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Optimal replication strategy for mitigating burst traffic in information-centric satellite networks: a focus on remote sensing image transmission

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frontiers of Information Technology & Electronic Engineering 2024年第6期25卷 791-808页

作者： Ziyang XING Xiaoqiang DI Hui QI Jing CHEN Jinhui CAO Jinyao LIU Xusheng LI Zichu ZHANG Yuchen ZHU Lei CHEN Kai HUANG Xinghan HUO Jilin key Laboratory of network and Information Security Changchun 130022China School of Computer science and Technology Changchun University of Science and TechnologyChangchun 130022China Information center Changchun University of Science and TechnologyChangchun 130022China

Information-centric satellite networks play a crucial role in remote sensing applications,particularly in the transmission of remote sensing ***,the occurrence of burst traffic poses significant challenges in meeting the increased bandwidth *** content delivery networks are ill-equipped to handle such bursts due to their pre-deployed *** this paper,we propose an optimal replication strategy for mitigating burst traffic in information-centric satellite networks,specifically focusing on the transmission of remote sensing *** strategy involves selecting the most optimal replication delivery satellite node when multiple users subscribe to the same remote sensing content within a short time,effectively reducing network transmission data and preventing throughput degradation caused by burst traffic *** formulate the content delivery process as a multi-objective optimization problem and apply Markov decision processes to determine the optimal value for burst traffic *** address these challenges,we leverage federated reinforcement learning ***,we use bloom filters with subdivision and data identification methods to enable rapid retrieval and encoding of remote sensing *** software-based simulations using a low Earth orbit satellite constellation,we validate the effectiveness of our proposed strategy,achieving a significant 17%reduction in the average delivery *** paper offers valuable insights into efficient content delivery in satellite networks,specifically targeting the transmission of remote sensing images,and presents a promising approach to mitigate burst traffic challenges in information-centric environments.

关键词： Information-centric satellite network Burst traffic Content delivery Federated reinforcement learning Mixed-integer linear programming model Bloom filter Dynamic network

molecular recognition of cyclophanes in water

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Chinese Chemical Letters 2024年第5期35卷 32-44页

作者： Fang-Yuan Chen Wen-Chao Geng Kang Cai Dong-Sheng Guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China College of Chemistry Nankai UniversityTianjin 300071China

molecular recognition in water,the biological solvent,always receives significant research focus in supramolecular *** mechanisms of molecular recognition in water is key to comprehending biological processes at the molecular *** the past five decades,supramolecular chemists have developed a vast array of synthetic receptors with highly diverse structures and recognition *** them,cyclophanes represent an important family of macrocyclic receptors that have been extensively *** aromatic moieties in cyclophanes not only facilitate chemical modifications to impart water solubility but also enable forming hydrophobic cavities for guest inclusion in aqueous *** by Koga et al.,who reported the first inclusion complex of cyclophanes in water and solid state,numerous water-soluble cyclophanes,including derivatives of blue box,calixarenes,resorcinarenes,pillararenes,octopusarenes,biphenarenes,coronarenes,and naphthotubes,etc.,have been synthesized and subjected to investigation of the recognition capabilities in aqueous *** review provides an overview of cyclophane receptors designed to bind organic guests in *** categorize them into two classes based on the modifications made to their hydrophobic cavities:those with“exo-functionalized hydrophobic cavities”and those with“endo-functionalized hydrophobic cavities”.We introduce their distinctive features and discuss strategies to enhance recognition affinity and *** review aims to inspire the development of novel synthetic receptors with intriguing properties and foster practical applications of cyclophanes.

关键词： Biomimetic receptor Cyclophane molecular recognition Hydrophobic effect High-affinity Macrocycles

A DNA Force Circuit for Exploring Protein-Protein Interactions at the Single-Molecule Level

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Chinese Journal of Chemistry 2024年第13期42卷 1456-1464页

作者： Kangkang Ma Luoan Xiong Zhuofei Wang Xin Hu Lihua Qu Xuetong Zhao Yao Li Zhongbo Yu State key Laboratory of Medicinal Chemical Biology Frontiers Science Center for Cell Responsesand College of PharmacyNankai University38 Tongyan RoadTianjin 300350China School of Physics and key Laboratory of Functional Polymer Materials of Ministry of Education Nankai Universityand Collaborative Innovation Center of Chemical Science and EngineeringTianjin 300071China

Protein-protein interactions(PPls)play a crucial role in drug discovery and disease ***,the development of effective drugs targeting PPls remains challenging due to limited methodologies for probing their spatiotemporal ***,we propose a single-molecule approach using a unique force circuit to investigate Ppl dynamics and anisotropy under mechanical *** conventional techniques,this approach enables the manipulation and real-time monitoring of individual proteins at specific amino acids with defined geometry,offering insights into molecular mechanisms at the single-molecule *** DNA force circuit was constructed using click chemistry conjugation methods and genetic code expansion techniques,facilitating orthogonal conjugation between proteins and nucleic *** SET domain of the MLL1 protein and the tail of histone H3 were used as a model system to demonstrate the application of the DNA force *** the use of atomic force microscopy and magnetic tweezers,optimized assembly procedures were *** DNA force circuit provides an exceptional platform for studying the anisotropy of PPis and holds promise for advancing drug discovery research targeted at PPIs.

关键词： Single-molecule studies Protein-protein interactions Click chemistry Genetic code expansion molecular dynamics

Myosin Va‑dependent Transport of NMDA Receptors in Hippocampal Neurons

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Neuroscience Bulletin 2024年第8期40卷 1053-1075页

作者： Ru Gong Linwei Qin Linlin Chen Ning Wang Yifei Bao Wei Lu Ministry of Education(MOE)key Laboratory of Developmental Genes and Human disease School of Life Science and TechnologySoutheast UniversityNanjing 210096China Department of Neurosurgery State Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai 200032China Department of Neurobiology Nanjing Medical UniversityNanjing 210096China Co‑innovation center of Neuroregeneration Nantong UniversityNantong 226001China

N-methyl-D-aspartate receptor(NMDAR)trafficking is a key process in the regulation of synaptic efficacy and brain ***,the molecular mechanism underlying the surface transport of NMDARs is largely *** we identified myosin Va(MyoVa)as the specific motor protein that traffics NMDARs in hippocampal *** found that MyoVa associates with NMDARs through its cargo binding *** association was increased during NMDAR surface *** of MyoVa suppressed NMDAR *** further demonstrated that Ca^(2+)/calmodulin-dependent protein kinase Ⅱ(CaMKⅡ)regulates NMDAR transport through its direct interaction with ***,MyoVa employed Rab11 family-interacting protein 3(Rab11/FIP3)as the adaptor proteins to couple themselves with NMDARs during their ***,the knockdown of FIP3 impairs hippocampal ***,we conclude that in hippocampal neurons,MyoVa conducts active transport of NMDARs in a CaMKII-dependent manner.

关键词： Myosin Va NMDA receptor CaMKⅡ Transport Memory

Precisely modulating covalent and coordination bonds in the porous network for highly selective metal ion extraction

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science China Chemistry 2024年第4期67卷 1039-1040页

作者： Jie Li Xiao Feng Beijing key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster ScienceMinistry of EducationAdvanced Technology Research Institute(Jinan)Frontiers Science Center for High Energy MaterialSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

Scandium(Sc)is recognized as a“strategic”and“critical”element by several countries,including the *** Russia,owing to its wide range of applications in high-tech fields such as superconductivity,alloys,lasers,nucle... 详细信息

关键词： alloys coordination network

Programmable silicon-photonic quantum simulator based on a linear combination of unitaries

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Photonics Research 2024年第8期12卷 1760-1767页

作者： YUE YU YULIN CHI CHONGHAO ZHAI JIESHAN HUANG QIHUANG GONG JIANWEI WANG State key Laboratory for Mesoscopic Physics School of Physics Peking University frontiers science center for Nano-optoelectronics & Collaborative Innovation center of Quantum Matter Peking University Collaborative Innovation center of Extreme Optics Shanxi University Yangtze Delta Institute of Optoelectronics Peking University Hefei National Laboratory

Simulating the dynamic evolution of physical and molecular systems in a quantum computer is of fundamental interest in many applications. The implementation of dynamics simulation requires efficient quantum algorithms. The Lie-Trotter-Suzuki approximation algorithm, also known as the Trotterization, is basic in Hamiltonian dynamics simulation. A multi-product algorithm that is a linear combination of multiple Trotterizations has been proposed to improve the approximation accuracy. However, implementing such multiproduct Trotterization in quantum computers remains challenging due to the requirements of highly controllable and precise quantum entangling operations with high success probability. Here, we report a programmable integrated-photonic quantum simulator based on a linear combination of unitaries, which can be tailored for implementing the linearly combined multiple Trotterizations, and on the simulator we benchmark quantum simulation of Hamiltonian dynamics. We modify the multi-product algorithm by integrating it with oblivious amplitude amplification to simultaneously reach high simulation precision and high success probability. The quantum simulator is devised and fabricated on a large-scale silicon-photonic quantum chip, which allows the initialization, manipulation, and measurement of arbitrary four-qubit states and linearly combined unitary gates. As an example, the quantum simulator is reprogrammed to emulate the dynamics of an electron spin and nuclear spin coupled system. This work promises the practical dynamics simulations of real-world physical and molecular systems in future large-scale quantum computers. ? 2024 Chinese Laser Press

关键词： Numerical simulation Quantum computation Quantum simulator Quantum technology Signal processing Silicon photonics

Portable fluorogenic probe for monitoring of volatile amine vapour and food spoilage

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Chinese Chemical Letters 2024年第3期35卷 257-261页

作者： Jian-Hao Zhao Wen-Xing Xu Bin Li Wei Xu Wu-Kun Zhang Ming-Shuai Yuan Hui-Zi Li Qing-Guo He Xiang Ma Jian-Gong Cheng Yan-Yan Fu State key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China center of Materials science and Optoelectronics Engineering University of the Chinese Academy of SciencesBeijing 100039China School of Physical science and Technology ShanghaiTech UniversityShanghai 201210China key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research center frontiers science center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

There are urgent needs of volatile amine gas sensors with high-performance in food quality control,disease monitoring and environmental ***-film fluorescent probe is suitable for amine vapour sensing due to its high sensitivity,high selectivity,and no polluting ***,a novel fluorescent probe based on indacenodithiophene structure withπconjugated system was designed and *** experimental results show that the films prepared by this material exhibit rapid and distinct fluorescence quenching after being exposed to saturated vapours of primary amine,secondary amine and tertiary amine represented by n-propylamine,diethylamine and trimethylamine,*** quenching of fluorescence is 84%,87%and 96%,respectively,within 10 *** detection mechanism of probe for primary amine is based on specific chemical reaction,while the detection mechanism for secondary amine and tertiary amine is intramolecular charge *** experiments show that the detection limit of the fluorescent probe for trimethylamine,an important marker of food spoilage,could reach 4.610 ***-site detection based on spoilage of small yellow croaker suggests the material possesses the potential for food freshness *** simple fluorogenic probe is an original approach to simplify real-time visual monitoring of volatile amine vapour.

关键词： Fluorescent probe Volatile amine Gas sensing Trimethylamine Food spoilage

利用定量单病毒示踪技术探究SARS-CoV-2与细胞膜融合动态过程

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science Bulletin 2024年第4期69卷 502-511页

作者：刘昊阳胡宇斯余聪王志刚刘书琳庞代文 State key Laboratory of Medicinal Chemical Biology Frontiers Science Center for New Organic MatterFrontiers Science Center for Cell ResponsesTianjin Key Laboratory of Biosensing and Molecular RecognitionResearch Center for Analytical SciencesCollege of Chemistryand School of MedicineNankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Viral envelope fusion with the host plasma membrane(PM)for genome release is a hallmark step in the life cycle of many enveloped *** process is regulated by a complex network of biomolecules on the PM,but robust tools to precisely elucidate the dynamic mechanisms of virus-PM fusion events are still ***,we developed a quantitative single-virus tracking approach based on highly efficient dual-color labelling of viruses and batch trajectory analysis to achieve the spatiotemporal quantification of fusion *** approach allows us to comprehensively analyze the membrane fusion mechanism utilized by pseudotyped severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the singlevirus level and precisely elucidate how the relevant biomolecules synergistically regulate the fusion *** results revealed that SARS-CoV-2 may promote the formation of supersaturated clusters of cholesterol to facilitate the initiation of the membrane fusion process and accelerate the viral genome release.

关键词： SARS-CoV-2 Fluorescence labelling Membrane fusion Quantum dot Single-virus tracking

Benzoyl cyanide,a general radical acylating reagent for photoredox-catalyzed benzylic site-selective acylation reactions

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science China Chemistry 2024年

作者： Zhaodong Zhu Jingjing Wu frontiers science center for Transformative Molecules Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of Chemistry and Chemical EngineeringZhangjiang Institute for Advanced StudyShanghai Jiao Tong University

Based on rational design,benzoyl cyanide,a well-known ionic acylating reagent,has been developed as a general radical acylating reagent for benzylic site-selective acylation reactions for the first *** visible-light photoredox-catalyzed single electron transfer (SET) and hydrogen atom transfer (HAT) strategies,two different direct benzylic C–H acylation reactions with high atom economy have been *** newly developed radical acylating reagent could also be used to achieve three component acyltrifluoromethylation of styrenes,which is usually challenging to achieve by other *** of these reactions proceed under mild nickel-free and NHC-free conditions with high functional group *** addition,based on our detailed mechanistic experiments,the process of radical-radical cross-coupling mechanism was suggested for these transformations.

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