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Relationship between mechanical load and surface erosion degradation of a shape memory elastomer poly(glycerol-dodecanoate)for soft tissue implant

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Regenerative Biomaterials 2023年第1期10卷 1085-1095页

作者： Kaixiang Jin Hanqin Li Mingkai Liang Yuqi Li Lizhen Wang Yubo Fan key laboratory of biomechanics and mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China State key laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100083China

Poly(glycerol-dodecanoate)(PGD)has aroused increasing attention in biomedical engineering for its degradability,shape memory and rubber-like mechanical properties,giving it potential to fabricate intelligent implants for soft *** degradation is important for biodegradable implants and is affected by various *** mechanical load has been shown to play an important role in regulating polymer degradation in *** in-depth investigation of PGD degradation under mechanical load is essential for adjusting its degradation behavior after implantation,further guiding to regulate degradation behavior of soft tissue implants made by *** vitro degradation of PGD under different compressive and tensile load has proceeded in this study and describes the relationships by empirical *** on the equations,a continuum damage model is designed to simulate surface erosion degradation of PGD under stress through finite element analysis,which provides a protocol for PGD implants with different geometric structures at varied mechanical conditions and provides solutions for predicting in vivo degradation processes,stress distribution during degradation and optimization of the loaded drug release.

关键词： poly(glycerol-dodecanoate) in vitro degradation mechanical load surface erosion numerical simulation

A surface-eroding poly(1,3-trimethylene carbonate)coating for magnesium based cardiovascular stents with stable drug release and improved corrosion resistance

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Bioactive Materials 2022年第1期7卷 144-153页

作者： Hongyan Tang Shuangshuang Li Yuan Zhao Cunli Liu Xuenan Gu Yubo Fan key laboratory for biomechanics and mechanobiology of ministry of education School of Biological Science and Medical EngineeringBeihang UniversityBeijing10083China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing102402China

Magnesium alloys with integration of degradability and good mechanical performance are desired for vascular stent ***-eluting coatings may optimize the corrosion profiles of magnesium substrate and reduce the incidence of restenosis *** this paper,poly(trimethylene carbonate)(PTMC)with different molecular weight(50,000 g/mol named as PTMC5 and 350,000 g/mol named as PTMC35)was applied as drug-eluting coatings on magnesium alloys.A conventional antiproliferative drug,paclitaxel(PTX),was incorporated in the PTMC *** adhesive strength,corrosion behavior,drug release and biocompatibility were *** with the PLGA control group,PTMC coating was uniform and gradually degraded from surface to inside,which could provide long-term protection for the magnesium ***35 coated samples exhibited much slower corrosion rate 0.05μA/cm^(2)in comparison with 0.11μA/cm^(2)and 0.13μA/cm^(2)for PLGA and PTMC5 coated *** addition,PTMC35 coating showed more stable and sustained drug release ability and effectively inhibited the proliferation of human umbilical vein vascular smooth muscle *** test indicated that few platelets were adhered on PTMC5 and PTMC35 ***35 coating,exhibiting surface erosion behavior,stable drug release and good biocompatibility,could be a good candidate as a drug-eluting coating for magnesium-based stent.

关键词： Magnesium alloy Polymeric coating Surface erosion Drug release Cardiovascular stents

Integrated gradient tissue-engineered osteochondral scaffolds:Challenges,current efforts and future perspectives

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Bioactive Materials 2023年第2期20卷 574-597页

作者： Xiaolian Niu Ning Li Zhipo Du Xiaoming Li key laboratory for biomechanics and mechanobiology of ministry of education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China Department of Orthopedics The Fourth Central Hospital of Baoding CityBaoding072350China

The osteochondral defect repair has been most extensively studied due to the rising demand for new therapies to diseases such as *** engineering has been proposed as a promising strategy to meet the demand of simultaneous regeneration of both cartilage and subchondral bone by constructing integrated gradient tissue-engineered osteochondral scaffold(IGTEOS).This review brought forward the main challenges of establishing a satisfactory IGTEOS from the perspectives of the complexity of physiology and microenvironment of osteochondral tissue,and the limitations of obtaining the desired and required ***,we comprehensively discussed and summarized the current tissue-engineered efforts to resolve the above challenges,including architecture strategies,fabrication techniques and in vitro/in vivo evaluation methods of the ***,we highlighted the advantages and limitations of various fabrication techniques of IGTEOS,and common cases of IGTEOS ***,based on the above challenges and current research progress,we analyzed in details the future perspectives of tissue-engineered osteochondral construct,so as to achieve the perfect reconstruction of the cartilaginous and osseous layers of osteochondral tissue *** comprehensive and instructive review could provide deep insights into our current understanding of IGTEOS.

关键词： Osteochondral tissue engineering Integrated gradient tissue-engineered osteochondral scaffold(IGTEOS) Tissue-engineered strategies Fabrication techniques Evaluation

Acupuncture Enhances Signalsat Sensitized Acupoints to Elevate Pressure Pain Thresholdin Knee Osteoarthritis Patients

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Chinese Journal of Integrative Medicine 2022年第12期28卷 1105-1110页

作者： WANG Xiao-yu NIE Zhong-yi YU Qing-quan CHEN Wei ZHANG Xiao-ning WAN Hong-ye SUYang-shuai HE Wei Li Ru-ya JING Xiang-hong Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China key laboratory for biomechanics and mechanobiology of ministry of education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China

Objective:To observe the pressure pain threshold(PPT),skin conductance(SC)and blood perfusion(BP)of the sensitized acupoints in patients with knee osteoarthritis(KOA),and explore the mechanism of acupuncture at the sensitized acupoints for treating ***:Eleven healthy subjects and 11 unilateral KOA patients were recruited from July 2020 to March 2021 in this *** PPT,SC and BP of control acupoints in healthy controls,and non-sensitized and sensitized acupoints in KOA patients were measured and compared between baseline and after manual acupuncture(MA)***:Before MA treatment,lower PPT was observed at the sensitized acupoints comparedwith non-sensitized andcontrol acupoints(P0.05).Compared with the control and non-sensitized acupoints,there were significant increases of SC and BP in sensitized acupoints of KOA patients after MA treatment(P<0.05 or P<0.01).Conclusion:MA at sensitized acupoints could elevate PPT of KOA patients,which may be associated with the increment of SC and BP.

关键词： sensitized acupoint pain manual acupuncture skin conductance blood perfusion

Coherent Raman scattering imaging of lipid metabolism in cancer

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Journal of Innovative Optical Health Sciences 2023年第3期16卷 3-12页

作者： Shuo Zhang Yexuan He Shuhua Yue key laboratory of biomechanics and mechanobiology(Beihang University) Ministry of EducationInstitute of Medical PhotonicsBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083P.R.China MoE key laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and TechnologyWuhan 430074P.R.China

Cancer cells dysregulate lipid metabolism to accelerate energy production and biomolecule synthesis for rapid *** metabolism is highly dynamic and intrinsically heterogeneous at the single cell ***°uorescence microscopy has been commonly used for cancer research,bulky°uorescent probes can hardly label small lipid molecules without perturbing their biological *** a challenge can be overcome by coherent Raman scattering(CRS)microscopy,which is capable of chemically selective,highly sensitive,submicron resolution and high-speed imaging of lipid molecules in single live cells without any *** developed hyperspectral and multiplex CRS microscopy enables quantitative mapping of various lipid metabolites in *** incorporation of CRS microscopy with Raman tags greatly increases molecular selectivity based on the distinct Raman peaks well separated from the endogenous cellular *** to these unique advantages,CRS microscopy sheds new insights into the role of lipid metabolism in cancer development and *** review focuses on the latest applications of CRS microscopy in the study of lipid metabolism in cancer.

关键词： Coherent Raman scattering microscopy cancer metabolism lipid metabolism

Aquatic unmanned aerial vehicles(AquaUAV):Bionic prototypes,key technologies,analysis methods,and potential solutions

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Science China(Technological Sciences) 2023年第8期66卷 2308-2331页

作者： WANG XinYang YANG XingBang ZHAO JiaWei PEI Xuan SU HaoHong WANG TianMiao HOU TaoGang School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100083China School of Biological Science and Medical Engineering Beijing Advanced Innovation Centre for Biomedical EngineeringKey Laboratory for Biomechanics and Mechanobiology of Ministry of EducationBeihang UniversityBeijing 100083China

Some research on aircraft is largely inspired by *** them,aerial-aquatic amphibians with trans-media locomotion capabilities have greatly promoted the development of aquatic unmanned aerial vehicles(Aqua UAV).In this article,the studies of Aqua UAV are sorted out by their biological counterpart and summarized in chronological order from 2005 to *** further understand the key technologies of Aqua UAV,we focus on the structural compatibility design of wing and aerial-aquatic propulsion methods by analyzing their advantages and *** addition,the analysis methods of kinematics and dynamics performance of Aqua UAV for simulation and experiment are involved in the process of studying the kinematics,lift/drag,and propulsion of ***,we present several challenges and propose some potential solutions to improve the ability of Aqua UAV in the future.

关键词： aquatic unmanned aerial vehicle(AquaUAV) variable wing design propulsion system computer simulation

Synthesis and Characterization of Chitosan-graft-Poly(lactic acid) Copolymer

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Chinese Journal of Polymer Science 2014年第1期32卷 43-50页

作者：牛旭锋 Feng Tian Li-zhen Wang Xiao-ming Li Gang Zhou 樊瑜波 key laboratory for biomechanics and mechanobiology of ministry of education School of Biological Science and Medical Engineering Beihang University BUAA Research Institute

Chitosan-graft-poly（lactic acid）（CS-g-PLA） copolymer was synthesized through emulsion self-assembly in a water-in-oil （W/O） microemulsion. The water phase was composed of CS aqueous solution, while the oil phase was made up of PLA in chloroform. The W/O microemulsion was fabricated in the presence of surfactant span-80 and the self-assembly was performed between PLA and CS under the effect of N-（3-dimethylaminopropyl）-N＇ethylcarbodiimide hydrochloride （EDC＇HCI）. FTIR and IH-NMR analysis indicated PLA was grafted onto the backbone of CS via the reaction between the carboxyl groups in PLA and the amino groups in CS. 1H-NMR characterization further revealed the grafting content of PLA was 16%. The obtained CS-g-PLA could self-assemble to form micelles, their size distributed in the range of 125-375 nm with average diameter of 142 nm. The present design integrates the favorable biological properties of CS and the excellent mechanical properties of PLA, which makes CS-g-PLA copolymer a promising candidate as a carrier for targeted bioactive molecules delivery.

关键词： Poly(lactic acid) Chitosan Copolymer Self-assembling Grafting.

Effect of covalent-binding modes of osteogenic-related peptides with artificial carriers on their biological activities in vivo

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Journal of Materials Science & Technology 2023年第9期140卷 163-175页

作者： Cunyang Wang Suxiang Yu Qi Guo Ke Zhang Yuntao Di Xiaoming Li key laboratory for biomechanics and mechanobiology of ministry of education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Neurosurgery The Fourth Central Hospital of Baoding CityBaoding 072350China Department of Biomedical Engineering City University of Hong KongKowloonHong Kong SAR 999077China

Covalent binding between bioactive substances and materials in different ways can significantly improve the bone inductivity and biological activity of bone repair ***,there is a lack of systematic understanding of how these binding modes affect biological activities of the active *** this study,four kinds of functionalized Multi-walled carbon nanotubes(MWCNTs)were prepared,ensuring the same grafting rate of different functional ***,two kinds of osteogenic-related peptides,bone morphogenetic protein-2 mimicking peptides and osteogenic growth mimicking peptides,were covalently bound to functionalized MWCNTs,ensuring the same molar mass of peptides bound to different functionalized MWCNTs in this *** the same amount of functionalized MWC-NTs/Peptides composites were introduced into the scaffolds,and through the ectopic osteogenesis model in rats and calvarial defect model in rabbits,ectopic osteogenesis and bone repair ability of the composites were ***,the effects of different covalent binding modes on peptide-induced osteogenesis and bone repair were *** results showed that the negative influencing trend of different covalent binding modes of osteogenic-related peptides with artificial carriers on their biological activities was in the order as follows:amide binding(carboxyl)>silane coupling>dopamine bind-ing>amide binding(amino),whose mechanism might be mainly that the covalent binding of peptides with different functional groups resulted in different *** believe that the results of this study have important guiding significance for the research and development of bone repair materials covalently bound with bioactive substances.

关键词： Osteogenic-related peptides Covalent binding Ectopic osteogenesis Calvarial defect

Magnesium based degradable biomaterials： A review

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Frontiers of Materials Science 2014年第3期8卷 200-218页

作者： Xue-Nan GU Shuang-Shuang LI Xiao-Ming LI Yu-Bo FAN key laboratory for biomechanics and mechanobiology of ministry of education School of Biological Science and Medical Engineering Beihang University Beijing 100191 China

Magnesium has been suggested as a revolutionary biodegradable metal for biomedical applications. The corrosion of magnesium, however, is too rapid to match the rates of tissue healing and, additionally, exhibits the localized corrosion mechanism. Thus it is necessary to control the corrosion behaviors of magnesium for their practical use. This paper comprehensively reviews the research progress on the development of representative magnesium based alloys, including Mg-Ca, Mg-Sr, Mg-Zn and Mg-REE alloy systems as well as the bulk metallic glass. The influence of alloying element on their microstructures, mechanical properties and corrosion behaviors is summarized. The mechanical and corrosion properties of wrought magnesium alloys are also discussed in comparison with those of cast alloys. Furthermore, this review also covers research carried out in the field of the degradable coatings on magnesium alloys for biomedical applications. Calcium phosphate and biodegradable polymer coatings are discussed based on different preparation techniques used. We also compare the effect of different coatings on the corrosion behaviors of magnesium alloys substrate.

关键词： magnesium alloy degradable biomaterial coating degradation corrosion