Cardiovascular disease is one of the leading causes of mortality *** studies have shown that circular RNAs(circRNAs)have emerged as imp.rtant p.ayers in the p.evention and treatment of cardiovascular *** are a class o...
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Cardiovascular disease is one of the leading causes of mortality *** studies have shown that circular RNAs(circRNAs)have emerged as imp.rtant p.ayers in the p.evention and treatment of cardiovascular *** are a class of endogenous noncoding RNAs that are generated by back-sp.icing and are involved in many p.thop.ysiological *** this review,we outline the current research p.ogress on the regulatory roles of circRNAs in cardiovascular ***,new technologies and methods availab.e for identifying,validating,synthesizing,and analyzing circRNAs,as well as their ap.lications in therap.utics,are highlighted ***,we summarize the increasing insights into the p.tential use of circRNAs as circulating diagnostic and p.ognostic ***,we discuss the p.osp.cts and challenges of circRNA therap.utic ap.lications for cardiovascular disease therap.,with a p.rticular focus on develop.ng circRNA synthesis and engineering delivery systems.
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