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Neuroscience Bulletin 2020年第3期36卷 202-216页

作者： Xutao Zhu Kunzhang Lin Qing Liu Xinpei Yue Huijie Mi Xiaoping Huang Xiaobin He Ruiqi Wu Danhao Zheng Dong Wei Liangliang Jia Weilin Wang Anne Manyande Jie Wang Zhijian Zhang Fuqiang Xu Shenzhen key Lab of Neuropsychiatric Modulation and Collaborative Innovation Center for Brain Science Guangdong Provincial Key Laboratory of Brain Connectome and BehaviorCAS Center for Excellence in Brain Science and Intelligence TechnologyBrain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China State key laboratory of magnetic resonance and Atomic and Molecular Physics Key Laboratory of Magnetic Resonance in Biological SystemsWuhan Center for Magnetic ResonanceWuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071China Wuhan National laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430071China College of Life Sciences Wuhan UniversityWuhan 430071China School of Human and Social Sciences University of West LondonLondonUK University of the Chinese Academy of Sciences Beijing 100049China

Efficient viral vectors for mapping and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain. The SAD strain rabies virus with the glycoprotein gene deleted pseudotyped with the N2 C glycoprotein(SAD-RV(DG)-N2 C(G)) shows strong neuro-tropism in cell culture, but its in vivo efficiency for retrograde gene transduction and neuro-tropism have not been systematically *** compared these features in different mouse brain regions for SAD-RV-N2 C(G) and two other widely-used retrograde tracers, SAD-RV(DG)-B19(G) and r AAV2-retro. We found that SAD-RV(DG)-N2 C(G) enhanced the infection efficiency of long-projecting neurons by^10 times but with very similar neuro-tropism, compared with SAD-RV(DG)-B19(G). On the other hand, SAD-RV(DG)-N2 C(G) had an infection efficiency comparable with r AAV2-retro, but a more restricted diffusion range, and broader tropism to different types and regions of longprojecting neuronal populations. These results demonstrate that SAD-RV(DG)-N2 C(G) can serve as an effective retrograde vector for studying neuronal circuits.

关键词： Viral vector N2C glycoprotein Neuronal circuits Retrograde tracing

Mathematical modeling reveals the mechanisms of feedforward regulation in cell fate decisions in budding yeast

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Frontiers of Electrical and Electronic Engineering in China 2015年第2期10卷 55-68页

作者： Wenlong Li Ming Yi Xiufen Zou School of Mathematics and Statistics Wuhan University Wuhan 430072 China key laboratory of magnetic resonance in biological systems Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 China Department of Physics College of Science Huazhong Agricultural University Wuhan 430070 China

The determination of cell fate is one of the key questions of developmental biology. Recent experiments showed that feedforward regulation is a novel feature of regulatory networks that controls reversible cellular transitions. However, the underlying mechanism of feedforward regulation-mediated cell fate decision is still unclear. Therefore, using experimental data, we develop a full mathematical model of the molecular network responsible for cell fate selection in budding yeast. To validate our theoretical model, we first investigate the dynamical behaviors of key proteins at the Start transition point and the G1/S transition point; a crucial three-node motif consisting of cyclin （Clnl/2）, Substrate/Subunit Inhibitor of cyclin-dependent protein kinase （Sic1） and cyclin B （C165/6） is considered at these points. The rapid switches of these important components between high and low levels at two transition check points are demonstrated reasonably by our model. Many experimental observations about cell fate decision and cell size control are also theoretically reproduced. Interestingly, the feedforward regulation provides a reliable separation between different cell fates. Next, our model reveals that the threshold for the amount of WHiskey OVhi5） removed from the nucleus is higher at the Reentry point in pheromone-arrested cells compared with that at the Start point in cycling cells. Furthermore, we analyze the hysteresis in the cell cycle kinetics in response to changes in pheromone concentration, showing that Cln3 is the primary driver of reentry and Clnl/2 is the secondary driver of reentry. In particular, we demonstrate that the inhibition of C1nl/2 due to the accumulation of Factor ARrest （Far1） directly reinforces arrest. Finally, theoretical work verifies that the three-node coherent feedforward motif created by cell FUSion （Fus3）, Farl and STErile （Stel2） ensures the rapid arrest and reversibility of a cellular state. The combination of our theoretical model

关键词： cell fate decision feedforward mechanism mathematical modeling hysteresis reversibility

First-principles calculations of 5d atoms doped hexagonal-AlN sheets: Geometry, magnetic property and the influence of symmetry and symmetry-breaking on the electronic structure

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Chinese Physics B 2014年第1期23卷 324-329页

作者：汤富领刘冉薛红涛路文江冯煜东芮执元黄敏 State key laboratory of Gansu Advanced Non-ferrous Metal Materials Department of Materials Science and EngineeringLanzhou University of Technology Science and Technology on Surface Engineering laboratory Lanzhou Institute of Physics State key laboratory of magnetic resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences

The geometry, electronic structure and magnetic property of the hexagonal AlN(h-AlN) sheet doped by 5d atoms(Lu, Hf, Ta, W, Re, Os, Ir, Pt, Au and Hg) are investigated by first-principles calculations based on the density functional theory. The influence of symmetry and symmetry-breaking is also studied. There are two types of local symmetries of the doped systems: C3v and D3h. The symmetry will deviate from exact C3v and D3h for some particular dopants after optimization. The total magnetic moments of the doped systems are 0μBfor Lu, Ta and Ir; 1μB for Hf, W, Pt and Hg; 2μB for Re and Au; and 3μB for Os and Al-vacancy. The total densities of state are presented, where impurity energy levels exist. The impurity energy levels and total magnetic moments can be explained by the splitting of 5d orbitals or molecular orbitals under different symmetries.

关键词： hexagonal-AlN sheet first-principles calculations 5d atoms symmetry and symmetry-breaking

Anatomical Evidence for the Neural Connection from the Emotional Brain to Autonomic Innervation in the Anterior Chamber Structures of the Eye

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Current Medical Science 2022年第2期42卷 417-425页

作者： Lin MA Fang YANG Qing LIU Xu-tao ZHU Xin LIU Sen JIN Hua-dong WANG Lei PEI Fu-qiang XU Hai-xia LIU Department of Ophthalmology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430033China Shenzhen key laboratory of Viral Vectors for Biomedicine the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China University of Chinese Academy of Sciences Beijing100049China State key laboratory of magnetic resonance and Atomic and Molecular Physics Key Laboratory of Magnetic Resonance in Biological SystemsWuhan Center for Magnetic ResonanceInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan430071China The Institute for Brain Research Collaborative Innovation Center for Brain ScienceHuazhong University of Science and TechnologyWuhan430074China

Objective Previous studies have shown that the autonomic nervous system(ANS),which can be affected by emotions,is important in the occurrence or progression of *** autonomic innervation distributed in the anterior chamber(AC)structures might play an efferent role in the neural regulation of intraocular pressure(IOP).This study aimed to investigate the anatomic neural connection from the emotional brain to autonomic innervation in the *** A retrograde trans-multisynaptic pseudorabies virus encoded with an enhanced green fluorescent protein(PRV531)and non-trans-synaptic tracer FAST Dil were injected into the right eye of mice,*** localization in the emotional brain and preganglionic nuclei was *** and a half days after PRV531 injection into the right AC,fluorescent signals were observed in several emotional brain regions,including the amygdala,agranular insular cortex,lateral septal nuclei,periaqueductal gray,and *** preganglionic nuclei,including Edinger-Westphal nucleus,superior salivatory nucleus,and intermediolateral nucleus,were labeled using *** The sensory trigeminal nuclei were not labeled using *** fluorescence signals in the nuclei mentioned above showed bilateral distribution,primarily on the ipsilateral *** days after injecting FAST Dil into the AC,we observed no FAST Dil-labeled neurons in the central nervous *** Our results indicate a neural connection from the emotional brain to autonomic innervation in the AC,which provides anatomical support for the emotional influence of IOP via the ANS.

关键词： intraocular pressure emotional brain amygdala anterior chamber autonomic innervation

Sensitivity of energy eigenstates to perturbation in quantum integrable and chaotic systems

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Communications in Theoretical Physics 2021年第1期73卷 40-44页

作者： Zao Xu Yin-Chenguang Lyu Jiaozi Wang Wen-Ge Wang Department of Modern Physics University of Science and Technology of ChinaHefei 230026China CAS key laboratory of Microscale magnetic resonance University of Science and Technology of ChinaHefei 230026China

We study the sensitivity of energy eigenstates to small perturbation in quantum integrable and chaotic *** is shown that the distribution of rescaled components of perturbed states in unperturbed basis exhibits qualitative difference in these two types of systems:being close to the Gaussian form in quantum chaotic systems,while,far from the Gaussian form in integrable systems.

关键词： quantum chaos sensitivity to perturbation energy eigenstates statistics

A new anterograde trans-synaptic tracer based on Sindbis virus

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Neural Regeneration Research 2022年第12期17卷 2761-2764页

作者： Xiang-Wei Shi Fan Jia Pei Lyu Fu-Qiang Xu State key laboratory of magnetic resonance and Atomic and Molecular Physics Key Laboratory of Magnetic Resonance in Biological SystemsWuhan Center for Magnetic ResonanceInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei ProvinceChina Guangdong Provincial key laboratory of Brain Connectome and Behavior CAS Key Laboratory of Brain Connectome and Manipulationthe Brain Cognition and Brain Disease Institute(BCBDI)Translational Research Center for the Nervous System(TRCNS)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhenGuangdong ProvinceChina NMPA key laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal Products Key Laboratory of Quality Control Technology for Virus-Based TherapeuticsGuangdong Provincial Medical Products AdministrationShenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese Academy of Sciences BeijingChina Wuhan National laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei ProvinceChina

Mapping neural circuits is critical for understanding the structure and function of the nervous *** viruses are a valuable tool for tracing neural ***,current tracers do not fully meet the needs for this approach because of various drawbacks,such as toxicity and characteristics that are difficult to ***,there is an urgent need to develop a new tracer with low toxicity and that allows for long-term *** this study,we constructed an engineered Sindbis virus(SINV)expressing enhanced green fluorescent protein(EGFP)reporter gene(SINV-EGFP)and found that it had no significant difference in biological characterization compared with the wild-type Sindbis virus in BHK-21 cells and neurons in *** injected the virus into the visual circuit of mouse brain and found that the virus infected neurons in the local injected site and anterogradely spread in the neural *** the efficiency of transmission was limited,the findings demonstrate that SINV can be used as a new anterograde tracer to map neural circuits in mouse brain and that it spreads exclusively in the anterograde ***,use of SINV in mouse brain research will provide longer time windows for circuit tracing than is possible with herpes simplex virus and vesicular stomatitis virus tracers.

关键词： anterograde lateral geniculate nucleus mouse brains neural circuit neurons retina Sindbis virus superior colliculus synapse tracer

Properties of One-Dimensional Highly Polarized Fermi Gases

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Chinese Physics Letters 2018年第11期35卷 6-10页

作者： Ya-Dong Song Xiao-Ming Cai State key laboratory of magnetic resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071 School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049

Using both the exact Bethe ansatz method and the variational method, we study properties of the one-dimensional Fermi polaron. We focus on the binding energy, effective mass, momentum distributions, Tan contact and correlation functions. As the attraction increases, the impurity is more tightly bound and correlated with the surrounding particles, and the size of formed polaron decreases. In addition, compared with the Bethe ansatz method, the variational method is totally qualified to study the one-dimensional Fermi polaron. The intrinsic reason is that the number of particle-hole excitations in a Fermi sea, caused by a single impurity, is always rather small. The variational method can be well extended to other impurity systems.

关键词： Properties of One-Dimensional Highly Polarized Fermi Gases As

Extreme Ultraviolet Frequency Comb with More than 100μW Average Power below 100nm

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Chinese Physics Letters 2020年第12期37卷 48-51页

作者： Jin Zhang Lin-Qiang Hua Zhong Chen Mu-Feng Zhu Cheng Gong Xiao-Jun Liu State key laboratory of magnetic resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

Extreme ultraviolet(XUV)frequency comb is a powerful tool in precision *** also brings many new opportunities to the field of strong field physics since high harmonic generation related phenomena can be studied with high repetition *** demonstrate the generation of an XUV frequency comb with the aid of intra-cavity high harmonic generation *** setup is driven by a high power infrared frequency comb,and an average power of 4.5 kW is reached in the femtosecond enhancement *** Xe gas as the working media,harmonics up to the 19th order are *** measurement indicates that as much as 115.9μW(1.3 mW)are generated at^94 nm(~148 nm).The shortest wavelength we can reach is^55 *** coherence of the generated light is tested with an optical-heterodyne-based measurement of the third *** resulted line width is^3 *** addition,with this system,we also observe a strong suppression of below threshold harmonics from O2 compared to that from *** results suggest that the current system is ready for precision spectroscopic measurements with few-electron atomic and molecular systems in XUV region as well as the study of strong field physics with an unprecedented 100 MHz repetition rate.

关键词： process. harmonic harmonics

Narrowband switchable dual-passband atomic filter with four-wave mixing optical amplification

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Chinese Optics Letters 2011年第2期9卷 53-56页

作者：谭政孙献平罗军程雍王谨詹明生 State key laboratory of magnetic resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan National Laboratory for Optoelectronics Center for Cold Atom Physics Chinese Academy of Sciences Graduate University of the Chinese Academy of Sciences

By using Faraday optical filter combined with four-wave mixing （FWM） amplifier, a narrow bandwidth optical amplifying atomic filter with switchable dual-passband is demonstrated experimentally. The two transmission peaks of the filter correspond to the Stokes and anti-Stokes frequencies, exhibiting a Raman gain in 13- and 17-fold, respectively, with bandwidth of ～120 MHz. By properly setting pump laser detuning, switching between filter passbands is realized. We also investigate the dependence of peak transmission on both pump laser intensity and Rb cell temperature. This atomic filter can find practical applications in long-distance laser communications and laser remote-sensing systems.

关键词： Atoms Bandwidth Pumping (laser) Remote sensing Rubidium