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A nanoplatform with oxygen self-supplying and heat-sensitizing capabilities enhances the efficacy of photodynamic therapy in eradicating multidrug-resistant biofilms

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Journal of materials Science & Technology 2024年第2期169卷 209-219页

作者： Haixin Zhang Yi Zou Kunyan Lu Yan Wu Yuancheng Lin Jingjing Cheng Chunxia Liu Hong Chen Yanxia Zhang Qian Yu State and Local Joint Engineering laboratory for Novel functional polymeric materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215007China

Bacterial biofilms,especially those caused by multidrug-resistant bacteria,have emerged as one of the greatest dangers to global public *** acceleration of antimicrobial resistance to conventional an-tibiotics and the severe lack of new drugs necessitates the development of novel agents for biofilm *** therapy(PDT)is a promising non-antibiotic method for treating bacterial ***,its application in biofilm eradication is hampered by the hypoxic microenvironment of biofilms and the physical protection of extracellular polymeric *** this study,we develop a composite nanoplatform with oxygen(O_(2))self-supplying and heat-sensitizing capabilities to improve the PDT efficacy against ***_(2)/ICG@PDA nanoparticles(CIP NPs)are fabricated by combining calcium peroxide(CaO_(2))with the photosensitizer indocyanine green(ICG)via electrostatic interactions,followed by coating with polydopamine(PDA).The CIP NPs can gradually generate O_(2)in response to the acidic microenvironment of the biofilm,thereby alleviating its hypoxic *** near-infrared(NIR)irradiation,the nanoplatform converts O_(2)into a significant amount of singlet oxygen(^(1)O_(2))and heat to eradicate *** generated heat enhances the release of O_(2),accelerates the generation of^(1)O_(2)in PDT,increases cell membrane permeability,and increases bacterial sensitivity to^(1)O_(2).This nanoplatform significantly improves the efficacy of PDT in eradicating biofilm-dwelling bacteria without fostering drug *** on biofilm eradication demonstrate that this nanoplatform can eradicate over 99.9999%of methicillin-resistant Staphylococcus aureus(MRSA)biofilms under 5-min NIR ***,these integrated advantages enable the system to promote the healing of MRSA biofilm-infected wounds with negligible toxicity in vivo,indicating great promise for overcoming the obstacles associated with bacterial biofilm eradication.

关键词： Bacterial biofilm Multidrug-resistant bacteria Photodynamic therapy Oxygen supplying Photothermal therapy

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高分子囊泡领域面临的挑战和未来研究方向

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Science China materials 2024年第1期67卷 18-30页

作者：石隽秋孙青梅王文立李畅尹海洋李浩澜滕润鑫范震朱云卿杜建忠 Department of Gynaecology and Obstetrics Shanghai Key Laboratory of Anesthesiology and Brain Functional ModulationClinical Research Center for Anesthesiology and Perioperative MedicineTranslational Research Institute of Brain and Brain-Like IntelligenceShanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Department of polymeric materials School of Materials Science and EngineeringTongji UniversityShanghai 201804China

作为细胞中的主要运输系统,天然囊泡在物质的定点输运过程中具有至关重要的作用.高分子囊泡是与之结构相似的一种人工囊泡,具有优异的膜稳定性和胶体稳定性、高药物负载率、低膜穿透性、优异的可修饰性和长循环时间等优势,在生物医用领... 详细信息

作为细胞中的主要运输系统,天然囊泡在物质的定点输运过程中具有至关重要的作用.高分子囊泡是与之结构相似的一种人工囊泡,具有优异的膜稳定性和胶体稳定性、高药物负载率、低膜穿透性、优异的可修饰性和长循环时间等优势,在生物医用领域具有广泛的应用前景.然而,目前该领域尚面临一系列重要挑战,如合成和制备方法较为复杂、生物相容性较难预测、功能和递送途径有限等,限制了其临床转化之路.本文从囊泡的构建模块合成、自组装技术和潜在的生物医学应用等角度,提出了设计和制备下一代高分子囊泡需要解决的五个关键科学问题,指出了未来面临的重要挑战和发展方向,例如简化设计和合成过程,优化和规范自组装过程,拓展潜在的应用前景.

关键词：生物医学应用胶体稳定性自组装技术运输系统膜稳定性输运过程穿透性高分子

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Superhydrophobic photothermal coatings based on candle soot for prevention of bioﬁlm formation

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Journal of materials Science & Technology 2023年第1期132卷 18-26页

作者： Yuancheng Lin Haixin Zhang Yi Zou Kunyan Lu Luohuizi Li Yan Wu Jingjing Cheng Yanxia Zhang Hong Chen Qian Yu State and Local Joint Engineering laboratory for Novel functional polymeric materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital Soochow UniversitySuzhou 215007China key laboratory of polymeric materials design and synthesis for biomedical function Soochow UniversitySuzhou 215123China

Bacterial biofilms formed on the material surfaces have posed a series of serious problems for human health and *** treatment of mature biofilms is particularly difficult because they are inher-ently highly resistant against antibiotics and other adverse *** prevention is strategically advan-tageous over the treatment,and thus the development of innovative surfaces with capability to inhibit biofilm formation is highly *** this work,we developed a superhydrophobic photothermal coating for prevention of biofilm formation,which was based on candle soot with hierarchical structure and excellent light-to-heat conversion *** coating was fabricated by deposition of a candle soot layer on the substrate,followed by sequential chemical vapor deposition of tetraethoxysilane and immo-bilization of fluorinated silane to make the coating robust and *** resulted coating could repel a majority of bacteria from the surface at the early stage,and then eradicate a small number of bacteria remained on the surface under a short-term irradiation of near-infrared *** combi-nation of anti-adhesive property and photothermal bactericidal property endowed the coating with good antibiofilm property to prevent biofilm formation for at least 2 *** coating is facile for deposition on various substrates with good storage stability,showing great potential for diverse practical applications to solve the biofilm-associated problems of materials and devices.

关键词： Antibiofilm Candle soot Superhydrophobic surface Anti-adhesive Photothermal surface

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An injectable alginate/fibrin hydrogel encapsulated with cardiomyocytes and VEGF for myocardial infarction treatment

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Journal of materials Science & Technology 2023年第12期143卷 198-206页

作者： Chunxia Liu Yong Wu Hong Yang Kunyan Lu Haixin Zhang Yuanyuan Wang Jingjing Wang Linan Ruan Zhenya Shen Qian Yu Yanxia Zhang Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215000China State and Local Joint Engineering laboratory for Novel functional polymeric materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China key laboratory of polymeric materials design and synthesis for biomedical function Soochow UniversitySuzhou 215123China

Myocardial infarction(MI)is one of the typical cardiovascular diseases,which persist as the leading cause of death *** to the poor regenerative capability of endogenous cardiomyocytes(CMs),the transplantation of exogenous CMs becomes a promising option for MI ***,the low retention and survival of transplanted cells still limit the clinical translation of cell ***,an alginate/fibrin-based injectable hydrogel was prepared for the delivery of neonatal CMs and an angiogen-esis agent vascular endothelial growth factor(VEGF)locally to the infarcted area of the *** hydro-gel combined the specific advantages of alginate and fibrin with proper mechanical properties and cell affinity,showing good biocompatibility to support the retention and integration of the transplanted CMs to the host ***,the delivered VEGF was favorable for the blood recovery to mitigate the ischemic microenvironment of the infarcted area and thus improved the survival of the transplanted *** injection of this hydrogel to the infarcted area of the heart promoted angiogenesis,inhibited fibrosis,and improved cardiac function,exhibiting great potential for MI treatment.

关键词： Injectable hydrogel Alginate Fibrin Cardiomyocytes VEGF Myocardial infarction

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Memorable full-color circularly polarized luminescence from chiral co-assembled polymer films enabled by multipath transfer

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中国科学：化学英文版 2023年第4期66卷 1169-1178页

作者： Gong Zhang Yinglong Bao Menghan Pan Nianwei Wang Xiaoxiao Cheng Wei Zhang State and Local Joint Engineering laboratory for Novel functional polymeric materials Jiangsu Engineering Laboratory of Novel Functional Polymeric MaterialsSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China School of Chemical and Environmental Engineering Anhui Polytechnic UniversityWuhu 241000China

The modulation of circularly polarized luminescence(CPL)is of importance for display and asymmetric chemical ***,the underlying mechanism of CPL transfer remains rarely ***,we rationally design a multipath transfer system including multistep chirality transfer(MCT)and sequential fluorescence resonance energy transfer(SFRET),and we are the first to fabricate memorable full-color CPL-active films with a high dissymmetry factor(~10^(-2)).Specifically,(P/M)-helical nanofibers are constructed by co-assembly between an achiral polymer,poly(9,9-di-n-octylfluorene)(PF8),and easy-to-remove R/*** matching achiral emitters are added,the PF8 mediates MCT and simultaneously triggers the SFRET ***,full-color CPL memory is realized after removing the chiral *** simulation and structure analysis indicate that the robust helical superstructure of PF8 provides chiral sites to accommodate emitters,which is essential for CPL transfer and *** work provides a novel strategy for constructing CPL-active materials in an aggregated state and insights into CPL transfer and memory.

关键词： chiral co-assembly chirality transfer multipath transfer memorable full-color CPL achiral polymer

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Chiroptical Generation,Switching,and Long-Term Memory in Supramolecular Azobenzene-Pendant Polymer: Regulation by Cellulose Peralkyl Esters,D-/L-Glucose Permethyl Esters,Solvents,UV Light Irradiation,and Thermal Annealing Process

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Chinese Journal of Chemistry 2023年第24期41卷 3625-3632页

作者： Shiyuan Yi Laibing Wang Xiaoxiao Cheng Michiya Fujiki Wei Zhang State and Local Joint Engineering laboratory for Novel functional polymeric materials Jiangsu Engineering Laboratory of Novel Functional Polymeric MaterialsSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisCollege of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu215123 China Graduate School of Science and Technology Nara Institute of Science and Technology8916-5 TakayamaIkomaNara630-0192 Japan School of Chemical and Environmental Engineering Anhui Polytechnic UniversityWuhuAnhui241000 China

Various optically active polymers are known to afford sophisticated chirality-related functionalities,i.e.,asymmetric catalysis,chiroptical switching and memory in UV-vis-NIR region,chromatographic separation of enantiomers,and sensors for molecular ***,material researchers have paid much attention to the design of chiral supramolecular architectures from achiral polymers upon intermolecular interactions with help of greener *** present article reports an instantaneous generation of ambidextrous supramolecules revealing light-driven chiroptical switching/memory in UV-vis region when achiral azobenzene-containing vinylpolymers are non-covalently interacted with alkyl ester derivatives of natural cellulose and D-/*** was recognized that the semi-synthetic biomaterials efficiently work as chirality-inducing scaffoldings to several achiral and optically inactive molecules,oligomers,and *** successful results shed light on a new approach of how inexpensive poly-/mono-saccharide derivatives can afford supramolecular chiroptical systems with the azobenzene pendant polymer as aggregates in suspension and liquid-crystalline films with minimal energy,time,and cost.

关键词： Aggregation Azobenzene Nanostructures functional polymers Supramolecular chirality

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Divergent synthesis of chiral amines via Ni-catalyzed chemo-and enantioselective hydrogenation of alkynone imines

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Science China Chemistry 2023年第11期66卷 3186-3192页

作者： Yuchuan Ma Kai Liu Lin He Hui Lv key laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832000China Hubei key Lab on Organic and polymeric Optoelectronic materials Engineering Research Center of Organosilicon Compounds&MaterialsMinistry of EducationSauvage Center for Molecular SciencesKey Laboratory of Biomedical Polymers of Ministry of Education&College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China

Ligand-mediated nickel-catalyzed asymmetric hydrogenation of alkynone imines has been achieved. By using Ni(OAc)_2·4H_2O/(S,S)-Ph-BPE complex as a catalyst, the chemo-and enantioselective hydrogenation of alkynone imines occurred efficiently to afford chiral propargyl amines with high yields and excellent enantioselectivities(up to 99% yield, >99% ee), leaving the readily reducible alkynyl group intact. Both the C=N and C≡C bonds of alkynone imines were hydrogenated efficiently in the presence of Ni(OAc)_2·4H_2O and Josiphos SL-J011-1, furnishing unfunctionalized chiral imines efficiently(up to 99% yield, >99% ee).The(Z)-allylamines and(E)-allylamines were also efficiently prepared from alkynone imines by the combination of the different catalytic systems. The preliminary mechanism study revealed that the reduction of alkynone imines was a stepwise process and the C=N bonds were preferably hydrogenated in the complete reduction of alkynone imines. The synthetic utility of this method was demonstrated by its application in the late-stage modification of the antiviral drug Zidovudine and the concise synthesis of chiral dibenzoazepine.

关键词： alkynone imine asymmetric hydrogenation propargyl amine enantioselectivity chiral amine

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Poly(ionic liquid)-Based Energy and Electronic Devices

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Chinese Journal of Chemistry 2022年第9期40卷 1099-1108页

作者： Jiangna Guo Zhe Sun Yingjie Zhou Feng Yan Jiangsu Engineering laboratory of Novel functional polymeric materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China State key laboratory for Modification of Chemical Fibers and Polymer materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

Poly(ionic liquid)s(PILs)refer to a polymeric architecture with repeating ionic liquid species in each *** are attracting rapidly increasing interest because of their diverse structures and facial *** group focused on the design and synthesis of PILs for various applications in the past decade,including polyelectrolytes,biomedical materials,and other related *** this review,we briefly summarized our recent studies on the application of PiLs for energy and electronic devices,emphasizing the controllable synthesis and regulation of specific structures and *** unique properties and designable structures of PILs will inspire further investigation in an extensive variety of potential applications.

关键词： Poly(ionic liquid)s Energy device Sensors Polymers materials science

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肽基多孔材料及其应用

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Science China materials 2023年第2期66卷 470-484页

作者：王跃飞闵继伟魏豪刘佳羽梁耀宇苏荣欣张弓张伟王跃飞齐崴 State key laboratory of Chemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China State key laboratory of Component-based Chinese Medicine Haihe Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin key laboratory of Membrane Science and Desalination Technology Tianjin UniversityTianjin 300072China key laboratory of polymeric materials design and synthesis for biomedical function Soochow UniversitySuzhou 215123China State and Local Joint Engineering laboratory for Novel functional polymeric materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou Industrial ParkSuzhou 215123China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

多肽自组装形成的多孔结构是新一代多孔材料,在催化、传感、分离和药物递送等领域具有很好的应用前景.肽基多孔材料的孔内充满氨基酸侧链,因此可以通过合理设计或修改肽序列来调节其孔径大小和性能.功能基团和金属离子的引入进一步扩展... 详细信息

多肽自组装形成的多孔结构是新一代多孔材料,在催化、传感、分离和药物递送等领域具有很好的应用前景.肽基多孔材料的孔内充满氨基酸侧链,因此可以通过合理设计或修改肽序列来调节其孔径大小和性能.功能基团和金属离子的引入进一步扩展了多肽基多孔材料的结构与性能.在这篇综述中,我们讨论了肽基多孔材料的设计、合成、组装及其性能,并综述了近年来其在不同领域的应用.

关键词：多孔材料药物递送氨基酸侧链自组装多孔结构功能基团金属离子孔径大小

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Host-Guest Strategy Enabling Nonhalogenated Solvent Processing for High-Performance All-Polymer Hosted Solar Cells

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Chinese Journal of Chemistry 2023年第9期41卷 1066-1074页

作者： Yuting Huang Haiyang Chen Qunping Fan Ziyuan Chen Junyuan Ding Heyi Yang Zhe Sun Rui Zhang Weijie Chen Changduk Yang Feng Gao Yaowen Li laboratory of Advanced Optoelectronic materials Suzhou Key Laboratory of Novel Semiconductor-optoelectronics Materials and DevicesCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China Jiangsu key laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhouJiangsu 215123China State and Local Joint Engineering laboratory for Novel functional polymeric materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China State key laboratory for Mechanical Behavior of materials Xi'an Jiaotong UniversityXi'anShaanxi 710049China Department of Energy Engineering School of Energy and Chemical EngineeringPerovtronics Research CenterLow Dimensional Carbon Materials CenterUlsan National Institute of Science and Technology(UNIST)UlsanRepublic of Korea Department of Physics Chemistry and Biology(IFM)Linkoping UniversityLinkopingSweden

The power conversion efficiencies(PCEs)of all-polymer solar cells(all-PSCs),usually processed from low-boiling-point and toxic sol-vents,have reached high values of 18%.However,poor miscibility and uncontrollable crystallinity in polymer blends lead to a nota-ble drop in the PCEs when using green solvents,limiting the practical development of ***,a third component(guest)BTO was employed to optimize the miscibility and enhance the crystallinity of PM6/PY2Se-F host film processed from green solvent toluene(TL),which can effectively suppress the excessive aggregation of PY2Se-F and facilitate a nano-scale interpenetrating net-work morphology for exciton dissociation and charge *** a result,TL-processed all-polymer hosted solar cells(all-PHSCs)exhibited an impressive PCE of 17.01%.Moreover,the strong molecular interaction between the host and guest molecules also en-hances the thermal stability of the *** host-guest strategy provides a unique approach to developing high-efficiency and stable all-PHSCs processed from green solvents,paving the way for the industrial development of all-PHSCs.

关键词： All-polymer solar cells Host-guest systems Crystal engineering Nonhalogenated green solvent Stability Morphology Miscibility Ternary blend solar cells

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