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Solution structure of the RNA recognition domain of METTL3-METTL14 N^6-methyladenosine methyltransferase

Protein & Cell 2019年第4期10卷 272-284页

作者： Jinbo Huang Xu Dong Zhou Gong Ling-Yun Qin Shuai Yang Yue-Ling Zhu Xiang Wang Delin Zhang Tingting Zou Ping Yin Chun Tang National key laboratory of Crop Genetic Improvement and National Center of Plant Gene Research Huazhong Agricultural UniversityWuhan 430070China CAS key laboratory of magnetic Resonanee in biological systems State Key Laboratory of Magnetic Resonance and Atomic Molecular Physicsand National Center for Magnetic Resonance at WuhanWuhan Institute of Physics and Mathematics of the Chinese Academy of SciencesWuhan 430071China

N^6-methyladenosine(m6A),a ubiquitous RNA modification,is installed by METTL3-METTL14 *** structure of the heterodimeric complex between the methyltransferase domains(MTDs)of METTL3 and METTL14 has been previously ***,the MTDs alone possess no enzymatic *** we present the solution structure for the zinc finger domain(ZFD)of METTL3,the inclusion of which fulfills the methyltransferase activity of *** show that the ZFD specifically binds to an RNA containing 5'-GGACU-3'consensus sequence,but does not to one *** ZFD thus serves as the target recognition domain,a structural feature previously shown for DNA methyltransferases,and cooperates with the MTDs of METTL3-METTL14 for ***,the interaction between the ZFD and the specific RNA is extremely weak,with the binding affinity at several hundred micromolar under physiological *** ZFD contains two CCCH-type zinc fingers connected by an anti-parallel *** analysis and NMR titrations have mapped the functional interface to a contiguous *** a division of labor,the RNA-binding interface comprises basic residues from zinc finger 1 and hydrophobic residues fromβ-sheet and zinc finger *** we show that the linker between the ZFD and MTD of METTL3 is flexible but partially folded,which may permit the cooperation between the two domains during ***,the structural characterization of METTL3 ZFD paves the way to elucidate the atomic details of the entire process of RNA m6A modification.

关键词： RNA modification N^6-methyladenosine,METTL3 target recognition domain zinc finger paramagnetic relaxation enhancement

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Facile Synthesis of Novel Perfluorocarbon-Modulated 4-Anilinoquinazoline Analogues

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Chinese Journal of Chemistry 2017年第11期35卷 1693-1700页

作者： Huiping Shi Bonan Lai Shizhen Chen Xin Zhou Jing Nie Jun-An Ma Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic Sciences Tianjin University Tianjin 300072 China Collaborative Innovation Center of Chemical Science andEngineering Tianjin 300072 China key laboratory of magnetic resonance in biological systems State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in Wuhan Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan Hubei 430071 China

4-Anilinoquinazoline analogues stand out among many kinds of small molecules that inhibit the tyrosine kinase activities of epidermal growth factor receptor （EGFR）, thus serving as significant molecular targets for anticancer drug design. Herein, a series of novel perfluorocarbon （PFC） modulated 4-anilinoquinazolines were designed and prepared straightforwardly by nucleophilic substitution reaction of various anilinoquinazolines and PFC-derived methanesulfonate. In the presence of base, the reaction proceeded smoothly to afford a wide range of 4-anilino- quinazolines with different substituents on aniline moiety in good to high yields. Furthermore, the PFC-modified analogues of gefitinib and erlotinib were also obtained in 93% and 90% respectively, which may have potential for developing new inhibitors of the epidermal growth factor receptor （EGFR） tyrosine kinase and fluorinated contrast agents （CA） for 19F MRI.

关键词： 4-anilinoquinazolines perfluorocarbon (PFC) nucleophilic substitution reaction synthesis epidermalgrowth factor receptor (EGFR)

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Li Plating on Carbon Electrode Surface Probed by Low-Field Dynamic Nuclear Polarization ^(7)Li NMR

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Chinese Physics Letters 2021年第12期38卷 33-37页

作者： Zhekai Zhang Jiyu Tian Junfei Chen Yugui He Chaoyang Liu Xinmiao Liang Jiwen Feng State key laboratory of magnetic resonance and Atomic and Molecular Physics Wuhan Center for Magnetic ResonanceKey Laboratory of Magnetic Resonance in Biological SystemsWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power SourcesWuhan UniversityWuhan 430072China

Lithium deposition on graphite electrode not only reduces fast-charging capability of lithium ion batteries but also causes safety ***,a low-field^(7)Li dynamic nuclear polarization(DNP)is used to probe Li plating on the surfaces of three types of carbon electrodes:hard carbon,soft carbon and *** to the strong Fermi contact interaction between^(7)Li and conduction electrons,the^(7)Li nuclear-magnetic-resonance(NMR)signal of Li metal deposited on electrode surface could be selectively enhanced by *** is suggested that low-field^(7)Li DNP spectroscopy is a sensitive tool for investigating Li deposition on electrodes during charging/discharging processes.

关键词： NMR electrode charging

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Evaluation of injuries caused by coronavirus disease 2019 using multi-nuclei magnetic resonance imaging

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magnetic resonance Letters 2021年第1期1卷 2-10页

作者： Qian Zhou Qiuchen Rao Haidong Li Ming Zhang Xiuchao Zhao Lei Shi Chaohui Ye Xin Zhou key laboratory of magnetic resonance in biological systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan430071China University of Chinese Academy of Sciences Beijing100049China

The ongoing pandemic of coronavirus disease 2019(COVID-19)has been a great burden for the healthcare system in many countries because of its high transmissibility,severity,and *** radiography and computed tomography(CT)play a vital role in the diagnosis,detection of complications,and prognostication of ***,magnetic resonance imaging(MRI),especially multi-nuclei MRI,is another important imaging technique for disease diagnosis because of its good soft tissue contrast and the ability to conduct structural and functional imaging,which has also been used to evaluate COVID-19-related organ injuries in previous ***,we briefly reviewed the recent research on multi-nuclei MRI for evaluating injuries caused by COVID-19 and the clinical 1 H MRI techniques and their applications for assessing injuries in lungs,brain,and ***,the emerging hyperpolarized 129Xe gas MRI and its applications in the evaluation of pulmonary structures and functional abnormalities caused by COVID-19 were also reviewed.

关键词： COVID-19 Multi-nuclei MRI Hyperpolarized 129Xe Lung Brain Heart

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Quantum metrology with single spins in diamond under ambient conditions

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National Science Review 2018年第3期5卷 346-355页

作者： Ming Chen Chao Meng Qi Zhang Changkui Duan Fazhan Shi Jiangfeng Du key laboratory of Microscale magnetic resonance and Department of Modern Physics University of Science and Technology of China

The detection of single quantum systems can reveal information that would be averaged out in traditional techniques based on ensemble measurements. The nitrogen-vacancy(NV) centers in diamond have shown brilliant prospects of performance as quantum bits and atomic sensors under ambient conditions, such as ultra-long coherence time, high fidelity control and readout of the spin state. In particular, the sensitivity of the NV center spin levels to external environmental changes makes it a versatile detector capable of measuring various physical quantities, such as temperature, strain, electric fields and magnetic fields. In this paper, we review recent progress in NV-based quantum metrology, and speculate on its future.

关键词： diamond nitrogen-vacancy centers quantum metrology quantum sensing quantum information process

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ROBUST DEPENDENCE MEASURE FOR DETECTING ASSOCIATIONS IN LARGE DATA SET

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Acta Mathematica Scientia 2018年第1期38卷 57-72页

作者：蒋杭进吴琼莉 University of Chinese Academy of Sciences Beijing 100049 China key laboratory of magnetic resonance in biological systems Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 China

In this paper, we proposed a new statistical dependency measure for two random vectors based on copula, called copula dependency coefficient （CDC）. The CDC is proved to be robust to outliers and easy to be implemented. Especially, it is powerful and applicable to high-dimensional problems. All these properties make CDC practically important in related applications. Both experimental and application results show that CDC is a good robust dependence measure for association detecting.

关键词： CDC dependence measure EDC association large dataset robust

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Conformational dynamics in GPCR signaling by NMR

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magnetic resonance Letters 2022年第3期2卷 139-146页

作者： Yunfei Hu Changwen Jin Joint laboratory of the National Centers for magnetic resonance in Wuhan and in Beijing Wuhan430071China Beijing Nuclear magnetic resonance Center College of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China State key laboratory of magnetic resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanKey Laboratory of Magnetic Resonance in Biological SystemsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan430071China

G-protein-coupled receptors(GPCRs)mediate a wide range of cellular responses to various ligands or stimuli,and are the most important drug targets associated with human *** major advances in GPCR structural biology have greatly deepened our understanding of its activation mechanism,the highly complex changes in the structural dynamics of GPCRs during activation remain underdetermined and their links to physiological functions largely *** nuclear magnetic resonance(NMR)spectroscopy is an essential technique that allows the characterization of protein structural dynamics at atomic level,and has been applied in the studies of GPCR structural-function relationship in the past ***,we summarize a few specific studies in which solution NMR methods were employed and provided novel insights into questions difficult to be addressed by other methods.

关键词： G-protein-coupled receptor(GPCR) Membrane protein Dynamics Nuclear magnetic resonance(NMR) Cell signaling

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Neuronal Network Dissection with Neurotropic Virus Tracing

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Neuroscience Bulletin 2020年第3期36卷 199-201页

作者： Xiaoping Rao Jie Wang Center of Brain Science State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanKey Laboratory of Magnetic Resonance in Biological SystemsWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China The Second Hospital of Shijiazhuang Shijiazhuang 050051China

The brain is a marvel of biological evolution,a highly complex organ including hundreds of different types of about 100 billion *** the structure and function of the brain is one of the most challenging scientific questions in the 21st ***,the structure of neural circuits and the mechanisms of neuronal information processing related to brain function are still poorly understood[1].A neural circuit is composed of a large number of synaptically connected neurons of different types and *** is the structural basis for the execution of various functions,such as perception,emotion,memory,and imagination,as well as other *** the structure of neural circuits is the basic premise for understanding the mechanism of information processing in the brain[2].

关键词： neural hundreds function

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Understanding Rotational Mode Specificity in the O（3P）+CHD3→OH+CD3 Reaction by Simple Reactant Alignment Pictures

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Chinese Journal of Chemical Physics 2019年第1期32卷 46-52,I0001页

作者： Rui Liu Hong-wei Song Ming-hui Yang key laboratory of magnetic resonance in biological systems National Center for Magnetic Resonance in Wuhan State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 China

The mode specificity plays an important role in understanding the fundamental reaction dynamics. This work reports a theoretical study of the rotational mode specificity of the reactant CHD3(JK) in the prototypical hydrocarbon oxidation reaction O(3P)+CHD3→OH+CD3. The time-dependent quantum wave packet method combined with a seven-dimensional reduced model is employed to calculate the reaction probability on an accurate potential energy surface. The obtained reaction probability depends on the values of both K and Ktot with PKtot=K=0>PKtot=K=J>PKtot=J,K=0=PKtot=0,K=J. This observation can be well rationalized by the reactant alignment pictures. Rotational excitations of CHD3 up to the angular momentum quantum number J=4 have a very weak enhancement effect on the reaction except for the state (J=4, K=0). In addition, the rotationally excited states of CHD3 with K=0 promote the reaction more than those with K=J. The quantum dynamics calculations indicate that the K=0 enhancements are mainly caused by the contributions from the components with K=Ktot=0. The components correspond to the tumbling rotation of CHD3, which enlarges the range of the reactive initial attack angles.

关键词： Polyatomic reaction Rotational excitation Time-dependent wave packet

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Balancing sub‐reaction activity to boost electrocatalytic urea synthesis using a metal‐free electrocatalyst

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Carbon Energy 2023年第10期5卷 40-49页

作者： Chen Chen Shuang Li Xiaorong Zhu Shuowen Bo Kai Cheng Nihan He Mengyi Qiu Chao Xie Dezhong Song Youzhen Liu Wei Chen Yafei Li Qinghua Liu Conggang Li Shuangyin Wang State key laboratory of Chem/Bio‐Sensing and Chemometrics Advanced Catalytic Engineering Research Center of the Ministry of EducationCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaChina College of Chemistry and Materials Science Nanjing Normal UniversityNanjingChina National Synchrotron Radiation laboratory University of Science and Technology of ChinaHefeiChina key laboratory of magnetic resonance in biological systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in Wuhan Collaborative Innovation Center of Chemistry for Life SciencesWuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhanChina

Electrocatalytic urea synthesis via coupling of nitrate with CO_(2)is considered as a promising alternative to the industrial urea synthetic ***,the requirement of sub-reaction(NO_(3)RR and CO_(2)RR)activities for efficient urea synthesis is not clear and the related reaction mechanisms remain ***,the construction,breaking,and rebuilding of the sub-reaction activity balance would be accompanied by the corresponding regulation in urea synthesis,and the balance of sub-reaction activities was proven to play a vital role in efficient urea *** rational design,a urea yield rate of 610.6 mg h−1 gcat.−1 was realized on the N-doped carbon electrocatalyst,superior to that of noble-metal *** on the operando SRFTIR measurements,we proposed that urea synthesis arises from the coupling of^(*)NO and^(*)CO to generate the key intermediate of^(*)*** work provides new insights and guidelines into urea synthesis from the aspect of activity balance.

关键词： activity balance C-N coupling electrocatalysis metal‐free urea synthesis

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