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Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases

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Science China Life Sciences 2025年第1期68卷 303-305页

作者： Ziqian Xu Lianpan Dai Jun Liu National key laboratory of Intelligent Tracking and Forecasting for Infectious diseases (NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention CAS key laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Vector-borne viruses, transmitted among humans and animal hosts through bites of vectors such as mosquitoes and ticks,pose a great and ongoing threat to public health and biosafety(Yang et al., 2022).Among them, dengue virus-induced epidemics, have dramatically increased worldwide in recent decades. The report released by the World Health Organization(WHO) at the end of 2023 showed that dengue epidemic globally surged in2023, with the number of reported cases nearing a historical peak.

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Copper homeostasis and neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi Li Kaifei Xu Guoqing Wang Feng Zhang International Research laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

Infusion of short chain fatty acids in the ileum improves the carcass traits,meat quality and lipid metabolism of growing pigs

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animal nutrition 2021年第1期7卷 94-100页

作者： Anran Jiao Hui Diao Bing Yu Jun He Jie Yu Ping Zheng Yuheng Luo Junqiu Luo Quyuan Wang Huifen Wang Xiangbing Mao Daiwen Chen Institute of animal nutrition Sichuan Agricultural UniversityKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationKey Laboratory of Animal Disease-resistant Nutrition and Feed of China Ministry of Agriculture and Rural AffairsKey Laboratory of Animal Disease-resistant Nutrition of Sichuan ProvinceYa'an625014China

Short chain fatty acids(SCFA)are the main products of indigestible carbohydrates undergoing bacterial fermentation in the hindgut,which are related to some physiological *** study was designed to investigate the effects of SCFA infusion by ileum on the carcass traits,meat quality and lipid meta-bolism of growing *** a 28-day study,24 growing barrows fitted with a T-cannula in distal ileum were divided into 4 treatments:1)Control,2)antibiotics(AB),3)AB+300 mL of SCFA1 solution(ABS1),4)AB+300 mL of SCFA2 solution(ABS2).The concentrations of acetate,propionate and butyrate in SCFA1 solution were respectively 61.84,18.62 and 12.55 mmol/L,and in SCFA2 were respectively 40.08,15.41 and 9.78 mmol/L The results showed that the SCFA infusion increased the average daily feed intake and average daily gain of pigs(P<0.05).Meanwhile,the SCFA treatments increased longissimus dorsi area(P<0.05)and carcass weight(P=0.058),decreased the drip loss of longissimus dorsi(P=0.059),and reduced serum concentrations of triglyceride,total cholesterol and urea nitrogen(P<0.05).Besides,the SCFA administration inhibited the mRNA expressions of fatty acid synthase(FAS)and acetyl-CoA carboxylase in longissimus dorsi(P<0.05),the mRNA expression of FAS in the liver(P<0.05),and the mRNA expression of hormone-sensitive lipase in abdominal fat(P<0.05).Short chain fatty acid infusion also enhanced the mRNA expression of carnitine palmitoyltransferase-1αin the liver(P<0.05),the mRNA expressions of peroxisome proliferator activated receptor gamma and lipoprotein lipase in abdominal fat(P<0.05),and the mRNA expressions of free fatty acid receptor 2,glucose-6-phosphatase and phosphoenolpyruvate carboxykinase 1 in the colon(P<0.05).These results suggested that SCFA administration in the ileum could improve the carcass traits and meat quality of growing pigs,which was possibly due to the fact that SCFA modulated lipid metabolism.

关键词： Short chain fatty acid Carcass trait Meat quality Lipid metabolism Growing pig

Effect of dietary supplementation with mulberry(Morus alba L.) leaves on the growth performance,meat quality and antioxidative capacity of finishing pigs

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Journal of Integrative Agriculture 2019年第1期18卷 143-151页

作者： ZENG Zhu JIANG Jun-jie YU Jie MAO Xiang-bing YU Bing CHEN Dai-wen key laboratory for animal disease-resistant nutrition Ministry of Education/Institute of Animal NutritionSichuan Agricultural University

The present study was conducted to evaluate the effect of dietary mulberry(Morus alba L.) leaves powder(MLP) supplementation on meat quality of finishing pigs.A total of 40 Duroc×Landrace×Yorkshire pigs(initial body weight of(40.5±0.63) kg) were randomly allotted into two treatments,fed either with control diet or 15% MLP diet for 85 *** results showed that MLP diet decreased(P≤0.05) average daily gain(ADG) and increased(P<0.05) feed/gain ratio(F/G) in the finishing and whole *** diet also decreased(P<0.05) carcass weight,dressing percentage,last rib and average backfat ***,MLP diet increased(P<0.05) intramuscular fat(IMF) content,decreased(P<0.05) shear force,cooking loss and drip *** addition,MLP diet increased(P<0.05) total antioxidative capacity,glutathione peroxidase and tended(P<0.10) to increase total superoxide dismutase in *** longissimus thoracis,myosin heavy chain(MyHC) I and IIa mRNA levels were increased(P≤0.05) for MLP *** conclusion,15% MLP supplementation reduced the growth performance and carcass traits,but improved meat quality of finishing pigs possibly through the change of myofiber characteristics,enhancement of antioxidative capacity and increase of IMF.

关键词： mulberry leaves powder meat quality myofibers antioxidation pigs

Lysine deficiency impaired growth performance and immune response and aggravated inflammatory response of the skin,spleen and head kidney in grown-up grass carp (Ctenopharyngodon idella)

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animal nutrition 2021年第2期7卷 556-568页

作者： Yangyang Hu Lin Feng Weidan Jiang Pei Wu Yang Liu Shengyao Kuang Ling Tang Xiaoqiu Zhou animal nutrition Institute Sichuan Agricultural UniversityChengduChina Fish nutrition and Safety Production University Key Laboratory of Sichuan ProvinceSichuan Agricultural UniversityChengduChina key laboratory of animal disease-resistant nutrition Sichuan ProvinceChina key laboratory of animal disease-resistant nutrition Ministry of EducationChina key laboratory of animal disease-resistant nutrition and Feed Ministry of Agriculture and Rural AffairsChina animal nutrition Institute Sichuan Academy of Animal ScienceChengduChina

This dissertation was primarily focused on the immune response,inflammatory response and molecular mechanisms in the skin,head kidney and spleen of grown-up grass carp(Ctenopharyngodon idella).Six iso-nitrogen diets differing in lysine concentrations(5.6,8.5,11.6,14.4,17.5 and 20.7 g/kg)were fed to 540 grass carp(164.85±0.79 g)for 60 *** that,grass carp were challenged by Aeromonas hydrophila for 6 *** study revealed that lysine deficiency(1)suppressed the growth performa,nce of the fish and decreased their ability to resist skin lesion morbidity,(2)impaired the immune organ s immune response by decreasing the gene expressions of mucin,liver-expressed antimicrobial peptide(LEAP)-2B,β-defensin-1 and LEAP-2A and the production of antibacterial compounds of grown-up grass carp,and(3)aggravated the inflammatory response of immune organs in the fish by increasing the gene expressions of pro-inflammatory cytokines(interferon y2[IFN-γ2],tumor necrosis factorα[TNF-α],interleukin[IL]-15,IL-17D,IL-12p40,IL-6 and IL-8)and down-regulating anti-inflammatory cytokines(IL-11,transforming growth factorβ1[TGF-β1],IL-10 and IL-4/13A),which were tightly correlated with signal transducer and activator of transcription(STAT)1 and STAT3 signaling pathway,*** different phenomenon in the skin,spleen and head kidney of fish may be correlated with the difference in gene *** addition,using quadratic regression analysis of percent weight gain(PWG),skin lesion morbidity,and the lysozyme activities in the spleen and head kidney,the dietary lysine requirements for grown-up grass carp were estimated to be 13.58,13.51,14.56 and 14.18 g/kg,respectively.

关键词： Lysine deficiency Grass carp(Ctenopharyngodon idella) Immune function Head kidney Spleen Skin

Next-generation probiotic candidates targeting intestinal health in weaned piglets: Both live and heat-killed Akkermansia muciniphila prevent pathological changes induced by enterotoxigenic Escherichia coli in the gut

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animal nutrition 2024年第2期17卷 110-122页

作者： Cong Lan Hua Li Yuqing Shen Yang Liu Aimin Wu Jun He Jingyi Cai Gang Tian Xiangbing Mao Zhiqing Huang Bing Yu Ping Zheng Jie Yu Junqiu Luo Hui Yan Yuheng Luo key laboratory for animal disease-Resistance nutrition of Ministry of Education of China Key Laboratory for Animal Disease-Resistance Nutrition and Feed of Ministry of Agriculture of ChinaKey Laboratory of Animal Disease-Resistant Nutrition of Sichuan ProvinceEngineering Research Center of Animal Disease-Resistance Nutrition Biotechnology of Ministry of Education of ChinaAnimal Nutrition InstituteSichuan Agricultural University

The use of next-generation probiotics （NGP） in pigs for combating diseases has been subject to limited *** we explored the potential of a well-known NGP candidate Akkermansia muciniphila targeting pig gut *** the first screening experiment,we found that the abundance of *** peaked at 14 d old but decreased at weaning （21 d old;P<0.05）,suggesting the weaning period may be an effective window for *** *** that,48 crossbred weaned pigs at 28 d old were randomly assigned to five groups:control （CON）,high/low live *** （HA/LA）,and high/low heatkilled *** （HIA/LIA）.From 1 to 28 d old,the CON group received gastric infusion of anaerobic sterile saline every other day;the HA and LA groups were gavaged every other day with 1×1010CFU/5 m L and 5×10～8CFU/5 mL live ***,respectively;and the HIA and LIA groups were gavaged every other day with 1×1010CFU/5 mL and 5×10～8CFU/5 mL heat-killed ***,*** d 29,pigs in the CON group were randomly and equally divided into two groups,one of which was named the enterotoxigenic Escherichia coli （ETEC） group,and all groups except CON received a 5-d ETEC *** supplementation of *** numerically reduced the diarrhea rate of weaned pigs compared to the pigs that only received the ETEC challenge （P=0.57）,but the LIA group had a higher diarrhea rate than the CON group （P<0.05）.Consistent with this,the supplementation of *** improved the small intestinal morphology and structure,proportion of CD4+T lymphocytes in the blood,as well as the expression of genes related to intestinal barrier and antioxidant indices of pigs with ETEC challenge,especially for the LA group （P<0.05）.Meanwhile,*** supplementation reduced the expression of ETEC virulence factor genes in the ileum and colon of pigs challenged by ETEC （P<0.05）.Therefore,*** may protect the intestinal health of weaned piglets from damage caused by

关键词： Akkermansia muciniphila Weaned piglet Enterotoxigenic Escherichia coli challenge Intestinal health

Secondary bile acids are associated with body lipid accumulation in obese pigs

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animal nutrition 2024年第3期18卷 246-256页

作者： Yaolian Hu Aimin Wu Hui Yan Junning Pu Junqiu Luo Ping Zheng Yuheng Luo Jie Yu Jun He Bing Yu Daiwen Chen key laboratory of animal disease-resistant nutrition Ministry of EducationAnimal Nutrition InstituteSichuan Agricultural UniversityYa'an 625014China

The aim of this study was to investigate the reasons for the differences in lipid accumulation between lean and obese *** bile acids with varying levels within two types of pigs were found and then in vitro experiments were conducted to identify whether these bile acids can directly affect lipid *** pigs,including seven lean and seven obese pigs with body weights of approximately 80 kg,were fed the same diet at an amount approximately equivalent to 3%of their respective body weights daily for 42 *** vitro,3T3-L1 preadipocytes were cultured in medium with high glucose levels and were differentiated into mature adipocytes using differentiation ***,bile acids were added to mature adipocytes for 4 *** results showed that there was a difference in body lipids levels and gut microbiota composition between obese and lean pigs(P<0.05).According to the results of gut microbial function prediction,the bile acid biosynthesis in colonic digesta of obese pigs were different from that in lean ***-five bile acids were further screened by metabolomics,of which 4 were upregulated(P<0.05)and 2 were downregulated(P<0.05)in obese pigs compared to lean *** results of the correlation analysis demonstrated that chenodeoxycholic acid-3-β-D-glucuronide(CDCA-3Gln)andω-muricholic acid(ω-MCA)had a negative correlation with abdominal fat weight and abdominal fat rate,while isoallolithocholic acid(IALCA)was positively associated with crude fat in the liver and abdominal fat *** was a positive correlation between loin muscle area and CDCA-3Gln andω-MCA(P<0.05),however,IALCA and 3-oxodeoxycholic acid(3-oxo-DCA)were negatively associated with loin eye muscle area(P<0.05).Isoallolithocholic acid increased the gene expression of peroxisome proliferator-activated receptor gamma(PPARG)and the number of lipid droplets(P<0.05),promoting the lipid storage when IALCA was added to 3T3-L1 mature adipocytes in *** conclusion,the concentration of bile ac

关键词： Lean or obese pig Lipid accumulation Bile acid profile Gut microbiota

Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation

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Science China Life Sciences 2025年

作者： Xinyu Cui Yu Dong Qiang Zhan Yixin Huang Qianshu Zhu Zihao Zhang Guang Yang Liping Wang Shijun Shen Jia Zhao Zhiyi Lin Jiatong Sun Zhongqu Su Yihan Xiao Chuyu Zhang Yuwei Liang Lu Shen Lichen Ji Xuguang Zhang Jiqing Yin Hong Wang Zhiyang Chen Zhenyu Ju Cizhong Jiang Rongrong Le Shaorong Gao Clinical and Translational Research Center of Shanghai First Maternity & Infant Hospital Frontier Science Center for Stem Cells School of Life Sciences and Technology Tongji University key laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopaedic Department of Tongji Hospital School of Life Sciences and Technology Tongji University key laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative Medicine Department of Developmental & Regenerative Medicine College of Life Science and Technology Jinan University Shandong key laboratory of animal Bioengineering and disease Prevention College of Animal Science and Technology Shandong Agricultural University Department of Joint Surgery Shanghai East Hospital Tongji University School of Medicine Shanghai Institute of nutrition and Health Chinese Academy of Sciences

Inflammation is a driving force of hematopoietic stem cells(HSCs) aging, causing irreversible exhaustion of functional HSCs. However, the underlying mechanism of HSCs erosion by inflammatory insult remains poorly understood. Here, we find that transient LPS exposure primes aged HSCs to undergo accelerated differentiation at the expense of self-renewal, leading to depletion of HSCs. Meanwhile, the central regulator nuclear factor kappa B(NF-κB) mediating functional impairment by inflammation insult induces differential transcriptional response in aged HSCs compared with young HSCs, with precocious activation of myeloid lineage genes. Altered compartmentalization and chromatin loop formation are associated with aging-related differential transcriptional response in HSCs upon lipopolysaccharide(LPS)stimulation. Mechanistically, enhancer and promoter regions of myeloid lineage genes in aged HSCs are more accessible and display more rapid and prominent CTCF occupancy upon LPS stimulation. Our study provides comprehensive resources for the three-dimensional(3D)genome structure of HSCs and sheds light into the ordered genome organization and the associated transcriptome signature underlying HSCs aging.

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Metabolome and RNA-seq reveal discrepant metabolism and secretory metabolism profile in skeletal muscle between obese and lean pigs at different ages

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Science China Life Sciences 2025年

作者： Liu Guo Junfei Xu Wenyue Zhou Sisi Chen Hanjing Shi Mengmeng Han Zekun Yang Yehui Duan Weijun Pang Yulong Yin Fengna Li laboratory of animal nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical Agriculture Chinese Academy of Sciences University of Chinese Academy of Sciences laboratory of animal Fat Deposition and Muscle Development College of Animal Science and Technology Northwest A&F University College of Advanced Agricultural Sciences University of Chinese Academy of Sciences

Metabolites and metabolism-related gene expression profiles in skeletal muscle change dramatically under obesity, aging and metabolic disease. Since obese and lean pigs are ideal models for metabolic research. Here, we compared metabolome and transcriptome of Longissimus dorsi(LD) muscle between Taoyuan black(TB, obese) and Duroc(lean) pigs at different ages. We defined the “window phase” of intramuscular fat(IMF) deposition in TB pig, which has significantly higher IMF than Duroc pig. Our results displayed discrepant lipid composition and different expression genes(DEGs) enriched in lipid metabolism, and both metabolome and transcriptome analyses revealed stronger energy expenditure and more active amino acid and protein metabolism in Duroc pig. 10 up-and 51 down-regulated biomarker metabolites with age-and breed-specificity were identified. Potential secretory metabolites, including organic acid(fumaric acid, succinate,malic acid, and gamma-aminobutyric acid), amino acid(L-lysine, and L-glutamic acid), lipid(2-hydroxyisovaleric acid, and L-carnitine) were demonstrated a significant correlation with IMF deposition. Our research highlights the huge difference of metabolic spectrum in skeletal muscle between obese and lean model and muscle-derived secretory metabolites might act as an ambassador of intercellular communication to regulate systematic metabolism.

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