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Diagonal-symmetrical and Midline-symmetrical Unit Cells with Same Porosity for Bone Implant: Mechanical Properties Evaluation

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Journal of Bionic Engineering 2019年第3期16卷 468-479页

作者： Jian Li Diansheng Chen Yingying Zhang Yan Yao Zhongjun Mo Lizhen Wang Yubo Fan Robotic Institute Beihang University Beijing 100191 China Beijing key laboratory of Rehabilitation Technical Aids for Old-Age and Disability and Key Laboratory of Rehabilitation Aids Technology and System of the Ministry of Civil Affairs National Research Center for Rehabilitation Technical Aids Beijing 100176 China Beijing Advanced Innovation Center for Biomedical Engineering Beihang University Beijing 100191 China key laboratory for biomechanics and mechanobiology of ministry of education School of Biological Science and Medical Engineering Beihang University Beijing 100191 China

In this study, mechanical properties of bionic porous structures with diagonal-symmetrical and midline-symmetrical unit cells were studied when the porosities were same. Three typical unit cells (Diamond (DO), Rhombic Dodecahedron (RD), and Octet Truss (OT)) were selected, in which DO has diagonal-symmetrical shape, while RD and OT share midline-symmetrical structure. Based on the same porosity, corresponding models were designed, and Ti6Al4V samples were manufactured by electron beam melting. Then, using Mechanical Properties Testing (MPT) and Finite Element Analysis (FEA) methodologies, mechanical properties and transmissions of different porous structures were evaluated. Besides, composition and details before and after printing were analyzed with Energy Dispersive Spectrometer (EDS), X-ray diffraction (XRD) and Scanning Electron Microscope (SEM). MPT results showed that midline-symmetrical shape would have superior compressive performance than diagonal-symmetrical shape, but opposite trend for the torsion performance, which were in line with FEA prediction. Furthermore, effective modulus of DO, RD and OT were 2.59 GPa, 4.89 GPa, and 1.77 GPa, approximating the mechanical properties of human bones. Additionally, manufacturing defects and discrepancies between FEA and MPT were found. This study would provide great helps for unit cell selection and initial mechanical properties matching for optimum bone implants.

关键词： bionic design porous implant mechanical properties unit cell additive manufacturing 3D printing

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The utilization of carbon-based nanomaterials in bone tissue regeneration and engineering:Respective featured applications and future prospects

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Medicine in Novel Technology and Devices 2022年第4期16卷 172-187页

作者： Ying Chen Xiaoming Li key laboratory for biomechanics and mechanobiology of ministry of education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

In recent years,with advancements in bone tissue regeneration and engineering technologies,carbon-based nanomaterials(CNMs)have progressively demonstrated advantages in the therapies of critical bone defects and related diseases that conventional substances fail to develop,such as excellent mechanical properties,large specific surface,tunable surface characteristics,and superior biocompatibility.More importantly,carbon-based nanomaterials with efficient cell proliferation and osteogenic differentiation could have a significant impact on bone tissue regeneration.In this paper,we have reviewed the characteristic applications of extraordinary types of carbon-based nanomaterials(fullerene,carbon dots,carbon nanotubes,as well as graphene and its derivatives)in bone tissue regeneration and engineering based on their structural properties,with a view to presenting their unique advantages,applications,and current directions of development as specifically and comprehensively as possible.

关键词： Carbon-based nanomaterials(CNMs) Fullerene Carbon dots(CDs) Carbon nanotubes(CNTs) Graphene and its derivatives(GDs) Bone tissue engineering

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A resazurin-based,nondestructive assay for monitoring cell proliferation during a scaffold-based 3D culture process

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Regenerative Biomaterials 2020年第3期7卷 271-281页

作者： Xianghui Gong Zhuqing Liang Yongxing Yang Haifeng Liu Jing Ji Yubo Fan key laboratory for biomechanics and mechanobiology of ministry of education School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083People’s Republic of China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing 102402People’s Republic of China National Research Center for Rehabilitation Technical Aids Beijing 100176People’s Republic of China

Development of viable cell estimation method without sacrificing proliferation and functions of cells cultured on regenerative biomaterials is essential for regenerative engineering.Cytotoxicity and depletion of resazurin are critical but often overlooked limitations that hindered applications of resazurin in viable cell estimation.The present work found that cytotoxicity and depletion of resazurin depended on cell concentration,resazurin concentration and resazurin incubation time.A simple strategy which only allowed cells to incubate with resazurin during each measurement was developed to eliminate negative effects of resazurin.This strategy was verified by monitoring proliferation of MC3T3-E1 preosteoblasts on poly(D,L-lactic acid)scaffold during a continuous 3D culture process for up to 21 days,comparing the accuracy with MTT assay which is a destructive assay with high sensitivity and accuracy and commonly used in regenerative engineering and comparing viability,proliferation and differentiation functions of MC3T3-E1,which were treated with/without this strategy for nondestructive evaluation.This method showed comparable linearity of standard curve and characteristics of growth curve to MTT assay.No major negative effects of this method on MC3T3-E1 viability and functions were found.Our work highlighted the importance of the concentration and incubation time of resazurin in designing application-specific nondestructive viability assay and would be helpful in improving the implanted medical devices as well as in regenerative engineering.

关键词： resazurin nondestructive viable cell estimation cytotoxicity resazurin depletion cell-based regenerative medicine

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Stretchable graded multichannel self-powered respiratory sensor inspired by shark gill

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Fundamental Research 2022年第4期2卷 619-628页

作者： Yang Zou Yansong Gai Puchuan Tan Dongjie Jiang Xuecheng Qu Jiangtao Xue Han Ouyang Bojing Shi Linlin Li Dan Luo Yulin Deng Zhou Li Zhong Lin Wang School of Life Science Institute of Enginering MedicinBejing Institute of TechnologyBejing 10oo81China CAs Center for Excellence in Nanoscience Bejing Key Laboratory of Micro-Nano Energy and SensorBejing Instute of Nanoenergy and NanosystemsChinese Acadermy of SciencesBeijing 101400China Center on Nanoenergy Research School of Chemistry and Chemical Engineering School of Physical Science and TechnologyGuangxi UniversiyNanning 53004China key laboratory for biomechanics and mechanobiology of Chinese education ministry Bejing Advanced Inovation Centre for Biomedical Engieering School of Biological Science and Medical EngineringBeihang UniversityBejing 100083China School of Nanoscience and Technology Universiy of Chinese Academy of ScienesBejing 100049China

Respiratory sensing provides a simple,non-invasive,and efficient way for medical diagnosis and health monitoring,but it relies on sensors that are conformal,accurate,durable,and sustainable working.Here,a stretchgll structure can convert transverse elastic deformation into longitudinal elastic deformation during stretching.able,multichannel respiratory sensor inspired by the structure of shark gill cleftis reported.The bionic shark Combining the optimized bionic shark gll structure with the piezoelectric and the triboelectric effect,the bionic shark gill respiratory sensor(BSG-RS)can produce a graded electrical response to different tensile strains.Based on this feature,BSG-RS can simultaneously monitor the breathing rate and breathing depth of the human body accurately,and realize the effective recognition of the different human body's breathing state under the supporting software,With good stretchability,wearabilit,acuracy,and long-term stability(50,0oo cycles),BSG-RS is expected to be applied as self-powered smart wearables for mobile medical diagnostic analysis in the future.

关键词： Bionic Sharkgill Graded Multichannel Respiratory sensing

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Effects of hypoxia on the biological behavior of MSCs seeded in demineralized bone scaffolds with different stiffness

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Acta Mechanica Sinica 2019年第2期35卷 309-320页

作者： Yuanyuan Sun Guobao Chen Yonggang Lv key laboratory of Biorheological Science and Technology (Chongqing University) Ministry of Education Bioengineering College Chongqing University Chongqing 400044 China mechanobiology and Regenerative Medicine laboratory Bioengineering College Chongqing University Chongqing 400044 China

Matrix stiffness has been demonstrated in many studies to adjust the biological behaviors of mesenchymal stem cells (MSCs). However, in the initial phase of bone restore, MSCs will encounter a hypoxic microenvironment. Studying the connection existing between the matrix stiffness and biological behavior of MSCs under hypoxic condition can better simulate the microenvironment at the prime period of bone repairment. In this work, three-dimensional (3D) decalcified bone scaffolds with diverse stiffness (high stiffness (66.06 ± 27.83) MPa, medium stiffness (26.90 ± 13.16) MPa, and low stiffness (0.67 ± 0.14) MPa) but same microstructure have been prepared by controlling decalcification time. In addition, the decellularized bone scaffold was regard as control group and its stiffness was (230.93 ± 72.65) MPa. The viability, proliferation, infiltration, and osteogenic differentiation of MSCs seeded into these 3D demineralized bone scaffolds were systematically investigated under 100 μM CoCl2-simulated hypoxic and normoxic environments. The results showed that the viability, proliferation, and extracellular matrix (ECM) secretion of MSCs had no significant difference on scaffolds with diverse stiffness but the degree of collagen deposition of MSCs gradually increased with the increase of scaffold stiffness both under normoxia and hypoxia. Compared to normoxia, the viability, proliferation, ECM secretion, vascular endothelial growth factor (VEGF) expression, and osteogenis of MSCs on the scaffolds with the same stiffness were evidently inhibited by hypoxia. Additionally, under hypoxic condition, the expression of VEGF and hypoxia inducible factor 1α(HIF-1α) in MSCs on the low stiffness scaffold was markedly increased comparing to those on other groups. In summary, we found that the low stiffness scaffold can improved the proliferation and osteoginic differentiation of MSCs under hypoxic environment, which may help to explore efficient methods for bone defect repairing.

关键词： Mesenchymal stem cells Hypoxia Matrix stiffness Demineralized bone scaffold Osteogenic differentiation

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Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli

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Acta Mechanica Sinica 2021年第2期37卷 201-217页

作者： Xinyu Shu Ning Li Yi Wu Wang Li Xiaoyu Zhang Peiwen Li Dongyuan Lu Shouqin Lu Mian Long Center for biomechanics and Bioengineering Key Laboratory of Microgravity(National Microgravity Laboratory)and Beijing Key Laboratory of Engineered Construction and MechanobiologyInstitute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Sciences University of Chinese Academy of SciencesBeijing 100049China

Liver sinusoidal endothelial cells(LSECs)are the gatekeeper of liver to maintain hepatic homeostasis.They are formed into the highly specialized endothelium between vascular lumen and the space of Disse and are mechanosensitive to respond varied microenvironments.Shear stress and mechanical stretch induced by blood perfusion and substrate stiffness enhancement derived from deposition of extracellular matrix(ECM)are major mechanical stimuli that surround LSECs.This review introduces how LSECs respond to the external forces in both physiological and pathological cases and what is the interplay of LSECs with other hepatic cells.Molecular mechanisms that potentiate LSECs mechanotransduction are also discussed.

关键词： Liver sinusoidal endothelial cell Shear stress Mechanical stretch Extracellular matrix Stiffness

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Muscle Strength Measurement and Analysis of Chinese Young Males

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Chinese Journal of Biomedical Engineering(English Edition) 2018年第2期27卷 68-73页

作者： ZHOU Qian-xiang LIU Zhong-qi key laboratory for biomechanics and mechanobiology of the ministry of education School of Biological Science and Medical Engineering Beihang University

To establish a database of muscle strength of the Chinese people. The study sampled data of 843 Chinese young males all over the country. Back force, hand twisting force and arm force of four different exerting directions(pull, push, adduction and abduction)were measured Comparisons were made between the results of this study and those from other documents. Different types of the strength were also compared. The factors of stature and weight influenced on muscle force were analyzed There are obvious difference of arm strength in four directions, which can be ordered as push, pull, adduction and abduction, the push force is the largest and the abduction force is the least The significant correlation exists between different types force. Weight has an obvious influence on one's force among above three factors. Chinese young males database is established at the first time. Results of the study can provide help for the ergonomists, the workers of occupation health and the researchers ofrehabilitation.

关键词： anthropometry strenthmeasurement ergonomics database correlation

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Highly integrated watch for noninvasive continual glucose monitoring

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Microsystems & Nanoengineering 2022年第1期8卷 331-339页

作者： Tianrui Chang Hu Li Nianrong Zhang Xinran Jiang Xinge Yu Qingde Yang Zhiyuan Jin Hua Meng Lingqian Chang key laboratory of biomechanics and mechanobiology Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Biomedical Engineering City University of Hong KongHong KongChina General Surgery Department&Obesity and Metabolic Disease Center China-Japan Friendship HospitalBeijing 100029China Sense Future(HangZhou)Co. LtdHangzhou 311217China

This article reports a highly integrated watch for noninvasive continual blood glucose monitoring.The watch employs a Nafion-coated flexible electrochemical sensor patch fixed on the watchband to obtain interstitial fluid(ISF)transdermally at the wrist.This reverse iontophoresis-based extraction method eliminates the pain and inconvenience that traditional fingerstick blood tests pose in diabetic patients’lives,making continual blood glucose monitoring practical and easy.All electronic modules,including a rechargeable power source and other modules for signal processing and wireless transmission,are integrated onto a watch face-sized printed circuit board(PCB),enabling comfortable wearing of this continual glucose monitor.Real-time blood glucose levels are displayed on the LED screen of the watch and can also be checked with the smartphone user interface.With 23 volunteers,the watch demonstrated 84.34%clinical accuracy in the Clarke error grid analysis(zones A+B).In the near future,commercial products could be developed based on this lab-made prototype to provide the public with noninvasive continual glucose monitoring.

关键词： Highly checked eliminate

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Effect of Sleep Deprivation on Eye Movement Behavior in Flight Simulation

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Chinese Journal of Biomedical Engineering(English Edition) 2013年第4期22卷 178-184页

作者： LIU Zhong-qi ZHOU Qian-xiang key laboratory for biomechanics and mechanobiology of the ministry of education School of Biological Science and Medical EngineeringBeihang University

To examine the effect of sleep deprivation(SD) on eye movement behavior in flight task,four subjects who were skilled in flight simulator participated in the experiment,which were asked to perform a level flight task in a flight simulator.Eye movement data and flight performance data were measured at the following hours:11:00,15:00,04:00,11:00,15:00.The subjects workload and fatigue were assessed with the method of national aeronautics and space administration-task load index(NASA-TLX) and rating of perceived exertion(RPE).Eye movement indices of average pupil area,average saccade amplitude and average saccade velocity decreased during the 32 h of SD and they all showed significantly change in the final SD while the index of average fixation time increased in the final SD.Flight performance deteriorated during the 32 h of SD,but not significantly.The feeling of fatigue and workload reported by subjects both increased during the 32 h of SD.Daily rhythm effects on the measured indices were also found,there were a obviously change at the hour of 04:00.32 h of SD has obvious effect on eye movement behaviors which have close relation to fatigue because of SD.The eye movement measurement can be served as a tool to continually monitor fatigue online.

关键词：飞行仿真睡眠剥夺眼动行为飞行模拟器眼球运动飞行任务测量时间

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Effect ofβ-cyclodextrin on the hemocompatibility of heparin-modified PMP hollow fibrous membrane for Extracorporeal Membrane Oxygenation(ECMO)

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Medicine in Novel Technology and Devices 2023年第2期18卷 143-151页

作者： Xingrui Zhong Ting He Zhaohui Wang Yawei Wang Linhao Li Zhaoliang Cui State key laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing210009China National Engineering Research Center for Special Separation Membrane Nanjing Tech UniversityNanjing210009China Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM) Nanjing Tech UniversityNanjing210009China key laboratory for biomechanics and mechanobiology of ministry of education Beijing Advanced Innovation Centre for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China Beijing Aerospace Changfeng Co. Ltd.Beijing100854China

In this paper,modified membranes containingβ-cyclodextrin(β-CD)and heparin coatings were prepared on the surface of poly-4-methyl-1-pentene(PMP)hollow fibrous membrane using the high strength adhesion of polydopamine(PDA).In this paper,β-CD was added to increase the hemocompatibility of the PMP hollow fibrous membranes and the stability of the heparin coating.The uniformity of the heparin coating withβ-CD addition was better than that of the groups withoutβ-CD.After seven days of saline rinsing,the surface of the modified membranes withβ-CD addition still had a large amount of heparin present,which was more stable compared to the control group.After surface modification,the modified membrane changed from hydrophobic to hydrophilic.Importantly,the protein adsorption,platelet adhesion,and hemolysis rates of the modified membranes were significantly reduced compared with the pristine membranes.The APTT values were also significantly increased.The results showed that the modified membranes with the addition ofβ-CD had better hydrophilicity,can maintain the stability of heparin coating for a long time,and finally showed good hemocompatibility.

关键词： β-cyclodextrin Heparin Dopamine Hemocompatibility

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