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marine Life Science & Technology 2024年第1期6卷 93-101页

作者： Juanjuan Su Hao Wu Chengying Yin Fengchao Zhang Feng Han Wengong Yu School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China laboratory for marine drugs and Bioproducts Qingdao Marine Science and Technology CenterQingdao 266237China key laboratory of marine drugs Ministry of EducationQingdao 266003China Shandong Provincial key laboratory of Glycoscience and Glycoengineering Qingdao 266003China

The application of chondroitinase requires consideration of the complex microenvironment of the *** previous research reported a marine-derived sodium dodecyl sulfate(SDS)-resistant chondroitinase *** study further investigated the mechanism of VhChlABC resistance to *** on the hydrophobic cluster on its strong hydrophilic surface,it was found that the reduction of hydrophobicity of surface residues Ala181,Met182,Met183,Ala184,Val185,and Ile305 significantly reduced the SDS resistance and *** dynamics(MD)simulation and molecular docking analysis showed that I305G had more conformational flexibility around residue 305 than wild type(WT),which was more conducive to SDS insertion and *** affinity of A181G,M182A,M183A,V185A and I305G to SDS was significantly higher than that of *** conclusion,the surface hydrophobic microenvironment composed of six residues was the structural basis for SDS *** feature could prevent the binding of SDS and the destruction of hydrophobic packaging by increasing the rigid conformation of protein and reducing the binding force of *** study provides a new idea for the rational design of SDS-resistant proteins and may further promote chondroitinase research in the targeted therapy of lung diseases under the pressure of pulmonary surfactant.

关键词： Hydrophobic cluster Protein surface SDS-resistance Chondroitinase

Recent Advances of Bioactive marine Natural Products in Drug Discovery

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Journal of Ocean University of China 2024年第5期23卷 1297-1318页

作者： ZHANG Qun LV Liuxia WANG Wenhui WEI Meiyan GU Yucheng SHAO Changlun key laboratory of marine drugs Ministry of Education of China School of Medicine and Pharmacy Ocean University of China laboratory for marine drugs and Bioproducts Qingdao Marine Science and Technology Center key laboratory of Tropical Medicinal Resource Chemistry of ministry of education College of Chemistry and Chemical Engineering Hainan Normal University Syngenta Jealott's Hill International Research Centre

marine natural products(MNPs) are valuable resources for drug development. To date, 17 drugs from marine sources are in clinical use, and 33 pharmaceutical compounds are in clinical trials. Presently the success of drug development from the marine resources is higher than the industry average. It is a feasible strategy to conduct the discovery of drug-lead compounds based on marine chemical ecology by fully exploiting the pharmacological potential of marine chemical defense matters. In the search for bioactive MNPs, our group has constructed a biological resources library including more than 1500 strains of fungi. Focusing on the strategy of Blue Drug Library, we have discovered a series of novel MNPs with abundant biological functions. Highly efficient and scalable total synthesis of(+)-aniduquinolone A(44) and pesimquinolone I(48) have been completed, which will facilitate access to sufficient quantities of candidates for in vivo pharmacological and toxicological studies. As a nucleoprotein(NP) inhibitor, QLA(75) possesses significant anti-influenza A virus(IAV) activities both in vitro and in vivo. CHNQD-00803(76) is a potent and selective AMPactivated kinase(AMPK) activator that can effectively inhibit metabolic disorders and metabolic dysfunction-associated steatohepatitis(MASH) progression. Moreover, we identified two new candidate molecules with potent anti-hepatocellular carcinoma effects. Particularly, as a natural guanine-nucleotide exchange factors for ADP-ribosylation factor GTPases(Arf-GEFs) inhibitor prodrug, CHNQD-01255(78) is qualified to be developed as a targeted candidate anticancer drug, which may be promising to apply for cancer immunotherapy. Hence, it is evident that MNPs play an important role in drug development.

关键词： discovery and optimization drug development marine drug marine medicinal organisms natural products

Sarcocinerenoids A—J,Eight Rare Capnosane-Type and Two New Cage-Type Cembranoids with Promoting Angiogenesis Activity from the South China Sea Soft Coral Sarcophyton cinereum

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Chinese Journal of Chemistry 2024年第8期42卷 815-822页

作者： Yue Mi Yanan Yang Xuli Tang Xiao Han Guoqiang Li key laboratory of marine drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong266003 China laboratory of marine drugs and Biological Products National Laboratory for Marine Science and TechnologyQingdaoShandong266235 China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdaoShandong266100 China

Backgroundand Originality Content,Cembranoids are a structurally diverse class of diterpenoids commonly occurring in marine and terrestrial organisms.(+)-Cembrene was the first reported cembranoid diterpenoid discovered in 1962,l and more than 1400 cembranoid diterpenoids have been identified in the last six decades,[2]Cembranoids are characterized by a 14-membered carbocyclic ring,an isopropyl group and three methyl groups,which form their core carbon *** processes such as oxidation,oxidative rearrangements and transannular cyclizations occur in organisms,leading to the formation of distinctive specialized metabolites such as epoxide,lactone,ester,furan,pyrane and other ringbased cembranoids.[2-3]

关键词： Soft coral Sarcophyton cinereum Capnosane-type cembranoids Absolute configurations Activities Natural products NMR spectroscopy Liquid chromatography X-raydiffraction Chiral resolution

Bioinspired synthesis of cochlearol B and ganocin A

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Chinese Chemical Letters 2024年第7期35卷 242-246页

作者： Zhenhao Wang Yuliang Tang Ruyu Li Shuai Tian Yu Tang Dehai Li key laboratory of marine drugs Chinese ministry of education/Sanya Oceanographic Institute Ocean University of ChinaQingdao 266003/Sanya 572025China laboratory for marine drugs and Bioproducts Pilot National Laboratory for Marine Science and TechnologyQingdao 266237China marine Biomedical Research Institute of Qingdao Ocean University of ChinaQingdao 266071China

Described here is a divergent,biosynthetically inspired synthesis of cochlearol B and ganocin *** steps of the synthesis include the chromene unit construction through a biomimetic acid-catalyzed[4+2]ring cyclization.A photochemical[2+2]cycloaddition was featured to construct the cyclobutane core of cochlearol *** skeletal rearrangements of cochlearol B afforded ganocin A,that one of them was Lewis acid mediated epoxide rearrangement and another was DDQ induced cyclobutane formed tetrahydrofuran *** described syntheses not only achieved these natural products in an efficient manner,but also provided insight into the biosynthetic relationship between the two different skeletons.

关键词： Biomimetic rearrangement Avarane skeleton Cascade reactions Lewis acid Total synthesis

Pyridapeptides F–I,cyclohexapeptides from marine sponge-derived Streptomyces ***-4539

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Chinese Chemical Letters 2024年第7期35卷 341-344页

作者： Shuige Zhao Pengcheng Yan Peipei Liu Haishan Liu Ning Li Peng Fu Weiming Zhu key laboratory of marine drugs Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China key laboratory for marine drugs and Bioproducts Laoshan LaboratoryQingdao 266237China School of Biological Science and Technology University of JinanJi'nan 250022China key laboratory for Biosensors of Shandong Province Biology InstituteQilu University of TechnologyJi'nan 250103China

Four new cyclohexapeptides,pyridapeptides F–I(1–4),were isolated from the fermentation broth of marine sponge-derived Streptomyces *** pyridapeptides F–H(1–3)are composed ofβ-hydroxyleucine,alanine,O-methylthreonine,hexahydropyridazine-3-carboxylic acid,5-hydroxytetrahydropyridazine-3-carboxylic acid,and(2S,3R,4E,6E)-2-amino-3–hydroxy-4,6-dienoic acid *** I(4)contains(2S,3R,4E,6E)-2-amino-3–hydroxy-8-methylnona-4,6-dienoic acid residue and a very rare glycose residue,*** structures were determined based on spectroscopic analysis and chemical *** G–I(2–4)have the 2,3,6-trideoxyhexose units glycosylated at theγ-OH-TPDA residue,displayed significant antiproliferative activity against four(PC9,MKN45,Hep G2,K562)or two(PC9,MKN45)human cancer cell lines.

关键词： marine microorganism Streptomyces Cyclopeptide glycosides Pyridapeptides Antiproliferative activity

Characterization,expression dynamics,and potential function of OPA1 for regulation of mitochondrial morphology during spermiogenesis in Phascolosoma esculenta

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Journal of Oceanology and Limnology 2024年第1期42卷 187-200页

作者： Xinming GAO Binbin FENG Chen DU Congcong HOU Shan JIN Daojun TANG Junquan ZHU key laboratory of Applied marine Biotechnology by the ministry of education and key laboratory of marine Biotechnology of Zhejiang Province School of Marine SciencesNingbo UniversityNingbo 315211China College of Ecology Lishui UniversityLishui 323000China

Mitochondria undergo morphological changes during spermatogenesis in some *** mechanism and role of mitochondrial morphology regulation,however,remain somewhat *** this study,we analyzed the molecular characteristics,expression dynamics and subcellular localization of optic atrophy protein 1(OPA1),a mitochondrial fusion and cristae maintenance-related protein,to reveal the possible regulatory mechanisms underlying mitochondrial morphology in Phascolosoma esculenta *** full-length cDNA of the *** opa1 gene(Pe-opa1)is 3743 bp in length and encodes 975 amino *** Pe-OPA1 protein is highly conservative and includes a transmembrane domain,a GTPase domain,two helical bundle domains,and a lipid-interacting *** and protein expression was higher in the coelomic fluid(a site of spermatid development)of male *** and increased first and then decreased from March to ***,their expression during the breeding stage was significantly higher than during the non-breeding stage,suggesting that Pe-OPA1 is involved in *** *** Pe-OPA1 protein was more abundant in components consisting of many spermatids than in components without,indicating that Pe-OPA1 mainly plays a role in the spermatid in coelomic ***,Pe-OPA1 was mainly detected in the spermatid *** experiments showed that the Pe-OPA1 are constitutively expressed and co-localized with mitochondria during spermiogenesis,suggesting its involvement in *** *** results provide evidence for Pe-OPA1's involvement in the regulation of mitochondrial morphology during spermiogenesis.

关键词： optic atrophy protein 1(OPA1) spermiogenesis Phascolosoma esculenta mitochondrial dynamics spermatid

Long-Chain Alkenones in the South Yellow Sea Sediments and Their Indicative Significance for Haptophytes Species

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Journal of Ocean University of China 2024年第5期23卷 1287-1296页

作者： XU Yakun YANG Xinxin XIAO Rui XING Lei key laboratory of marine Chemistry Theory and Engineering Technology Ministry of Education Ocean University of China laboratory of marine Ecology and Environment Science Qingdao National Laboratory for Marine Science and Technology

Long-chain alkenones（LCAs） have been widely used as important biomarkers in palaeoceanographic ***,the commonly used LCAs proxies are mainly based on C37alkenones,and it is still lack of the studies about the distribution and indications of LCAs with different chain lengths other than ***,the composition and distribution of LCAs were analyzed in surface sediments from the southern Yellow Sea（SYS） and a sedimentary core（A02-C） from the central Yellow Sea（YS）mud *** results showed that C37,C38and C39alkenones were the major LCAs in surface sediments of the SYS,and the relative contents of C38:2Et,C37:2Me,C37:3Me,C38:2Me,C38:3Et,C38:3Me,C39:2Et and C39:3Et were 18.3%-59.8%,22.6%-41.2%,7.4%-23.0%,6.6%-15.4%,3.8%-13.3 %,3.6%-8.7%,2.8%-6.0% and 0.7%-3.0%,*** the relationships of U38MeK-U38EtKand U37K'-U38EtKindicate that LCAs are mainly derived from Emiliania huxleyi（***）.High ratios of total C37alkenones to total C38alkenones(K37/K38)（1-1.2） were found in the central SYS,corresponding to the relatively high abundance of ***;while low ratios of K37/K38（0.7-0.9） were observed at nearshore area of the SYS where Gephyrocapsa oceanica（***） has relatively high *** spatial distribution of K37/K38ratio is also consistent with that of coccolithophores nannofossil in the *** addition,K37/K38ratio in core A02-C varied from 0.7 to 1.1 with a gradual decreasing trend during the past 5.5 *** suggests that the relative abundance of *** decreased gradually,caused by the changes in the Yellow Sea Warm Current（YSWC） and the East Asian Winter Monsoon（EAWM） during this period.

关键词： alkenones sediment southern Yellow Sea Yellow Sea Warm Current

Exceptional points enhance sensing in silicon micromechanical resonators

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Microsystems & Nanoengineering 2024年第1期10卷 17-25页

作者： Man-Na Zhang Lei Dong Li-Feng Wang Qing-An Huang key laboratory of MEMS of the ministry of education Southeast UniversityNanjing 210096China

Exceptional points(EPs)have recently emerged as a new method for engineering the response of open physical systems,that is,systems that interact with the *** systems at the EPs exhibit a strong response to a small ***,we show a method by which the sensitivity of silicon resonant sensors can be enhanced when operated at *** our experiments,we use a pair of mechanically coupled silicon micromechanical resonators constituting a parity-time(PT)-symmetric *** perturbations introduced on the mechanically coupled spring cause the frequency to split from the EPs into the PT-symmetric regime without broadening the two spectrum linewidths,and this frequency splitting scales with the square root of the perturbation *** overall signal-tonoise ratio is still greatly enhanced,although the measured noise spectral density of the EP sensing scheme has a slight increase comparable to the traditional *** results pave the way for resonant sensors with ultrahigh sensitivity.

关键词： resonant symmetric points

Constructing porous ZnFC-PA/PSF composite spheres for highly efficient Cs^(+) removal

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Journal of Environmental Sciences 2024年第9期143卷 126-137页

作者： Senjian Han Chao Gao Wenfeng Yan Yafei Guo Shiqiang Wang Tianlong Deng College of marine and Environmental Sciences Tianjin University of Science and TechnologyTianjin 300457China key laboratory of marine Resource Chemistry and Food Technology Ministry of EducationTianjin 300457China

Radioisotope leaking from nuclear waste has become an intractable problem due to its gamma radiation and strong water *** this work,a novel porous ZnFC-PA/PSF composite sphere was fabricated by immobilization of ferrocyanides modified zinc phytate into polysulfone(PSF)substrate for the treatment of Cs-contaminated *** maximum adsorption capacity of ZnFC-PA/PSF was 305.38 mg/g,and the removal efficiency of Cs+was reached 94.27%within 2 *** ZnFC-PA/PSF presented favorable stability with negligible dissolution loss of Zn^(2+)and Fe^(2+)(<2%).The ZnFC-PA/PSF achieved high-selectivity towards Cs+(K_(d)=2.24×10^(4)mL/g)even in actual geothermal *** adsorption mechanism was inferred to be the ion-exchange between Cs^(+)and K^(+).What’s more,ZnFC-PA/PSF worked well in the fixed-bed adsorption(E=91.92%),indicating the application potential for the hazardous Cs^(+)removal from wastewater.

关键词： Adsorption Cesium Metal ferrocyanide Composite adsorbent

Correlation of gut microorganisms and non-volatile flavor substances provides new insights for breeding Scylla paramamosain

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Journal of Oceanology and Limnology 2024年第4期42卷 1336-1347页

作者： Gao GAO Xing LI Kangxiang QIN Yun HU Xiaosong JIANG Chenxi CHE Yuntao LI Changkao MU Chunlin WANG Huan WANG School of marine Science Ningbo UniversityNingbo 315211China key laboratory of Applied marine Biotechnology Ministry of EducationNingbo UniversityNingbo 315211China

The farming of Scylla paramamosain with specific flavors has a higher commercial value,and the flavors are related to the integrated farming environment and non-volatile flavor substances,while the survival environment is one of the important ways to source gut microorganisms in the *** this study,the levels of dominant taxa in the gut flora of *** from Mong Cai,Vietnam(VN),Taishan City,Guangdong Province(TS)of China,and Ninghai County,Ningbo City(NB)Zhejiang Province of China converged with those of *** from Sanmen County,Ningbo City(CK 1,CK 2,and CK 3)at 28 d of *** top 15 genera with the highest abundance of VN,TS,and NB gut flora were the same as CK 1,CK 2,and CK 3,but with different percentages,and gradually converged to CK 1,CK 2,and CK 3,respectively,at 28 d of *** between intestinal flora and non-volatile flavor substances in the hepatopancreas at the percentage level of relative abundance of bacterial genera found that above 28 d of domestication,Muribaculaceae,Psychrilyobacter,Clostridia_vadinBB 60_group,Halarcobacter Carboxylicivirga,Sediminispirochaeta may be the most important genera affecting flavor amino acids of ***,Carboxylicivirga,Halarcobacter,Photobacterium,ZOR 0006,Psychrilyobacter,and Pseudomonas may be the most important genera affecting flavor amino acids of ***,Carboxylicivirga,Halarcobacter,Photobacterium,ZOR 0006,Vibrio,and Sphingomonas may be the most important genera affecting flavor amino acids of *** results show that the intestinal flora structure of crabs from different areas were domesticated in the same area for at least 28 d before they converged to that of the domesticated crab,and the most important genera affecting the flavor amino acids of TS,VN,and NB were also *** results of this study provide a reference and basis for the technique of directional cultivation of the flavor quality of the crab.

关键词： survival environment Scylla paramamosain intestinal flora structure non-volatile flavor substance directional breeding