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Large-scale multiferroic complex oxide epitaxy with magnetically switched polarization enabled by solution processing

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National Science Review 2020年第1期7卷 84-91页

作者： Cong Liu Feng An Paria S.M.Gharavi Qinwen Lu Junkun Zha Chao Chen Liming Wang Xiaozhi Zhan Zedong Xu Yuan Zhang Ke Qu Junxiang Yao Yun Ou Zhiming Zhao Xiangli Zhong Dongwen Zhang Nagarajan Valanoor Lang Chen Tao Zhu Deyang Chen Xiaofang Zhai Peng Gao Tingting Jia Shuhong Xie Gaokuo Zhong Jiangyu Li Shenzhen key laboratory of Nanobiomechanics Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences School of Materials Science and Engineering Xiangtan University School of Materials Science and Engineering University of New South Wales Hefei National laboratory for Physical Sciences at Microscale and Department of Chemical Physics University of Science and Technology of China Institute for Advanced Materials and Guangdong Provincial key laboratory of Optical Information Materials and Technology South China Academy of Advanced Optoelectronics South China Normal University Dongguan Neutron Science Center Department of Physics Southern University of Science and Technology International Center for Quantum Materials and Electron Microscopy laboratory School of Physics Peking University hunan Provincial key laboratory of health maintenance for mechanical equipment Hunan University of Science and Technology Department of Physics College of Science National University of Defense Technology Beijing National laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Songshan Lake Materials laboratory Dongguan Neutron Science Center

Complex oxides with tunable structures have many fascinating properties, though high-quality complex oxide epitaxy with precisely controlled composition is still out of reach. Here we have successfully developed solution-based single-crystalline epitaxy for multiferroic（1-x）BiTi;/;Fe;Mg;/;O;–（x）CaTiO;（BTFM–CTO） solid solution in large area, confirming its ferroelectricity at the atomic scale with strong spontaneous polarization. Careful compositional tuning leads to a bulk magnetization of 0.07 ± 0.035 μB/Fe at room temperature, enabling magnetically induced polarization switching exhibiting a large magnetoelectric coefficient of 2.7–3.0 × 10;s/m. This work demonstrates the great potential of solution processing in large-scale complex oxide epitaxy and establishes novel room-temperature magnetoelectric coupling in epitaxial BTFM–CTO film, making it possible to explore a much wider space of composition,phase, and structure that can be easily scaled up for industrial applications.

关键词： complex oxide solution method epitaxy multiferroic

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Evaporative Condensers in Comfortable Air Conditioning System

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湖南大学学报（自然科学版） 2009年第S1期36卷 136-140页

作者： YIN Ying-de1,ZHU Dong-sheng1,DU Gui-mei2,LI Yuan-xi1,SUN He-jing1,LIU Qing-ming1(1.key lab of Enhancement Heat Transfer and Energy Conservation,the Ministry of Education,South China University of Technology,Guangzhou,Guangdong 510641,China 2.College of Civil Engineering,hunan University,Changsha,hunan 410082,China) key lab. of Enhancement Heat Transfer and Energy Conservation South China University of Technology Guangzhou 510641 China College of Civil Engineering Hunan University Changsha 410082 China

The operating theory of an evaporative condenser was *** difference between an evaporative condensing refrigeration system and a general refrigeration system was *** with the air-cooled and the water-cooled,the virtues of energy-conservation and water-conservation of evaporative condensers were *** questions existing in the application of evaporative condensers were pointed out,the corresponding solving methods were analyzed accordingly,and the development trend of evaporative condensing technique in mechanical refrigeration system field and the applied foreground of evaporative condensers in comfortable air conditioning were prospected.

关键词： evaporative condensers evaporative condensing refrigeration system general refrigeration system comfortable air conditioning system

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Recent advances in nano scaffolds for bone repair

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Bone Research 2016年第4期4卷 206-216页

作者： Huan Yi Fawad Ur Rehman Chunqiu Zhao Bin Liu Nongyue He State key laboratory of Bioelectronics (Chien-Shiung Wu lab) School of Biological Science and Medical Engineering Southeast UniversityNanjing China Department of Biomedical Engineering School of Basic Medical Sciences Nanjing Medical University Nanjing China hunan key laboratory of Green Chemistry and Application of Biological Nanotechnology Hunan University of Technology Zhuzhou China

Biomedical applications of nanomaterials are exponentially increasing every year due to analogy to various cell receptors, ligands, structural proteins, and genetic materials(that is, DNA). In bone tissue, nanoscale materials can provide scaffold for excellent tissue repair via mechanical stimulation, releasing of various loaded drugs and mediators, 3D scaffold for cell growth and differentiation of bone marrow stem cells to osteocytes. This review will therefore highlight recent advancements on tissue and nanoscale materials interaction.

关键词： bone Recent advances in nano scaffolds for bone repair

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Wear behavior of light-weight and high strength Fe-Mn-Ni-Al matrix self-lubricating steels

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Journal of Materials Science & Technology 2019年第4期35卷 623-630页

作者： Liuliu Han Kun Li Cheng Qian Jingwen Qiu Chengshang Zhou Yong Liu State key laboratory of Powder Metallurgy Central South University Materials Science and Engineering School Hunan University of Science and Technology

The good combination of mechanical and tribological properties for self-lubricating materials is crucial. In this work, novel self-lubricating Fe-16.4 Mn-4.8 Ni-9.9 Al-xC(wt%) steels containing graphite phase were fabricated using mechanical alloying and spark plasma sintering. The compositions of the steels were designed by using thermodynamic calculation, and the effect of carbon addition on the microstructure was further investigated. The steel possesses high hardness of 621 HV, high yield strength of 1437 MPa and good fracture toughness at room temperature. The yield strengths are still above 600 MPa at 600?*** tribological behavior and mechanical properties from room temperature to 800?C were studied, and the wear mechanisms at elevated temperatures were discussed. The steel has a stable friction coefficient of 0.4 and wear rate in a magnitude of 10^(-6) mm^3/N·m below 600?C. The good tribological properties of the steels were mainly attributed to the high hardness, lubrication of graphite and stable surface oxide layer.

关键词： Metal matrix composites mechanical alloying mechanical properties Tribological properties Alloy design

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A MESHLESS LOCAL PETROV-GALERKIN METHOD FOR GEOMETRICALLY NONLINEAR PROBLEMS

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Acta Mechanica Solida Sinica 2005年第4期18卷 348-356页

作者： Xiong Yuanbo Long Shuyao Hu De＇an Li Guangyao Department of Engineering Mechanics Hunan University Changsha 410082 China key laboratory of Advanced Technology for Vehicle Body Design ~ Manufacture Ministry of Education of China Hunan University Changsha 410082 China

Nonlinear formulations of the meshless local Petrov-Galerkin （MLPG） method are presented for geometrically nonlinear problems. The method requires no mesh in computation and therefore avoids mesh distortion difficulties in the large deformation analysis. The essential boundary conditions in the present formulation axe imposed by a penalty method. An incremental and iterative solution procedure is used to solve geometrically nonlinear problems. Several examples are presented to demonstrate the effectiveness of the method in geometrically nonlinear problems analysis. Numerical results show that the MLPG method is an effective one and that the values of the unknown variable are quite accurate.

关键词： local Petrov-Galerkin method moving least square approximation total Lagranian method geometrically nonlinear problems

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An enhanced hybrid and adaptive meta-model based global optimization algorithm for engineering optimization problems

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Science China(Technological Sciences) 2016年第8期59卷 1147-1155页

作者： ZHOU Guan DUAN LiBin ZHAO WanZhong WANG ChunYan MA ZhengDong GU JiChao College of Energy and Power Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China State key laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan University Changsha 410082 China Department of mechanical Engineering and Applied Mechanics University of Michigan Ann Arbor Michigan 48109 USA

由于在高效率和精确性之间的好平衡，元模型基于优化算法是一个重要全球优化范畴并且广泛地被使用了。更好解决高度非线性并且集中的工程优化问题，一个提高的混血儿和适应元模型基于的计算全球优化(电子火腿) 首先在这个工作被建议。... 详细信息

由于在高效率和精确性之间的好平衡，元模型基于优化算法是一个重要全球优化范畴并且广泛地被使用了。更好解决高度非线性并且集中的工程优化问题，一个提高的混血儿和适应元模型基于的计算全球优化(电子火腿) 首先在这个工作被建议。重要区域更改方法(IRU ) 和不同采样尺寸策略在优化方法被建议提高表演。由使用自动、可伸缩的策略，重要区域将根据搜索结果适应地被更新改进产生精确和集中率。不平的采样策略和集中的采样策略在优化的不同阶段被使用高效地改进搜索并且避免过早地在一个小设计空格聚在一起的结果。新优化算法的有效性被与不同变量凳子标记优化问题作比较到六个优化方法验证。电子火腿优化方法然后被使用优化实际否定泊松比率(NPR ) 的设计参数在这个工作的碰撞盒子。结果显示建议电子火腿在优化计算有高精确性和效率集中的问题和罐头广泛地在设计工业被使用。

关键词：优化问题全局优化环境工程混合动力自适应算法模型采样策略优化算法

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Bearing Fault Diagnosis with DDCNN Based on Intelligent Feature Fusion Strategy in Strong Noise

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Computers, Materials & Continua 2023年第12期77卷 3423-3442页

作者： Chaoqian He Runfang Hao Kun Yang Zhongyun Yuan Shengbo Sang Xiaorui Wang College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan030024China key lab of Advanced Transducers and Intelligent Control System of the Ministry of Education Taiyuan030024China

Intelligent fault diagnosis in modern mechanical equipment maintenance is increasingly adopting deep learning ***,conventional bearing fault diagnosis models often suffer from low accuracy and unstable performance in noisy environments due to their reliance on a single input ***,this paper proposes a dual-channel convolutional neural network(DDCNN)model that leverages dual data *** DDCNN model introduces two key ***,one of the channels substitutes its convolution with a larger kernel,simplifying the structure while addressing the lack of global information and shallow ***,the feature layer combines data from different sensors based on their primary and secondary importance,extracting details through small kernel convolution for primary data and obtaining global information through large kernel convolution for secondary *** experiments conducted on two-bearing fault datasets demonstrate the superiority of the two-channel convolution model,exhibiting high accuracy and robustness even in strong noise ***,it achieved an impressive 98.84%accuracy at a Signal to Noise Ratio(SNR)of−4 dB,outperforming other advanced convolutional models.

关键词： Fault diagnosis dual-data dual-channel feature fusion noise-resistance

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SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5338-5352页

作者： Rongzhang He Xingyu Zheng Jian Zhang Bo Liu Qijie Wang Qian Wu Ziyan Liur Fangfang Chang Yabin Hu Ting Xie Yongchen Liu Jun Chen Jing Yang Shishan Teng Rui Lu Dong Pan You Wang Liting Peng Weijin Huang Velislava Terzieva Wenpei Liu Youchun Wang Yi-Ping Li Xiaowang Qu College of Basic Medical Sciences Hengyang Medical SchoolUniversity of South China&MOE Key Lab of Rare Pediatric Diseases421001 HengyangChina Translational Medicine Institute The First People's Hospital of ChenzhouHengyang Medical SchoolUniversity of South China423000 ChenzhouChina The Central Hospital of Shaoyang 422000 ShaoyangChina Institute of Human Virology Zhongshan School of Medicineand Key Laboratory of Tropical Disease Control of Ministry of EducationSun Yat-sen University501180 GuangzhouChina School of Public health University of South China421001 HengyangChina National Institutes for Food and Drug Control Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech ProductsKey Laboratory of Biological Product Quality Research and Evaluation of National Medical Products Administration102629 BejingChina laboratory of OMICs Technologies Institute of Biology and Immunology of Reproduction"Acad.Kiril Bratanov"BulgarianAcademyof SciencesSofia 1113Bulgaria

Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb)and B cell differentiation are tightly regulated by T follicular help (T_(FH)) cells. However, the longevity and functional role of T_(FH) cellsubsets in COVID-19 convalescents and vaccine recipients remain poorly defined. Here, we show that SARS-CoV-2 infection andinactivated vaccine elicited both spike-specific CXCR3^(+) T_(FH) cell and CXCR3^(-) T_(FH) cell responses, which showed distinct responsepatterns. Spike- specific CXCR3^(+) T_(FH) cells exhibit a dominant and more durable response than CXCR3^(-) T_(FH) cells that positivelycorrelated with antibody responses. A third booster dose preferentially expands the spike-specific CXCR3^(+) T_(FH) cell subset inducedby two doses of inactivated vaccine, contributing to antibody maturation and potency. Functionally, spike-specific CXCR3^(+) T_(FH) cellshave a greater ability to induce spike-specific antibody secreting cells (ASCs) differentiation compared to spike-specific CXCR3^(-) T_(FH)cells. In conclusion, the persistent and functional role of spike-specific CXCR3^(+) T_(FH) cells following SARS-CoV-2 infection andvaccination may play an important role in antibody maintenance and recall response, thereby conferring long-term protection. Thefindings from this study will inform the development of SARS-CoV-2 vaccines aiming to induce long-term protective immunememory.

关键词： vaccine doses protective

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Effects of high temperature on the microstructure and mechanical behavior of hard coal

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International Journal of Mining Science and Technology 2020年第5期30卷 643-650页

作者： Chengdong Su Jiadong Qiu Qiuhong Wu Lei Weng School of Energy Science and Engineering Collaborative Innovation Center of Coal Work SafetyHenan Polytechnic UniversityJiaozuo 454003China key laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring(Central South University) Ministry of EducationChangsha 410083China Work Safety key lab on Prevention and Control of Gas and Roof Disasters for Southern Coal Mines Hunan Provincial Key Laboratory of Safe MiningXiangtan 411201China School of Civil Engineering Wuhan UniversityWuhan 430072China

Coal is a common porous sedimentary rock whose microstructure and mechanical behavior are often affected by high *** order to deeply investigate the effect of high temperature on the structure and mechanical properties of coal,six groups of coal samples with different heating temperatures were *** testing methods,including ultrasonic test,scanning electron microscopy,nuclear magnetic resonance and uniaxial compression test,were used in this *** results showed that the physical and chemical change processes of coal samples under high temperature can be divided into two stages:the stage of drying and degassing and the stage of pyrolysis of the coal *** the increase of heating temperature,the total porosity of coal samples increases,while the integrity and the deformation resistance of coal samples *** addition,the elastic modulus and uniaxial compressive strength of the coal sample decrease with the increase of heating *** Poisson’s ratio decreases firstly and then increases with the increase of heating temperature.

关键词： High temperature Coal Microstructure mechanical behavior Nuclear magnetic resonance

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FUS-mediated HypEVs: Neuroprotective effects against ischemic stroke

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Bioactive Materials 2023年第11期29卷 196-213页

作者： Yousheng Wu Xiaoxiong Huang Zefeng Tan Jiankun Zang Min Peng Niu He Tao Zhang Hongcheng Mai Anding Xu Dan Lu Department of Neurology and Stroke Center The First Affiliated Hospital of Jinan UniversityGuangzhouChina Clinical Neuroscience Institute The First Affiliated Hospital of Jinan UniversityGuangzhouChina key lab of Guangzhou Basic and Translational Research of Pan-vascular Diseases The First Affiliated Hospital of Jinan UniversityGuangzhouChina Department of Neurology and Stroke Center The Central Hospital of ShaoyangHunanChina Department of Neurology The First People’s Hospital of FoshanGuangdongChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhouChina Munich Medical Research School(MMRS) Ludwig-Maximilians University MunichMunichGermany Insititute for Tissue Engineering and Regenerative Medicine(iTERM) Helmholtz Zentrum MünchenNeuherbergGermany

Few studies have investigated the properties and protein composition of small extracellular vesicles (sEVs) derived from neurons under hypoxic conditions. Presently, the extent of the involvement of these plentiful sEVs in the onset and progression of ischemic stroke remains an unresolved question. Our study systematically identified the characteristics of sEVs derived from neurons under hypoxic conditions (HypEVs) by physical characterization, sEV absorption, proteomics and transcriptomics analysis. The effects of HypEVs on neurites, cell survival, and neuron structure were assessed in vitro and in vivo by neural complexity tests, magnetic resonance imaging (MRI), Golgi staining, and Western blotting of synaptic plasticity-related proteins and apoptotic proteins. Knockdown of Fused in Sarcoma (FUS) small interfering RNA (siRNA) was used to validate FUS-mediated HypEV neuroprotection and mitochondrial mRNA release. Hypoxia promoted the secretion of sEVs, and HypEVs were more easily taken up and utilized by recipient cells. The MRI results illustrated that the cerebral infarction volume was reduced by 45% with the application of HypEVs, in comparison to the non- HypEV treatment group. Mechanistically, the FUS protein is necessary for the uptake and neuroprotection of HypEVs against ischemic stroke as well as carrying a large amount of mitochondrial mRNA in HypEVs. However, FUS knockdown attenuated the neuroprotective rescue capabilities of HypEVs. Our comprehensive dataset clearly illustrates that FUS-mediated HypEVs deliver exceptional neuroprotective effects against ischemic stroke, primarily through the maintenance of neurite integrity and the reduction of mitochondria-associated apoptosis.

关键词： Hypoxia FUS Neuron-derived small extracellular vesicle Neuroprotection Mitochondrial mRNA

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