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Propagating subduction initiation of the Caroline Plate at the Mussau Trench

Science China Earth Sciences 2025年第1期68卷 253-269页

作者： Chun-Feng LI Yongkang DENG Tao WU Dongdong DONG Guoliang ZHANG Jiazheng ZHANG Yutao LIU Yaqing LI Fugui TANG Lulu ZHANG Department of marine Sciences Zhejiang University laboratory of marine Mineral Resources Laoshan Laboratory key lab of marine Geology and Environment Institute of Oceanology Chinese Academy of Sciences key lab of Ocean and Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sciences Science & Technology on Integrated Information System lab Institute of Software Chinese Academy of Sciences

New seismic imaging from the Mussau Trench confirms that, under horizontal compression on an oceanic plate boundary, it is within the young and weak oceanic plate that a trench will develop, and it is the young plate, not so long after its birth, that starts to subduct toward the old plate. The Mesozoic Pacific Plate cannot easily bend, under the joint horizontal compression and vertical gravity pull, even with a pre-existing weak zone in place and with a large age offset across the plate boundary. The bending of the Caroline Plate near the northern end of the Mussau Trench started only after a long-time span of trench migration, and/or after a prolonged transition from initial compression to trench development. Highly contrasting trench deformation and sedimentary accretion between two parallel seismic sections support an evident migration of underthrusting or significant longitudinal heterogeneity along the trench. The swift transition from underthrusting to non-thrusting can be explained by a counter-clockwise rotation of the Caroline Plate. That miniature accretionary wedges develop even before the subduction initiates imply strong compression and uplifting before the underthrusting can kick-start. Rotation of the Caroline Plate have been halted as the Mussau Trench is seismically rather quiet and the Lyra Trough to the east shows relaxational extension.

关键词： Mussau Trench Subduction initiation Seismic reflection Caroline Plate

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Purification and Characterization of Alginate Lyase from marine Vibrio ***

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Acta Biochimica et Biophysica Sinica 2006年第9期38卷 633-638页

作者： Yuan-Hong WANG* Guang-Li YU Xin-Min WANG Zhi-Hua LV Xia ZHAO Zhi-Hong WU Wei-Shang JI marine Drug and Food Institute,key laboratory of marine drugs of Shandong Province,key laboratory of marine drugs,Ministry of Education,Ocean University of China,Qingdao 266003,China marine Drug and Food Institute Key Laboratory of Marine Drugs of Shandong Province Key Laboratory of Marine Drugs Ministry of Education Ocean University of ChinaQingdao 266003 China

Extracellular alginate lyase secreted by marine Vibrio ***,isolated from decayedLaminaria japonica,was purified by a combination of ammonium sulfate precipitation and diethylaminoethyl-Sephacel column *** results show that the molecular mass of alginate lyase wasapproximately 62.5 kDa,with an optimal pH and temperature at pH 7.0 and 25℃,*** wasapproximately 72.73 g/*** activity of the enzyme was enhanced by EDTA and Zn2+,but inhibited by Ba2+.The substrates specificity analysis shows that it was specific for hydrolyzing poly-β-D-1,4-mannuronate inalginate.

关键词： marine Vibrio alginate alginate lyase purification characterization

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A New Cytotoxic Compound from Penicillium auratiogriseum, Symbiotic or Epiphytic Fungus of Sponge Mycale plumose

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Chinese Chemical Letters 2005年第9期16卷 1227-1229页

作者： Zhi Hong XIN Wei Ming ZHU Qian Qun GU Yu Chun FANG Lin DUAN Cheng Bin CUI key laboratory of marine drugs of Chinese Ministry of Education Marine Drugs and Food Institute Ocean University of China Qingdao 266003

A new compound, （S）-2, 4-dihydroxy-1-butyl （4-hydroxy） benzoate （1）, and a known compound, fructigenines A （2）, were isolated from fungus Penicillium auratiogriseum derived from sponge Mycale plumose, by bioassay-guided fractionation. Their structures were established by spectroscopic and chemical methods. Both compounds *** cytotoxic activity against tsFT210 cells.

关键词： Penicillium auratiogriseum Mycale plumose aromatic ester alkaloid anti-tumoractivity

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What Depth Should Deep-Sea Water be Pumped up from in the South China Sea for Medicinal Research?

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Journal of Ocean University of China 2013年第1期12卷 134-138页

作者： HE Shan LIU Hongbing YANG Xue LI Chunxia GUAN Huashi key laboratory of marine drugs Ministry of Education Marine Drugs and Food Institute Ocean University of China

In this study, seawater was pumped up from 150, 200, 300, 500 and 1000 m in the South China Sea and analyzed to make certain what depth should deep-sea water (DSW) be pumped up for medicinal usage. The pumping depth of DSW was determined on the basis of chemical ingredients. The analyses of inorganic elements and dissolved organic matter (DOM) were performed by inductively coupled plasma mass spectrometry (ICP-MS) and ultra performance liquid chromatography-mass spectrometry (UPLC-MS) respectively. The raw data were used for hierarchical cluster analysis (HCA) and principal component analysis (PCA). The results showed that seawater pumped up from 500 m and 1000 m was similar in their chemical ingredients, and was different from the seawater pumped up from other depths. These results indicated that seawater from more than 500 m depth had relatively stable chemical ingredients and could be used as DSW in the South China Sea.

关键词： Deep-sea water (DSW) depth, chemical ingredients hierarchical cluster analysis (HCA) principal component analysis (PCA)

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Three new aspochalasin derivatives from the marine-derived fungus Spicaria elegans

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Chinese Chemical Letters 2010年第7期21卷 824-826页

作者： Zhen Jian Lin Tian Jiao Zhu Li Chen Qian Qun Gu key laboratory of marine drugs Chinese Ministry of EducationInstitute of Marine Drugs and FoodOcean University of ChinaQingdao 266003China

Three new aspochalsins（R-T）（1-3） were isolated from the marine-derived fungus Spicaria *** structures were elucidated on the basis of comprehensive spectral analysis including 1D and 2D NMR techniques,and HR-ESI-MS.

关键词： Aspochalasin Spicaria elegans marine fungus

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Total Synthesis of marine Cyclic Enol-Phosphotriester Salinipostin Compounds

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Journal of Ocean University of China 2018年第3期17卷 683-689页

作者： ZHAO Mingliang WEI Xianfeng LIU Xuemeng DONG Xueyang YU Rilei WAN Shengbiao JIANG Tao key laboratory of marine drugs The Ministry of Education of China School of Medicine and Pharmacy Ocean University of China laboratory for marine drugs and Bioproducts Qingdao National Laboratory for Marine Science and Technology

Due to their structural diversity and variety of biological activities, marine natural products have been the subject of extensive study. These compounds, especially phospholipid polycyclic aromatic hydrocarbons, have a wide range of pharmacological applications, including embedded DNA and central nervous system, anti-tumor, anti-virus, anti-parasite, anti-bacterial, and antithrombotic effects. Unfortunately, the insufficient drug sources have limited the development of these compounds. In this study, we isolated salinpostin compounds from a fermentation solution of marine-derived Salinospora sp., which has a common bicyclic enol-phosphotriester core framework, as well as potent and selective antimalarial activities against P. falciparum with EC_(50)=50 nmolL^(-1). The chemical synthesis of these compounds in greater quantities is necessary for their use in bioactivity studies. Thus we explored a short route with high yields and mild reaction conditions, which can generate combinatorial libraries for drug discovery and lead optimization. We developed a new total synthesis method for six cyclic enol-phosphotriester salinipotin compounds and their diastereomers. For the total synthesis of cyclipostin P, we prepared cyclic enol-phosphotriester salinipostin compounds in 10 steps from a readily accessible starting material, 1,3-dihydroxyacetone, and obtained an overall yield of 1.29%. We fully characterized these compounds by proton nuclear magnetic resonance(~1H-NMR), carbon-13 NMR(^(13)C-NMR), and high-resolution mass spectrometry(HRMS) analyses, and found they coincide absolutely with the same compounds reported previously.

关键词： total synthesis Salinipostin enolphosphate trimester

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Chemical Characteristics and Anticoagulant Activities of Two Sulfated Polysaccharides from Enteromorpha linza (Chlorophyta)

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Journal of Ocean University of China 2013年第1期12卷 175-182页

作者： QI Xiaohui MAO Wenjun CHEN Yin CHEN Yanli ZHAO Chunqi LI Na WANG Chunyan key laboratory of marine drugs Ministry of Education Institute of Marine Drug and Food Ocean University of China

Two sulfated polysaccharides, designated MP and SP, were extracted from the marine green alga Enteromorpha linza using hot water and then purified using ion-exchange and size-exclusion chromatography. The anticoagulant activities of MP and SP were examined by determination of their activated partial thromboplastin time （APTT）, thrombin time （TT） and prothrombin time （PT） using human plasma. Results showed that MP and SP were composed of abundant rhamnose with small amounts of xylose and glucuronic acid, whereas SP also contained a small amount of galactose. Approximate molecular weights of MP and SP were 535 and 502 kDa, respectively. As compared with SP, MP had higher contents of sulfate ester （19.0%） and uronic acid （14.9%）. The MP mainly consisted of （1→4）-linked rhamnose residues with partially sulfated groups at the C-3 position, and small amounts of （1→3, 4）-linked rhamnose, （1→2,4）-linked rhamnose, （1→4）-linked glucuronic acid and （1→4）-linked xylose residues. The SP contained abundant （1→4）-linked rhamnose with minor amounts of （1→3）-linked rhanmose, （1→3, 4）-linked rhamnose, （1→2, 4）-linked rhanmose, （1→4）4inked glucuronic acid, （1→4）-linked xylose, and （1→3）-linked galactose residues. The sulfate groups were mainly located at C-3 of （1→4）-linked rhamnose residues. Both MP and SP, in particular the former, effectively prolonged APTT and TT. This work demonstrates that MP and SP have unique structural characteristics distinct from those of other sulfated polysaccharides from Enteromorpha. The MP is a potential source of anticoagulant, and the difference in anticoagulant activities of the two sulfated polysaccharides is directly linked to the discrepancy of their chemical features.

关键词： marine green alga Enteromorpha linza sulfated polysaccharide chemical characteristic anticoagulant activity

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Engineering DNA logic systems with non-canonical DNA-nanostructures:basic principles,recent developments and bio-applications

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Science China Chemistry 2022年第2期65卷 284-297页

作者： Daoqing Fan Jun Wang Jiawen Han Erkang Wang Shaojun Dong State key laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China key laboratory of marine drugs Ministry of EducationSchool of Medicine and PharmacyOcean University of China laboratory for marine drugs and Bioproducts Pilot National Laboratory for Marine Science and TechnologyQ

Engineering DNA logic systems is considered as one of the most promising strategies for next-generation molecular *** to the inherent features of DNA,such as low cost,easy synthesis,and controllable hybridization,various DNA logic devices with different functions have been developed in the recent ***,a variety of logic-programmed biological applications are also explored,which initiates a new chapter for DNA logic *** this field has gained rapid developments,a systematical review that could not only elaborate the logic principles of diverse DNA logic devices but also outline recent representative works is urgently *** this review,we first elaborate the general classification and logical principle of diverse DNA logic devices,in which the operating strategy of these devices and representative examples are selectively ***,we review state-of-the-art advancements in DNA computing based on different non-canonical DNA-nanostructures during the past decade,in which some classical works are *** that,the innovative applications of DNA computing to logic-controlled bioanalysis,cell imaging,and drug load/delivery are selectively ***,we analyze current obstacles and suggest appropriate prospects for this area.

关键词： DNA logic systems molecular logic non-canonical DNA-nanostructures arithmetic/non-arithmetic functions logical bio-applications

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Barnacle inspired strategy combined with solvent exchange for enhancing wet adhesion of hydrogels to promote seawater-immersed wound healing

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Bioactive Materials 2024年第11期41卷 46-60页

作者： Guiyuan Zhao Aijia Zhang Xiangyan Chen Guangli Xiang Tianze Jiang Xia Zhao key laboratory of marine drugs Ministry of EducationShandong Key Laboratory of Glycoscience and GlycotechnologySchool of Medicine and PharmacyOcean University of ChinaQingdao266003China laboratory for marine drugs and Bioproducts of Qingdao National laboratory for marine Science and Technology Qingdao266237China

Hydrogels are promising materials for wound protection,but in wet,or underwater environments,the hydration layer and swelling of hydrogels can seriously reduce adhesion and limit their *** this study,inspired by the structural characteristics of strong barnacle wet adhesion and combined with solvent exchange,a robust wet adhesive hydrogel(CP-Gel)based on chitosan and 2-phenoxyethyl acrylate was obtained by breaking the hydration layer and resisting *** a result,CP-Gel exhibited strong wet adhesion to various interfaces even underwater,adapted to joint movement and skin twisting,resisted sustained rushing water,and sealed damaged *** importantly,on-demand detachment and controllable adhesion were achieved by promoting *** addition,CP-Gel with good biosafety significantly promotes seawater-immersed wound healing and is promising for use in water-contact wound care,organ sealing,and marine emergency rescue.

关键词： Barnacle Solvent exchange Hydrogel Wet adhesion Wound healing

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Differentiation of the Agonists and Antagonists of the α7 Nicotinic Acetylcholine Receptor

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Journal of Ocean University of China 2019年第5期18卷 1193-1198页

作者： WU Guanzhao XU Qingliang BAO Yilei LIU Yuwei LI Qian FANG Zhengyu FU Jingyi DING Yuhang LIANG Zhiqing JIANG Tao YU Rilei key laboratory of marine drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China laboratory for marine drugs and Bioproducts of Qingdao National laboratory for marine Science and Technology Qingdao 266003China

Theα7 nicotinic acetylcholine receptors(nAChRs)are widely expressed in the central and peripheral nervous systems and are important drug targets for the treatment of neurological ***,differentiation of the agonists and antagonists of the nAChR is *** this study we aimed to develop a reliable and efficient computational approach for differentiation of the agonists from the antagonists of the nAChR based on a systematical analysis of 123 ligands(87 agonists,12 partial agonists,and 24 antagonists)binding with the extracellular domain of theα7 n AChR *** results suggest that the ligand size and ligand binding affinity cannot differentiate the agonists from the antagonists of the *** ligand efficiency that considers both ligand binding affinity and size for the agonists is overall more left shifted in comparison to the antagonists,but the values of the ligand efficiency still cannot differentiate the agonists from the antagonists unless the values are either relatively high(more than-0.3 kcal mol^-1)or relatively low(less than-0.45 kcal mol^-1).Our results suggest that accurate prediction of the agonist or antagonist of the nAChR is challenging and the ligand innate configuration has to be considered as an extra for differentiation of the agonists from the antagonists of the nAChR.

关键词： nicotinic acetylcholine receptors ligand efficacy ligand binding affinity ligand efficiency

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