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Superparamagnetic iron oxide nanoparticles assembled magnetic nanobubbles and their application for neural stem cells labeling

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Journal of Materials Science & Technology 2021年第4期63卷 124-132页

作者： Jing Li Zhenqiang Feng Ning Gu Fang Yang State key laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Sciences and Medical EngineeringSoutheast UniversityNanjing 210096China

Micro/nanobubbles for use as ultrasound contrast agents have been fabricated with different shell *** various biomedical nanoparticles have been embedded in the shells of bubbles,the composite structures have shown promising applications in multi-modal imaging,drug/gene delivery,and biomedical *** this study,we developed a new gas-liquid interface self-assembly method to prepare magnetic nanobubbles embedded with superparamagnetic iron oxide nanoparticles(SPIONs).The diameter of the generated assembled nanobubbles was 227.40±87.21 nm with a good polydispersity index(PDI)of *** the condition of 150 compression cycles,the nanobubble concentration could reach about 6.12×10^(9)/*** electron microscopy(TEM)and scanning electronic microscopy(SEM)demonstrated that the assembled nanobubbles had a hollow gas core with SPIONs adsorbed on the ***(US)imaging and magnetic resonance imaging(MRI)experiments indicated that the assembled magnetic nanobubbles exhibited good US and MR contrast ***,the assembled magnetic nanobubbles were used to label neural stem cells under ultrasound *** 40 s US exposure,the magnetic nanobubbles could be delivered into cells with 2.80 pg Fe per cell,which could be observed in the intracellular endosome by *** with common incubation methods,the ultrasound exposure method did not introduce the potential cytotoxicity of transfection reagents and the efficiency was about twice as high as the efficiency of ***,the assembled magnetic nanobubbles prepared through the pressure-driven gas-liquid interface assembly approach could be a potential US/MRI dual model imaging nanocarrier for regenerative applications.

关键词： magnetic shells bubble

Generating Kerr nonlinearity with an engineered non-Markovian environment

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Chinese Physics B 2020年第4期29卷 146-153页

作者： Fei-Lei Xiong Wan-Li Yang Mang Feng State key laboratory of magnetic resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071China Department of Physics Zhejiang Normal UniversityJinhua 321004China School of Physics and Engineering Zhengzhou UniversityZhengzhou 450001China

Kerr nonlinearity is an important resource for creating squeezing and entanglement in quantum *** we propose a scheme for generating Kerr nonlinearity originated from an engineered non-Markovian environment,which is different from the previous efforts using nonlinear media or quantum systems with special energy *** the present work,the generation of Kerr nonlinearity depends on the system-environment interaction time,the energy spectrum of the environment,and the system-environment coupling strength,regardless of the environmental initial *** scheme can be realized in systems originally containing no Kerr interaction,such as superconducting circuit systems,optomechanical systems,and cavity arrays connected by transmission lines.

关键词： Kerr nonlinearity quantum non-Markovianity engineered environment

Engineered AAV13 variants with enhanced transduction and confined spread

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Zoological Research 2024年第4期45卷 781-790页

作者： Neng-Song Luo Yu-Xiang Cai Zeng-Peng Han Xiao-Kai Sui Wen-Jia Yuan Zi-Lian Zhang Hao-Dong Guo Jie Wang Kun-Zhang Lin Fu-Qiang Xu Wuhan National laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Shenzhen key laboratory of Viral Vectors for Biomedicine Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China key laboratory of magnetic resonance in biological systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China key laboratory of Quality Control Technology for Virus-Based Therapeutics Guangdong Provincial Medical Products AdministrationNMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsBrain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China University of Chinese Academy of Sciences Beijing 100049China Zhongnan Hospital Wuhan UniversityWuhanHubei 430072China Brain Case Biotechnology Co. Ltd.ShenzhenGuangdong 518107China College of Life Sciences Wuhan UniversityWuhanHubei 430072China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Precise targeting of specific regions within the central nervous system(CNS)is crucial for both scientific research and gene therapy in the context of brain ***-associated virus 13(AAV13)is known for its restricted diffusion range within the CNS,making it an ideal choice for precise labeling and administration within small brain ***,AAV13 mediates relatively low expression of target ***,we introduced specifically engineered modifications to the AAV13 capsid protein to enhance its transduction *** first constructed AAV13-YF by mutating tyrosine to phenylalanine on the surface of the AAV13 *** then inserted the 7m8 peptide,known to enhance cell transduction,into positions 587/588 and 585/586 of the AAV13 capsid,resulting in two distinct variants named AAV13-587-7m8 and AAV13-585-7m8,*** found that AAV13-YF exhibited superior in vitro infectivity in HEK293T cells compared to AAV13,while AAV13-587-7m8 and AAV13-585-7m8 showed enhanced CNS infection capabilities in C57BL/6 mice,with AAV13-587-7m8 infection retaining a limited spread *** modified AAV13 variants hold promising potential for applications in gene therapy and neuroscience research.

关键词： Adeno-associated virus 13 AAV13-YF AAV13-587-7m8 AAV13-585-7m8 transduction efficiency

Observation of non-Markovianity at room temperature by prolonging entanglement in solids

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Science Bulletin 2018年第6期63卷 336-339页

作者： Shijie Peng Xiangkun Xu Kebiao Xu Pu Huang Pengfei Wang Xi Kong Xing Rong Fazhan Shi Changkui Duan Jiangfeng Du CAS key laboratory of Microscale magnetic resonance and Department of Modern Physics University of Science and Technology of China (USTC) Hefei 230026 China Hefei National laboratory for Physical Sciences at Microscale USTC Hefei 230026 China Synergetic Innovation Center of Quantum Information and Quantum Physics USTC Hefei 230026 China

Open quantum systems are always exposed to an external environment,which result in interacting and exchanging information between quantum systems and their *** dynamics of real open quantum systems are often expected to deviate from the idealized Markovian process of losing information to their surrounding environment and to exhibit non-Markovian

关键词：房间温度外部环境纠纷固体动力学系统信息理想化

FPGA based hardware platform for trapped-ion-based multi-level quantum systems

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Chinese Physics B 2023年第9期32卷 42-50页

作者：朱明东闫林秦熙张闻哲林毅恒杜江峰 CAS key laboratory of Microscale magnetic resonance and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Hefei National laboratory University of Science and Technology of ChinaHefei 230088China

We report a design and implementation of a field-programmable-gate-arrays(FPGA)based hardware platform,which is used to realize control and signal readout of trapped-ion-based multi-level quantum *** platform integrates a four-channel 2.8 Gsps@14 bits arbitrary waveform generator,a 16-channel 1 Gsps@14 bits direct-digital-synthesisbased radio-frequency generator,a 16-channel 8 ns resolution pulse generator,a 10-channel 16 bits digital-to-analogconverter module,and a 2-channel proportion integration differentiation *** hardware platform can be applied in the trapped-ion-based multi-level quantum systems,enabling quantum control of multi-level quantum system and highdimensional quantum *** platform is scalable and more channels for control and signal readout can be implemented by utilizing more parallel duplications of the *** hardware platform also has a bright future to be applied in scaled trapped-ion-based quantum systems.

关键词： FPGA hardware platform trapped-ion multi-level quantum system

Testing Evolution Equation for Entanglement of Two-Qubit systems in Noisy Channels on Ensemble Quantum Computers

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Chinese Physics Letters 2010年第9期27卷 20-23页

作者：张晗罗军任婷婷孙献平 State key laboratory of magnetic resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 Center for Cold Atom Physics Chinese Academy of Sciences Wuhan 430071 Graduate School of the Chinese Academy of Sciences Beijing 100049

We report the experimental demonstration of decoherence dynamics of entanglement for the four Bell states in two-qubit nuclear-spin systems on ensemble quantum computers. Using artificial error operators to simulate noisy channels, we experimentally investigate the effect of noises on the four Bell states, and furthermore observe the time evolution of entanglement for the four Bell states in different noisy channels by calculating concurrences. Our experimental results show that the concurrences of the different Bell states under the same artificial error operations have the same values within the experimental error, and are independent of the different Bell states. These experimental results verify the theoretical evolution equation developed by Konrad et al.

关键词： Experimentation Evolution Computers

An integrated microfluidics platform with high-throughput single-cell cloning array and concentration gradient generator for efficient cancer drug effect screening

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Military Medical Research 2023年第3期10卷 325-341页

作者： Biao Wang Bang-Shun He Xiao-Lan Ruan Jiang Zhu Rui Hu Jie Wang Ying Li Yun-Huang Yang Mai-Li Liu key laboratory of magnetic resonance in biological systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and Technology-Wuhan National Laboratory for OptoelectronicsChinese Academy of SciencesWuhan 430071China Department of laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Department of Hematology Renmin HospitalWuhan University Wuhan 430060China University of Chinese Academy of Sciences Beijing 10049China Canary Center at Stanford for Cancer Early Detection Department of RadiologySchool of MedicineStanford UniversityPalo AltoCA 94304USA

Background:Tumor cell heterogeneity mediated drug resistance has been recognized as the stumbling block of cancer *** the cytotoxicity of anticancer drugs at single-cell level in a high-throughput way is thus of great value for developing precision ***,current techniques suffer from limitations in dynamically characterizing the responses of thousands of single cells or cell clones presented to multiple drug ***:We developed a new microfluidics-based“SMART”platform that is Simple to operate,able to generate a Massive single-cell array and Multiplex drug concentrations,capable of keeping cells Alive,Retainable and Trackable in the *** features are achieved by integrating a Microfluidic chamber Array(4320 units)and a sixConcentration gradient generator(MAC),which enables highly efficient analysis of leukemia drug effects on single cells and cell clones in a high-throughput ***:A simple procedure produces 6 on-chip drug gradients to treat more than 3000 single cells or single-cell derived clones and thus allows an efficient and precise analysis of cell *** statistic results reveal that Imatinib(Ima)and Resveratrol(Res)combination treatment on single cells or clones is much more efficient than Ima or Res single drug treatment,indicated by the markedly reduced half maximal inhibitory concentration(IC50).Additionally,single-cell derived clones demonstrate a higher IC_(50) in each drug treatment compared to single ***,primary cells isolated from two leukemia patients are also found with apparent heterogeneity upon drug treatment on ***:This microfluidics-based“SMART”platform allows high-throughput single-cell capture and culture,dynamic drug-gradient treatment and cell response monitoring,which represents a new approach to efficiently investigate anticancer drug effects and should benefit drug discovery for leukemia and other cancers.

关键词： Microfluidics Single-cell analysis Leukemia High-throughput drug screening Single-cell cloning

Improved plasmon-assisted photoelectric conversion efficiency across entire ultraviolet-visible region based on antenna-on zinc oxide/silver three-dimensional nanostructured films

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Nano Research 2018年第1期11卷 520-529页

作者： Lijuan Yan Yang Liu Yaning Yan Lanfang Wang Juan Han Yanan Wang Guowei Zhou Mark T. Swihart Xiaohong Xu School of Chemistry and Materials Science of Shanxi Normal University & key laboratory of magnetic Molecules and magnetic Information Materials of Ministry of Education Linfen 041004 China Department of Chemical and biological Engineering University at Buffalo (SUNY) Buffalo New York 14260-4200 USA Research Institute of Materials Science of Shanxi Normal University Linfen 041004 China

ZnO has received tremendous attention for applications in photoelectrochemical water splitting, photocatalysis, and photovoltaic devices. However, the photoelectric conversion efficiency of ZnO is limited by the rapid recombination of photoexcited electron-hole pairs and the wide band gap, which allows only a small fraction of the solar spectrum to be absorbed. Recently, substantial research efforts have aimed to increase the photoelectric conversion efficiency across the entire ultraviolet-visible （UV-vis） spectrum by coupling semiconductors such as ZnO with noble metal nanoparticles （NPs）. In this stud~ we compare the performance of a pure ZnO film and ZnO/Ag nanostructured films as photoelectrodes. We show that under broad-spectrum UV-vis illumination, the photocurrent generated in the ZnO/Ag three-dimensional （3D） nanostructured films increases 3.75 times relative to the photocurrent generated in the pure ZnO films. We attribute the high photocurrent to the electric-field enhancement associated with the localized surface plasmon resonance of the Ag NPs, which are present at a high density in the 3D nanostructured films, and to the creation of photoexcited hot electrons in Ag that are transferred to ZnO, promoting electron-hole pair separation. We propose a mechanism to explain the observed enhancement of the photoelectric conversion efficiency.

关键词： photoelectric conversionefficiency localized surface plasmonresonance ZnO/Ag nanostructuredfilms Ag nanoparticles

Microfluidics-based strategies for molecular diagnostics of infectious diseases

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Military Medical Research 2022年第6期9卷 727-753页

作者： Xin Wang Xian-Zhe Hong Yi-Wei Li Ying Li Jie Wang Peng Chen Bi-Feng Liu The key laboratory for Biomedical Photonics of MOE at Wuhan National laboratory for Optoelectronics-Hubei Bioinformatics&Molecular Imaging key laboratory Systems Biology ThemeDepartment of Biomedical EngineeringCollegeof Life Science and TechnologyHuazhong University of Scienceand TechnologyWuhan 430074China State key laboratory of magnetic resonance and Atomic Molecular Physics Wuhan National Laboratory for OptoelectronicsNational Centre for Magnetic Resonancein WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430071China Department of Radiology Canary Center at Stanford for Cancer Early DetectionSchool of MedicineStanford UniversityPalo AltoCA 94304USA

Traditional diagnostic strategies for infectious disease detection require benchtop instruments that are inappropriate for point-of-care testing(POCT). Emerging microfluidics, a highly miniaturized, automatic, and integrated technology,are a potential substitute for traditional methods in performing rapid, low-cost, accurate, and on-site *** diagnostics are widely used in microfluidic devices as the most effective approaches for pathogen *** review summarizes the latest advances in microfluidics-based molecular diagnostics for infectious diseases from academic perspectives and industrial outlooks. First, we introduce the typical on-chip nucleic acid processes,including sample preprocessing, amplification, and signal read-out. Then, four categories of microfluidic platforms are compared with respect to features, merits, and demerits. We further discuss application of the digital assay in absolute nucleic acid quantification. Both the classic and recent microfluidics-based commercial molecular diagnostic devices are summarized as proof of the current market status. Finally, we propose future directions for microfluidics-based infectious disease diagnosis.

关键词： Microfluidics Molecular diagnostics Infectious disease Point-of-care testing(POCT) Digital assay