(+)-ATPase:ion pump,signal transducer,or cytoprotective protein,and novel biological functions

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第12期19卷 2684-2697页

作者： Songqiang Huang Wanting Dong Xiaoqian Lin Jinsong Bian Department of pharmacology Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and DiseasesSchool of MedicineSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Department of pharmacology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into ***,Na^(+)/K^(+)-ATPase participates in Ca^(2+)-signaling transduction and neurotransmitter release by coordinating the ion concentration gradient across the cell ***^(+)/K^(+)-ATPase works synergistically with multiple ion channels in the cell membrane to form a dynamic network of ion homeostatic regulation and affects cellular communication by regulating chemical signals and the ion balance among different types of *** re,it is not surprising that Na^(+)/K^(+)-ATPase dysfunction has emerged as a risk factor for a variety of neurological ***,published studies have so far only elucidated the important roles of Na^(+)/K^(+)-ATPase dysfunction in disease development,and we are lacking detailed mechanisms to clarify how Na^(+)/K^(+)-ATPase affects cell *** recent studies revealed that membrane loss of Na^(+)/K^(+)-ATPase is a key mechanism in many neurological disorders,particularly stroke and Parkinson's *** of plasma membrane Na^(+)/K^(+)-ATPase with an antibody is a novel strategy to treat these *** this reason,Na^(+)/K^(+)-ATPase acts not only as a simple ion pump but also as a sensor/regulator or cytoprotective protein,participating in signal transduction such as neuronal autophagy and apoptosis,and glial cell ***,the present review attempts to summarize the novel biological functions of Na^(+)/K^(+)-ATPase and Na^(+)/K^(+)-ATPase-related *** potential for novel strategies to treat Na^(+)/K^(+)-ATPase-related brain diseases will also be discussed.

关键词： antibody biological functions cellular communication electrochemical gradient ion balance ion channels Na^(+)/K^(+)-ATPase neurological diseases neurotransmitter release signal transduction