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Chinese Chemical Letters 2025年第2期36卷 373-377页

作者： Shaojie Deng Peihua Ma Qinghong Bai Xin Xiao key laboratory of Macrocyclic and Supramolecular Chemistry of guizhou province Department of Chemistry Guizhou University

Nor-seco-cucurbit[10]uril(ns-CB[10]) is a kinetic product with unique structure. The single bridged methylene in its structure makes the molecular cavity of ns-CB[10] more deformable when compared to ordinary cucurbit[n]uril, reducing its structural stability. Repeated experiments showed that ns-CB[10] gradually cracks in an acidic solution and changes the specificity of cucurbit[5]uril(CB[5]) and cucurbit[8]uril(CB[8]) under more robust acidic solutions and when heated. A series of experiments were designed to study the transformation behavior of ns-CB[10]. It was found that the concentration of ns-CB[10] was correlated with the content distribution of CB[5] and CB[8]. This study explores the influencing factors and mechanisms of the transformation of ns-CB[10] to CB[5] and CB[8]. The results are of great significance for the application of ns-CB[10], understanding the formation mechanism of cucurbit[n]urils. Furthermore,it provides a new pathway for synthesizing new cucurbit[n]urils.

关键词： Concentration control Cracking Mechanism Nor-seco-cucurbituril Transformation

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao key laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Copper homeostasis and neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi Li Kaifei Xu Guoqing Wang Feng Zhang International Research laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

A novel supramolecular assembly based on nor-seco-cucurbit[10]uril for spermine sensing and artificial light-harvesting

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Chinese Chemical Letters 2025年第1期36卷 262-266页

作者： Ran Cen Yan-Yan Tang Li-Xia Chen Zhu Tao Xin Xiao National key laboratory of Green Pesticide State Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationKey Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou ProvinceGuizhou UniversityGuiyang 550025China

A supramolecular assembly composed of perylene diimide derivative(PDI-nm)and nor-secocucurbit[10]uril(ns-Q[10])was *** excellent host-guest interaction between PDI-nm and nsQ[10]prevented the aggregation-caused quenching(ACQ)effect of PDI-nm,resulting in a luminescent *** addition of spermine to the PDI-nm/ns-Q[10]assembly restored the ACQ of PDI-nm due to the competitive binding of spermine to ns-Q[10],which released *** assembly based on this principle showed ultra-high sensitivity for the detection of spermine with a detection limit as low as7.84×10^(-7)mol/L in aqueous solution and 3.69×10^(-7)mol/L in plasma ***,an artificial light-harvesting system based on this assembly was proposed,benefiting from its good luminescent *** red(Ni R)functioned as an acceptor loaded into assembly,and a highly efficient energy transfer process occurred from PDI-nm/ns-Q[10]to Ni R,with an efficiency up to 87%.

关键词： Nor-seco-cucurbituril Perylene diimide derivative Spermine Light-harvesting

Interfacial Zn^(2+)-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang Li Shan Guo Zhuang Tong Xiaotao Zhou Xu Li Zhaohui Hou Shuquan Liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional MaterialsHunan Institute of Science and TechnologyYueyang 414006HunanChina School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan ProvinceCentral South UniversityChangsha 410083HunanChina College of Materials and Metallurgy Guizhou UniversityGuiyang 550000GuizhouChina National Energy Metal resources and New Materials key laboratory Central South UniversityChangsha 410083HunanChina

Aqueous zinc-ion batteries (AZIBs) are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc (Zn) deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn^(2+)-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups (such as hydroxyl,carboxyl,etc.) have the potential to significantly optimize the solvation structure of Zn^(2+)and regulate the interfacial electric double layer (EDL).By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn (H-Zn) anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH_(4)V_(4)O^(10)(NVO) full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A g^(-1).This study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Zn^(2+)-solvation structure Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode

Characterization and acid leaching of rare earth elements in coal gangue using pretreatment of selective grinding,tailings discarding and alkali roasting

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Journal of Rare Earths 2025年第2期43卷 384-396,I0006页

作者： Xiaorui Wang Wei Cheng Ruidong Yang Jingkun Zang College of resources and Environmental Engineering Guizhou UniversityGuiyang550025China College of Mining Guizhou UniversityGuiyang550025China National&Local Joint laboratory of Engineering for Effective Utilization of Regional Mineral resources from Karst Areas Guiyang550025China guizhou key laboratory of Comprehensive Utilization of Non-metallic Mineral resources Guiyang550025China

Co-associated rare earth elements(lanthanide and yttrium,REY)in coal and its by-products have been considered important potential nontraditional rare earth *** this study,a coal gangue sample collected from a coal processing plant in Jinsha County of guizhou province,southwest China,was used as the research *** content,modes of occurrence,and extraction(acid leaching after pretreatment of selective grinding,tailings discarding,and alkali roasting)of REY from the sample were *** result shows that the content of REY(1038.26μg/g)in pyrite and quartz is low but mainly enriched in *** the following conditions of a filling ratio of 40%(grinding media steel ball)and grinding time of 8 min,selective grinding pretreatment is applied to achieve 176.95μg/g(yield 24.08%)and 1104.93μg/g(yield 75.92%)of REY in+2 mm and-2 mm fractions,***,the-2 mm coal gangue fraction is selected,used as the feed,and roasted and leached with *** Na_(2)CO_(3)and NaCl are separately used as roasting activators,the REY leaching ratios are 91.41%and 68.88%,respectively,under the optimum *** contents of REY in the final leachate are 1010.02 and 761.08μg/g when Na_(2)CO_(3)and NaCl are used,*** two REY contents are relatively higher than the impurity ions in the leachate,which facilitates further REY *** mechanism study reveals that high-temperature roasting increases the pore size and the total pore area of the gangue,which promotes leachate penetration and improves reaction *** addition,roasting facilitates the reaction between the sodium salt activator and kaolinite and other aluminosilicate minerals in the coal gangue to generate soluble salts,thus releasing REY into the *** appropriate roasting temperature transforms the activator into a molten ***,the reaction between coal gangue and activator is a solid-liquid reaction rather than a solid-solid reaction,which improves the efficiency

关键词： Coal gangue Rare earth elements Selective grinding Tailings discarding Alkali roasting Leaching

Strengths,weaknesses,opportunities,and threats analysis of combination therapy for inflammatory bowel disease

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World Journal of Gastroenterology 2025年第9期31卷 176-182页

作者： Jia-Wang Yan Mei Nie Hang Zhang Yan-Miao Liu Fu-Shan Tang Department of Clinical Pharmacy Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina key laboratory of Basic Pharmacology of Ministry of Education and Joint International Research laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina key laboratory of Basic Pharmacology of guizhou province and School of Pharmacy Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina The First Clinical Institute Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

Inflammatory bowel disease(IBD),encompassing Crohn’s disease and ulcerative colitis,manifests as a chronic,recurrent,and refractory intestinal inflammatory condition significantly impacting patients’quality of *** ongoing research,its etiology and pathogenesis remain incompletely *** advancements in medical research highlight the critical role of drug combination therapies in managing *** paper employs the strengths,weaknesses,opportunities,and threats framework to evaluate the four strategic elements(strengths,weaknesses,opportunities,and threats)pertaining to combination therapies for *** the strengths,the paper underscores the efficacy of multi-targeted strategies,the advancement of personalized medicine,and the mitigation of drug ***,the analysis identifies significant weaknesses,including the prohibitive cost of treatment,issues with patient compliance,and the necessity for comprehensive long-term safety *** paper also delineates opportunities to augment therapeutic success through the incorporation of biomarkers,the application of artificial intelligence,and extensive international collaborative *** contrast,the paper does not shy away from addressing the threats,which include the potential for therapeutic resistance and the logistical challenges inherent in global therapy *** initiatives aim to refine future therapeutic practices,fostering safer,more effective,and personalized treatment paradigms for IBD patients.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease Combination therapy Strengths,weaknesses,opportunities,threats analysis

Research progress on piperidine-containing compounds as agrochemicals

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Chinese Chemical Letters 2025年第1期36卷 58-67页

作者： Wei Sun Anjing Liao Li Lei Xu Tang Ya Wang Jian Wu State key laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China

Piperidine is a crucial pharmacophore and a special scaffold in the realm of drug *** flexibility increases the molecule’s capability to bind to the *** piperidine-containing compounds are distinguished by their remarkable activity,and are increasingly becoming a vital category of *** this review,the research progress of piperidines in the discovery of pesticides was updated according to their active *** structure-activity relationships(SARs),and mechanisms of action of piperidine-containing compounds were also *** article is meant to enable readers to quickly understand piperidines,while providing ideas for creating piperidines with novel structures and unique mechanisms of action.

关键词： Piperidine Agrochemicals Biological activity Structure-activity relationships Mechanism of action

Hp FBH3 transactivates HpCO7 via binding to the E-boxes in the promoter and may accelerate flower formation in pitaya

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Journal of Integrative Agriculture 2025年第2期24卷 575-593页

作者： Xiaowei Cai Ling Xiao Xiangmei Nie Qiandong Hou Sulin Wen Kun Yang Xiaopeng Wen key laboratory of Plant resources Conservation and Germplasm Innovation in mountainous Region (Ministry of Education) Institute of Agro-Bioengineering/College of Life SciencesGuizhou University guizhou key laboratory of Agro-Bioengineering Guizhou University

Hylocereus polyrhizus,also known as pitaya or dragon fruit,is a climbing cactus grown worldwide because of its excellent performance under drought stress and appealing red-purple *** practice,accelerating flower formation and inducing more flowers usually result in higher ***,the genes for this purpose have not been well characterized in ***,FLOWERING BHLHs （FBHs） have been identified as positive regulators of flower *** the present work,a total of eight FBHs were identified in *** is a greater number than in beet and spinach,possibly because of the recent whole-genome duplication that occurred in the pitaya *** phylogenetic tree indicated that the FBHs could be divided into three *** TYPE Ⅱ,the genes of Caryophyllales encode atypical FBHs and are generated by dispersed *** Ka/Ksratios indicated that HpFBHs are under purifying *** and expression analysis of HpFBHs revealed that they are spatiotemporally activated in flower-related tissues and responsive to multiple abiotic *** results indicated that HpFBHs are involved in the flower formation of ***,typical HpFBH1/3 from TYPE ⅡI and an atypical HpFBH8 from TYPE Ⅱ were selected for functional ***3 was found to heterodimerize with HpFBH1 in the nucleus using subcellular localization,yeast two-hybrid and luciferase complementation *** bioinformatic analysis,all HpFBHs were predicted to transactivate downstream genes via binding to the E-boxes,which were frequently detected in the promoters of HpCOs,HpFTs and ***-Seq datasets showed that these flowering accelerators were expressed in coordination with *** one-hybrid and dual-luciferase reporter assays further verified that HpFBH3 transactivated HpCO7 by selectively binding to the E-boxes in the ***,ectopic overexpression of HpFBH3 accelerated flower formation in *** summary,this study systematical

关键词： pitaya FLOWERING BHLH dimerization transactivation flower formation

Environmental colloid behaviors of humic acid-Cadmium nanoparticles in aquatic environments

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Journal of Environmental Sciences 2025年第3期149卷 663-675页

作者： Ruyi Zheng Jian Zhu Peng Liao Dengjun Wang PanWu Wenjian Mao Yuqin Zhang Weiwei Wang College of resources and Environment Engineering Key Laboratory of Karst Georesources and EnvironmentMinistry of EducationGuizhou UniversityGuiyang 550025China guizhou Karst Environmental Ecosystems Observation and Research Station Ministry of EducationGuizhou UniversityGuiyang 550025China State key laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of ScienceGuiyang 550081China School of Fisheries Aquaculture and Aquatic SciencesAuburn UniversityAuburnAL 36849USA

Humic acid(HA),a principal constituent of natural organic matter(NOM),manifests ubiquitously across diverse ecosystems and can significantly influence the environmental behaviors of Cd(II)in aquatic *** studies on NOM-Cd(II)interactions have primarily focused on the immobilization of Cd(II)solids,but little is known about the colloidal stability of organically complexed Cd(II)particles in the *** this study,we investigated the formation of HA-Cd(II)colloids and quantified their aggregation,stability,and transport behaviors in a saturated porous media representative of typical subsurface *** from batch experiments indicated that the relative quantity of HA-Cd(II)colloids increased with increasing C/Cd molar ratio and that the carboxyl functional groups of HA dominated the stability of HA-Cd(II)*** results of correlation analysis between particle size,critical aggregation concentration(CCC),and zeta potential indicated that both Derjaguin-Landau-Verwey-Overbeek(DLVO)and non-DLVO interactions contributed to the enhanced colloidal stability of HA-Cd(II)*** results further confirmed that the stable HA-Cd(II)colloid can transport fast in a saturated media composed of clean ***,this study provides newknowledge of the colloidal behaviors of NOM-Cd(II)nanoparticles,which is important for better understanding the ultimate cycling of Cd(II)in aquatic systems.

关键词： HA-Cd(II)colloids Colloid formation Colloid aggregation Transport