检索结果-南通市图书馆

Enterochromaffin Cell:Friend or Foe for Human Health?

在线全文

学校读者我要写书评

暂无评论

neuroscience Bulletin 2023年第11期39卷 1732-1734页

作者： Yang Yu Yong-Chang Li Fu-Chao Zhang Guang-Yin Xu Jiangsu key laboratory of Neuropsychiatric Diseases and Institute of neuroscience Soochow UniversitySuzhou 215123China

Enterochromaffin(EC)cells are a type of enteroendocrine cells that reside in the epithelial lining of the gastrointestinal tract.They function as sensory transducers of stimuli present in the intestinal lumen,as afferent nerves do not protrude into the lumen,but have been shown to act as a friend or a foe depending on various conditions.It has been well-described that EC cells play their role by releasing 5-HT to activate neighboring afferent nerves in a paracrine fashion,while emerging evidence suggests the existence of synaptic-like connections between enteroendocrine cells and adjacent afferent nerves based on in vitro co-culture and in vivo viral tracing studies.

关键词： nerves releasing Human

Can You Feel the Love Tonight: A Dipeptidergic Circuit for Pleasant Touch

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

neuroscience Bulletin 2022年第8期38卷 966-968页

作者： Jing-Jing Yan Wen Zhang Xiao-Hong Xu Institute of neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China

Soft and gentle touches such as the maternal caressing of infants foster a sense of well-being,promote social bonding,and have long-lasting impacts on the brain and behaviors.Dr.Xiang Yu's group recently identified a dipeptidergic excitatory circuit,from tachykinin 1(Tacl)-expressing neurons in the ventrolateral periaqueductal gray(/vIPAG)to oxytocin neurons in the paraventricular hypothalamus(PVH),that mediates the enduring effects of gentle touch on social behaviors.

关键词： peptidergic gentle hypothalamus

Distributions of Visual Receptive Fields from Retinotopic to Craniotopic Coordinates in the Lateral Intraparietal Area and Frontal Eye Fields of the Macaque

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

neuroscience Bulletin 2024年第2期40卷 171-181页

作者： Lin Yang Min Jin Cong Zhang Ning Qian Mingsha Zhang key laboratory of Cognitive neuroscience and Learning Division of PsychologyBeijing Normal UniversityBeijing 100875China Institute of neuroscience Key Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Department of neuroscience and Zuckerman Institute Columbia UniversityNew York 10027USA

Even though retinal images of objects change their locations following each eye movement,we perceive a stable and continuous world.One possible mechanism by which the brain achieves such visual stability is to construct a craniotopic coordinate by integrating retinal and extraretinal information.There have been several proposals on how this may be done,including eye-position modulation(gain fields)of retinotopic receptive fields(RFs)and craniotopic RFs.In the present study,we investigated coordinate systems used by RFs in the lateral intraparietal(LIP)cortex and frontal eye fields(FEF)and compared the two areas.We mapped the two-dimensional RFs of neurons in detail under two eye fixations and analyzed how the RF of a given neuron changes with eye position to determine its coordinate representation.The same recording and analysis procedures were applied to the two brain areas.We found that,in both areas,RFs were distributed from retinotopic to craniotopic representations.There was no significant difference between the distributions in the LIP and FEF.Only a small fraction of neurons was fully craniotopic,whereas most neurons were between the retinotopic and craniotopic representations.The distributions were strongly biased toward the retinotopic side but with significant craniotopic shifts.These results suggest that there is only weak evidence for craniotopic RFs in the LIP and FEF,and that transformation from retinotopic to craniotopic coordinates in these areas must rely on other factors such as gain fields.

关键词： Reference frames Eye-centered Headcentered Visual stability

Towards the Framework of Understanding Autism Spectrum Disorders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

neuroscience Bulletin 2019年第6期35卷 1110-1112页

作者： Zilong Qiu Bo Yuan Institute of neuroscience State Key Laboratory of Neuroscience CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences

The prevalence of autism spectrum disorders(ASD)has been high worldwide,reaching 1/59 children in the United States as reported by the Centers of Disease Control and Prevention.Since genetic components play a major role in ASD[1],it is astonishing that the occurrence of ASD would be this high probabily due to genetic causes.It is worthy to note that autistic phenotypes of ASD patients show great diversity.The severity of autistic symptoms may be correlated with whether genetic mutations affect neural development.Thus,we argue that the prevalence of severe ASD may be much lower than the common ASD usually reported.

关键词： prevalence ed. severity

Characterization of gut microbial alterations in cynomolgus macaques during growth and maturation

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2022年第2期43卷 176-179页

作者： Yun-Peng Yang Yong Lu Pei-Jun Yu Qi-Ming Liu Chang-Shan Gao Xiao-Tong Zhang Qiang Sun Institute of neuroscience CAS Key Laboratory of Primate NeurobiologyState Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China

Aging is closely related to physiology and disease development in animals.Gut microbiota varies with lifecycle and exerts profound influences on the host.To investigate gut microbial alterations during growth and maturation,41 female cynomolgus monkeys(Macaca fascicularis)ranging in age from 1 month to 15 years were divided into four groups(infant,young,adult,and middle-aged).

关键词： alterations infant maturation

Adrenomedullin: an important participant in neurological diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第7期15卷 1199-1207页

作者： Feng-Jiao Li Si-Ru Zheng Dong-Mei Wang College of Life Sciences Laboratory of Neuroendocrinology Provincial Key Laboratory of Developmental Biology and Neuroscience Fujian Normal University

Adrenomedullin,a peptide with multiple physiological functions in nervous system injury and disease,has aroused the interest of researchers.This review summarizes the role of adrenomedullin in neuropathological disorders,including pathological pain,brain injury and nerve regeneration,and their treatment.As a newly characterized pronociceptive mediator,adrenomedullin has been shown to act as an upstream factor in the transmission of noxious information for various types of pathological pain including acute and chronic inflammatory pain,cancer pain,neuropathic pain induced by spinal nerve injury and diabetic neuropathy.Initiation of glia-neuron signaling networks in the peripheral and central nervous system by adrenomedullin is involved in the formation and maintenance of morphine tolerance.Adrenomedullin has been shown to exert a facilitated or neuroprotective effect against brain injury including hemorrhagic or ischemic stroke and traumatic brain injury.Additionally,adrenomedullin can serve as a regulator to promote nerve regeneration in pathological conditions.Therefore,adrenomedullin is an important participant in nervous system diseases.

关键词： adrenomedullin brain injury glia mechanism morphine tolerance neural regeneration neuroprotective effect pathological pain regeneration sensitization target

Accelerated passage of gene-modified monkeys by hormone-induced precocious puberty

在线全文

学校读者我要写书评

暂无评论

National Science Review 2021年第7期8卷 68-71页

作者： Zhen Liu Kui Li Yijun Cai Qiming Liu Tikui Zhang Yong Lu Yanhong Nie Yan Wang Zhiguang Yan Yinwei Qu Yuzhuo Li Zhanyang Wang Zhi-Qi Xiong Qiang Sun Institute of neuroscience State Key Laboratory of Neuroscience CAS Key Laboratory of Primate Neurobiology CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai Research Center for Brain Science and Brain-Inspired Intelligence

Mosaicism occurs in most founder genemodified monkeys generated by virus infection and programmable-nucleases[1–3]. In addition, macaque monkeys have a long preadolescence period, with four or more years usually required for male macaque monkeys to become sexually mature [4,5]. The mosaicism and long time to sexual maturity have largely prevented wide usage of gene-modified monkey models.

关键词： non-human primates gene editing passage acceleration precocious puberty

Non-human Primate Models for Brain Disorders – Towards Genetic Manipulations via Innovative Technology

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

neuroscience Bulletin 2017年第2期33卷 247-250页

作者： Zilong Qiu Xiao Li Institute of neuroscience Key Laboratory of Primate Neurobiology State Key Laboratory of Neuroscience Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institute for Biological Sciences Chinese Academy of Sciences

Modeling brain disorders has always been one of the key tasks in neurobiological studies. A wide range of organisms including worms, fruit ？ies, zebra？sh, and rodents have been used for modeling brain disorders. However,whether complicated neurological and psychiatric symptoms can be faithfully mimicked in animals is still debatable.In this review, we discuss key ？ndings using non-human primates to address the neural mechanisms underlying stress and anxiety behaviors, as well as technical advances for establishing genetically-engineered non-human primate models of autism spectrum disorders and other disorders.Considering the close evolutionary connections and similarity of brain structures between non-human primates and humans, together with the rapid progress in genome-editing technology, non-human primates will be indispensable for pathophysiological studies and exploring potential therapeutic methods for treating brain disorders.

关键词： Non-human primates Brain disorders Genome editing Autism Neurological disorders Psychiatric disorders

Bi-directional Control of Synaptic Input Summation and Spike Generation by GABAergic Inputs at the Axon Initial Segment

在线全文

学校读者我要写书评

暂无评论

neuroscience Bulletin 2023年第1期39卷 1-13页

作者： Ziwei Shang Junhao Huang Nan Liu Xiaohui Zhang State key laboratory of Cognitive neuroscience and Learning IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China

Differing from other subtypes of inhibitory interneuron,chandelier or axo-axonic cells form depolarizing GABAergic synapses exclusively onto the axon initial segment(AIS)of targeted pyramidal cells(PCs).However,the debate whether these AIS-GABAergic inputs produce excitation or inhibition in neuronal processing is not resolved.Using realistic NEURON modeling and electrophysiological recording of cortical layer-5 PCs,we quantitatively demonstrate that the onset-timing of AIS-GABAergic input,relative to dendritic excitatory glutamatergic inputs,determines its bi-directional regulation of the efficacy of synaptic integration and spike generation in a PC.More specifically,AIS-GABAergic inputs promote the boosting effect of voltage-activated Na+channels on summed synaptic excitation when they precede glutamatergic inputs by>15 ms,while for nearly concurrent excitatory inputs,they primarily produce a shunting inhibition at the AIS.Thus,our findings offer an integrative mechanism by which AIS-targeting interneurons exert sophisticated regulation of the input-output function in targeted PCs.

关键词： GABAergic inputs Axon initial segment Synaptic integration Axo-axonic cell Chandelier cell NEURON simulation Dynamic clamp